LOCUS       NM_001396034            6326 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily A member 3
            (Abca3), mRNA.
ACCESSION   NM_001396034 XM_220219
VERSION     NM_001396034.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6326)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   2  (bases 1 to 6326)
  AUTHORS   Whitsett,J.A., Wert,S.E. and Xu,Y.
  TITLE     Genetic disorders of surfactant homeostasis
  JOURNAL   Biol Neonate 87 (4), 283-287 (2005)
   PUBMED   15985750
  REMARK    Review article
REFERENCE   3  (bases 1 to 6326)
  AUTHORS   Wulf,G.G., Modlich,S., Inagaki,N., Reinhardt,D., Schroers,R.,
            Griesinger,F. and Trumper,L.
  TITLE     ABC transporter ABCA3 is expressed in acute myeloid leukemia blast
            cells and participates in vesicular transport
  JOURNAL   Haematologica 89 (11), 1395-1397 (2004)
   PUBMED   15531465
REFERENCE   4  (bases 1 to 6326)
  AUTHORS   Yoshida,I., Ban,N. and Inagaki,N.
  TITLE     Expression of ABCA3, a causative gene for fatal surfactant
            deficiency, is up-regulated by glucocorticoids in lung alveolar
            type II cells
  JOURNAL   Biochem Biophys Res Commun 323 (2), 547-555 (2004)
   PUBMED   15369786
  REMARK    GeneRIF: These findings demonstrate that glucocorticoid-induced
            up-regulation of ABCA3 expression in vivo is mediated by
            transcriptional activation through the GRE in the promoter.
REFERENCE   5  (bases 1 to 6326)
  AUTHORS   Salaun,B., de Saint-Vis,B., Pacheco,N., Pacheco,Y., Riesler,A.,
            Isaac,S., Leroux,C., Clair-Moninot,V., Pin,J.J., Griffith,J.,
            Treilleux,I., Goddard,S., Davoust,J., Kleijmeer,M. and Lebecque,S.
  TITLE     CD208/dendritic cell-lysosomal associated membrane protein is a
            marker of normal and transformed type II pneumocytes
  JOURNAL   Am J Pathol 164 (3), 861-871 (2004)
   PUBMED   14982840
REFERENCE   6  (bases 1 to 6326)
  AUTHORS   Mulugeta,S., Gray,J.M., Notarfrancesco,K.L., Gonzales,L.W.,
            Koval,M., Feinstein,S.I., Ballard,P.L., Fisher,A.B. and Shuman,H.
  TITLE     Identification of LBM180, a lamellar body limiting membrane protein
            of alveolar type II cells, as the ABC transporter protein ABCA3
  JOURNAL   J Biol Chem 277 (25), 22147-22155 (2002)
   PUBMED   11940594
  REMARK    GeneRIF: Identification of LBM180, a lamellar body limiting
            membrane protein of alveolar type II cells, as the ABC transporter
            protein ABCA3.
REFERENCE   7  (bases 1 to 6326)
  AUTHORS   Yamano,G., Funahashi,H., Kawanami,O., Zhao,L.X., Ban,N., Uchida,Y.,
            Morohoshi,T., Ogawa,J., Shioda,S. and Inagaki,N.
  TITLE     ABCA3 is a lamellar body membrane protein in human lung alveolar
            type II cells
  JOURNAL   FEBS Lett 508 (2), 221-225 (2001)
   PUBMED   11718719
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Sep 20, 2021 this sequence version replaced XM_220219.11.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2425535.1,
                                           SRR26360190.2130757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000010.1  13887084-13887246
            164-362             JAXUCZ010000010.1  13896091-13896289
            363-472             JAXUCZ010000010.1  13900181-13900290
            473-737             JAXUCZ010000010.1  13900398-13900662
            738-865             JAXUCZ010000010.1  13901652-13901779
            866-1031            JAXUCZ010000010.1  13902804-13902969
            1032-1291           JAXUCZ010000010.1  13910586-13910845
            1292-1408           JAXUCZ010000010.1  13912676-13912792
            1409-1529           JAXUCZ010000010.1  13912990-13913110
            1530-1703           JAXUCZ010000010.1  13914001-13914174
            1704-1885           JAXUCZ010000010.1  13917700-13917881
            1886-2029           JAXUCZ010000010.1  13919671-13919814
            2030-2159           JAXUCZ010000010.1  13920238-13920367
            2160-2314           JAXUCZ010000010.1  13921315-13921469
            2315-2470           JAXUCZ010000010.1  13921707-13921862
            2471-2681           JAXUCZ010000010.1  13922030-13922240
            2682-2832           JAXUCZ010000010.1  13923318-13923468
            2833-2931           JAXUCZ010000010.1  13927889-13927987
            2932-3118           JAXUCZ010000010.1  13931174-13931360
            3119-3422           JAXUCZ010000010.1  13932008-13932311
            3423-3696           JAXUCZ010000010.1  13932988-13933261
            3697-3901           JAXUCZ010000010.1  13934551-13934755
            3902-4121           JAXUCZ010000010.1  13935115-13935334
            4122-4280           JAXUCZ010000010.1  13935535-13935693
            4281-4453           JAXUCZ010000010.1  13937128-13937300
            4454-4582           JAXUCZ010000010.1  13939066-13939194
            4583-4777           JAXUCZ010000010.1  13939327-13939521
            4778-4965           JAXUCZ010000010.1  13941567-13941754
            4966-5136           JAXUCZ010000010.1  13942118-13942288
            5137-5327           JAXUCZ010000010.1  13942520-13942710
            5328-5401           JAXUCZ010000010.1  13942848-13942921
            5402-6326           JAXUCZ010000010.1  13943362-13944286
FEATURES             Location/Qualifiers
     source          1..6326
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..6326
                     /gene="Abca3"
                     /note="ATP binding cassette subfamily A member 3"
                     /db_xref="GeneID:302973"
                     /db_xref="RGD:1307174"
     exon            1..163
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            164..362
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            363..472
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..5533
                     /gene="Abca3"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.1"
                     /note="ATP-binding cassette sub-family A member 3;
                     ATP-binding cassette, sub-family A (ABC1), member 3;
                     ATP-binding cassette, subfamily A (ABC1), member 3;
                     xenobiotic-transporting ATPase ABCA3"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase ABCA3"
                     /protein_id="NP_001382963.1"
                     /db_xref="GeneID:302973"
                     /db_xref="RGD:1307174"
                     /translation="MVVLRQLRLLLWKNYTLKKRKVLVTVLELFLPLLFSGILIWLRL
                     KIQSENVPNATVYPDQHIQELPLFFSFPPPGGSWELAYVPSHSDAARTITEAVRREFM
                     IKMRVHGFSSEKDFEDYVRYDNHSSNVLAAVVFEHTFNHSKDPLPLAVRYHLRFSYTR
                     RNYMWTQTGNLFLKETEGWHTASLFPLFPSPGPREPSSPDGGEPGYIREGFLAVQHAV
                     DKAIMHYHANASAHQLFQKLTVITKRFPFPPYISDPFLIAIQYQLPLLLMLSFTYTSL
                     TIIRAVVQEKEKKLKEYMRMMGLSSWLHWSAWFLMFLLFSLIVVSFMTLLFCVKVKKD
                     IAVLSNSDPSLVLAFLLCFAISSISFSFMVSTFFSKANMAATVGGFLYFFTYTPYFFV
                     APRYNWMTLSQKLLSCLLSNVAMAMGAQLIGKFEAKGTGIQWCDLLNPVNVDDDFCFG
                     QVLGMLLLDSVLYGLVTWYVEAVFPGQFGVPQPWYFFLMPSYWCGNPRTVVGKEEEGG
                     DPEKAFRTEYFEAEPEDLAAGIKIKHLSKVFQVGNKDKMGIRDLTLNLYEGQITVLLG
                     HNGAGKTTTMSMLTGLFPPTSGHAYIRGYEISQDMVQIRKSLGLCPQHDVLFDNLTVA
                     EHLYFYAQLKGLSVQKCPEEVKQMLHTLGLEDKRDSRSKFLSGGMKRKLAIGIALIAG
                     SKVLMLDEPTSGMDAVSRRAIWDLLQQQKSDRTVLLTTHFMDEADLLGDRIAILAKGE
                     LQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEGISQLVHHHVPNAMLESHAGAELSFIL
                     PKESTHRFESLFAKLEKKQKELGIASFGASVTTMEEVFLRVGKLVDTSMDIQAIQLPA
                     LQYQHERRASDWALDSNLCGVMDPTNGIGALIEEEEVLVKLNTGLALHCQQFWAMFLK
                     KAAYSWREWRMVAAQILVPVTCLTLALLAINYTSEIFDDPPLKLSLNEYGTTVVPFSV
                     PGTSRLGQQLSEHLRDMLQAERQEPREVLGDLEEFLVFRASVEGGGFNERCLVATSFK
                     DSGERTVVTALFNNQAYHSPATALAIVDNLLFKLLCGPRASIEISNYPQPRSTLQVAK
                     DQFNEGRKGFDIALNLLIAMAFLASTFSILAVSERAVQAKHVQFVSGVHVATFWLSAL
                     LWDLISFLVPSLLLLVVFRAFDVHAFTRDGHMADLLLLLMLYGWAIIPLMYLLSFFFS
                     AASTAYTRLTIFNILSGIATFIVVTIMRIPAVKLEELSRTLDHVFLVLPNHCLGMAVS
                     NFYENYETRRYCTSSEVATHYCKKYNIQYQENFYAWSTPGIGKFVTSMAASGGIYLTL
                     LFLIETNLLWRLRTFVCAFRRRWTLAELQNRTSVLPEDQDVADERSRVLVPSLDSMLD
                     TPLIINELSKVYDQRAPLLAVDRISLAVQKGECFGLLGFNGAGKTTTFKMLTGEETIT
                     SGDAFVGGYSISSDIGKVRQRMGYCPQFDALLDHMTGREMLVMYARLRGIPERLIDAC
                     VENTLRGLLLEPHANKLVKTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRL
                     LWDTVARARESGKAIVITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYS
                     LQAKVRSEGKQEVLEEFKAFVDLTFPGSVLEDEHQDMVHYHLPGCDLSWAKVFGILEK
                     AKEKYGVDDYSVSQISLEQVFLSFAHLQPPTTEDGR"
     exon            473..737
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..865
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1031
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1291
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1408
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1529
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1703
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1885
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2029
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2159
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2314
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2470
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2681
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2832
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..2931
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3118
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3422
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3696
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3901
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..4121
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            4122..4280
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            4281..4453
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            4454..4582
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            4583..4777
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            4778..4965
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            4966..5136
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            5137..5327
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            5328..5401
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
     exon            5402..6326
                     /gene="Abca3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccacccgc gcctgtggca ggcgcctcct ctctgcccgg cggcctcagc tgccagcttc
       61 ggccgcagcg gcccctgcga ggctggagca gaaccgggaa tctaagggag ggaacctggc
      121 gagagagctg cgccgaccgc cgccagcctg gcgctgaggg tcggtgccag cgcgtcatgc
      181 ctgtaagccc caggtccctc cagatgtccc tggagatctc agcgctcctg ctccctaagg
      241 ctgctgtttc tgcccagggg cccactggct ccaccccggg ttcgtctgtg tagaactgca
      301 gctccaggcc acccgcccgc agccttgcag ggacgcctcc agcaaccttt cctggaacta
      361 agttgtccat ctttaagtct tgatctctgg ttggcgctgg caccgtgcct gcaggaagat
      421 ggtggtgctg cggcagctca ggctcctact ctggaagaac tatactctga agaaacggaa
      481 ggtcctagtg acagtcttgg agcttttcct gcccctgctg ttttctggga tcctgatttg
      541 gcttcgcttg aagatccagt cggagaatgt gcccaatgct actgtttacc cagaccagca
      601 catccaggag ctgcccctgt ttttctcatt ccctccacct ggggggagct gggagctcgc
      661 ctatgtccct tcccacagcg atgctgccag gaccatcaca gaggcagtga gaagggaatt
      721 catgatcaag atgagagtgc acggcttttc ctctgagaag gacttcgagg actacgttcg
      781 ctatgacaac cactcctcca acgtgctggc agctgtggta tttgagcaca ccttcaacca
      841 cagcaaggac cccctgccat tggcggtgag ataccaccta cgcttcagtt acacgcgaag
      901 aaattacatg tggacccaaa caggaaatct tttcctcaaa gagactgaag gctggcacac
      961 cgcttctctt ttcccgcttt tcccaagccc aggaccaagg gaaccttcat cacctgatgg
     1021 cggtgaaccg gggtacatcc gtgagggctt cctggcagtg caacacgctg tagacaaagc
     1081 catcatgcat taccatgcca acgcctctgc acaccagctg ttccagaagc tcacggtgat
     1141 caccaaaagg ttcccgttcc cgccatacat ctcagaccca ttcctcattg ccatccagta
     1201 ccagcttcct ctgctgctca tgctgagctt cacctacacc tccctcacca tcatccgggc
     1261 tgtggtgcag gagaaagaga aaaaactaaa ggagtacatg cgcatgatgg ggctcagcag
     1321 ctggctacac tggagcgctt ggttcctcat gttcctcctg ttctccctca tcgtggtctc
     1381 cttcatgacc ctcctgttct gtgtcaaagt gaagaaggac atagcagtcc tttccaacag
     1441 cgacccctcc ctggttctgg ccttcctgct gtgttttgca atctcctcca tttccttcag
     1501 cttcatggtc agcaccttct tcagtaaagc caacatggca gcaaccgtgg gcggcttcct
     1561 ttacttcttc acctacaccc cttacttttt cgtggctcct cggtacaact ggatgacact
     1621 gagtcagaag ctcttgtcct gcctcctatc taatgttgcc atggcgatgg gagcccagct
     1681 catcggaaaa tttgaagcca aaggcactgg catccagtgg tgtgacctcc tgaaccctgt
     1741 caacgtagat gatgatttct gctttggaca agtgctgggg atgctgctgc tggattcagt
     1801 actctatggc ctggtgacct ggtacgtgga ggccgtcttc ccaggccagt ttggcgtgcc
     1861 ccagccctgg tacttcttcc ttatgccctc ctactggtgt gggaacccaa gaacggtcgt
     1921 agggaaggaa gaggaaggcg gcgacccaga aaaggctttc agaaccgagt actttgaagc
     1981 tgagccggag gacttggcag ctgggatcaa gatcaagcac ctgtccaagg tgttccaagt
     2041 gggtaataag gacaagatgg gcatcagaga cctgacgctg aacctgtatg aaggacagat
     2101 aacagtcctc ctgggccaca acggtgctgg gaagaccacg accatgtcta tgctgacagg
     2161 tctcttcccc cctaccagtg ggcatgctta tattcgtggg tacgagattt cccaagacat
     2221 ggttcagatc cgcaagagtc tgggcctgtg cccccagcat gatgtcctgt ttgacaacct
     2281 gacagttgca gaacaccttt acttctacgc acagttgaaa ggcctctctg tccagaagtg
     2341 tcctgaagag gtcaagcaga tgctgcacac cctcgggctg gaagacaagc gggactcaag
     2401 gtccaagttc ctgagcgggg ggatgaagcg caagctcgcc atcggcatcg ccctcatagc
     2461 gggctctaag gtgctgatgt tagatgagcc cacctcaggc atggatgcag tgtccaggag
     2521 ggccatctgg gaccttcttc agcagcagaa gagtgaccgc actgtcctgc tgaccactca
     2581 cttcatggat gaagctgacc tgctgggaga ccgcattgcc atcttggcca agggagagct
     2641 ccagtgctgt gggtcttcac tgttcctcaa gcagaaatat ggagctggct accacatgac
     2701 actggtgaaa gaaccacact gcaatcctga aggtatctct cagctggtgc accaccatgt
     2761 ccccaatgcc atgctggaga gccatgctgg ggccgagttg tcctttattc ttcccaagga
     2821 aagcacacac aggtttgaaa gtctgtttgc taaactggaa aagaagcaga aggaactggg
     2881 cattgcaagc ttcggggcct ctgtcaccac catggaggag gtcttccttc gggttggtaa
     2941 gctggtggac accagcatgg acattcaagc catccagctt cctgctctgc agtaccagca
     3001 tgagaggcgg gcaagcgact gggctctgga tagtaacttg tgtggggtga tggacccaac
     3061 gaacggcatt ggagccctca tagaggaaga agaagttttg gtcaagctca acaccgggct
     3121 tgccctccac tgccagcagt tctgggccat gttcctgaag aaggctgcgt acagctggcg
     3181 ggaatggagg atggtagccg ctcagatcct ggtccccgtg acctgcctca ccctggccct
     3241 cctggctatc aactacacct cagagatctt tgatgaccct cccctgaagc taagcctgaa
     3301 cgagtatggt acaacagttg tgcccttctc agtcccaggc acatccaggc tgggccagca
     3361 gctgtctgag catctaagag acatgctgca ggctgagagg caggagcccc gtgaagtgct
     3421 aggtgaccta gaggagttcc tggttttcag ggcctcagtg gaagggggcg gctttaatga
     3481 gaggtgcctg gtagcgacat ccttcaaaga cagtggagag cggacagtgg tcactgccct
     3541 gttcaacaac caggcatacc actccccagc cactgccctg gccattgtgg acaaccttct
     3601 gttcaagctt ctgtgtggcc ctcgggcctc cattgagatc tccaactatc cccagccccg
     3661 gagcaccctg caggtcgcca aggaccagtt caacgagggc cggaagggat ttgacattgc
     3721 cctcaatttg ctcatcgcca tggcatttct ggccagcacg ttttcgatcc tggcagtcag
     3781 tgagagggcc gtccaagcca agcacgttca gtttgtgagc ggtgtccatg tggctacttt
     3841 ctggctctct gctctgctgt gggacctcat ctctttcctc gttcccagtc tactacttct
     3901 ggtggtgttc cgagccttcg atgtgcacgc cttcacgagg gatggccaca tggctgactt
     3961 gctgctgctg ctcatgctct atggctgggc catcatcccc ctcatgtacc tcctgagctt
     4021 cttcttctca gctgcgtcca cggcttacac caggctgacc atattcaaca tcctgtcggg
     4081 catagccacc ttcatcgtgg tcactatcat gaggatccca gctgtgaagt tagaagagct
     4141 ttccagaacc ttagatcatg tgttcttggt gctgccaaac cactgcctgg ggatggcggt
     4201 cagcaacttc tatgagaact atgagactcg gcgctactgc acgtcctcgg aggttgctac
     4261 ccactactgc aagaagtaca acatccaata ccaggagaac ttctatgcct ggagcacccc
     4321 aggcattggc aagtttgtga cttccatggc tgcctcaggg ggcatctacc tcaccctgct
     4381 cttcctcatt gagaccaacc tgctgtggag actgagaacc tttgtctgcg ccttccggag
     4441 gaggtggact ctggcagaat tgcagaaccg gacatcagtg cttcctgagg accaggatgt
     4501 agctgatgag aggagccgag tcctggtccc tagcttggac tccatgcttg acacaccgct
     4561 gatcatcaat gagctctcca aggtgtatga ccagcgtgca ccgctccttg ccgtggacag
     4621 gatctccctt gcagtccaga aaggggagtg ctttggcctg ttgggtttca atggagctgg
     4681 aaaaactaca acattcaaaa tgctgactgg ggaggagacg atcacctcgg gggatgcctt
     4741 tgttggtggt tacagcatca gttctgatat tgggaaggta cggcagcgga tgggctactg
     4801 cccccagttt gatgcactgc ttgatcacat gactggcagg gaaatgctgg tcatgtatgc
     4861 acggctccga ggcatcccag agcgtctcat cgatgcctgt gtggagaaca ctctgcgggg
     4921 tctgctcctg gagccacatg ccaataaact ggtcaagact tacagtggtg gtaacaagcg
     4981 caagttaagc actggcatcg ccctcattgg agagcctgca gtcatcttcc tggatgagcc
     5041 atctactggc atggaccccg tggcccggcg cctactctgg gacactgtag cccgggcccg
     5101 agagtctggc aaagccattg tcatcacctc ccacagtatg gaggagtgtg aagccttatg
     5161 tacccggctg gccatcatgg tacagggcca gttcaagtgc ctgggcagcc cacagcacct
     5221 caagagcaag tttggcagcg gctactccct gcaggccaag gtccggagtg aggggaagca
     5281 agaagtacta gaggagttca aggcatttgt ggacctgacc ttcccaggca gcgtcctaga
     5341 agatgagcac caagacatgg tccactacca tctgcctggc tgtgacctca gctgggccaa
     5401 ggtatttggt atcctggaga aggccaagga gaagtatgga gtggacgatt actctgtgag
     5461 tcagatctcg ctggagcagg tctttctgag ctttgcccac ctgcagcccc ccaccactga
     5521 ggatggacga tgaggagctc ttccgcctcc agagcaccag gcgtggaagg ggagccagtg
     5581 cttagcctcg catcctcccc tcccagtctc tgttctttca tttttaatca ctcttttcta
     5641 tgatggacat gacaagaatc aaggtgatat gcacaaagtg gaccatgtgt gtctgtcagt
     5701 gcctgcaggc aggagtcagc atgcaggttt ccactcctga agtcaggtct ctggaaccgc
     5761 agtccccggc cccatcccgc tgtgcacgca gacaggcctt ggtctttgga tggggactgt
     5821 cccagctggt attgcagcta acctgggggt tgagcttctg tccagtgctt atcctgtcta
     5881 tgtttacata ggacactaag ctcccctggg ggtggggggt ggagaaagcc aacagggttg
     5941 agcaacaagg actttgaggc tgccaggaat gagcagcaaa gttgcaaata actccatgaa
     6001 gggaagatac tggctatgac taggtgctga gacctttggc tcccaatgca actagagaca
     6061 tccttggatg tcaacattcc tttgggtatg gacactgcac cgggctgatc tgatcctgag
     6121 ccagatgtca tcccacagag catcggcagc acaagagaga tgtggtcaga cttgaagcac
     6181 agacctatgt tcccagctct gtgccttcaa gaacttactg gccacaggac agtcagggac
     6241 cactacaggg ctgagtagtg tcatctcttg aggatgcact taaacatatt gtgattctat
     6301 agaaaataaa ggctaagggg acatga
//
