LOCUS       NM_024396               8040 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily A member 2
            (Abca2), mRNA.
ACCESSION   NM_024396
VERSION     NM_024396.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8040)
  AUTHORS   Davis,W. Jr.
  TITLE     The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression
            Modulates Sphingosine Levels and Transcription of the Amyloid
            Precursor Protein (APP) Gene
  JOURNAL   Curr Alzheimer Res 12 (9), 847-859 (2015)
   PUBMED   26510981
REFERENCE   2  (bases 1 to 8040)
  AUTHORS   Davis,W. Jr.
  TITLE     The ATP-binding cassette transporter-2 (ABCA2) regulates
            esterification of plasma membrane cholesterol by modulation of
            sphingolipid metabolism
  JOURNAL   Biochim Biophys Acta 1841 (1), 168-179 (2014)
   PUBMED   24201375
  REMARK    GeneRIF: control of ABCA2 expression level may be a key locus of
            regulation for esterification of plasma membrane-derived
            cholesterol through modulation of sphingolipid metabolism.
REFERENCE   3  (bases 1 to 8040)
  AUTHORS   Michaki,V., Guix,F.X., Vennekens,K., Munck,S., Dingwall,C.,
            Davis,J.B., Townsend,D.M., Tew,K.D., Feiguin,F., De Strooper,B.,
            Dotti,C.G. and Wahle,T.
  TITLE     Down-regulation of the ATP-binding cassette transporter 2 (Abca2)
            reduces amyloid-beta production by altering Nicastrin maturation
            and intracellular localization
  JOURNAL   J Biol Chem 287 (2), 1100-1111 (2012)
   PUBMED   22086926
  REMARK    GeneRIF: Down-regulation of the ATP-binding cassette transporter 2
            (Abca2) reduces amyloid-beta production by altering Nicastrin
            maturation and intracellular localization.
REFERENCE   4  (bases 1 to 8040)
  AUTHORS   Davis,W. Jr.
  TITLE     The ATP-binding cassette transporter-2 (ABCA2) regulates
            cholesterol homeostasis and low-density lipoprotein receptor
            metabolism in N2a neuroblastoma cells
  JOURNAL   Biochim Biophys Acta 1811 (12), 1152-1164 (2011)
   PUBMED   21810484
REFERENCE   5  (bases 1 to 8040)
  AUTHORS   Davis,W. Jr.
  TITLE     The ATP-binding cassette transporter-2 (ABCA2) increases endogenous
            amyloid precursor protein expression and Abeta fragment generation
  JOURNAL   Curr Alzheimer Res 7 (7), 566-577 (2010)
   PUBMED   20704561
REFERENCE   6  (bases 1 to 8040)
  AUTHORS   Zhou,C.J., Inagaki,N., Pleasure,S.J., Zhao,L.X., Kikuyama,S. and
            Shioda,S.
  TITLE     ATP-binding cassette transporter ABCA2 (ABC2) expression in the
            developing spinal cord and PNS during myelination
  JOURNAL   J Comp Neurol 451 (4), 334-345 (2002)
   PUBMED   12210128
  REMARK    GeneRIF: ATP-binding cassette transporter ABCA2 (ABC2) expression
            in the developing spinal cord and PNS during myelination.
REFERENCE   7  (bases 1 to 8040)
  AUTHORS   Vulevic,B., Chen,Z., Boyd,J.T., Davis,W. Jr., Walsh,E.S.,
            Belinsky,M.G. and Tew,K.D.
  TITLE     Cloning and characterization of human adenosine
            5'-triphosphate-binding cassette, sub-family A, transporter 2
            (ABCA2)
  JOURNAL   Cancer Res 61 (8), 3339-3347 (2001)
   PUBMED   11309290
REFERENCE   8  (bases 1 to 8040)
  AUTHORS   Kaminski,W.E., Piehler,A., Pullmann,K., Porsch-Ozcurumez,M.,
            Duong,C., Bared,G.M., Buchler,C. and Schmitz,G.
  TITLE     Complete coding sequence, promoter region, and genomic structure of
            the human ABCA2 gene and evidence for sterol-dependent regulation
            in macrophages
  JOURNAL   Biochem Biophys Res Commun 281 (1), 249-258 (2001)
   PUBMED   11178988
REFERENCE   9  (bases 1 to 8040)
  AUTHORS   Zhou,C., Zhao,L., Inagaki,N., Guan,J., Nakajo,S., Hirabayashi,T.,
            Kikuyama,S. and Shioda,S.
  TITLE     Atp-binding cassette transporter ABC2/ABCA2 in the rat brain: a
            novel mammalian lysosome-associated membrane protein and a specific
            marker for oligodendrocytes but not for myelin sheaths
  JOURNAL   J Neurosci 21 (3), 849-857 (2001)
   PUBMED   11157071
REFERENCE   10 (bases 1 to 8040)
  AUTHORS   Zhao,L.X., Zhou,C.J., Tanaka,A., Nakata,M., Hirabayashi,T.,
            Amachi,T., Shioda,S., Ueda,K. and Inagaki,N.
  TITLE     Cloning, characterization and tissue distribution of the rat
            ATP-binding cassette (ABC) transporter ABC2/ABCA2
  JOURNAL   Biochem J 350 Pt 3 (Pt 3), 865-872 (2000)
   PUBMED   10970803
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB037937.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8040
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..8040
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /note="ATP binding cassette subfamily A member 2"
                     /db_xref="GeneID:79248"
                     /db_xref="RGD:620238"
     exon            1..133
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..7372
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /note="ATP-binding cassette 2; ATP-binding cassette
                     transporter 2; ATP-binding cassette, sub-family A (ABC1),
                     member 2; ATP-binding cassette, subfamily A (ABC1), member
                     2"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family A member 2"
                     /protein_id="NP_077372.1"
                     /db_xref="GeneID:79248"
                     /db_xref="RGD:620238"
                     /translation="MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQ
                     KKPTISVKEAFYTAAPLTSAGILPVMQSLCPDGQRDEFGFLQYANSTVTQLLERLNRV
                     VEESNLFDPERPSLGSELEALHQRLEALSSGPGTWESHSARPAVSSFSLDSVARDKRE
                     LWRFLMQNLSLPNSTAQALLAARVDPSEVYRLLFGPLPDLDGKLGFLRKQEPWSHLGS
                     NPLFQMEELLLAPALLEQLTCAPGSGELGRILTMPEGHQVDLQGYRDAVCSGQATARA
                     QHFSDLATELRNQLDIAKIAQQLGFNVPNGSDPQPQAPSPQSLQALLGDLLDVQKVLQ
                     DVDVLSALALLLPQGACAGRAPAPQAGSPSGPANSTGVGANTGPNTTVEEGTQSPVTP
                     ASPDTLQGQCSAFVQLWAGLQPILCGNNRTIEPEALRRGNMSSLGFTSKEQRNLGLLV
                     HLMTSNPKILYAPAGSEADHVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRL
                     QQHLHWLQQYVADLRLHPEAMNLSLDELPPALRLDYFSLPNGTALLQQLDTIDNAACG
                     WIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYK
                     IRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFVWIQDMIERAIINTFVGHDVVEP
                     GNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKT
                     MGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVLIIWLFLAVYAVATIM
                     FCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTT
                     AFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDTVVYGVLTWYIE
                     AVHPGMYGLPRPWYFPLQKSYWLGSGRTETWEWSWPWAHAPRLSVMEEDQACAMESRH
                     FEETRGMEEEPTHLPLVVCVDKLTKVYKNDKKLALNKLSLNLYENQVVSFLGHNGAGK
                     TTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDQLTVEEHLWFY
                     SRLKSMAQEEIRKEMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIIL
                     DEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGS
                     PLFLKGAYGDGYRLTLVKRPAEPGTSQEPGMASSPSGRPQLSNCSEMQVSQFIRKHVA
                     SSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHSLDALHLSSFGLMDTTLEEVFLK
                     VSEEDQSLENSEADVKESRKDALPGAEGLTAVESQAGNLARCSELAQSQASLQSASSV
                     GSARGDEGAGYTDGYGDYRPLFDNLQDPDSVSLQEAEMEALARVGQGSRKLEGWWLKM
                     RQFHGLLVKRFHCARRNSKALCSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQY
                     HNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSL
                     GPMLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPLSPDEDSLL
                     AWNTSLPPTAGPETWTWAPSLPRLVHEPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTG
                     DILTDITGHNVSEYLLFTSDRFRLHRYGAITFGNIQKSIPAPIGTRTPLMVRKIAVRR
                     VAQVLYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSL
                     DYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPVIYWLANYV
                     WDMLNYLVPATCCIIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEV
                     PSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGL
                     MEIAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMTVEGFVGFFLTIMCQYNFLR
                     QPQRLPVSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRL
                     CLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKDLLQVQQSLGY
                     CPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVVRWALEKLELTKCADKPAGSYSGG
                     NKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEE
                     CEAVCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQNVKDVVRFFNRNFPE
                     AMLKERHHTKVQYQLKSEHISLAQVFSKMEHVVGVLGIEDYSVSQTTLDNVFVNFAKK
                     QSDNVEQQEAEPSTLPSPLGLLSLLRPRPAPTELRALVADEPEDLDTEDEGLISFEEE
                     RAQLSFNTDTLC"
     exon            134..227
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            228..339
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..503
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            504..631
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..742
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..961
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1329
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1489
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1618
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1786
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1883
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2057
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2160
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2275
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2466
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2617
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2822
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2987
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3168
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3381
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3578
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3761
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..3946
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4067
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4068..4304
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4305..4511
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4512..4614
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4615..4934
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4935..5148
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5149..5254
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5255..5366
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5367..5427
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5428..5602
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5603..5718
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5719..5866
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5867..5990
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5991..6123
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6124..6241
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6242..6420
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6421..6562
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6563..6697
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6698..6801
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6802..6894
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6895..6997
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            6998..7135
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            7136..7336
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
     exon            7337..8028
                     /gene="Abca2"
                     /gene_synonym="Abc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcggggccc ggcagggcgc gcagagaaga gggccgcggc gctgaggcgg cggagcgcgg
       61 cccggccatg ggcttcctgc accagctgca gctgctgctc tggaagaacg tgacgctgaa
      121 gcgccggagc ccgtgggtcc tggcgtttga gatcttcatc ccccttgtcc tcttcttcat
      181 cctgttggga ctgcggcaga agaagcccac catctctgtg aaggaagctt tctacacggc
      241 agcaccgctg acatcggccg gcatcctgcc tgtcatgcag tcgctttgcc ctgatggcca
      301 gcgtgatgag tttggcttcc tgcagtatgc caactccacg gtcacccagc ttctggaacg
      361 cctcaaccgt gtagtggaag agagcaactt gtttgaccca gagcgaccta gcctgggctc
      421 agagcttgag gcactgcacc aacgtctgga ggccctcagc tcgggccctg gcacctggga
      481 gagccactca gctagacctg cagtttcatc cttctctctg gactcggtgg ccagggacaa
      541 aagagagctt tggcgtttcc tgatgcagaa cctgtcactg cccaacagca cggcccaggc
      601 cctcctggct gcccgtgtag acccttctga ggtctatcgc ttgctttttg gtcctttacc
      661 tgacctggat ggaaagttgg ggttcctcag gaagcaggag ccctggagtc acctgggtag
      721 caatcctctg ttccaaatgg aggagctgct gctggctcct gcccttttgg agcaactcac
      781 atgtgctcca ggctctgggg agctgggccg gattcttacc atgcctgagg gtcatcaggt
      841 agaccttcag ggctaccggg atgctgtctg cagcgggcag gctacagctc gtgcccagca
      901 tttcagtgat ctagccactg agctccggaa ccagctggac atagccaaga ttgcccagca
      961 gctgggcttc aatgtcccca acggctcaga tccacagccg caggcaccgt ccccacagag
     1021 tctgcaggca ctcttagggg acctgctgga tgtccagaag gttctacagg atgtggatgt
     1081 cctatcagcc cttgccctgc tgctgcctca aggtgcctgt gctggccggg cccccgcacc
     1141 tcaagctggc agcccgagtg gcccggccaa cagcaccggg gtaggggcaa atacaggtcc
     1201 caacaccacc gttgaggagg gcacccagtc acctgtcacc ccagcctctc cggacactct
     1261 gcaaggccag tgctcagcct ttgtgcagct ctgggctggc ttgcagccca tcttgtgtgg
     1321 caacaaccgt accattgagc ctgaagcact ccggaggggc aacatgagct cactgggctt
     1381 tacgagcaaa gaacaacgga acctgggcct tcttgtgcac ctcatgacca gcaaccccaa
     1441 aatcctgtat gcacccgcag gctctgaagc tgaccatgtt atcctcaagg caaatgagac
     1501 ctttgccttt gtgggcaacg tgacgcacta cgcccaggtc tggctcaaca tctccgcaga
     1561 gatccggagc ttcctggagc agggcaggct gcagcagcat ctgcactggc tgcagcagta
     1621 cgtggctgac ctccggctac accctgaagc aatgaacctg tcactggacg agctgccccc
     1681 tgctctgcgc ctggactact tttctctgcc caatggcaca gcccttctgc agcagctaga
     1741 cacaatagac aatgcagcct gtggctggat ccagttcatg tccaaggtga gtgtggacat
     1801 cttcaagggg tttcctgatg aggagagcat cgtgaactac actctcaatc aggcctacca
     1861 ggacaatgtt acagtatttg ccagcgtgat tttccagaca cggaaggatg gttccctccc
     1921 cccacatgtc cattacaaga ttcgccagaa ctcaagcttc accgagaaaa ccaacgagat
     1981 ccgtcgtgct tactggcgtc cagggcccaa cactggtggc cgcttctact tcctctacgg
     2041 cttcgtctgg atccaggaca tgatagaacg tgccatcatc aacacgtttg tggggcacga
     2101 cgtggtcgaa cccggcaact acgtgcagat gttcccgtac ccctgctaca cccgtgacga
     2161 cttcctgttt gtcattgagc acatgatgcc actgtgcatg gtgatctcct gggtttactc
     2221 tgtggccatg accatacagc acatcgtggc ggagaaagag catcggctaa aggaggtgat
     2281 gaagacgatg ggcctgaaca acgccgtgca ctgggtggcc tggttcatca cgggctttgt
     2341 gcagctgtcc atctccgtga cagccctgac cgccatcctc aagtatggcc aggtcctcat
     2401 gcacagccac gtgctcatca tatggctctt ccttgctgtc tatgctgtgg ccactatcat
     2461 gttctgcttc ctggtgtctg tgctgtactc taaggccaag ttggcctcgg cctgcggcgg
     2521 catcatctac ttcctgagct acgttcccta catgtatgta gcaatccgtg aggaagtagc
     2581 ccacgataag atcactgcct tcgagaagtg cattgcgtcc ctgatgtcca caacagcctt
     2641 cggcctgggt tccaagtact ttgctctgta tgaagtggca ggtgtgggca tccagtggca
     2701 cacgttcagc cagtccccag tggaagggga tgacttcaac ctgctccttg ctgtcaccat
     2761 gctgatggtg gacacagtgg tctatggcgt actcacttgg tacattgagg ctgtgcaccc
     2821 aggtatgtat gggctgcccc ggccctggta cttcccacta cagaagtcct attggctggg
     2881 cagtgggcgg acagagacct gggagtggag ctggccatgg gcacacgcac cacgcctcag
     2941 cgttatggag gaggaccagg cctgtgccat ggagagccgg cacttcgagg agactcgcgg
     3001 tatggaggag gagcccaccc acctgccttt ggtcgtctgc gtggacaagc tcaccaaggt
     3061 ctataaaaat gacaagaagc tggccttaaa caaactgagc ctcaatctct acgagaacca
     3121 ggtggtctct ttcctaggcc ataacggggc tggcaagacc actaccatgt ctatcctgac
     3181 tggactgttc ccacccacgt cgggctcagc cactatctat ggccacgaca tccgcacaga
     3241 gatggatgag atccgtaaga acctgggcat gtgcccacag cacaacgtgc tctttgacca
     3301 gctcactgtg gaggaacacc tctggttcta ctcacgcctc aaaagcatgg cacaagagga
     3361 gatccgcaaa gagatggaca agatgatcga ggacctggag ctctccaaca agcgccactc
     3421 gctggtacag acgctgtctg gaggcatgaa gcgcaagctt tcagtagcca ttgccttcgt
     3481 gggtggctct agagccatta tcttagatga gcccacagct ggcgtggacc cctatgctcg
     3541 acgtgccatc tgggacctca ttctgaagta caagccgggt cgcactatcc tcctgtccac
     3601 ccatcacatg gatgaggccg acctgctggg ggaccgcatt gccatcatct cccatgggaa
     3661 gctcaaatgc tgcggctctc ccctcttcct caagggtgcc tacggcgatg gctaccgcct
     3721 cacactggtc aagcggcctg cggagcctgg cacctcccaa gagccaggga tggcttccag
     3781 cccctcaggt cgtcctcagc tgagcaactg ctcagagatg caagtgtccc agttcatccg
     3841 caagcatgtg gcttcctccc tgctggtgtc agacacgagc accgagctct cctacatcct
     3901 gcccagcgag gctgtcaaga aaggggcctt cgagcgcctc tttcagcaat tggagcacag
     3961 cctggacgca ctgcatctga gcagttttgg gctgatggac acaaccctgg aggaggtgtt
     4021 cctcaaggtg tctgaagaag accagtcact ggagaatagt gaggccgatg tgaaggagtc
     4081 ccggaaggat gcactgcctg gggcagaggg cctgacggct gtggagagtc aagcaggcaa
     4141 cctggctcgg tgctcagagc tggcacagtc ccaggcttca ctgcagtctg catcttctgt
     4201 gggctccgcc cgtggggatg agggtgctgg ctacaccgac ggctacggtg actaccgtcc
     4261 cctctttgac aacttgcagg acccagacag tgtcagctta caagaggctg aaatggaggc
     4321 cctggctcgg gtaggccagg gcagccgcaa gctagagggc tggtggctga agatgcggca
     4381 gttccatggg ctcctggtga agcgcttcca ctgtgctcgc cggaactcca aagcgctctg
     4441 ctcccagatt ctgctgcctg ccttcttcgt ctgtgtggcc atgactgtgg cattgtctgt
     4501 ccctgagatc ggtgacctgc ctccactggt cctgtcgcct tctcagtacc acaactatac
     4561 ccagccccgt ggcaacttta tcccctatgc caatgaggaa cgccgcgagt accgattacg
     4621 gctgtcacct gatgccagcc cccagcagtt ggtgagcaca ttccggctgc cctctggtgt
     4681 gggtgccact tgtgtgctca agtctccagc caacggctcc ctggggccca tgctgaactt
     4741 gagcagtgga gagtcccgcc tgctggccgc acggttcttc gacagtatgt gcctggagtc
     4801 cttcacacag gggctgccac tgtccaactt cgtgccaccc ccaccctcgc ccgccccttc
     4861 cgactcaccc ctgtccccgg atgaggattc actgctagcc tggaatacgt ccctgccccc
     4921 tactgctgga ccagagacgt ggacgtgggc gccttctctg ccacgcctgg ttcacgagcc
     4981 ggtccgctgt acctgctctg cacagggcac gggcttctcg tgccccagca gtgtgggtgg
     5041 gcacccaccc cagatgagag tggtcacggg ggacatcctg actgacatca ccggccacaa
     5101 tgtttccgag tacctgctct tcacctctga ccgtttccga ctgcaccgct atggagccat
     5161 cacctttggt aatatccaga agtccatccc agcacccatt ggtacccgga cccctctcat
     5221 ggtccggaag attgcagtgc ggagggtggc ccaggtgctc tacaacaaca agggctacca
     5281 cagcatgccc acctacctca acagcctcaa caatgccatt ctgcgtgcaa acctacccaa
     5341 aagcaagggc aatccagcag cctacggtat caccgtcacc aaccacccca tgaacaagac
     5401 cagtgctagc ctctccctgg attacctact gcagggcaca gacgtggtca tcgccatctt
     5461 catcattgtg gccatgtcct tcgtgccggc cagcttcgtg gtcttccttg tggccgagaa
     5521 atccaccaag gccaaacacc tgcagttcgt cagcgggtgc aaccctgtca tctactggct
     5581 agccaactac gtgtgggaca tgctcaatta cctggtcccg gccacctgct gcatcatcat
     5641 cctcttcgtg tttgacttgc cggcctacac gtcacccacc aacttccccg cggtgctctc
     5701 cttgttcctg ctctatggat ggtccatcac acccatcatg tacccggcct ccttctggtt
     5761 tgaggtccct agctcagcct acgtgttcct catcgtcatc aacctcttca ttggcatcac
     5821 ggccacagtg gccaccttcc ttctgcagct ctttgagcat gacaaggatc tgaaggttgt
     5881 caacagttac ctgaaaagct gcttcctcat cttccccaac tacaacctgg gccacggact
     5941 catggagata gcctacaacg aatacatcaa cgaatactat gccaagatcg gccagtttga
     6001 caagatgaag tccccgtttg agtgggacat tgtcacacgt ggactggtgg ccatgacagt
     6061 cgagggcttc gtgggattct ttctcaccat catgtgtcaa tataacttcc tacggcagcc
     6121 acagcgtctg cctgtgtcta ctaaacctgt ggaagacgat gtagacgtgg ccagtgagcg
     6181 gcaaagagtg ctccgtggcg atgctgacaa tgacatggtc aagatcgaga acctgactaa
     6241 ggtgtacaag tctcggaaga tcggccgcat cctggcagtg gaccgccttt gcctgggtgt
     6301 gcgccccgga gagtgctttg ggctcctcgg ggtcaatggt gccgggaaga ccagcacctt
     6361 caagatgttg actggagatg agagcacaac agggggcgag gcctttgtca atggacacag
     6421 tgtgctcaag gacctgctcc aggttcagca gagccttggc tactgcccac agttcgacgc
     6481 cctgttcgat gagctcacgg ctcgcgaaca cctgcagctg tatactcggc ttcgaggcat
     6541 cccctggaag gatgaggcgc aggtggtgag gtgggccctg gagaagctgg agctgacgaa
     6601 gtgtgcagac aagccagccg gtagctacag tgggggcaac aaacggaaac tttccacagc
     6661 catcgctctc attgggtacc ctgccttcat ctttctagac gagcccacca ctggcatgga
     6721 ccctaaggcc cggcgcttcc tgtggaacct cattctggac ctcatcaaga caggacgttc
     6781 agtggtgctg acctcacaca gcatggagga atgcgaggct gtgtgcacac ggctggccat
     6841 catggtgaat ggacggctgc gctgcctggg gagtatccag cacctcaaga acaggtttgg
     6901 ggacggctac atgatcactg taaggaccaa aagcagccag aacgtgaagg atgtggtgcg
     6961 gttcttcaac cggaacttcc cagaggccat gctcaaggaa cgccaccata cgaaggtgca
     7021 gtatcagctc aagtcggagc acatctcgct ggctcaggtg ttcagcaaga tggagcacgt
     7081 ggtcggtgta ctgggcatcg aggactactc agtcagccag accactctgg ataacgtgtt
     7141 tgtgaacttc gccaagaagc aaagtgacaa tgtggagcag caagaggctg agccatccac
     7201 cttgccgtcc ccccttggac tacttagcct gctgcggccc cgccctgcac ccacagagct
     7261 ccgggcactg gtggccgatg agcctgagga cctggacacg gaggacgagg gcctcatcag
     7321 cttcgaggaa gagcgggccc agctctcctt caacaccgat acgctctgct gacgttcaag
     7381 agtcacatca gggatgcagc tgtttggggc agaagtcagg cggtggccgt agccccagtc
     7441 acacatgcca ggccctggaa aggcaggttc aggaccaaag ggctcccgcc ctcctcccaa
     7501 ctaccatcct ccccgatcgt gccaaaggct gggctggccc tgggctgcac acaccctcac
     7561 cctgctttgc cttaaagcct tgggtcctgg cccagcccct taccctgccc agcaccatcc
     7621 accttcccag ggtgacatgg gctgccccaa gtatcctgtg acccttctct gcagcggcca
     7681 ccagtctacc caggccagca tcttgcacag atgtctttca tgaaaagact gcagttgggg
     7741 aggtggcagc ttgcctactt attttgcttt aagagcctcc ctcactctgc tgttgtgaag
     7801 aagttaggct accatgggaa gccatgaatg tggctgcctc agccctggtg gaatggcagg
     7861 aacggagaag ctgggcttgc tggctaggtg aggggccact gctccctccc tgccccctca
     7921 agctgccttt gctctcccgc tcagcttggc ccttcctgcc acccatgtgg gagtaggacc
     7981 ttgtatatag cacacagatg tttgttttca ataaataagc aaaaaggaaa aaaaaaaaaa
//
