LOCUS       NM_178095              10316 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ATP binding cassette subfamily A member 1
            (Abca1), mRNA.
ACCESSION   NM_178095 XM_039109847 XM_232954
VERSION     NM_178095.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10316)
  AUTHORS   Shinohata,R., Shibakura,M., Arao,Y., Watanabe,S., Hirohata,S. and
            Usui,S.
  TITLE     A high-fat/high-cholesterol diet, but not high-cholesterol alone,
            increases free cholesterol and apoE-rich HDL serum levels in rats
            and upregulates hepatic ABCA1 expression
  JOURNAL   Biochimie 197, 49-58 (2022)
   PUBMED   35085709
  REMARK    GeneRIF: A high-fat/high-cholesterol diet, but not high-cholesterol
            alone, increases free cholesterol and apoE-rich HDL serum levels in
            rats and upregulates hepatic ABCA1 expression.
REFERENCE   2  (bases 1 to 10316)
  AUTHORS   Zheng,Y., Xiao,Y., Zhang,D., Zhang,S., Ouyang,J., Li,L., Shi,W.,
            Zhang,R., Liu,H., Jin,Q., Chen,Z., Xu,D. and Wu,L.
  TITLE     Geniposide Ameliorated Dexamethasone-Induced Cholesterol
            Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis
  JOURNAL   Cells 10 (12), 3424 (2021)
   PUBMED   34943934
  REMARK    GeneRIF: Geniposide Ameliorated Dexamethasone-Induced Cholesterol
            Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis.
            Erratum:[Cells. 2022 Nov 30;11(23):. PMID: 36497203]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10316)
  AUTHORS   Xia,X.D., Yu,X.H., Chen,L.Y., Xie,S.L., Feng,Y.G., Yang,R.Z.,
            Zhao,Z.W., Li,H., Wang,G. and Tang,C.K.
  TITLE     Myocardin suppression increases lipid retention and atherosclerosis
            via downregulation of ABCA1 in vascular smooth muscle cells
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (4), 158824 (2021)
   PUBMED   33035679
REFERENCE   4  (bases 1 to 10316)
  AUTHORS   Feng,Y., Qu,X., Chen,Y., Feng,Q., Zhang,Y., Hu,J. and Li,X.
  TITLE     MicroRNA-33a-5p sponges to inhibit pancreatic beta-cell function in
            gestational diabetes mellitus LncRNA DANCR
  JOURNAL   Reprod Biol Endocrinol 18 (1), 61 (2020)
   PUBMED   32505219
  REMARK    GeneRIF: MicroRNA-33a-5p sponges to inhibit pancreatic beta-cell
            function in gestational diabetes mellitus LncRNA DANCR.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10316)
  AUTHORS   Zhou,R.R., Li,H.B., You,Q.S., Rong,R., You,M.L., Xiong,K.,
            Huang,J.F., Xia,X.B. and Ji,D.
  TITLE     Silencing of GAS5 Alleviates Glaucoma in Rat Models by Reducing
            Retinal Ganglion Cell Apoptosis
  JOURNAL   Hum Gene Ther 30 (12), 1505-1519 (2019)
   PUBMED   31608710
  REMARK    GeneRIF: We found abundant GAS5 expression and a reduction in RGC
            density in the retinal tissues of glaucoma rats. Silencing of GAS5
            led to increased EZH2 expression and decreased ABCA1 expression in
            RGCs. In addition, upregulation of EZH2 promoted trimethylation of
            lysine 27 on histone H3, thereby suppressing ABCA1 expression and
            eventually leading to the inhibition of RGC apoptosis.
REFERENCE   6  (bases 1 to 10316)
  AUTHORS   Hamon,Y., Broccardo,C., Chambenoit,O., Luciani,M.F., Toti,F.,
            Chaslin,S., Freyssinet,J.M., Devaux,P.F., McNeish,J., Marguet,D.
            and Chimini,G.
  TITLE     ABC1 promotes engulfment of apoptotic cells and transbilayer
            redistribution of phosphatidylserine
  JOURNAL   Nat Cell Biol 2 (7), 399-406 (2000)
   PUBMED   10878804
REFERENCE   7  (bases 1 to 10316)
  AUTHORS   McNeish,J., Aiello,R.J., Guyot,D., Turi,T., Gabel,C., Aldinger,C.,
            Hoppe,K.L., Roach,M.L., Royer,L.J., de Wet,J., Broccardo,C.,
            Chimini,G. and Francone,O.L.
  TITLE     High density lipoprotein deficiency and foam cell accumulation in
            mice with targeted disruption of ATP-binding cassette transporter-1
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4245-4250 (2000)
   PUBMED   10760292
REFERENCE   8  (bases 1 to 10316)
  AUTHORS   Lawn,R.M., Wade,D.P., Garvin,M.R., Wang,X., Schwartz,K.,
            Porter,J.G., Seilhamer,J.J., Vaughan,A.M. and Oram,J.F.
  TITLE     The Tangier disease gene product ABC1 controls the cellular
            apolipoprotein-mediated lipid removal pathway
  JOURNAL   J Clin Invest 104 (8), R25-R31 (1999)
   PUBMED   10525055
REFERENCE   9  (bases 1 to 10316)
  AUTHORS   Brooks-Wilson,A., Marcil,M., Clee,S.M., Zhang,L.H., Roomp,K., van
            Dam,M., Yu,L., Brewer,C., Collins,J.A., Molhuizen,H.O., Loubser,O.,
            Ouelette,B.F., Fichter,K., Ashbourne-Excoffon,K.J., Sensen,C.W.,
            Scherer,S., Mott,S., Denis,M., Martindale,D., Frohlich,J.,
            Morgan,K., Koop,B., Pimstone,S., Kastelein,J.J., Genest,J. Jr. and
            Hayden,M.R.
  TITLE     Mutations in ABC1 in Tangier disease and familial high-density
            lipoprotein deficiency
  JOURNAL   Nat Genet 22 (4), 336-345 (1999)
   PUBMED   10431236
REFERENCE   10 (bases 1 to 10316)
  AUTHORS   Becq,F., Hamon,Y., Bajetto,A., Gola,M., Verrier,B. and Chimini,G.
  TITLE     ABC1, an ATP binding cassette transporter required for phagocytosis
            of apoptotic cells, generates a regulated anion flux after
            expression in Xenopus laevis oocytes
  JOURNAL   J Biol Chem 272 (5), 2695-2699 (1997)
   PUBMED   9006906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Jun 3, 2021 this sequence version replaced
            XM_039109847.1, NM_178095.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.19525.1,
                                           SRR26643292.21694.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               JAXUCZ010000005.1  72596252-72596473   c
            223-388             JAXUCZ010000005.1  72580258-72580423   c
            389-482             JAXUCZ010000005.1  72569570-72569663   c
            483-624             JAXUCZ010000005.1  72565861-72566002   c
            625-743             JAXUCZ010000005.1  72564710-72564828   c
            744-865             JAXUCZ010000005.1  72545381-72545502   c
            866-1042            JAXUCZ010000005.1  72543177-72543353   c
            1043-1135           JAXUCZ010000005.1  72532250-72532342   c
            1136-1376           JAXUCZ010000005.1  72528861-72529101   c
            1377-1516           JAXUCZ010000005.1  72526648-72526787   c
            1517-1633           JAXUCZ010000005.1  72526200-72526316   c
            1634-1831           JAXUCZ010000005.1  72522240-72522437   c
            1832-2037           JAXUCZ010000005.1  72521356-72521561   c
            2038-2214           JAXUCZ010000005.1  72520633-72520809   c
            2215-2437           JAXUCZ010000005.1  72519967-72520189   c
            2438-2659           JAXUCZ010000005.1  72517911-72518132   c
            2660-2864           JAXUCZ010000005.1  72516754-72516958   c
            2865-2978           JAXUCZ010000005.1  72515547-72515660   c
            2979-3150           JAXUCZ010000005.1  72513942-72514113   c
            3151-3282           JAXUCZ010000005.1  72512906-72513037   c
            3283-3425           JAXUCZ010000005.1  72511238-72511380   c
            3426-3563           JAXUCZ010000005.1  72510909-72511046   c
            3564-3784           JAXUCZ010000005.1  72510193-72510413   c
            3785-3857           JAXUCZ010000005.1  72508842-72508914   c
            3858-4060           JAXUCZ010000005.1  72507737-72507939   c
            4061-4109           JAXUCZ010000005.1  72506007-72506055   c
            4110-4223           JAXUCZ010000005.1  72505709-72505822   c
            4224-4372           JAXUCZ010000005.1  72504612-72504760   c
            4373-4497           JAXUCZ010000005.1  72503212-72503336   c
            4498-4596           JAXUCZ010000005.1  72502038-72502136   c
            4597-4786           JAXUCZ010000005.1  72498451-72498640   c
            4787-4881           JAXUCZ010000005.1  72497576-72497670   c
            4882-4914           JAXUCZ010000005.1  72496369-72496401   c
            4915-5020           JAXUCZ010000005.1  72495319-72495424   c
            5021-5095           JAXUCZ010000005.1  72494240-72494314   c
            5096-5265           JAXUCZ010000005.1  72493601-72493770   c
            5266-5443           JAXUCZ010000005.1  72492173-72492350   c
            5444-5559           JAXUCZ010000005.1  72489245-72489360   c
            5560-5704           JAXUCZ010000005.1  72488991-72489135   c
            5705-5828           JAXUCZ010000005.1  72487359-72487482   c
            5829-5958           JAXUCZ010000005.1  72485935-72486064   c
            5959-6079           JAXUCZ010000005.1  72485588-72485708   c
            6080-6142           JAXUCZ010000005.1  72484801-72484863   c
            6143-6249           JAXUCZ010000005.1  72483716-72483822   c
            6250-6391           JAXUCZ010000005.1  72481218-72481359   c
            6392-6526           JAXUCZ010000005.1  72480755-72480889   c
            6527-6630           JAXUCZ010000005.1  72479621-72479724   c
            6631-6723           JAXUCZ010000005.1  72478997-72479089   c
            6724-6967           JAXUCZ010000005.1  72478114-72478357   c
            6968-10316          JAXUCZ010000005.1  72473676-72477024   c
FEATURES             Location/Qualifiers
     source          1..10316
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q23-q24"
     gene            1..10316
                     /gene="Abca1"
                     /note="ATP binding cassette subfamily A member 1"
                     /db_xref="GeneID:313210"
                     /db_xref="RGD:631344"
     exon            1..222
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..388
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..7108
                     /gene="Abca1"
                     /EC_number="7.6.2.1"
                     /note="ATP-binding cassette sub-family A member 1;
                     ATP-binding cassette, sub-family A (ABC1), member 1;
                     ATP-binding cassette, subfamily A (ABC1), member 1"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase ABCA1"
                     /protein_id="NP_835196.2"
                     /db_xref="GeneID:313210"
                     /db_xref="RGD:631344"
                     /translation="MACWSQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRL
                     SYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIV
                     SRLFSDAQRILLYSQKDTSIRDMHKVLRTLQQIKHPNSNLKLQDFLVDNETFSGFLQH
                     SLSLPRSAVDNLLQADVSLQKVFLQGYQLHLASLCNGSKLEEIIRLGDLEVSALCSLP
                     REKLDAAERELRSNMDILKPVMTKLNSTSLLPTQHLAEATTTLLDSLGGLAQELFSTK
                     SWSDMRQEVMFLTNVNNSGSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALF
                     GGNGTEEDTDTFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLIGKILYTPDTPAT
                     RQVMAEVNKTFQELALFHDLEGMWEELSPQIWTFMESSQEMDLVRTMLDSRGNDQFWE
                     RKLDGLDWTAQDIMAFLAKNPEDVQSPNGSVYTWREAFNETNQAIQTISRFMECVNLN
                     KLEPIPTEVRLINKSMELLDERKFWAGIVFTGITPDSVELPHHVKYKIRMDIDNVERT
                     NKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYVQQMPY
                     PCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILW
                     FSWFISSLIPLLVSAGLLVIILKLGDLLPYSDPSVVFVFLSVFAVVTILQCFLISTLF
                     SRTNLAAACGGIIYFTLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFE
                     EQGIGVQWDNLFKSPVEEDGFNLTTSVSMMLFDTFIYGVMTWYIEAVFPGQYGIPRPW
                     YFPCTKSYWFGEEIDEKSHPGSSQKGASEICMEEEPTHLKLGVSIQNLVKVYRDGMKV
                     AVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMNSIR
                     QNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKT
                     SQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILST
                     HHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSS
                     STVSCLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHEL
                     TYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETS
                     DGTLPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDLDPESRETDLLSGMDGKGSYQLK
                     GWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPNLE
                     LQPWMYNEQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPNTPCLVGEEDW
                     TTGPVPQTLMDLFQNGNWTMKNPSPSCQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTA
                     DILQNLTGRNISDYLVKTYVQIIAKSLKNKVWVNEFRYGGFSLGVSDSQALPPSQEVN
                     NAIKQMKKLLKLTKDSSADRFLSSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVIN
                     NAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFV
                     PASFVVFLIQERVSKAKHLQFICGVKPVIYWLSNFVWDMCNYVVPATLVVIIFICFQQ
                     KSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVA
                     TFVLELFTNNKFNDINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVS
                     PLSWDLVGRNLFAMAVEGVVFFLVTVLIQYRFFIRPRPVKARLPPLNDEDEDVRRERQ
                     RILEGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKTSTFKM
                     LTGDTAVTRGDALLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHLEFFALLRGV
                     PEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAIALIGGPPVVFLDEPTTG
                     MDPKARRFLWNCALSIIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLK
                     NRFGDGYTIVVRIAGSNPDLKPVQEFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARI
                     FSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLT
                     SFLQDEKVKESYV"
     exon            389..482
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..624
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..743
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..865
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1042
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1135
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1376
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1516
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1633
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1831
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2037
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2214
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2437
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2659
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2864
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..2978
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3150
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3282
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3425
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..3563
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3784
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..3857
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3858..4060
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4109
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4110..4223
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4372
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4373..4497
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4498..4596
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4597..4786
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4787..4881
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..4914
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            4915..5020
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5021..5095
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5096..5265
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5266..5443
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5444..5559
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5560..5704
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5705..5828
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5829..5958
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            5959..6079
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            6080..6142
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            6143..6249
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            6250..6391
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            6392..6526
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            6527..6630
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            6631..6723
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            6724..6967
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
     exon            6968..10316
                     /gene="Abca1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattccgaga gcgagcgagc gggccgggac cggcagagcc cacttctgtc tctgcggctc
       61 agcgcaaagc tgggcagggg gcgccgcggg acccgcgcaa ccacagccgg cttggggagc
      121 tgctctgctc cctgtcccca ccccctactt ttttctcccg gtttctggaa gggtttgtgt
      181 aggggttggg taaacagacg caaacagcaa agtggaaaac agttaatgac cagccacagt
      241 gtcacagctc cgtgctctgg ctgcttcctc cagggctctc aagccacaca cacagatcac
      301 tgtgggtgct ggcagaggta acatggcttg ttggtctcag ttaaggttgc tgctgtggaa
      361 gaatctgaca tttcgaagaa gacaaacatg tcagctgtta ctggaagtgg cctggcctct
      421 ctttatcttc ctgatcctga tttctgtccg cctgagctac ccaccctatg aacaacatga
      481 gtgtcacttt ccaaataaag ccatgccttc tgcaggaacc cttccctggg tccaggggat
      541 tatctgtaat gccaataacc cttgcttccg ttatccaact ccaggcgagg ctcccggtgt
      601 tgttggaaac tttaacaagt ccattgtgtc ccgcctattc tcagatgctc aacggattct
      661 tttgtacagc caaaaggaca ccagcattag ggacatgcac aaggtcctga gaacattaca
      721 gcagatcaag catcccaact caaatttgaa gcttcaggat ttcctggtgg acaatgaaac
      781 cttctctgga ttcctacagc acagtttgtc ccttccaagg tccgctgtgg acaatctgct
      841 acaggctgat gtcagtctcc agaaggtgtt tttgcaaggc taccagttac atttggccag
      901 tctgtgtaat ggatcaaaat tagaagaaat cattcggctt ggagatctgg aagtttctgc
      961 cctttgtagt ctacctaggg agaagctaga tgcagcagag cgcgagctgc gttctaacat
     1021 ggacatcctg aagccagtca tgacaaaact aaactccacg tctcttctcc cgacccagca
     1081 tctggctgaa gccaccacaa cgttgcttga cagcttaggg gggctggccc aagagctctt
     1141 cagcacaaag agctggagcg acatgcggca ggaggtgatg tttctgacca acgtgaacaa
     1201 ctccggctcc tccacccaga tataccaggc tgtgtcccga atcgtctgtg gtcacccaga
     1261 gggcgggggc ctgaagatca agtccctcaa ctggtacgag gataacaact acaaagccct
     1321 ctttggaggg aatggcaccg aggaagacac agacaccttc tatgacaatt ctacaactcc
     1381 ttattgcaat gatttgatga agaacttgga gtctagtcct ctttctcgaa ttatttggaa
     1441 ggcactcaag ccactgctca ttgggaagat tctgtataca cctgacacac cagctacaag
     1501 gcaggtcatg gctgaggtga acaagacctt tcaggagctg gctttgttcc atgacctgga
     1561 gggcatgtgg gaagaactca gcccccaaat ttggaccttc atggagagca gccaagagat
     1621 ggaccttgtg cggacgatgt tggacagcag aggcaatgac cagttttggg aacgaaagtt
     1681 ggatggatta gattggactg cccaagacat catggcattt ctggccaaga acccagagga
     1741 tgttcagtcc ccaaatggct ctgtgtatac atggagagaa gctttcaatg agaccaacca
     1801 ggcaatccag acgatatctc gattcatgga gtgtgtcaac ctgaacaagc tggagcccat
     1861 cccaacagaa gtcaggctca tcaacaagtc catggagctg ctggatgaga ggaagttctg
     1921 ggctggtatc gtgttcacag gaatcactcc tgatagtgtg gagctgcccc accatgtaaa
     1981 gtacaagatc cggatggaca ttgacaatgt tgagagaacc aataagatca aggatgggta
     2041 ctgggaccct ggtccccggg ctgacccttt tgaagatatg cgctatgtct ggggtggctt
     2101 cgcctacttg caggatgtgg tggagcaggc gatcatcaga gtgctgacgg ggactgagaa
     2161 gaaaacgggc gtctatgtgc aacagatgcc ctacccctgt tatgttgatg acatttttct
     2221 gcgggtcatg agccgctcaa tgcccctctt catgactctg gcctggatct actctgtggc
     2281 tgtgatcatc aagagcattg tgtatgagaa ggaggctcgg ttgaaggaga ccatgcgcat
     2341 catgggcctg gacaatggca tcctctggtt tagctggttc attagtagtc tcatccctct
     2401 gctcgtgagc gctggcctgt tggtgatcat cttgaagtta ggagatctgc tgccctatag
     2461 tgaccccagc gtggtgttcg tcttcctctc tgtgtttgcc gtggtgacca ttctacagtg
     2521 cttcctcatt agcacactct tctcccggac caacctggca gcagcctgtg ggggcatcat
     2581 ctacttcacg ctgtacctgc cctatgtgct gtgtgtagca tggcaggact atgtgggctt
     2641 ctccatcaag atctttgcta gcctgctgtc tcctgtggct tttggattcg gctgtgagta
     2701 ttttgctctt tttgaggagc aaggcatcgg ggtccaatgg gacaatctct ttaagagccc
     2761 agtggaggag gatggcttca atcttaccac ctcagtgtcc atgatgctgt ttgacacctt
     2821 catctatggc gtgatgacat ggtacatcga agccgtcttc ccaggacagt acggaattcc
     2881 caggccctgg tattttcctt gtaccaagtc ctactggttt ggggaggaaa ttgatgagaa
     2941 gagccaccct ggttccagcc agaagggtgc gtcagaaatc tgcatggaag aggagcccac
     3001 tcacctgaag ctgggggtat ccattcagaa cctggtgaag gtttaccgag atggcatgaa
     3061 ggttgctgtg gatggtttgg cgctaaattt ttacgagggc cagatcacct ccttcctggg
     3121 ccacaatgga gcagggaaga ccaccaccat gtcaatactg actgggttgt ttcccccaac
     3181 ttctggcact gcctacatcc tggggaagga cattcgatct gagatgaact ctatccggca
     3241 gaacctggga gtctgtcccc agcataatgt gttgtttgac atgctgacag tcgaagagca
     3301 catctggttc tatgcccgcc taaaggggct ctcagagaag catgtgaaag cagagatgga
     3361 gcagatggcc ctggatgttg gcttaccccc cagcaagctg aaaagcaaaa caagtcagct
     3421 ctctggtggg atgcagagaa agctgtctgt ggccttggcc ttcgtgggtg gatccaaggt
     3481 tgtcattctg gatgagccca cagcaggtgt ggacccatac tctcgcaggg gaatatggga
     3541 gctcctgctg aaataccgac aaggccgcac cattattttg tctacacacc acatggatga
     3601 agcagacatc ctaggggaca gaattgccat catttcccat gggaagctgt gttgtgtggg
     3661 ctcctccctg tttttgaaaa accagttggg aacgggttac tacctgaccc tggtcaagaa
     3721 agatgtggaa tcgtccctca gttcctgcag aaacagtagc agtactgtgt cttgtctgaa
     3781 aaaggaggac agtgtttctc agagcagttc tgatgctggc ctgggcagcg accatgaaag
     3841 tgacacgctg accatcgatg tctctgctat ctccaacctc atcaggaaac atgtgtccga
     3901 agcccggctg gtggaggaca ttgggcacga actgacctat gtgctgccgt acgaagctgc
     3961 taaggaggga gcctttgtgg agctcttcca cgagattgat gaccgcctct cagacctggg
     4021 catctccagt tacggcatct cagagaccac cctagaagaa atattcctca aagtggctga
     4081 agagagtggg gtggatgctg agacctcaga cggtactttg ccagcaagac gaaacagacg
     4141 ggccttcggt gacaagcaga gctgtctgca cccatttaca gaggacgatg ctgtggatcc
     4201 gaatgactct gacctagacc cagaatccag ggagacagac ctgctcagcg ggatggatgg
     4261 caaaggctcc taccagctaa agggctggaa actcacccag cagcagtttg tggccctctt
     4321 gtggaaaagg ctgctgattg cccggcggag tagaaagggt ttctttgctc agattgtcct
     4381 gccggctgtc tttgtttgca tcgccctggt cttcagcctg atcgtgccac cctttggcaa
     4441 gtaccccaac ctggaacttc aaccctggat gtataacgag cagtatacat ttgtcagtaa
     4501 cgatgctcca gaggacatgg gcacccagga actcctcaat gctctaacca aagatccagg
     4561 cttcgggacc cgttgtatgg aaggaaaccc aatcccaaac actccttgct tggtcgggga
     4621 ggaggactgg accactggcc cagttcccca gaccctcatg gacctcttcc aaaatgggaa
     4681 ctggacgatg aagaacccct caccttcgtg ccagtgtagc agtgacaaaa tcaagaagat
     4741 gctgcctgtg tgtcctccag gggcaggggg gctgccgcct cctcagagaa aacagaagac
     4801 tgcagacatc cttcagaatc tgaccggaag aaatatttca gattacctgg tgaagacata
     4861 tgtgcagatc atagcaaaaa gcttaaagaa taaggtctgg gtgaatgagt ttcggtatgg
     4921 cgggttttcc ctgggtgtca gtgattctca agcacttcct ccgagccaag aagttaataa
     4981 tgctatcaag caaatgaaga aactcctgaa gctgaccaag gacagctctg cagatcggtt
     5041 cctcagcagc ttgggaaggt tcatgacagg actggacacc aaaaacaatg tcaaggtgtg
     5101 gttcaataac aagggctggc atgccatcag ttcattcctg aatgtcatca acaatgccat
     5161 tctccgggcc aacctgcaga agggagagaa cccaagccag tatgggatta ctgctttcaa
     5221 ccatcccctg aacctcacca agcagcagct ctcggaggtg gctctgatga ccacatctgt
     5281 cgacgtcctt gtgtccatct gtgtcatctt tgcaatgtcc tttgtgccag ccagctttgt
     5341 tgtgttcctg atccaggagc gtgtgagcaa agccaaacac cttcagttca tctgcggcgt
     5401 gaagcctgtc atctactggc tctccaactt tgtctgggat atgtgtaatt atgtggtccc
     5461 tgctacactg gtcgttatca tcttcatctg cttccagcag aagtcctatg tatcctccac
     5521 caacctgcct gttctagccc ttctgctctt gctatatggg tggtcgatca ctcctctcat
     5581 gtacccagcg tcctttgtgt tcaagatccc cagcactgcc tacgtggtcc tcaccagtgt
     5641 gaacctcttc atcggcatca atggtagtgt ggccactttc gtcctggagc tctttacaaa
     5701 caataaattc aatgacatca atgacatcct gaaatctgtg tttcttattt tcccacattt
     5761 ttgcctgggg cgagggctta ttgacatggt gaaaaaccag gcgatggctg atgccctgga
     5821 gaggtttggg gagaaccgct tcgtctctcc actctcttgg gacttagtag gacggaacct
     5881 ttttgccatg gccgtggaag gggtggtgtt cttcctcgtt acggttctaa tccagtaccg
     5941 atttttcatc aggcccagac ctgtaaaggc gaggcttcct cctttgaatg acgaggacga
     6001 ggacgtgagg agggagagac agaggattct ggagggtgga ggacagaatg acatcctaga
     6061 gatcaaagaa ctgaccaaga tctacagaag gaagcggaag cctgcagtgg acagaatctg
     6121 cgttggcatc cctcctggag agtgctttgg actcctggga gttaatggag ctgggaagac
     6181 atcaacattc aagatgctga ctggagatac cgctgtgacc agaggggatg ctcttcttaa
     6241 caagaacagc atcttatcaa acatccatga agtacatcaa aacatgggct actgccctca
     6301 gttcgatgcc atcacggagc ttctgactgg aagagagcat ctggagttct ttgcccttct
     6361 caggggagtc ccagaaaaag aagttggcaa ggttggtgaa tgggcaattc gcaaactggg
     6421 ccttgttaag tatggagaaa aatacgccag caactacagt ggcggtaaca agcggaagct
     6481 ttccacagcc attgctctga ttggcgggcc tcctgtggtg tttctggatg aaccaaccac
     6541 aggcatggac cccaaagccc ggagattcct gtggaattgt gccctaagca ttatcaagga
     6601 gggaagatcc gtagttctta catctcatag catggaggaa tgtgaagctc tttgtaccag
     6661 gatggccata atggtcaatg ggaggttcag gtgcctcggc agtgtccaac atctgaaaaa
     6721 caggtttgga gatggttata ccatagttgt acgaatagcg ggctccaacc ctgacctaaa
     6781 gcctgtccag gagttctttg gacttgcctt tcctggaagt gttctgaaag agaaacatcg
     6841 aaacatgcta cagtaccagc ttccgtcctc cttgtcatct ctggccagga tattcagcat
     6901 tctctcccag agcaaaaagc gactccacat agaagactac tctgtctctc agacaacact
     6961 tgaccaagta ttcgtgaact ttgccaagga ccaaagtgat gatgaccact taaaggacct
     7021 gtcactacac aaaaaccaga cagtggtgga tgtggctgtt ctcacatcct tcctgcagga
     7081 cgagaaagtg aaagaaagtt acgtatgaag aatcctgtta acacaggggg aatgaaagga
     7141 agggagagct aggtctccct ttgcaccggg tcaagtgttc cagaagaaag cgtcccgcgt
     7201 ttctgtggag tggaacaaac tggattctgt actgacacta ttcaatgcaa tgcacttcaa
     7261 tgcaacaaga acacgattcc attacagggg cagtgccttt gtagcctatg tcttgtatgg
     7321 ctctctagtt aaaatgactt gaagttagtt cattatctta tgcagatgtg aaactctggt
     7381 gtggaaccaa gcagactctg ggtttggatt catactgttt gttcctgtgt attctcactg
     7441 ggattgcaac aacaatccgt caagtagtaa tggccagtga taatcaacgt cgaaggcatg
     7501 tacatcctca tccactaagc catgctgacc cacaaacctg gtttcccggt gacacatcca
     7561 ttgctggcaa tgagtgtgcc agatttatta gtgccaagtt gctcagaaag tctgaagcac
     7621 taagtatgtc acaaacactt ttgtgaaaac cgccctgctg tctgttgaca tcattaaata
     7681 tcaggtgaca aaacggtgcc gtgtgtgact aagtccccat tttccttctc tctgatgagc
     7741 tgctgtggtg gccgtcttgt gcgagatgtg gatctctgta acccaggtcc ttggttctgc
     7801 tgttcactgt tgcccatgtc catgcccatg tccatcccca tgaccatgct cgtgtcatgc
     7861 attaccagag catctttctg agactttttc aaacacatta gatcccgata cgcaacaaag
     7921 gtcagcagcc aaactgctgg ggctgcaatc agctgagttc agggtgtggc aggaaaaatc
     7981 tggtgcactt acacgtgaga ggtctgggtc tgttcgtccc gactgtctgc taacacaaga
     8041 tggtatactc catctcgaga tccttcgtta tttgacagaa acatagttct ttccagctgt
     8101 tggaattagc ttagaaaacg aaagggtggc attttatttt gatgaaaatg tttgcattgc
     8161 tcgtattatt tggaactttt aagttttatc aatgcttctg gaagctcaga accaaaccaa
     8221 acctcagtgc tcagtcgcat agagggatgt ggccacactg cctcatgcct tattttcctt
     8281 ggtaaatttg caggtggaat gtccgactag cccagtgacc agaaaacaat gttgtggtta
     8341 acatctcaga ccatatttta agatccggta gaacactatt catttccagt tgcagattga
     8401 gtattttttt tttttttttg cgtacaatca ctgggtagat tcctggatgg gagtgagggg
     8461 gagctcgcag attttctgtg ccattgactc agctgactga tttacagata caggctgttt
     8521 tgttaaatcc actgaaagaa tacggccaca cccttgccta cttgatagca tcagtacaaa
     8581 agccaaggag ggtcactaaa caaccaactc ttcccagggg aaaaccgcta gcttgaaatt
     8641 tcttggatat aatttatact tgtgaccttt gagaccttca aactatgggc aaacaatggg
     8701 tttagcagga tgtgagacac ccatttaaac ctccgacgat ctcaaacagt ccatctcttt
     8761 actcactaac cagtcatgaa aaacagtcag ctgttctaca tggagcattt ttcagacttt
     8821 tctaacccaa acttaatttg ctttcatccg caagcaatgt gaaaaaagag agagagaaag
     8881 aaaaacttat ttcaccaatt ctcgatgtca ttcgtcttca tacaaaacaa gacatgagta
     8941 aaattccggt attgggcaaa gttcaagtga gcttttgata tctctaattt cttcatcttc
     9001 taaaaattgg gaagaataag aaagatttca gatctattca aattatgttt atgtaacact
     9061 gttatgtaac tcactgcttg aaaggaaaaa aatgatggtt ttgatactca tgtcaacata
     9121 ggtctctaaa atgacaagaa aagtgtgttt ccaggagcta ttggcacacc actatatttt
     9181 atcaaagtta cagaattcaa agaaacaagt ctctattttt caaaatcaaa cgttagttga
     9241 cttcctcagc ccactgtcat tgtgtcctaa cttttcaata tactacagcc ctgagaaaaa
     9301 tctttgtttt aatcactgat ttttgaggcc acattaaaaa gaaagaatca agcaacagca
     9361 aaaataaggc actattttgg aaaagattca attcagtgta gatttaaaat cattcctaaa
     9421 actagagaca atctgtaggt attgtattac cttttatact atctgaatag ttaatcttca
     9481 gttttccttt gtaaacgtaa ttatcttaga tatttaaaaa tcaatcttat cttcaaataa
     9541 aatcccctat ggagatgtgg tacgtgagtt gagaaattct caagcgcaaa cacttctggt
     9601 ttactatttt ttttttaata ttggaaaact tactaactgt gaatatgaga aagacaaaag
     9661 aaagtaagtc ctctcgctag acatcctagc gcaattcatt ttgaaacaaa caaggaaacc
     9721 tcaaactact gtatttaggt gtctgtactg caaacatatg cctcatgaca atgtcataca
     9781 tcaatcgctc tctgtaagca ggcattgact taaagggatt gtctgttgtc ttctcacggt
     9841 tgtatatatc aggtaaaatt gttccaaaga gccatgtgtt gtgtaatggg gaaccacttt
     9901 gatactgaaa tactaatttg tactctcgtt actattaact ggtaatagtg taatgccaca
     9961 gtaatactgt tccgattgaa aattgttgcg tccctttttg tagaacattt atatttccat
    10021 ataaggatgc ggtatgttct ttccccgtgt accctaggat gaagctgttt ttgtgctttt
    10081 tctttatcat tggccctcat cccaagcact ttatgctgtc tgtaatggat ctatttttgc
    10141 actggaatat ctgagatttg caaaactaga caaaagtttc agagcagatt tctaagttaa
    10201 ataattttca ttaaaagaaa aaaactgaaa aaaattgtat tgtgaataac tttatacgaa
    10261 gtgtttttaa aagcctgttt ctatgttatg agtcacaaaa taaagctgtg acagtc
//
