LOCUS       NM_031003               1725 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus 4-aminobutyrate aminotransferase (Abat), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_031003
VERSION     NM_031003.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1725)
  AUTHORS   Shen,J., Wang,C., Ying,J., Xu,T., McAlinden,A. and O'Keefe,R.J.
  TITLE     Inhibition of 4-aminobutyrate aminotransferase protects against
            injury-induced osteoarthritis in mice
  JOURNAL   JCI Insight 4 (18), 128568 (2019)
   PUBMED   31534049
  REMARK    GeneRIF: Inhibition of 4-aminobutyrate aminotransferase protects
            against injury-induced osteoarthritis in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1725)
  AUTHORS   Dieb,W. and Hafidi,A.
  TITLE     Mechanism of GABA involvement in post-traumatic trigeminal
            neuropathic pain: activation of neuronal circuitry composed of
            PKCgamma interneurons and pERK1/2 expressing neurons
  JOURNAL   Eur J Pain 19 (1), 85-96 (2015)
   PUBMED   24890317
REFERENCE   3  (bases 1 to 1725)
  AUTHORS   Briggs,S.W., Mowrey,W., Hall,C.B. and Galanopoulou,A.S.
  TITLE     CPP-115, a vigabatrin analogue, decreases spasms in the
            multiple-hit rat model of infantile spasms
  JOURNAL   Epilepsia 55 (1), 94-102 (2014)
   PUBMED   24321005
REFERENCE   4  (bases 1 to 1725)
  AUTHORS   De Ita-Perez,D., Mendez,I., Vazquez-Martinez,O., Villalobos-Leal,M.
            and Diaz-Munoz,M.
  TITLE     Synchronization by food access modifies the daily variations in
            expression and activity of liver GABA transaminase
  JOURNAL   Biomed Res Int 2014, 590581 (2014)
   PUBMED   24809054
  REMARK    GeneRIF: Daytime restricted feeding influences the daily variations
            of GABA-T mRNA levels, stability, and catalytic activity of GABA-T.
REFERENCE   5  (bases 1 to 1725)
  AUTHORS   Yu,X., He,G.R., Sun,L., Lan,X., Shi,L.L., Xuan,Z.H. and Du,G.H.
  TITLE     Assessment of the treatment effect of baicalein on a model of
            Parkinsonian tremor and elucidation of the mechanism
  JOURNAL   Life Sci 91 (1-2), 5-13 (2012)
   PUBMED   22634324
REFERENCE   6  (bases 1 to 1725)
  AUTHORS   Singewald,N., Pfitscher,A. and Philippu,A.
  TITLE     Effects of gamma-vinyl GABA (vigabatrin) on blood pressure and body
            weight of hypertensive and normotensive rats
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 345 (2), 181-186 (1992)
   PUBMED   1570022
REFERENCE   7  (bases 1 to 1725)
  AUTHORS   Sherif,F., Gottfries,C.G., Alafuzoff,I. and Oreland,L.
  TITLE     Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine
            oxidase (MAO) in patients with Alzheimer's disease
  JOURNAL   J Neural Transm Park Dis Dement Sect 4 (3), 227-240 (1992)
   PUBMED   1627256
REFERENCE   8  (bases 1 to 1725)
  AUTHORS   Beeler,T. and Churchich,J.E.
  TITLE     4-Aminobutyrate aminotransferase fluorescence studies
  JOURNAL   Eur J Biochem 85 (2), 365-371 (1978)
   PUBMED   648527
REFERENCE   9  (bases 1 to 1725)
  AUTHORS   Stoof,J.C. and Mulder,A.H.
  TITLE     Increased dopamine release from rat striatal slices by inhibitors
            of GABA-aminotransferase
  JOURNAL   Eur J Pharmacol 46 (2), 177-180 (1977)
   PUBMED   590329
REFERENCE   10 (bases 1 to 1725)
  AUTHORS   Schwarcz,R., Bennett,J.P. Jr. and Coyle,J.T.
  TITLE     Inhibitors of GABA metabolism: implications for Huntington's
            disease
  JOURNAL   Ann Neurol 2 (4), 299-303 (1977)
   PUBMED   152600
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D87839.1.
            
            On Aug 31, 2012 this sequence version replaced NM_031003.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87839.1, BC081787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1725              D87839.1           2-1726
FEATURES             Location/Qualifiers
     source          1..1725
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1725
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /note="4-aminobutyrate aminotransferase"
                     /db_xref="GeneID:81632"
                     /db_xref="RGD:620948"
     exon            1..57
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            58..171
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1604
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /EC_number="2.6.1.19"
                     /EC_number="2.6.1.22"
                     /note="GABA-T; GABA-AT; L-AIBAT; GABA transaminase;
                     gamma-amino-N-butyrate transaminase;
                     (S)-3-amino-2-methylpropionate transaminase; GABA
                     aminotransferase; beta-AlaAT I"
                     /codon_start=1
                     /product="4-aminobutyrate aminotransferase, mitochondrial"
                     /protein_id="NP_112265.1"
                     /db_xref="GeneID:81632"
                     /db_xref="RGD:620948"
                     /translation="MAFLLTTRRLVCSSQKNLHLFTPGSRYISQAAAKVDFEFDYDGP
                     LMKTEVPGPRSQELMKQLNTIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISS
                     VPIGYNHPALAKLVQQPQNASTFINRPALGILPPENFVDKLRESLMSVAPKGMCQLIT
                     MACGSCSNENAFKTIFMWYRSKERGQRGFSKEELETCMVNQSPGCPDYSILSFMGAFH
                     GRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVTDNQQEEARCLEEVEDL
                     IVKYRKKKRTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGC
                     TGKFWAHEHWGLDDPADVMSFSKKMMTGGFFHKEEFRPSAPYRIFNTWLGDPSKNLLL
                     AEVINIIKREDLLNNVAHAGKTLLTGLLDLQAQYPQFVSRVRGRGTFCSFDTPDKAIR
                     NKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSGILADFK"
     exon            172..269
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            270..299
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            300..417
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            418..467
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            468..548
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            549..641
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            642..704
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            705..768
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            769..917
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1055
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1223
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1370
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1482
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1725
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1725
                     /gene="Abat"
                     /gene_synonym="beta-AlaAT; Gabat"
                     /note="14 A nucleotides"
ORIGIN      
        1 gatcgcgcaa gtcggacccg tggatcacag cctgtagatc gcggcccggg cctggaggac
       61 aacagcaagt gaagggggtt cctcttcctg aaggaggggt catggccttc ttgttgacta
      121 cccgacggct ggtctgcagt tcccagaaaa acctccacct cttcacacct ggatccagat
      181 acatcagcca agctgctgcc aaagttgact ttgagtttga ttatgatgga ccactcatga
      241 agacagaagt cccgggccct agatctcagg agctaatgaa acagctgaac acaatccaga
      301 atgcagaggc cgtgcacttt ttctgcaact acgaagagag ccgaggcaac tacctcgtgg
      361 acgtggatgg caaccgcatg ttggacctgt attctcagat ctcctctgta cccatcggtt
      421 acaaccatcc ggctctggcg aaactcgttc aacagcctca aaacgcgagc actttcatca
      481 acagacctgc cctgggcatc ctgcctccag agaactttgt ggacaagctc cgggagtcct
      541 tgatgtcggt ggcgcccaaa ggcatgtgtc agctcatcac gatggcctgc gggtcctgct
      601 ccaatgagaa tgcattcaag accatcttca tgtggtaccg gagtaaagaa cgaggtcaga
      661 gaggtttctc caaagaggag ctggagactt gcatggttaa ccagagtcct ggatgcccag
      721 actacagcat cctctccttc atgggtgctt tccacgggag gaccatgggt tgcttagcga
      781 ccacacactc caaagcaatt cacaagattg acatcccttc ctttgactgg cccattgctc
      841 cattcccacg gctgaaatat cccctggagg agtttgtgac ggacaatcag caagaggagg
      901 cccgctgtct agaagaggtg gaggatctaa ttgtgaaata tcggaaaaag aagagaacag
      961 tggctgggat catcgtggag cccatccagt ccgaaggtgg agacaaccac gcatcagatg
     1021 acttcttccg gaagctgaga gacatagcca ggaagcatgg ctgtgccttc ttggtggacg
     1081 aggttcagac tggaggaggc tgtacaggca agttctgggc ccatgaacac tggggcttgg
     1141 atgacccagc cgacgtgatg tcgttcagca agaagatgat gactgggggc ttcttccaca
     1201 aggaggagtt tcgaccaagt gctccttacc ggatcttcaa cacctggctg ggggacccat
     1261 ccaagaactt gctgctggct gaggtcatca acatcatcaa gcgggaagac ctgctcaaca
     1321 acgtggccca tgccgggaag accctactga ccgggctgct ggacctccag gcccagtacc
     1381 cccagttcgt cagccgggtg aggggacgag gcaccttctg ttccttcgac actcccgaca
     1441 aagccatacg gaataaactc atcctaattg ccaggaacaa aggtgtggta ctggggggct
     1501 gcggtgacaa atccatacgt ttccgtccca cgctggtctt cagggatcac catgcccact
     1561 tgttcctcaa cattttcagt ggtatcttag cagacttcaa gtaaagaagc catctccacg
     1621 acattcagag aaagctctgt cccagcggtg tcaacttgat tagtttgcct aattcatatt
     1681 ttcacttcaa agtttatcag aggcgaatgc ataaactaaa gggtc
//
