LOCUS       NM_001394586            5413 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus apoptosis-associated tyrosine kinase (Aatk),
            transcript variant 1, mRNA.
ACCESSION   NM_001394586 XM_006247926
VERSION     NM_001394586.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5413)
  AUTHORS   Takano,T., Tomomura,M., Yoshioka,N., Tsutsumi,K., Terasawa,Y.,
            Saito,T., Kawano,H., Kamiguchi,H., Fukuda,M. and Hisanaga,S.
  TITLE     LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via
            Rab11 in a Cdk5-dependent manner
  JOURNAL   J Neurosci 32 (19), 6587-6599 (2012)
   PUBMED   22573681
REFERENCE   2  (bases 1 to 5413)
  AUTHORS   Kos,A., Olde Loohuis,N.F., Wieczorek,M.L., Glennon,J.C.,
            Martens,G.J., Kolk,S.M. and Aschrafi,A.
  TITLE     A potential regulatory role for intronic microRNA-338-3p for its
            host gene encoding apoptosis-associated tyrosine kinase
  JOURNAL   PLoS One 7 (2), e31022 (2012)
   PUBMED   22363537
  REMARK    GeneRIF: miR-338-3p participates in the regulation of its host gene
            by modulating the levels of AATK mRNA.
REFERENCE   3  (bases 1 to 5413)
  AUTHORS   Tsutsumi,K., Tomomura,M., Furuichi,T. and Hisanaga,S.
  TITLE     Palmitoylation-dependent endosomal localization of AATYK1A and its
            interaction with Src
  JOURNAL   Genes Cells 13 (9), 949-964 (2008)
   PUBMED   18691334
REFERENCE   4  (bases 1 to 5413)
  AUTHORS   Tomomura,M., Morita,N., Yoshikawa,F., Konishi,A., Akiyama,H.,
            Furuichi,T. and Kamiguchi,H.
  TITLE     Structural and functional analysis of the apoptosis-associated
            tyrosine kinase (AATYK) family
  JOURNAL   Neuroscience 148 (2), 510-521 (2007)
   PUBMED   17651901
REFERENCE   5  (bases 1 to 5413)
  AUTHORS   Tomomura,M., Fernandez-Gonzales,A., Yano,R. and Yuzaki,M.
  TITLE     Characterization of the apoptosis-associated tyrosine kinase
            (AATYK) expressed in the CNS
  JOURNAL   Oncogene 20 (9), 1022-1032 (2001)
   PUBMED   11314040
REFERENCE   6  (bases 1 to 5413)
  AUTHORS   Gaozza,E., Baker,S.J., Vora,R.K. and Reddy,E.P.
  TITLE     AATYK: a novel tyrosine kinase induced during growth arrest and
            apoptosis of myeloid cells
  JOURNAL   Oncogene 15 (25), 3127-3135 (1997)
   PUBMED   9444961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 27, 2021 this sequence version replaced XM_006247926.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.38272.1,
                                           SRR26643288.44476.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JAXUCZ010000010.1  105825335-105825618 c
            285-418             JAXUCZ010000010.1  105803461-105803594 c
            419-566             JAXUCZ010000010.1  105800763-105800910 c
            567-646             JAXUCZ010000010.1  105798596-105798675 c
            647-765             JAXUCZ010000010.1  105798209-105798327 c
            766-853             JAXUCZ010000010.1  105797988-105798075 c
            854-987             JAXUCZ010000010.1  105797328-105797461 c
            988-1072            JAXUCZ010000010.1  105795448-105795532 c
            1073-1194           JAXUCZ010000010.1  105795253-105795374 c
            1195-1344           JAXUCZ010000010.1  105794598-105794747 c
            1345-3928           JAXUCZ010000010.1  105791708-105794291 c
            3929-4073           JAXUCZ010000010.1  105791486-105791630 c
            4074-4274           JAXUCZ010000010.1  105791154-105791354 c
            4275-5413           JAXUCZ010000010.1  105789171-105790309 c
FEATURES             Location/Qualifiers
     source          1..5413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..5413
                     /gene="Aatk"
                     /note="apoptosis-associated tyrosine kinase"
                     /db_xref="GeneID:690853"
                     /db_xref="RGD:1590980"
     exon            1..284
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..4315
                     /gene="Aatk"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LMTK1"
                     /protein_id="NP_001381515.1"
                     /db_xref="GeneID:690853"
                     /db_xref="RGD:1590980"
                     /translation="MPIALLALAMSSSFFNPSFAFSSHFDPDGAPLSELSWSSSLAVV
                     AVSFSGIFTVIVLMLACLCCKKGGIGFKEFENAEGEEYVADFSEQGSPAATVQNGPDV
                     YVLPLTEVSLPMAKQPGRSVQLLKSTDLGRHSLLYLKEIGHGWFGKVFLGEVHSGVSG
                     TQVVVKELKASASVQEQMQFLEEAQPYRALQHSNLLQCLAQCAEVTPYLLVMEFCPLG
                     DLKGYLRSCRVTESMAPDPLTLQRMACEVACGVLHLHRHNYVHSDLALRNCLLTADLT
                     VKVGDYGLAHCKYREDYLVTADQLWVPLRWIAPELVDEVHGNLLVVDQTKTSNVWSLG
                     VTIWELFELGAQPYPQHSDRQVLAYAVREQQLKLPKPQLQLTLSDRWYEVMQFCWLQP
                     EQRPTAEEVHLLLSYLCAKGTTELEEEFERRWRSLRPGGSAGLGSASTVPAAAASELT
                     AASSFPLLEQFTSDGFHVDSDDVLTVTETSHGLNFEYKWEAGCGAEAYPPPGAAFSPG
                     SAGRLQELCAPDSSPPGVVPVLSAHSPSVGSEYFIRLEGAVPAAGHDPDCAGCAPSPQ
                     AVSEQDNNSEESTAASLVMEPLLGHAPPTGGLWGPCDHHSRRRQEPPCPSRSPSPGTP
                     MLPAEDIDWGVATFCPPFFDDPLGTSPSGSPGAQPSPSDEELEEGKTGRAAQCGHWSS
                     NMSANNNSGSRDPESWDPGYVSSFTDSYRDDCSSLEQTPRASPELGHPLSQEDSRDFL
                     PGLVAASPGQESSRCFNLLPLCPAKGLAPAACLVPPPWTEAAVGGAENPIVEPKLAQE
                     AEGSAEPQLPLPSVPSPSHEGASLPSEEASAPDIQPASPTPAAGSWVTVPEPAPTLDS
                     SSSSLGQEVPSSEDEDTTEVTSGVFTDLSSDGPHTEKSGIVPALRCLQKQVGTPDSLD
                     SLDIPSSASDGGCEVLSPSAAGPAGGQPRAMDSGYDTENYESPEFVLKEAHESSEPEA
                     FGEPASEGESPGPDTLLSVSLGDLSRKNPYRDSAYFSDLDAESEPNFGPEKHSGIQDS
                     QKEQDLRSPPSPGHESVQAFPRPEVSSEVLPPPQQSEEPMPEGPGSEPLEAQGPVEVE
                     PVPGPSHSKCLLLTSAPLSSEGNGTESRGPPGPLSGPAQTGRMGNPSTSRSPLCLALP
                     GHPGTSEGRPEDDEDTEDSEESDEELRCYSVQEPSEDSEEEPSAVPVVVAESQSARNL
                     RSLLKMPSLLSEAFCDDLERKKKAVSFFDDVTVYLFDQESPTREAGEPFPSTKECPTF
                     LEGSPGSPSATGVPLRAGHSPDSSAPEPGSRFEWDGDFPLVPGKAALVTALDPADPVL
                     AAPPTPAAPFSRFTVSPAPPSRFSITQVSDSDAQSMGGPAADAEGRCTKA"
     exon            285..418
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     exon            419..566
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     exon            567..646
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     exon            647..765
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     exon            766..853
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     exon            854..987
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1072
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1194
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1344
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..3928
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     exon            3929..4073
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4274
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
     exon            4275..5413
                     /gene="Aatk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccccgc ggcgccgcgg cggcgggcgg aggcgcctag tctgtcgccg cccctactgg
       61 tgcccgcgct gcggcggtgg ctgggggcgc taggagccgg gggccgtgca ctccgcacct
      121 gcggaggccg ctgggcgatg atgccggaac gccggcccag gccgccggcg ttctgagctt
      181 aagcgcagcg cccgccccgg ggatgcccat cgcgctgctg gccctggcca tgtcgtcgtc
      241 cttcttcaac cccagctttg ccttcagctc ccacttcgac ccggacggtg ccccgctcag
      301 tgagctatcc tggtcctcgt cccttgcagt ggttgctgtg tccttctctg ggatcttcac
      361 tgtcattgtc ctcatgctgg cctgcctgtg ctgtaagaag ggcggcattg ggttcaagga
      421 gtttgagaat gctgaagggg aagagtatgt ggccgacttc tcggagcagg gctccccggc
      481 tgctactgta cagaacggcc ccgatgtgta tgtcctgcct ctcactgagg tctccctgcc
      541 catggctaag cagccgggtc gctcagtgca actcctcaag tccacggacc tgggccgcca
      601 cagcctcctg tacttgaagg agattggcca cggttggttt gggaaggtgt tcttggggga
      661 ggtgcactcg ggtgtcagtg gcacgcaggt ggtggtgaag gagctgaagg ccagcgccag
      721 tgtgcaggag cagatgcagt tcctggagga ggcgcagccc tacagggccc tgcagcacag
      781 caacctgctt cagtgcctgg cccagtgtgc tgaggtgacc ccctatttgc tggttatgga
      841 gttctgtccc ctgggggacc tcaaaggtta tctacggagc tgccgggtga cagagtccat
      901 ggcgcctgac ccccttacct tgcagcgcat ggcgtgcgag gtggcgtgtg gtgtcttgca
      961 tctacatcgt cacaactatg tgcacagtga cctggccctg aggaactgcc tgctgacggc
     1021 tgacctgaca gtgaaggttg gcgactatgg cctggcccat tgcaaataca gggaagacta
     1081 cctcgtgacg gccgaccagt tgtgggtgcc gctgcgttgg atcgcgccag agctggtgga
     1141 tgaggtgcat ggcaacctac tggtggtgga ccagactaag accagcaatg tgtggtccct
     1201 gggtgtgacc atctgggagc ttttcgagtt gggcgcgcag ccctaccccc agcactcgga
     1261 ccggcaggtg ctggcttacg ccgtccgaga acagcaactt aagttgccca agccccagct
     1321 acagctgact ctgtctgatc gatggtacga ggtgatgcag ttctgctggc ttcagccaga
     1381 acagaggcct acggctgagg aggttcatct gctgctgtcc tacttgtgcg ccaagggcac
     1441 cacggagctg gaggaggagt tcgagcggcg ctggcgctcc ctgcggccgg ggggcagcgc
     1501 ggggctgggc tcagcttcca cagtcccggc agctgccgca tctgaactca ctgctgcttc
     1561 atctttcccg ctgctggagc agttcaccag tgacggcttc cacgtggaca gcgacgacgt
     1621 gctgacagtc actgagacga gccacggcct caacttcgaa tacaagtggg aggctggctg
     1681 tggcgctgag gcttacccgc ccccaggcgc tgctttcagc ccaggttccg cagggcgcct
     1741 gcaggagctg tgtgcacccg acagctcgcc gccgggtgtg gtgccggtcc tcagtgccca
     1801 cagcccctca gtgggtagcg agtacttcat ccgcctggag ggggcagtgc cggctgctgg
     1861 ccatgaccca gactgtgccg gctgtgctcc cagcccccaa gctgtgtccg agcaggacaa
     1921 taactctgag gagagcaccg ctgcatccct tgtcatggag ccgcttctgg gccacgcacc
     1981 acccactggg ggcctgtggg gcccctgcga ccatcattct cgaaggaggc aagagccacc
     2041 ctgcccctca cgctcaccct ctcctgggac cccgatgttg ccagctgaag acatagactg
     2101 gggtgtagct accttctgcc cacccttttt tgatgaccca ctgggcacat ctccctctgg
     2161 gagtcctggg gcccagccat cccccagtga tgaggagctg gaggagggaa agactgggag
     2221 ggctgctcag tgtggacact ggagctctaa catgtctgcc aacaataaca gtggcagtcg
     2281 agacccagaa tcctgggatc ctggctatgt gagcagcttc acagacagct acagggacga
     2341 ctgctccagc ttagagcaga cccctcgggc ctcccctgag ctgggccatc ccctgtccca
     2401 ggaggattcc agagattttt tacctgggct agtagcagct tcccctggcc aggagtcaag
     2461 ccgttgcttc aacctgctcc ctctgtgtcc tgccaaaggc ctggcacctg ctgcttgcct
     2521 cgtcccaccc ccctggacag aggcagctgt aggtggggct gagaacccca ttgtcgaacc
     2581 caaacttgcc caggaggctg agggctctgc tgaaccccag ctaccccttc cttctgtccc
     2641 ctccccatcc cacgaaggag cctcgcttcc ctcggaggag gcaagcgctc ctgacatcca
     2701 gcctgcctct cctacacccg ctgctggcag ctgggtgacc gtccctgagc cagcccccac
     2761 cctggatagc agcagcagtt ctctggggca agaggtaccc agcagcgagg atgaagacac
     2821 aaccgaggtt acgtcaggag tcttcaccga cctgtccagc gacggcccac acacggagaa
     2881 gtcaggcata gtaccagcct tgcgctgtct gcagaagcag gtggggaccc ctgactccct
     2941 ggactctttg gacatcccgt cctcagccag cgatggcggc tgtgaggtct taagcccatc
     3001 agctgctggc cccgctggtg ggcagccccg tgccatggac agtggctatg atacagagaa
     3061 ctatgagtcc cctgagtttg tgctcaagga ggcccatgag tcaagtgagc ctgaggcctt
     3121 tggggagcca gcctcagagg gtgagagccc agggcccgat actctgctct ctgtctccct
     3181 tggtgacctc agcagaaaga acccctaccg agactctgcc tacttttcag acctggatgc
     3241 tgagtccgaa cccaactttg gccctgagaa gcacagtggg atccaggact cccaaaagga
     3301 gcaagacctg aggagcccac ctagtccagg gcatgagtct gtgcaggctt ttcccaggcc
     3361 tgaggtgtcc agcgaggtgc tgccccctcc acagcagtca gaggagccca tgccagaagg
     3421 ccccgggtca gagcctcttg aggctcaagg cccagttgaa gtggagcccg tgccaggccc
     3481 aagtcattcc aaatgtctcc tgttgacctc cgctccactg agctcggaag gcaatggcac
     3541 ggagtcccgg ggtcccccag gaccactgtc agggccagcc cagaccgggc ggatggggaa
     3601 tcctagcaca tccagatccc cgctctgcct ggccctgcct ggccaccctg ggacttcaga
     3661 gggacggcca gaggatgacg aggacaccga ggacagtgag gagtctgacg aggagctccg
     3721 gtgctacagc gtccaggagc ccagtgagga cagtgaggag gagccatcag cggtgcctgt
     3781 ggtagtggct gagagccaga gtgcccggaa tctacgcagc ctgctgaaga tgcccagcct
     3841 gctgtcggag gccttctgcg acgacctgga gcgcaagaag aaggctgtgt ccttctttga
     3901 tgacgtcacg gtctacctct ttgaccagga gagccccacc cgagaagctg gggagccctt
     3961 ccccagcacg aaggagtgtc ccacgttcct ggagggtagc cccggctcac ccagtgccac
     4021 tggcgtgcca ctgcgggctg gtcactcgcc agacagctct gctcccgaac cgggcagtag
     4081 gttcgaatgg gatggagatt tcccactggt gccgggcaag gctgctttgg tgactgcgct
     4141 ggatcctgcc gaccctgtcc tggctgcgcc tcccacgcca gctgcaccat tttcacgctt
     4201 cacggtgtcg cccgcacctc cctcccgctt ttccatcaca caagtatccg actcagatgc
     4261 ccagtccatg ggaggcccgg cagcagatgc tgagggccga tgcacaaagg cttgagaccc
     4321 aggtagtccc acccttcgga ggctggcgtc actggagccc ctgccatcct gcccaggcag
     4381 caacaaggat ggtgaccagg aatgaatggg gaccaccggc accctacggc atcctggaga
     4441 agcaggtgga cgagaggcct ctatctagcc ctggacgtat tgggctgtgt accttctgtg
     4501 tcctgggtgg acgccggggt ttgctgctag cccctggaga tacctgtagc ttaagggcct
     4561 atgggtatct gtaagcatat atatatatac atatatatac acacacacac tcaagaaggg
     4621 ccccctggcc cttaggtgac tctctgctcc tggtaagact cccaagcctc agccactctt
     4681 cctatatggc tgttggtggt gaactggcct caggccagga ccaggcagtc catgggcctg
     4741 tatgcccttg ttgactaggt cctgccatat gttcaaagaa cacttggtca ggtttcaaga
     4801 tggctttaag cctgcaggtc ccttttgggt cccccccacc tttcttactg gggtctaggt
     4861 ttgctcggag caaggttgga cctctgggct ccaagccctt atctcagatt ttccgtggct
     4921 atttcccctt cactgcctct gtggaagccc ttccccacag ggtctgtctg gattattctg
     4981 gcctaggtcc tgcccagtag caggggcttc caggctgcag ccggactgcc ccagtgatgc
     5041 cctctgcagg gtagtgtggg cagctctccc tcgcagagca gtgcctgccc cacaccctgg
     5101 tggctagagg agaggaccct acagccacta tggggctcct gcctgcaggc agggctggga
     5161 gaaaacaggg ctggggtggg cagtacaggg agtatttttg taacttgctg gagtgaatga
     5221 aagggggcga ttctaagtta ttgttgccaa agacgtgtat acctttgctt tgggggtggg
     5281 ggcaatgttt tcttttttgt ttttgttttg tttttagttt gaggcttagg atgctggtgc
     5341 aatgattttc ttgttccttg ttttttaaga gaaaccaagc taagaaaaaa aaaaacaaaa
     5401 acaaaaacaa aca
//
