LOCUS       NM_053720               1805 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus apoptosis antagonizing transcription factor
            (Aatf), mRNA.
ACCESSION   NM_053720
VERSION     NM_053720.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Xu,J., Jin,W., Wu,X., Wu,X., Li,A., Ke,K., Cao,J., Liu,X., Tan,X.,
            Fu,H., Gao,Y. and Gao,Z.
  TITLE     Up-regulation of Che-1 relates to neuronal apoptosis after
            traumatic brain injury in adult rats
  JOURNAL   Cell Mol Neurobiol 33 (1), 85-97 (2013)
   PUBMED   23007641
  REMARK    GeneRIF: Che-1 plays an important role in neuronal apoptosis
            following traumatic brain injury.
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Ishigaki,S., Fonseca,S.G., Oslowski,C.M., Jurczyk,A.,
            Shearstone,J.R., Zhu,L.J., Permutt,M.A., Greiner,D.L., Bortell,R.
            and Urano,F.
  TITLE     AATF mediates an antiapoptotic effect of the unfolded protein
            response through transcriptional regulation of AKT1
  JOURNAL   Cell Death Differ 17 (5), 774-786 (2010)
   PUBMED   19911006
  REMARK    GeneRIF: Ectopic expression of AATF or a constitutively active form
            of AKT1 confers on cells resistance to ER stress-mediated cell
            death, whereas RNAi-mediated knockdown of AATF or AKT1 renders
            cells sensitive to ER stress.
REFERENCE   5  (bases 1 to 1805)
  AUTHORS   Bruno,T., Iezzi,S., De Nicola,F., Di Padova,M., Desantis,A.,
            Scarsella,M., Di Certo,M.G., Leonetti,C., Floridi,A., Passananti,C.
            and Fanciulli,M.
  TITLE     Che-1 activates XIAP expression in response to DNA damage
  JOURNAL   Cell Death Differ 15 (3), 515-520 (2008)
   PUBMED   18049476
REFERENCE   6  (bases 1 to 1805)
  AUTHORS   Guo,Q. and Xie,J.
  TITLE     AATF inhibits aberrant production of amyloid beta peptide 1-42 by
            interacting directly with Par-4
  JOURNAL   J Biol Chem 279 (6), 4596-4603 (2004)
   PUBMED   14627703
REFERENCE   7  (bases 1 to 1805)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   8  (bases 1 to 1805)
  AUTHORS   Thomas,T., Voss,A.K., Petrou,P. and Gruss,P.
  TITLE     The murine gene, Traube, is essential for the growth of
            preimplantation embryos
  JOURNAL   Dev Biol 227 (2), 324-342 (2000)
   PUBMED   11071758
REFERENCE   9  (bases 1 to 1805)
  AUTHORS   Page,G., Kogel,D., Rangnekar,V. and Scheidtmann,K.H.
  TITLE     Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP
            kinase and Par-4 results in cytoplasmic retention and apoptosis
  JOURNAL   Oncogene 18 (51), 7265-7273 (1999)
   PUBMED   10602480
REFERENCE   10 (bases 1 to 1805)
  AUTHORS   Page,G., Lodige,I., Kogel,D. and Scheidtmann,K.H.
  TITLE     AATF, a novel transcription factor that interacts with Dlk/ZIP
            kinase and interferes with apoptosis
  JOURNAL   FEBS Lett 462 (1-2), 187-191 (1999)
   PUBMED   10580117
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ238717.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ238717.3, BC078769.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1805
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /note="apoptosis antagonizing transcription factor"
                     /db_xref="GeneID:114512"
                     /db_xref="RGD:620685"
     exon            1..223
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1704
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /codon_start=1
                     /product="protein AATF"
                     /protein_id="NP_446172.1"
                     /db_xref="GeneID:114512"
                     /db_xref="RGD:620685"
                     /translation="MAELQPLALQLEQLLNPRPREADPEADPEEATRARVIDRFDEGE
                     EEEDDLPVSSIRKLAPVSLLDTDKRYSGKTTSRKAWKEDHWDQTLPSSSDNEIPDEGG
                     SEAGDSEGLEELSEDVEEDLEDNEIPDEGGSEDGDSEGLEEEISEDVEEDLEGEDEED
                     REEDRNSEDDGVVMAFSGVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQL
                     PQPDVFPVFKDKGGPEFASALKNSHKALKALLRSLVDLQEELLFQYPDTRYLVKGTKP
                     NAESEEISSEDDELVGEKKKQRKAPPKRKLEMEDYPSFMAKRSADFTVYRNRTLQKWH
                     DKTKLASGKLGKGFGAFERSILTQIDHILMDKERLLRRTQTKRSAYRVLGKPEPVPEP
                     VAETLPGEPESLPQVPANAHLKDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAM
                     GRQWLAIQKLRSKIRKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTAMNDEARTELYR
                     SLFGQLNRLDADHGQ"
     exon            224..412
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     exon            413..502
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     exon            503..718
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     exon            719..856
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     exon            857..971
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1170
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1335
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1419
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1487
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1568
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1640
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1800
                     /gene="Aatf"
                     /gene_synonym="Ded"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1791
                     /gene="Aatf"
                     /gene_synonym="Ded"
ORIGIN      
        1 gaacgctgcc tccgcgaggt ccccgcttgt acttgcggag tagagtcggg ctgtagcacc
       61 gctgacggga gtgtcgtgcc cgggctcggc ctccaggttc acgagcgcag tgccgacagt
      121 gacctggtga ccatggcgga gctgcagccc ctggctctgc agctggaaca gttgttgaat
      181 ccaagaccgc gtgaggcgga tcctgaggcg gacccggagg aggccactag agccagagtg
      241 attgacaggt ttgatgaagg ggaagaggaa gaagatgatc tgccagtgag tagtattaga
      301 aagttggcac cggtctccct cttggacacc gacaaaaggt attctggcaa gaccacttct
      361 cggaaagctt ggaaagaaga ccattgggac cagactctgc caagttcatc ggacaatgaa
      421 atacctgatg aaggaggctc tgaagctggg gattcagagg gcctggagga gctctcagaa
      481 gatgttgagg aagacttgga agacaatgaa atacctgatg aaggaggctc tgaagatggg
      541 gattcagagg gcctggagga ggagatctca gaagatgttg aggaagactt agaaggtgag
      601 gatgaggaag acagagaaga ggacaggaac agtgaagatg acggcgtggt gatggccttc
      661 tccggtgtta aagtttctga ggaagtggaa aaaggaagag ctgtgaagaa ccagatagcg
      721 ttgtgggacc agctcttgga aggaaggatc aaactacaaa aagctctctt gactaccaat
      781 caattgcctc aaccagatgt tttccctgtc ttcaaggaca aaggtggccc agaatttgcc
      841 agtgctctga aaaatagtca caaagcactt aaagcattgt taagatcatt ggtggatctt
      901 caggaagagt tgcttttcca gtacccagat acaagatatt tagtaaaagg gacgaaaccc
      961 aatgcagaga gtgaggagat ttccagtgaa gatgatgagc tagtgggaga gaagaagaaa
     1021 caaagaaagg ccccaccaaa gaggaagcta gagatggagg actatcccag cttcatggca
     1081 aagcgctctg ctgactttac cgtctacagg aaccgcacac tacaaaaatg gcatgataaa
     1141 accaagcttg cttctggaaa actgggcaag ggtttcggtg cctttgaacg ctccatcttg
     1201 actcagattg atcatattct gatggacaaa gaaagattac ttcgaaggac gcagaccaag
     1261 cgctctgcct accgagttct tggcaaacct gagccagtcc ctgagcctgt tgcagagact
     1321 ttgccaggag aaccggagag ccttcctcag gtccctgcca atgctcacct gaaggacttg
     1381 gacgaggaga tatttgatga tgatgacttc taccaccagc tccttcgaga actcatagag
     1441 cggaagacca gctctttgga tccaaatgat caggtggcca tgggaaggca gtggcttgca
     1501 atccagaaac tacgaagcaa aatccgcaag aaggtagata gaaaagccag caaaggaaga
     1561 aaacttcggt tccatgtgct tagcaagctc ctgagtttca tggcgcctat tgaccacact
     1621 gcaatgaatg atgaggccag gaccgagttg tatcgatctc ttttcggcca gctcaaccgt
     1681 ctggacgcag accatgggca gtgacattag catcctctca cgctaacctc tcacaggacc
     1741 cacctgctgc ttccattaaa atggtcgaaa ctacaataaa tcttttttta aaaaaaaaaa
     1801 aaaaa
//
