LOCUS       NM_001100963            3300 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus aminoadipate-semialdehyde synthase (Aass), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001100963 XM_001061005 XM_231524
VERSION     NM_001100963.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3300)
  AUTHORS   Papes,F., Kemper,E.L., Cord-Neto,G., Langone,F. and Arruda,P.
  TITLE     Lysine degradation through the saccharopine pathway in mammals:
            involvement of both bifunctional and monofunctional
            lysine-degrading enzymes in mouse
  JOURNAL   Biochem J 344 Pt 2 (Pt 2), 555-563 (1999)
   PUBMED   10567240
REFERENCE   2  (bases 1 to 3300)
  AUTHORS   Markovitz,P.J., Chuang,D.T. and Cox,R.P.
  TITLE     Familial hyperlysinemias. Purification and characterization of the
            bifunctional aminoadipic semialdehyde synthase with
            lysine-ketoglutarate reductase and saccharopine dehydrogenase
            activities
  JOURNAL   J Biol Chem 259 (19), 11643-11646 (1984)
   PUBMED   6434529
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128771.1.
            
            On or before Aug 12, 2007 this sequence version replaced
            XM_231524.4, XM_001061005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128771.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3300
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3300
                     /gene="Aass"
                     /note="aminoadipate-semialdehyde synthase"
                     /db_xref="GeneID:296925"
                     /db_xref="RGD:1310811"
     exon            1..34
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            35..258
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2829
                     /gene="Aass"
                     /EC_number="1.5.1.8"
                     /EC_number="1.5.1.9"
                     /note="alpha-aminoadipic semialdehyde synthase,
                     mitochondrial; LKR/SDH"
                     /codon_start=1
                     /product="alpha-aminoadipic semialdehyde synthase,
                     mitochondrial precursor"
                     /protein_id="NP_001094433.1"
                     /db_xref="GeneID:296925"
                     /db_xref="RGD:1310811"
                     /translation="MLRAQRLRLARLRACVSRGLHHKPVMALRREDVNAWERRAPLAP
                     KHIKGITKLGYKVLIQPSNRRAIHDKEYVRAGGILQEDITEACLILGVKRPPEEKLMS
                     KKTYAFFSHTIKAQEANMSLLDEVLKQEIRLIDYEKMVDHRGSRIVAFGHWAGVAGMI
                     NILHGMGLRLLALGHHTPFMHLGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLT
                     FVFTGTGNVSKGAQEVFNELPCEYVEPHELKEVSKTGDLRKVYGTVLSRHHHLVRKTD
                     GVYDPVEYEKYPERYISRFNADIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLVPVKS
                     SVVPVEGCPELPHKLVAICDISADTGGSIDFMTECTTIERPFCMYDADQHIIHDSVEG
                     SGILMCSIDNLPAQLPIEATEYFGDMLYPYVEEMLLSDASQPLESQNFSPVVRDAVIT
                     SNGLLTDKYKYIQKLRESRERIQFLSMSTKKKVLVLGSGYVSGPVLEYLSRGNNIEIT
                     LGSDMTNQMQQLSKKYDINTVNVTVGKQEDKLQSLVESQDLVISLLPYVLHPVVAKAC
                     IDSKVNMVTASYITPAMKELEKSVDDAGITVIGELGLDPGLDHMLAMETIDKAKDLGA
                     TIESYVSYCGGLPAPEHSDNPLRYKFSWSPVGVLMNIMQPASYLLNGKVVNVTGGVSF
                     LNSVTPMDYFPGLNLEGYPNRDSTKYAEIYGISSAHTLLRGTLRYKGYSKALNGFVKL
                     GLINRETYPALRPEANPLTWKQLLCDLVGISRSSSCEKLKEVVFTKLGGDSTQLEAAE
                     WLGLLGDEQVPQAESIVDAFSKHLVSKLSYGPEEKDMIVMRDSFGIRHPSGHLENKTI
                     DLVVYGDFNGFSAMAKTVGLPTAMAAKMLLDGEIETKGLMGPFSKEIYGPILERIKAE
                     GIVFNTQSTIKL"
     exon            259..435
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            436..520
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            521..588
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            589..735
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            736..814
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            815..942
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1091
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1214
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1326
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1386
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1454
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1576
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1703
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1814
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1923
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2064
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2232
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2328
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2444
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2533
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2710
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..3276
                     /gene="Aass"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggaggct ggggactgat ccataaccta caagctacca gattgaagat gctgagagca
       61 cagaggctga gactggccag gctgagagcc tgcgtctcca gaggcctcca ccacaagccg
      121 gtcatggcgc tccgaaggga ggacgtgaac gcctgggagc gcagggcgcc tctggctccc
      181 aagcacatca agggcatcac caaactggga tacaaggtct tgatacagcc ttccaataga
      241 cgagccattc acgacaagga gtatgtcagg gccggtggca ttcttcagga ggacattaca
      301 gaagcctgcc tgattttggg ggtaaaaagg cctccagagg aaaaactgat gtccaagaag
      361 acttatgcct tcttctccca cacaataaaa gctcaggaag ctaatatgag cttgctggat
      421 gaggtcctga aacaggaaat ccggcttatt gattatgaga aaatggtgga tcacagaggg
      481 tctcggatag tggcttttgg acattgggca ggtgtggcag gaatgattaa tattttacat
      541 ggaatgggtt taaggctcct tgctttggga catcatacgc ctttcatgca tctcggcatg
      601 gctcacaact acaggaacag cagtcaagct gtacaggctg tccgcgatgc tggctatgaa
      661 atatctctgg gtttaatgcc aaagtcaata gggcccttaa cgtttgtatt cacagggact
      721 ggcaacgtat ccaagggagc ccaagaagtc tttaatgagc taccttgtga gtatgtggag
      781 ccccatgaat taaaagaagt ttcaaaaact ggagacctca ggaaagtgta tgggacggtg
      841 ttaagtcgcc atcatcatct tgtcaggaaa acagatggtg tgtacgatcc tgtagaatac
      901 gagaaatatc ctgagcgcta cataagtcgt tttaatgcag atattgcacc ctacacaact
      961 tgtttaatca atggaatcta ctgggagcaa aacacccctc ggctgctcac acgtcaggat
     1021 gcccagagtc tcctggtccc agtgaagtcc tcagttgttc ctgttgaagg atgtcctgaa
     1081 ttaccacaca aacttgtggc aatatgtgac atttcagcag acacaggagg ctctatagat
     1141 tttatgactg agtgcactac catagaacgg cccttttgca tgtatgacgc agaccagcat
     1201 attattcacg acagtgttga aggctccggg attctgatgt gctccattga caatttgcca
     1261 gcgcagcttc caattgaggc cacagaatac tttggagaca tgctttaccc ttatgtcgaa
     1321 gagatgctgt tatcagatgc gtcacagcct ctggaaagcc agaacttctc tccggtcgtg
     1381 cgagatgcag tgattacatc caatggtcta ttgacggaca aatacaaata tatacagaaa
     1441 ctccgggaaa gcagagaacg aatccaattc ctttcaatga gtaccaagaa gaaggttttg
     1501 gttcttgggt ctggctatgt atctgggcct gttttggagt acctgtcaag aggcaacaat
     1561 atagaaataa cactaggctc tgacatgacg aaccaaatgc agcagctgag caagaaatac
     1621 gacattaaca ctgtcaatgt gaccgtcggc aagcaggaag acaagctgca gtccctggtc
     1681 gaatcccagg atcttgtcat cagcttgttg ccttatgtgt tgcatcctgt tgtggccaag
     1741 gcctgcattg atagcaaggt taatatggtc actgcaagct acatcacacc agctatgaaa
     1801 gaactggaaa aaagtgtgga tgacgctggc atcacagtca ttggagaatt gggattagat
     1861 cctggtcttg atcacatgtt ggcaatggaa acaattgata aagccaaaga tctgggagcc
     1921 acgattgagt cgtatgtttc ctactgcggt ggtcttccag ccccagagca ttcagataat
     1981 cccttgcgat ataagttcag ctggagtcca gtgggagtct tgatgaacat aatgcagcct
     2041 gctagctatc tcctcaacgg aaaggttgtg aatgtgacag ggggagtctc ttttctcaat
     2101 tctgtcacac ccatggatta cttcccaggc ctaaacttgg aagggtatcc taacagagat
     2161 agcacaaaat atgctgagat ttatggaatt tcatctgccc atacattgtt gaggggaaca
     2221 ctgagatata agggatattc caaagctttg aacggatttg tgaagttggg actcatcaac
     2281 agagaaacat atcctgccct ccgacctgag gccaaccctc tcacgtggaa acagctcctg
     2341 tgtgacctag ttgggatttc ccgctcctcc tcatgtgaga agcttaagga agttgtcttt
     2401 acaaagttgg gaggggacag tacccagcta gaggctgctg aatggttggg cttactgggg
     2461 gatgagcagg ttcctcaggc agagtccatt gtggatgcat tctccaagca cttggtctca
     2521 aagctctcct atggccccga agaaaaggat atgattgtga tgcgggacag ctttggcatt
     2581 agacatccat ctggacattt agaaaacaag accattgatc ttgtggttta tggagacttc
     2641 aatggctttt cggcaatggc taagactgtg gggttgccaa cagccatggc agccaaaatg
     2701 ttactcgatg gtgaaattga aaccaaaggc ctaatgggac cattttcaaa ggagatctac
     2761 gggccaatat tggagcggat taaagcagaa ggcattgtgt ttaatacaca gagcacaatc
     2821 aagctataaa tggggattta ttttcctagg catcacagct gttaccttgt atatgacaaa
     2881 cgtgcttgct gatatactga agctgatatg aagaatatgt tttctggaag tttatgcaat
     2941 ggtgttttcg aaactcaaat ctctaaagct tttagagtag aagattccaa acatcatagg
     3001 aacctttaat aagtctcctg tgtccttttt gtgtgtatgt aaaggtgatg atgatcatag
     3061 tttgttaatt tattacactt cctttttcct gaggacatat catcagcaaa tgcagttgta
     3121 ctattttttc ccacttcgtg tagttatatt tttgtatttt tcaaattgat tccgctatat
     3181 accttttaga ctgacatatc gaagaacggt cgcaaacgta ctgcctcgtg ccttttgtaa
     3241 agttatgatt tatttagtaa atcattttga aaatcaaaaa aaaaaaaaaa aaaaaaaaaa
//
