LOCUS       NM_001399022            3632 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus aminoadipate-semialdehyde dehydrogenase (Aasdh),
            mRNA.
ACCESSION   NM_001399022 XM_039092930
VERSION     NM_001399022.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3632)
  AUTHORS   Drozak,J., Veiga-da-Cunha,M., Kadziolka,B. and Van Schaftingen,E.
  TITLE     Vertebrate Acyl CoA synthetase family member 4 (ACSF4-U26) is a
            beta-alanine-activating enzyme homologous to bacterial
            non-ribosomal peptide synthetase
  JOURNAL   FEBS J 281 (6), 1585-1597 (2014)
   PUBMED   24467666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Dec 29, 2021 this sequence version replaced XM_039092930.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.81694.1,
                                           SRR26643297.43164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000014.1  31609488-31609541
            55-206              JAXUCZ010000014.1  31610513-31610664
            207-474             JAXUCZ010000014.1  31613821-31614088
            475-595             JAXUCZ010000014.1  31614751-31614871
            596-909             JAXUCZ010000014.1  31616223-31616536
            910-1102            JAXUCZ010000014.1  31620988-31621180
            1103-1344           JAXUCZ010000014.1  31623055-31623296
            1345-1451           JAXUCZ010000014.1  31623750-31623856
            1452-1624           JAXUCZ010000014.1  31624326-31624498
            1625-1817           JAXUCZ010000014.1  31625630-31625822
            1818-1933           JAXUCZ010000014.1  31627836-31627951
            1934-2726           JAXUCZ010000014.1  31628946-31629738
            2727-2890           JAXUCZ010000014.1  31631927-31632090
            2891-3013           JAXUCZ010000014.1  31633397-31633519
            3014-3145           JAXUCZ010000014.1  31634606-31634737
            3146-3632           JAXUCZ010000014.1  31635580-31636066
FEATURES             Location/Qualifiers
     source          1..3632
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..3632
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /note="aminoadipate-semialdehyde dehydrogenase"
                     /db_xref="GeneID:364136"
                     /db_xref="RGD:1311135"
     exon            1..54
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            55..206
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            207..474
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..3544
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /note="acyl-CoA synthetase family member 4"
                     /codon_start=1
                     /product="beta-alanine-activating enzyme"
                     /protein_id="NP_001385951.1"
                     /db_xref="GeneID:364136"
                     /db_xref="RGD:1311135"
                     /translation="MTLQELVHQAASIYLDRTAVCFDEGNNQPPVCYTYKALLSEASE
                     LSAFLLAHCDLGGIREIGLYCQPGINLPSWILGILQIPAAYAPIDPDSLPSLATHFMK
                     KCGLKYVLVEKRQITKFKSSHETVLNYDTVSVEHKDLVLLRLHWEDGAVNSVLSDRTD
                     KCKVNDREERVNGENGSQEKGHMDMRREGCLAYVLHTSGTTGTPKIVRVPHACILPNI
                     QHFRSLFDITQEDVLFLASPLTFDPSVVEIFVALSSGACLLISPTSVKVLPSKLADVL
                     FSRHRVTVLQATPTLLRRFGSELMKSTVLSAHTSLRVLALGGEAFPSLTVLQSWRGKS
                     NRTQIFNIYGITEVSSWATFYRIPEEILNSSVRLESPVQLGSPLLGTVVEVRDKNGSP
                     VHEGTGQVFLGGKNRICFLDEEMTVPLGTMRATGDFVTVKGGEIFFLGRKDSQIKRHG
                     KRLSIALVQQVAEELRQVESCAVTWYNQEKLILFIVSKVDLVKDYIFKELQKHLPAHA
                     LPDDMVLIGSLPVTCHGKVDVSELNKIYLDYISSQPRNKLHGKEELWGKLQCLWKSIL
                     CLPEDPELKVPDNSVFLDSGGDSLKSLWLLGEVEKLTGAPVPGLLEVILSSSFLDVYN
                     HIIQAVLTREDLKGDRRYTTKRKFSDPDSEETSGKPARLEAAWPWHRDSETNSVVALS
                     RGSQTLYLGTGRLLTELGLCPNAVHPPDLIPQTNTEILKSLSPPALDETLEKPPLSQE
                     RSPGTGAEPMVLRERWRSDTGKCVDASPLLVVAAVGDTSSTTVYIGSHSHTVKAVDLH
                     SGEMRWERRVGDRIESSACVSKCGNFIVVGCYDGLVYVLKSNSGEKHWTFPTEDAVKS
                     SPAVDPTTGLIYVGSHDQHAYALDIYEKKCVWKLKCEGALFSSPCLSLGPHHLYCATL
                     GGLLLAVNPATGSLIWKRPCGKPLFSSPRCYQHYVCIGCVDGSLLCFSHSGEQVWRFS
                     AGGPIFSSPCISASEQDIYFGSHDCFLYCCSTEGGLRWKFETTARVYSTPFAFPNHLC
                     GSGTLLAAASTDGKLWVLESQSGELRSVYELPGEVFSSPVVWESMLVIGCRNNYIYCL
                     DLSCGDKNNQV"
     exon            475..595
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            596..909
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1102
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1344
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1451
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1624
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1817
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1933
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2726
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2890
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3013
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3145
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3632
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgagcgtc cgctactggg ctggaaagtg caggccgcgc actgtcgtga aaaggtatgg
       61 ggatgtttta cctacatgta tgtaagtgcc ccatgttcct gcctggtgtc ttcaaaggct
      121 gtcggatccc cttgaattgg aactatggac tgtattgagc tcccaactgg gtgctggcat
      181 ggaacctgta ttctctgaaa gaacagattt ctcggcccct ggtgtttaaa caaacctcag
      241 taaaatgact ctgcaggagt tggttcatca ggctgcctcc atctatctgg atagaacagc
      301 tgtatgcttt gatgaaggca acaaccagcc cccggtgtgc tatacctaca aggctctgct
      361 gagcgaggct tcagaattat ccgcttttct gctagcacac tgtgaccttg gaggaattcg
      421 ggaaattggt ctctattgtc aacctgggat aaacttaccc tcctggattt tagggattct
      481 tcagatcccg gcagcttatg cacccattga tccagactcc ctgccatcgt tagcaaccca
      541 ctttatgaaa aaatgtggcc taaagtatgt tctggttgaa aaacggcaga tcactaaatt
      601 caaatcttca catgaaacag ttttgaacta tgatacagtt tcagtggaac ataaggacct
      661 ggtactcctc agactgcact gggaagatgg tgcggtgaac tcagtgctca gtgacagaac
      721 agataaatgc aaggtaaatg acagagaaga gcgagtgaat ggtgagaacg ggagccaaga
      781 gaaggggcac atggacatgc ggcgtgaggg ttgcctggcc tatgtcctac atacttcagg
      841 gaccacaggg acaccgaaga ttgtcagagt gcctcacgcg tgcatactac ctaacatcca
      901 gcacttccgg tcgctttttg acatcactca agaagatgtt ttgtttctgg cttctcctct
      961 gaccttcgat ccatctgtgg tagagatatt tgttgctctg tccagtgggg cctgcctgct
     1021 tatctcgcca acctctgtca aagtgctccc atcaaaatta gctgacgttc tcttttcccg
     1081 ccacagagtg actgttctac aggcaacgcc aacattgctg agaagatttg gatctgagct
     1141 catgaagtcc actgtgctgt cagcgcatac ttctctgcga gtcctagccc ttggagggga
     1201 agccttcccc tcactgaccg tcctccaaag ctggcgaggc aaaagcaata gaacgcagat
     1261 atttaacatt tatggtatca cagaggtatc cagttgggcc actttctaca ggatcccaga
     1321 ggagattctt aattcttctg tgagactcga gtcccctgtg cagctggggt ctcccctact
     1381 tggaacagtg gtcgaagtca gagacaaaaa tggttctcca gttcacgaag gcactggcca
     1441 agtattttta ggtgggaaga acagaatttg ttttcttgat gaggaaatga cagtgcccct
     1501 tggcaccatg cgagccacag gagactttgt gactgtaaaa ggtggagaga tatttttctt
     1561 gggaagaaag gacagccaga tcaagcgcca tggcaaacgt ctgagcatcg cgcttgtgca
     1621 acaggtagct gaagagcttc gccaggtgga gtcctgtgca gttacatggt ataatcagga
     1681 aaagttgatt ctcttcatcg tatccaaagt cgacttagta aaggattaca tctttaaaga
     1741 attgcagaaa caccttccag cacacgccct gcctgatgac atggtgctga ttggttccct
     1801 tccggttacc tgccacggta aagtcgatgt ttctgagcta aacaagatat atttagacta
     1861 cataagctca cagcctagga ataaactcca tggaaaagag gaactttggg gaaaattaca
     1921 gtgtttatgg aagtctatcc tgtgtctccc tgaggatcca gagttgaagg tccccgacaa
     1981 ctccgtcttt ttggatagtg gtggagattc cctcaagtcc ctgtggctcc tcggtgaggt
     2041 ggagaaactt actggtgcac ccgtgcctgg ccttctggaa gtaattctca gcagctcctt
     2101 cttagacgtt tacaaccaca tcattcaagc cgtgcttaca cgggaggacc tgaaaggcga
     2161 caggcgctac accaccaaaa ggaaattcag tgaccctgat tcagaggaaa ccagcgggaa
     2221 gcctgcacgt ctggaggccg cctggccttg gcaccgagac agcgagacaa actctgtggt
     2281 cgctctgagc agagggagcc agactttgta tctgggcact gggaggcttt taactgagtt
     2341 aggactctgc cctaatgcag tccatccccc agatttaatt ccacagacta acactgaaat
     2401 actgaaaagc ctaagtcctc ccgctctgga tgaaacgttg gaaaagccac cgctttctca
     2461 ggagaggagc cctgggactg gggctgagcc gatggtgttg cgtgagcggt ggcggtcaga
     2521 cacaggcaaa tgcgtagatg cttcccctct gcttgtggta gcagctgtgg gggatacgtc
     2581 ctccacaacc gtgtatatcg gctcccactc acacacagtg aaggcagtgg accttcactc
     2641 tggggagatg aggtgggaac ggcgtgttgg agaccggatt gagtcctcag cctgtgtgtc
     2701 taaatgtggg aactttattg tagtgggctg ttacgatgga ttagtttatg ttctaaaaag
     2761 taatagtgga gaaaaacatt ggacatttcc tacggaagat gctgtcaaaa gctcaccagc
     2821 cgtggatcca accacaggac tcatttacgt cggatctcat gaccagcacg catatgcctt
     2881 agacatttac gaaaagaagt gtgtctggaa gctaaaatgt gaaggagctc tcttttcttc
     2941 tccgtgtttg agcctgggtc cacaccatct gtactgtgct acgctgggcg gactcttact
     3001 ggctgtaaat cctgctaccg ggagtctgat ctggaaacgt ccctgtggaa agccgttatt
     3061 ctcttcccca cggtgttacc agcactacgt ttgtatcggc tgcgtggatg gcagtctgct
     3121 ctgcttctca cactcaggag agcaggtttg gcgcttttct gctggaggac caatcttttc
     3181 atccccatgt atctctgcat cagaacaaga catatatttt ggttcccacg attgctttct
     3241 ctactgctgt agcacggaag gcggcctccg gtggaaattc gagaccacag ccagggtgta
     3301 ctcgacgccc tttgctttcc ctaaccacct ctgcggcagc ggcacactgt tggcagcggc
     3361 gtccaccgac gggaaactgt gggtcctcga gtctcagagt ggagagctgc gaagtgtgta
     3421 cgaactcccc ggagaagtct tttcttctcc cgtggtctgg gaatcaatgc ttgttattgg
     3481 gtgcagaaat aattatattt actgtctgga tttatcgtgt ggtgataaaa ataaccaagt
     3541 gtagccctta taagtataca tcagtgagat ggttcggaat gtcattgtaa agcttatgga
     3601 tggttttata ttaaagattc tattttagtt aa
//
