LOCUS       NP_001385951            1099 aa            linear   ROD 31-MAR-2024
DEFINITION  beta-alanine-activating enzyme [Rattus norvegicus].
ACCESSION   NP_001385951 XP_038948858
VERSION     NP_001385951.1
DBSOURCE    REFSEQ: accession NM_001399022.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1099)
  AUTHORS   Drozak,J., Veiga-da-Cunha,M., Kadziolka,B. and Van Schaftingen,E.
  TITLE     Vertebrate Acyl CoA synthetase family member 4 (ACSF4-U26) is a
            beta-alanine-activating enzyme homologous to bacterial
            non-ribosomal peptide synthetase
  JOURNAL   FEBS J 281 (6), 1585-1597 (2014)
   PUBMED   24467666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Dec 29, 2021 this sequence version replaced XP_038948858.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.81694.1,
                                           SRR26643297.43164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     Protein         1..1099
                     /product="beta-alanine-activating enzyme"
                     /note="acyl-CoA synthetase family member 4"
                     /calculated_mol_wt=121120
     Region          16..532
                     /region_name="A_NRPS_acs4"
                     /note="acyl-CoA synthetase family member 4; cd17654"
                     /db_xref="CDD:341309"
     Site            order(194,197..202,204..205)
                     /site_type="other"
                     /note="acyl-activating enzyme (AAE) consensus motif"
                     /db_xref="CDD:341309"
     Site            order(197..198,318..319,341..346,374,427,438,441,526)
                     /site_type="other"
                     /note="AMP binding site [chemical binding]"
                     /db_xref="CDD:341309"
     Region          751..786
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          791..1011
                     /region_name="PQQ_2"
                     /note="PQQ-like domain; pfam13360"
                     /db_xref="CDD:433144"
     Region          793..847
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          854..898
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          906..932
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <964..>1079
                     /region_name="PQQ"
                     /note="Outer membrane protein assembly factor BamB,
                     contains PQQ-like beta-propeller repeat [Cell
                     wall/membrane/envelope biogenesis]; COG1520"
                     /db_xref="CDD:441129"
     CDS             1..1099
                     /gene="Aasdh"
                     /gene_synonym="RGD1311135"
                     /coded_by="NM_001399022.1:245..3544"
                     /db_xref="GeneID:364136"
                     /db_xref="RGD:1311135"
ORIGIN      
        1 mtlqelvhqa asiyldrtav cfdegnnqpp vcytykalls easelsafll ahcdlggire
       61 iglycqpgin lpswilgilq ipaayapidp dslpslathf mkkcglkyvl vekrqitkfk
      121 sshetvlnyd tvsvehkdlv llrlhwedga vnsvlsdrtd kckvndreer vngengsqek
      181 ghmdmrregc layvlhtsgt tgtpkivrvp hacilpniqh frslfditqe dvlflasplt
      241 fdpsvveifv alssgaclli sptsvkvlps kladvlfsrh rvtvlqatpt llrrfgselm
      301 kstvlsahts lrvlalggea fpsltvlqsw rgksnrtqif niygitevss watfyripee
      361 ilnssvrles pvqlgspllg tvvevrdkng spvhegtgqv flggknricf ldeemtvplg
      421 tmratgdfvt vkggeifflg rkdsqikrhg krlsialvqq vaeelrqves cavtwynqek
      481 lilfivskvd lvkdyifkel qkhlpahalp ddmvligslp vtchgkvdvs elnkiyldyi
      541 ssqprnklhg keelwgklqc lwksilclpe dpelkvpdns vfldsggdsl kslwllgeve
      601 kltgapvpgl levilsssfl dvynhiiqav ltredlkgdr ryttkrkfsd pdseetsgkp
      661 arleaawpwh rdsetnsvva lsrgsqtlyl gtgrlltelg lcpnavhppd lipqtnteil
      721 kslsppalde tlekpplsqe rspgtgaepm vlrerwrsdt gkcvdaspll vvaavgdtss
      781 ttvyigshsh tvkavdlhsg emrwerrvgd riessacvsk cgnfivvgcy dglvyvlksn
      841 sgekhwtfpt edavksspav dpttgliyvg shdqhayald iyekkcvwkl kcegalfssp
      901 clslgphhly catlggllla vnpatgsliw krpcgkplfs sprcyqhyvc igcvdgsllc
      961 fshsgeqvwr fsaggpifss pcisaseqdi yfgshdcfly ccstegglrw kfettarvys
     1021 tpfafpnhlc gsgtllaaas tdgklwvles qsgelrsvye lpgevfsspv vwesmlvigc
     1081 rnnyiycldl scgdknnqv
//
