LOCUS       NM_001106891            3323 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus alanyl-tRNA synthetase 2, mitochondrial (Aars2),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001106891 XM_001067517 XM_236942
VERSION     NM_001106891.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3323)
  AUTHORS   Gotz,A., Tyynismaa,H., Euro,L., Ellonen,P., Hyotylainen,T.,
            Ojala,T., Hamalainen,R.H., Tommiska,J., Raivio,T., Oresic,M.,
            Karikoski,R., Tammela,O., Simola,K.O., Paetau,A., Tyni,T. and
            Suomalainen,A.
  TITLE     Exome sequencing identifies mitochondrial alanyl-tRNA synthetase
            mutations in infantile mitochondrial cardiomyopathy
  JOURNAL   Am J Hum Genet 88 (5), 635-642 (2011)
   PUBMED   21549344
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473987.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_236942.4, XM_001067517.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3323
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..3323
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /note="alanyl-tRNA synthetase 2, mitochondrial"
                     /db_xref="GeneID:301254"
                     /db_xref="RGD:1310617"
     exon            1..237
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2967
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /EC_number="6.1.1.7"
                     /note="alanyl-tRNA synthetase, mitochondrial; alanyl-tRNA
                     synthetase like; probable alanyl-tRNA synthetase,
                     mitochondrial; alanyl-tRNA synthetase 2, mitochondrial
                     (putative)"
                     /codon_start=1
                     /product="alanine--tRNA ligase, mitochondrial"
                     /protein_id="NP_001100361.1"
                     /db_xref="GeneID:301254"
                     /db_xref="RGD:1310617"
                     /translation="MAASVAAAAGRLRRAIGRSCPWQRFSTEPHPPHGAAVRDAFLSF
                     FRDRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQK
                     CVRAGGRHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKKEACSMAWELLTQVYGIPED
                     RLWVSYFSGDSKTGLDPDLETRDIWLSLGVPASRVLSFGLQENFWEMGDTGPCGPCTE
                     IHYDLAGGMGPPQLVELWNLVFMQHYREADGSLHLLPQQHVDTGMGLERLVAVLQGKH
                     STYDTDLFSPLLDAIHQSCRVPPYSGRVGAADEGRIDTAYRVVADHIRTLSVCIADGV
                     SPGMSGAPLVLRRILRRAVRYSTEVLQAPPGFLGNLVPVVVATLGAAYPELQKNSVKV
                     LIWEIANLVSEDEAAFLASLQRGRRIIDRTVKRLGPSDLFPAEVAWSLSLSGNLGIPL
                     DLVQLMLEEKGVKLDTAGLEQLAQKEAQHRAQQAEAAQEEGLCLDVHALEELHRQGIP
                     TTDDSPKYNYSLRPNGDYEFGLCEAQVLQLYSETGTAVASVGEGQRCGLLLDRTNFYA
                     EQGGQASDRGYLIRTGQQDVLFPVARAQVCGGFILHEAMAPECLQVGDRVQLYVDKAW
                     RMGCMVKHTATHLLNWALRQTLGPTTEQRGSHLNPERLRFDVATQTPLTTEQLRTVES
                     YVQEAVGQDKPVYMEEVPLAHTARIPGLRSLDEVYPDPVRVVSVGVPVAQALAPASQA
                     ALQTSVELCCGTHLLSTGAVGDLVIIGDRQLVKGITRLLAITGEQAQQAREVGQSLSQ
                     EVEVASERLSRGSRDLLEAHRLSKDIGRLIEFTESAVIPQWQRQEQQTTLKMLQRRAN
                     TAIRKLEKSQATEKSQELLKRHSEGPLIVDTVSAQSLSVLVKVVRQLCKQAPSMSVLL
                     LSPQPTGSVLCACQVAQGATPTFTAEAWALAVCSHMGGKAWGSPVIAQGTGHTADLEA
                     ALRTARAYALNQL"
     exon            238..429
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            430..575
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            576..743
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            744..888
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1034
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1143
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1197
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1309
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1443
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1588
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1761
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1875
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2016
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2154
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2264
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2373
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2496
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2607
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2691
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2802
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..3323
                     /gene="Aars2"
                     /gene_synonym="Aarsl; AlaRS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagctaaaa tggcggcgtc agtggctgct gcggccggga ggctgcggcg agccattggg
       61 aggtcgtgcc catggcagcg gttctcaacc gagccccacc caccccacgg agcggccgtg
      121 cgggacgcct tcctgagctt cttccgagat cgccacggcc accggctcgt gccctccgct
      181 tccgtgaggc cgcgcggcga ccccagcctg cttttcgtca acgcaggcat gaaccagttc
      241 aagcccatct tcctgggcac ggtggatcca cgaagcgaga tggcaggctt ccgacgagta
      301 gctaacagcc agaaatgtgt cagggctgga ggacgccata acgacctgga agatgtgggc
      361 cgtgatctct ctcatcatac tttttttgag atgcttggca actgggcttt tgggggtgaa
      421 tattttaaga aagaagcatg tagcatggcc tgggaactgc tgactcaagt ctatgggatc
      481 cctgaggaca ggttatgggt ctcctatttc agtggtgact ccaagacagg gttggaccca
      541 gacctggaga ccagagacat ctggctcagc ttgggggtac ctgccagccg tgtgctctcg
      601 ttcggactgc aagagaactt ctgggagatg ggagacaccg gaccttgtgg gccttgtacc
      661 gagatccatt acgatctggc tggtggaatg ggaccccccc agctggttga gctatggaat
      721 ctggtcttca tgcaacacta cagagaggca gacggaagcc tgcatctgct gccacagcaa
      781 catgtggaca caggaatggg cctggaaaga ctggtggctg tactgcaggg caagcattcc
      841 acctacgaca ccgacctctt ttctccactg cttgatgcta tacaccagag ctgcagggtt
      901 cccccgtact ctggccgcgt aggggcagcg gatgagggac gaatagacac agcgtaccga
      961 gttgtagctg atcacatccg cacgctcagt gtctgcattg ctgatggcgt ctccccgggg
     1021 atgtcaggcg ccccgctagt tcttcgtcgg attctccgtc gagctgtgcg ctattccaca
     1081 gaggtcttgc aggcaccacc tggctttctg ggcaacctgg taccagtggt ggtggcgaca
     1141 ttgggagctg cttacccaga acttcagaag aactcagtca aggtattgat ctgggagata
     1201 gccaacctgg tgtcagagga tgaggcagcc ttcctggcct ccctgcagag aggccgtcgg
     1261 atcattgatc gcaccgttaa gcgcttgggc ccttctgatt tgttccctgc cgaagtggcc
     1321 tggtcactgt cactgtctgg gaatctgggg atccccctgg acctggtgca gctaatgttg
     1381 gaggagaagg gggtgaagct ggacactgcg ggcctggagc agctagccca gaaggaagcc
     1441 cagcaccggg cccagcaggc agaggcagct caggaggagg gattgtgtct tgatgtccac
     1501 gcactggagg agctgcaccg tcaaggcata cccacaactg atgacagccc caaatataac
     1561 tactctcttc gccccaatgg ggattatgag tttggcctct gtgaggccca ggtattacag
     1621 ctgtattcag agactgggac agctgtggcc tccgtgggag aaggccagcg ctgtggcctc
     1681 ctattggaca gaaccaactt ctatgctgaa caagggggtc aggcttcgga ccgaggctac
     1741 ctcattcgta cagggcagca ggatgtgttg ttccctgtgg cccgggctca ggtctgtgga
     1801 ggcttcatcc tgcatgaggc catggctccc gagtgcttac aagtcgggga ccgagtgcag
     1861 ctctatgtgg ataaggcctg gcgaatggga tgcatggtga agcacacagc cacccacctg
     1921 ctgaactggg cacttcggca gacgctcgga ccaaccaccg aacagcgggg ctcccatctc
     1981 aacccggagc ggctgcgctt tgatgtggcc acgcagaccc cactgaccac agagcagcta
     2041 cggacagtag agagctacgt gcaggaagct gtggggcagg ataagcctgt atacatggag
     2101 gaagtgcccc tggcacacac tgcccgtatc cccggccttc gctcactgga tgaggtgtac
     2161 ccagaccccg ttcgggtcgt gtcagtgggg gttcctgtgg cccaggcact ggcaccagcc
     2221 tcccaagctg cactgcagac ttcggtggag ctgtgctgcg ggacgcacct gctaagtact
     2281 ggggctgtgg gagacctggt gattattggg gatcgccagc tggtcaaagg catcactcgc
     2341 ctactggcca tcaccgggga gcaggcccaa caggcccgag aggtgggcca gagcctgtcg
     2401 caggaggtgg aagtggcaag cgaacggcta agtcggggca gccgggacct gctggaggct
     2461 caccggctat ctaaggacat aggacgtctc attgagttca cagagtctgc tgtgatacct
     2521 cagtggcagc ggcaggagca gcagaccaca ctgaagatgc tacagcgccg tgccaacacc
     2581 gccatccgga aactggagaa gagccaggct acggagaaat cccaggagct gttgaaacgg
     2641 cactcggagg ggcctctgat tgtggacact gtctccgccc agtccctctc ggtgctggta
     2701 aaggtcgtgc ggcagctgtg caaacaggcc cccagcatgt ccgtgctgct gctcagcccc
     2761 cagcccactg gcagtgtcct gtgtgcctgc caggtggccc agggtgccac acctaccttc
     2821 acagctgagg cctgggccct agctgtgtgc agccacatgg gaggcaaggc ttggggctct
     2881 ccagtgatag cccagggtac tggacacact gctgacctgg aggctgccct caggacagcc
     2941 cgagcttatg cactcaacca gctctgacga ggcccaccca ggacacagag gaatagaagg
     3001 caggcaagca tctggagcca cataatcttc ccggaggcgg gagcagagga ccagcggctg
     3061 gaggccaggt ctccgagcca aagcagggca ccagggccac tgagaggcga gcaggaagaa
     3121 gtgtggattg aggggcagca accccagcaa atggaagacc tgggctgctg tggttgggag
     3181 cacccattca aagtgtttca ccggctgcag actcagctca gtggttaaga gcacttgttc
     3241 ctagaaggga cccaggttcg gttcccagca tccacatgga ggttccccac cccatcaggc
     3301 accagaaata catgtggtac aca
//
