LOCUS       NM_001173450            7976 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus AP2 associated kinase 1 (Aak1), mRNA.
ACCESSION   NM_001173450 XM_001070331 XM_575594
VERSION     NM_001173450.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7976)
  AUTHORS   Chen,Y., Gao,X. and Pei,H.
  TITLE     miRNA-384-3p alleviates sevoflurane-induced nerve injury by
            inhibiting Aak1 kinase in neonatal rats
  JOURNAL   Brain Behav 12 (7), e2556 (2022)
   PUBMED   35726359
  REMARK    GeneRIF: miRNA-384-3p alleviates sevoflurane-induced nerve injury
            by inhibiting Aak1 kinase in neonatal rats.
REFERENCE   2  (bases 1 to 7976)
  AUTHORS   Taoufiq,Z., Ninov,M., Villar-Briones,A., Wang,H.Y., Sasaki,T.,
            Roy,M.C., Beauchain,F., Mori,Y., Yoshida,T., Takamori,S., Jahn,R.
            and Takahashi,T.
  TITLE     Hidden proteome of synaptic vesicles in the mammalian brain
  JOURNAL   Proc Natl Acad Sci U S A 117 (52), 33586-33596 (2020)
   PUBMED   33376223
REFERENCE   3  (bases 1 to 7976)
  AUTHORS   Ultanir,S.K., Hertz,N.T., Li,G., Ge,W.P., Burlingame,A.L.,
            Pleasure,S.J., Shokat,K.M., Jan,L.Y. and Jan,Y.N.
  TITLE     Chemical genetic identification of NDR1/2 kinase substrates AAK1
            and Rabin8 Uncovers their roles in dendrite arborization and spine
            development
  JOURNAL   Neuron 73 (6), 1127-1142 (2012)
   PUBMED   22445341
  REMARK    GeneRIF: This study demonistrated that AAK1 contributes to dendrite
            growth regulation.
REFERENCE   4  (bases 1 to 7976)
  AUTHORS   Kuai,L., Ong,S.E., Madison,J.M., Wang,X., Duvall,J.R., Lewis,T.A.,
            Luce,C.J., Conner,S.D., Pearlman,D.A., Wood,J.L., Schreiber,S.L.,
            Carr,S.A., Scolnick,E.M. and Haggarty,S.J.
  TITLE     AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent
            neurotrophic factor signaling using integrative chemical genomics
            and proteomics
  JOURNAL   Chem Biol 18 (7), 891-906 (2011)
   PUBMED   21802010
  REMARK    GeneRIF: AAK1 is a relevant target of K252a, that the loss of AAK1
            alters ErbB4 trafficking and expression levels, providing evidence
            for a previously unrecognized role for AAK1 in Nrg1-mediated
            neurotrophic factor signaling.
REFERENCE   5  (bases 1 to 7976)
  AUTHORS   Gupta-Rossi,N., Ortica,S., Meas-Yedid,V., Heuss,S., Moretti,J.,
            Olivo-Marin,J.C. and Israel,A.
  TITLE     The adaptor-associated kinase 1, AAK1, is a positive regulator of
            the Notch pathway
  JOURNAL   J Biol Chem 286 (21), 18720-18730 (2011)
   PUBMED   21464124
REFERENCE   6  (bases 1 to 7976)
  AUTHORS   Sorensen,E.B. and Conner,S.D.
  TITLE     AAK1 regulates Numb function at an early step in clathrin-mediated
            endocytosis
  JOURNAL   Traffic 9 (10), 1791-1800 (2008)
   PUBMED   18657069
REFERENCE   7  (bases 1 to 7976)
  AUTHORS   Henderson,D.M. and Conner,S.D.
  TITLE     A novel AAK1 splice variant functions at multiple steps of the
            endocytic pathway
  JOURNAL   Mol Biol Cell 18 (7), 2698-2706 (2007)
   PUBMED   17494869
REFERENCE   8  (bases 1 to 7976)
  AUTHORS   Conner,S.D., Schroter,T. and Schmid,S.L.
  TITLE     AAK1-mediated micro2 phosphorylation is stimulated by assembled
            clathrin
  JOURNAL   Traffic 4 (12), 885-890 (2003)
   PUBMED   14617351
REFERENCE   9  (bases 1 to 7976)
  AUTHORS   Conner,S.D. and Schmid,S.L.
  TITLE     Identification of an adaptor-associated kinase, AAK1, as a
            regulator of clathrin-mediated endocytosis
  JOURNAL   J Cell Biol 156 (5), 921-929 (2002)
   PUBMED   11877461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_575594.3, XM_001070331.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.23912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-699               JAXUCZ010000004.1  120858567-120859265
            700-818             JAXUCZ010000004.1  120931757-120931875
            819-927             JAXUCZ010000004.1  120940531-120940639
            928-1070            JAXUCZ010000004.1  120941876-120942018
            1071-1192           JAXUCZ010000004.1  120949368-120949489
            1193-1274           JAXUCZ010000004.1  120951128-120951209
            1275-1407           JAXUCZ010000004.1  120951867-120951999
            1408-1511           JAXUCZ010000004.1  120954528-120954631
            1512-1591           JAXUCZ010000004.1  120955732-120955811
            1592-1746           JAXUCZ010000004.1  120959855-120960009
            1747-2072           JAXUCZ010000004.1  120960982-120961307
            2073-2315           JAXUCZ010000004.1  120964624-120964866
            2316-2548           JAXUCZ010000004.1  120969627-120969859
            2549-2706           JAXUCZ010000004.1  120970899-120971056
            2707-2811           JAXUCZ010000004.1  120972683-120972787
            2812-2907           JAXUCZ010000004.1  120975738-120975833
            2908-3009           JAXUCZ010000004.1  120988271-120988372
            3010-3111           JAXUCZ010000004.1  120989449-120989550
            3112-3222           JAXUCZ010000004.1  120990821-120990931
            3223-3333           JAXUCZ010000004.1  120992637-120992747
            3334-7976           JAXUCZ010000004.1  120993572-120998214
FEATURES             Location/Qualifiers
     source          1..7976
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..7976
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /note="AP2 associated kinase 1"
                     /db_xref="GeneID:500244"
                     /db_xref="RGD:1305520"
     exon            1..699
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..3428
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /EC_number="2.7.11.1"
                     /note="adaptor-associated kinase 1"
                     /codon_start=1
                     /product="AP2-associated protein kinase 1"
                     /protein_id="NP_001166921.1"
                     /db_xref="GeneID:500244"
                     /db_xref="RGD:1305520"
                     /translation="MKKFFDSRREQGSSGLGSGSSGGGGSSSGLGSGYIGRVFGIGRQ
                     QVTVDEVLAEGGFALVFLVRTSNGVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKN
                     IVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCE
                     AVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQAEGVNAVEDEIK
                     KYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGSFTI
                     PDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPVPNVQNSPIPTKLP
                     EPVKASEAAVKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRK
                     RATVQPLPQATGPSNQPSLLASVSQPKAQATPSQPLQSSQPKQPQAPPTPQQTPAPQT
                     QGLPTQAQATPQHQQQLLLKQQQQQQQQQQQQQPQQPTAPPQPSGTFYQQQQPQQQQA
                     QTQQFQAVHPAAQQSVTAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQLMAQQAALQ
                     QKTAVVVPQPQAQPATAPQAAAAQEPAQIQAPARQQPKVQTTPPPTIQGQKVGSLTPP
                     SSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLHAAAAEASLSKSKSATTTPSGSPR
                     TSQQNVSNASEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKLPEKLGGSAESLIPG
                     FQATQGDAFATSSFSAGTAEKRKGGQAVDSGIPLLSVSDPFIPLQVPDAPEKLIEGLK
                     SPDTSLLLPDLLPMTDPFGSTSDAVIEKADAAVESLIPGLEPPVAQRLPSHTESVTSN
                     RTDSLTGEDSLLDCSLLSNPTADLLDEFAPIALSASTHKAAEDSNLISGFGVAEGSEK
                     VAEDEFDPIPVLITKNTQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL"
     exon            700..818
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            819..927
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1070
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1192
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1274
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1407
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1511
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1591
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1746
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..2072
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2315
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2548
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2706
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2811
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2907
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3009
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3111
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3222
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3333
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..7976
                     /gene="Aak1"
                     /gene_synonym="RGD1563580"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcggggatca gctggcgggc gggcgccgaa gcggccccgg ctctgcggca gcgccgcctc
       61 cttcgcgtcg caggccggcg gccgtggcca tgtcgcgggg ctggtagctg ggctcgccgc
      121 cgagcggccg ctagtgggtg tccggggccc ggggtggggg tccgggcagg gggccggtgc
      181 gtttccaggg ctttcctgaa gaaaatgcac gcagcgtttc ctctagatga cggcctttgc
      241 ttcccctagg acccggcagt tgggctctgg agtgtgttac tgattcatcc tctctctgcc
      301 tctgtcatcg caggtttaaa cttaaacgat cgctccccga ggaggagggg acccgccgca
      361 cgattgacag tatattcctg caggcgccgt ccctcagccc ccaccccacg gccggattcc
      421 cgtagctctc tgctcagggc tgaaaccgga gaagaaatcc ttagatctcg tttctttact
      481 acaaatacga acctagaaac catcggcatt ctgccttggc gtttcatatt ggaaagatga
      541 agaagttttt cgactccagg cgggagcagg ggagctctgg cctgggttcg ggctccagcg
      601 gaggaggggg cagcagctca ggcctgggca gtggctacat cgggagggtc ttcggcatcg
      661 ggaggcagca agtcaccgtg gacgaggtct tggcagaagg tggattcgct ctcgtctttc
      721 tggtgagaac aagcaatggg gtgaaatgtg ccttgaaacg catgtttgtc aacaatgagc
      781 atgaccttca ggtgtgcaag agggagatcc agatcatgag ggacctatca gggcacaaga
      841 acattgtggg ctacattgat tctagtatca acaatgtgag cagtggcgac gtatgggaag
      901 ttctcattct catggacttc tgcagaggag gccaggtggt aaacctgatg aaccagcgtc
      961 tccagacagg ctttacagag aatgaagtgc tgcagatctt ctgtgacacc tgtgaggctg
     1021 tggcccgcct gcatcagtgc aaaactccca ttatccaccg ggacctgaag gttgaaaata
     1081 tcctcttgca tgaccgaggc cactatgtct tgtgtgactt tggaagtgcc accaacaaat
     1141 tccagaatcc acaggccgag ggagtcaatg cagtagaaga tgagattaag aaatacacaa
     1201 cgctctccta tcgagcccca gaaatggtca acttgtacag tggcaaaatc atcaccacga
     1261 aggcagatat ttgggctctt ggctgtttgt tgtataaatt atgctacttc actttgccat
     1321 ttggggagag ccaggtggca atttgtgatg gaagcttcac aattcctgat aactctcgat
     1381 attcacaaga tatgcactgc cttattaggt atatgttgga accagaccct gacaaaaggc
     1441 cggatattta ccaggtttct tacttctcat ttaaactact caagaaagaa tgcccagttc
     1501 caaatgtaca gaattctccc attcctacaa aacttcctga accagtgaaa gccagtgagg
     1561 cagctgtaaa aaagacccag ccaaaggcca gactgacaga tcccattccc accacagaga
     1621 cttcaattgc accccgccag aggcctaaag ctgggcagac tcagccaaac cccggaatcc
     1681 ttcccattca gccagccctg actcctcgta agagggccac tgttcagccc ctacctcagg
     1741 ctacaggacc cagcaatcag cctagccttc tagccagtgt ttcccagcct aaagcccaag
     1801 ccacgcccag tcaacctctt cagtcatctc aacccaagca gccacaagct ccacccaccc
     1861 cacagcagac gcctgctccc cagacccagg gtctgcccac ccaggcccag gctactcctc
     1921 agcaccagca gcagctcctc ctcaagcagc agcagcagca gcaacagcag cagcagcagc
     1981 aacagccaca gcagccaaca gcaccaccac agccatcagg caccttttac cagcagcagc
     2041 agccccagca gcagcaggct cagactcagc agtttcaggc agtgcatcca gcagcccagc
     2101 aatcagtcac tgctcagttc cctgtggtgt cccagggagg ctctcagcaa cagctgatgc
     2161 agaacttcta ccagcagcag cagcagcagc aacagcagca gcaacagctg atggctcagc
     2221 aggccgccct gcagcagaag actgctgtgg tagtaccaca gcctcaggca cagccagcca
     2281 cagccccaca ggcagctgct gcccaggagc ctgcgcagat tcaagcccca gcaagacaac
     2341 agccaaaagt tcagaccact ccacctccaa ccatccaggg acagaaagtt ggctctctca
     2401 ctcctccatc atctccgaaa acccaacgtg ctgggcacag gcggattctc agtgatgtaa
     2461 cccacagtgc agtcttcggg gttcctgcca gcaagtcaac ccagctgctc cacgcggctg
     2521 cagctgaggc cagtctcagt aaatctaagt ctgcaaccac cactccttca ggctctccac
     2581 ggacttccca gcagaatgtc tctaatgctt ccgaaggctc cacatggaat ccttttgatg
     2641 atgacaactt ctccaaactc acggctgaag agctgctgaa caaggatttc gcgaagcttg
     2701 gggaaggaaa gcttcctgag aagcttggag gctctgcaga gagtttgatc ccaggtttcc
     2761 aggcaacaca aggagatgcc tttgccactt cctccttttc tgctggaacc gctgagaaga
     2821 gaaagggggg acaggctgtg gattctggca tcccacttct aagtgtgtct gatcctttca
     2881 ttcctcttca ggtacctgat gctccagaaa aactaatcga gggactcaaa tctcctgaca
     2941 cttctcttct gctccctgac ctcttgccta tgacagatcc ttttggcagc acttccgatg
     3001 ctgtgattga aaaagctgat gctgctgttg agagtctcat acctgggctg gagccacctg
     3061 ttgcccagcg cctcccatct cacacggaat ctgtgacttc aaaccgcaca gactctctca
     3121 cgggggaaga ctctctcctt gactgttctc tgctttctaa ccctactgct gaccttctgg
     3181 acgagtttgc ccccatagca ctctctgctt ccactcataa agctgcagaa gatagtaatc
     3241 tcatctcagg gtttggtgtc gctgagggct ccgaaaaggt ggcagaagat gagtttgacc
     3301 ctattcctgt actgataacc aaaaacacac aaggtgggca ctctaggaac agcagtggga
     3361 gctctgagtc cagtcttccc aacctagcca ggtctttgct gctggtggat cagctcatag
     3421 acctgtagcc gtgagccagg agcagacaca gttctgtaac cttcatgccg taatatacat
     3481 tttcattacg gagttatgag aaaaatgatt ttttttttaa atctgcaaat aaggggccct
     3541 caagctcctt tctcctaccc ctttccttct cctatagaaa tgataaggaa agaaaaatct
     3601 ctgcccctcc agatccatcc cttggccagc tcctctcgtt agtgtgctgt gttttctcat
     3661 tccccatctt caatagcatt atcttaactc aagcgctaac cgccctgagc ttcacctctg
     3721 ctggaatcca ctcacagaag cttggctgtc actgagcctg tgctgaacac tttttgtctc
     3781 attcttgcta ggaatggccc cgtgtcagtc ctgtagcccg tctcccagat gctgatgaat
     3841 gtgtgtccat cctgcttttt atcctgatgc actcatgagg acagggcagc tatggctggt
     3901 ctcaccccag gcagaagtct ggagaaggcc atgcagtttc aacagggcag acccagtagg
     3961 atgtgtttgt gaagagaaag tgagctcagc tctagccagc caactttgac cttgtttgag
     4021 ccaagggatc ttacacccca tgtgcagcct tcttggcatt tgtctagcta tctggcttcc
     4081 attgaatcgt ggtttctcaa atctagaggt gtgactgcaa gtgtttgtga tccttgaata
     4141 aatgtgtatg tgatataaac accaagcatt gccatccttc catgttacct ggcccaagct
     4201 gggatctcag aatcagacca aaacaagaca gtggtgggaa catgatacct tttactagaa
     4261 gacttttcat ggggggtgga ggggaaggga aggaattgta gcagaaacag atgtattttt
     4321 cttgtgattt ttttattttg aatcaaatat tgtaaattgt gtataaatga agatgctgaa
     4381 tagttctgtt tccacttggc atttcaagtc tgacatcaga tgtctgtaca gggttttgct
     4441 ctttcctgtg tataaccata tagcagtcct agagtggtgg agttatgtct tgctggaagc
     4501 tttcagcagc ctctgtctct gtatacccgg gcatgttgtt tattttcaga tcatcagaaa
     4561 taagtgtgcc gggcacagtt cggctggctg cttaccttct ctctggtgtt taagtcgaag
     4621 gctgaagctg atgaaatatg tgcggctggc tttccttggc ttcctagatt tcaaagacca
     4681 aacaaagaat agttcttcac taaccttaga ctgttgttat agagttaaat agaggctctg
     4741 cacttgctct acaacatgcc tcctggtcac ccctgtgtac ttacatcaag gtgtgtggag
     4801 agcactttgg taaaaatcac ccgttagaag aggagcaggc acagggagct cccttcctcc
     4861 agtgccatcc tccagggttg gacggggact ctcagttcat cagggctgta caatcccaaa
     4921 ccccatggtg ttctctacat gatgctgttc tttcttgctc acattgcact ttaagtggcg
     4981 gggaaccacc agcagcacga gcctgcaaac actgccctct ggagggccac cgttgtctcc
     5041 atcaatgtga cagcaggaag agtggacact cagtcttcct tctgacttta aatacttcct
     5101 gtgccagctg aacctagatg agctgaggaa aggcctctga tagaagagat gtttccacaa
     5161 gtaagcaaga cgcggtgtgc agcgaggatg gggatatcac ggaggagctc tccacacgag
     5221 ggctgaggga agcaggactt ggttaacccc ttggtggaca ggaaatgatt gtgtcctctt
     5281 tcctggacat agaaagaatg tataaactaa tgaaggaaat gtttattttt aaataaggat
     5341 gttttaggtc tgtgtttcat atttgttttt tttctcatac aaacgttagc aatataatga
     5401 aatgtctact ttcccagttt aattgcagct atgaagagtg cagtctagaa attaggttaa
     5461 gtgtctctaa acctttcttc cgtgtgtcaa gcataattat attgagatat attgtgtagt
     5521 catttggctc aaaaaggctt aatagagaca ctaatgaaaa ctcacagact tttaccaagg
     5581 aagatggttg aagcctgggt gagacagcag agactgggct ggtcttcaag aataagcctt
     5641 ctgtgggcag agctgctttt ctgttgagga atactttcta gtgacttggt cagtgcagcc
     5701 ttccttagat cagtatcagc ctaagctgag ggagtgacct gagaagagca ttgtgtgtgg
     5761 taactggaga tgcgtggaac aagcctgaac tgtaagaggg ctgcacgcct gttcgctagc
     5821 ccgtttactt tgtctcactg gtatgcctca gagctggcaa aggcaggatg gtaagagaag
     5881 gggctggggc agctcaggct tctgggacct catccagacc ttaacagtta agaccttgaa
     5941 cagtcatttt actcctcaga gctgctgttg gctgtttaca cagaattaat ctggataggt
     6001 gctctgtgag acagcagaag cctagcaaca ttgtgctact ggtttagaag gactatgaag
     6061 gatggtacaa tccagatgtc cttcaggtag cttctgtgct cctaccattc ctacagcttt
     6121 cctcagcatt tactcagact tagaatgagc agttataacc ttattgctac ttgctagtta
     6181 cctgaataaa agcccacatc atcaaaagct tgaagataga ttttcctact gtaatattgg
     6241 gtacacacaa ccttacctgt tgcagtaaaa cagaatccag aggtttctat tattttaatc
     6301 atataatcag ggatttgttg ttaaaatatg gacaaatacc atatgcacat tttttatttg
     6361 atcttctctc tgatgaatag aagtaattac tgtaccagaa aatatcacaa attggtattc
     6421 cctgtagaaa accaaaccta attcccaaag tttctgaaaa tatggtcctc aagaggagat
     6481 attttaaaat gttcacctct aagtagctta atcgttacaa tgatttctga agtagacata
     6541 tcagaaataa atcatgtaac tgaatgttcc ctccagaacc atctgatttt gcttgggaag
     6601 tgaatggtga cccttggcag gccagtggca tctgagttgt ttaaactctc gtttttagat
     6661 ataacatcac cagataaaat agcaaggacg tggttgcatt ttcctagtag cctcgctccc
     6721 agcatattct ttcttatgtg tttctcccac gcctctgcct tcgagtaaga ttgagctatt
     6781 ccaaaaggca gaactactgg gcgagatgaa gagcagttac cattgaagac atgtgacagc
     6841 cacgggcaat ttctagagaa gccttcatag ccaagaggga tcacaccctc actttatgta
     6901 agggacagtt tgcagtccct ggtctttagg gtatttaaag acaaccccta aaggaggctg
     6961 tcatttactc acattccatg ttggacttgg ctctttctga tcaggtcaga attctagaac
     7021 ttggatcact gataattgaa gattcaatat tttttatggt ttacaattct catttcctat
     7081 gcttttcctg ataagtgttt gttttgattc aaaccaacat agccttccac caggtgatta
     7141 gttctgtctt cagcagtgct gtgggagtga ggagatgggg ctgggggtcc atgcttagct
     7201 gaacaaccaa atgctgtgga catcttggac caagctaaag tccccatgac aaggcctctc
     7261 tggcttctga cggtctttac cttcctgctc tgtaaggtgg tccacagtct gttgccactg
     7321 actggagtct aggggatgac agacacttca gcaaatgaga ggctgctggc gtaagggtta
     7381 cagtggggtt gttgagtgag acacttcaga tactgctagc tgattcatag ccctctctag
     7441 agactcattt taccagtgca aaattagacc tttcctttcc gtgatgataa tgttccccaa
     7501 gttagatgta cttggctttg tggactgaat gggtcccagt tggcctccat ttcaaagtct
     7561 ttaacaagat atcctatata tttcccctgg gtttcctttc tctaaggggg agggttgagg
     7621 cctgttggct gcctgggtaa tgctacctta tgcagagttc tcaaaggatt acaacggttg
     7681 gtgggaggga agtccttcgt tgcttctcac ttcgatgcag tgtcccagat tcactctctg
     7741 tgggtatttt cctctgccct gttgtacatg cctttatcac atggatggat tcttacctta
     7801 gtctaacttg tcttccccag ggaagctaag caaagtgatg taatgaagct atcttgtgca
     7861 gtaaaatgtg aaaaatgaat actgcttcgc aagtattgta taaaataagt ctgtaaacaa
     7921 atttcttatg taaacataca gaggaataaa gcttttatct gttcaaacaa gtgcat
//
