LOCUS       NM_134398               1087 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus alpha- and gamma-adaptin binding protein (Aagab),
            mRNA.
ACCESSION   NM_134398
VERSION     NM_134398.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1087)
  AUTHORS   Furniss,M., Higgins,C.A., Martinez-Mir,A., Horev,L., Petukhova,L.,
            Stanimirovic,A., Miljkovic,J., Zlotogorski,A. and Christiano,A.M.
  TITLE     Identification of distinct mutations in AAGAB in families with type
            1 punctate palmoplantar keratoderma
  JOURNAL   J Invest Dermatol 134 (6), 1749-1752 (2014)
   PUBMED   24390136
REFERENCE   2  (bases 1 to 1087)
  AUTHORS   Burman,J.L., Wasiak,S., Ritter,B., de Heuvel,E. and McPherson,P.S.
  TITLE     Aftiphilin is a component of the clathrin machinery in neurons
  JOURNAL   FEBS Lett 579 (10), 2177-2184 (2005)
   PUBMED   15811338
REFERENCE   3  (bases 1 to 1087)
  AUTHORS   Page,L.J., Sowerby,P.J., Lui,W.W. and Robinson,M.S.
  TITLE     Gamma-synergin: an EH domain-containing protein that interacts with
            gamma-adaptin
  JOURNAL   J Cell Biol 146 (5), 993-1004 (1999)
   PUBMED   10477754
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF178669.1.
            
            On Aug 31, 2012 this sequence version replaced NM_134398.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF178669.1, SRR8487231.85333.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1087              AF178669.1         3-1089
FEATURES             Location/Qualifiers
     source          1..1087
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1087
                     /gene="Aagab"
                     /gene_synonym="P34"
                     /note="alpha- and gamma-adaptin binding protein"
                     /db_xref="GeneID:171435"
                     /db_xref="RGD:621601"
     exon            1..107
                     /gene="Aagab"
                     /gene_synonym="P34"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..982
                     /gene="Aagab"
                     /gene_synonym="P34"
                     /codon_start=1
                     /product="alpha- and gamma-adaptin-binding protein p34"
                     /protein_id="NP_599225.1"
                     /db_xref="GeneID:171435"
                     /db_xref="RGD:621601"
                     /translation="MAAGVPCALVTSCSATFTGDRLVQHILGTEDAVVEATSSDAVRF
                     YPWTIDNKYYSAEVNLCVVPSKCRVTAEIAEAVQAFVVYFDSTQKSGLDSVSSWLPLA
                     ETWLPEVMILVCDRVCEDGINRQQAQEWCIKHGFELVELCPEELPEEDDDFPESTGVK
                     RIVQALNANVWSNVVMKNDRSQGFSLLNSLAGASRSVGSAESCQCEQEPSPTAERTES
                     LPGHRSGACGPAGAQVDSIVDPMLDLDIQELASLTTGGGDLENFERLFSKLKEMKDKA
                     ATLPHEQRKLHAEKVAKAFWMAIGGDRDEIEGLSSDDEH"
     exon            108..298
                     /gene="Aagab"
                     /gene_synonym="P34"
                     /inference="alignment:Splign:2.1.0"
     exon            299..395
                     /gene="Aagab"
                     /gene_synonym="P34"
                     /inference="alignment:Splign:2.1.0"
     exon            396..485
                     /gene="Aagab"
                     /gene_synonym="P34"
                     /inference="alignment:Splign:2.1.0"
     exon            486..569
                     /gene="Aagab"
                     /gene_synonym="P34"
                     /inference="alignment:Splign:2.1.0"
     exon            570..652
                     /gene="Aagab"
                     /gene_synonym="P34"
                     /inference="alignment:Splign:2.1.0"
     exon            653..749
                     /gene="Aagab"
                     /gene_synonym="P34"
                     /inference="alignment:Splign:2.1.0"
     exon            750..854
                     /gene="Aagab"
                     /gene_synonym="P34"
                     /inference="alignment:Splign:2.1.0"
     exon            855..904
                     /gene="Aagab"
                     /gene_synonym="P34"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1087
                     /gene="Aagab"
                     /gene_synonym="P34"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcgccgg cgcggaaccc gctctgctgc agcgatggct gccggtgttc cttgtgcgct
       61 ggtcaccagc tgctccgcca ccttcaccgg ggaccggctg gtgcaacata tccttggaac
      121 agaagatgct gttgtggaag cgacttccag cgatgctgtg aggttttacc cctggaccat
      181 cgataacaag tactactctg cagaggtcaa cctgtgtgtg gtgccaagca agtgccgggt
      241 cactgccgag atcgcagagg cagtccaggc gtttgtagtt tactttgata gcacacagaa
      301 atcaggtctt gacagcgtct cctcgtggct tcctctggca gaaacatggc tgcctgaggt
      361 gatgatcctg gtctgtgata gagtgtgtga agatggaata aaccgacaac aggctcaaga
      421 gtggtgcatc aaacatggct ttgagctggt ggagctctgc ccagaggagc tacctgagga
      481 ggacgatgac ttccctgaat ctacaggcgt aaagcggatt gtacaagcat tgaatgccaa
      541 tgtctggtcc aatgtcgtga tgaagaatga caggagccag ggcttcagcc ttctcaactc
      601 actggctgga gcaagccgca gcgttggatc agcagagagc tgtcagtgtg agcaggagcc
      661 atcaccaaca gctgagagga cagagtccct ccccgggcat cgcagtggcg cgtgtggccc
      721 agcaggtgca caggttgaca gcattgttga ccccatgtta gacctggata ttcaagaatt
      781 agccagtctt accactggag gaggggatct ggagaacttt gagagactct tttcaaagtt
      841 aaaagaaatg aaagacaagg ctgcgacgct tcctcatgag caaagaaagt tgcatgcaga
      901 aaaggtggcc aaagccttct ggatggcaat agggggagac cgagatgaga tcgagggcct
      961 ttcttctgat gacgagcact aagttctgcc tgctaggttt gactgacacc gatgatgcca
     1021 gcactgtgcg tcccaagtgc ttcccttctc aaccgggttc tgttctgcca agactgccgt
     1081 ttgcacg
//
