LOCUS       NM_017193               1828 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Rattus norvegicus aminoadipate aminotransferase (Aadat), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_017193
VERSION     NM_017193.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1828)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1828)
  AUTHORS   Han,Q., Cai,T., Tagle,D.A. and Li,J.
  TITLE     Structure, expression, and function of kynurenine aminotransferases
            in human and rodent brains
  JOURNAL   Cell Mol Life Sci 67 (3), 353-368 (2010)
   PUBMED   19826765
  REMARK    Review article
REFERENCE   3  (bases 1 to 1828)
  AUTHORS   Han,Q., Cai,T., Tagle,D.A., Robinson,H. and Li,J.
  TITLE     Substrate specificity and structure of human aminoadipate
            aminotransferase/kynurenine aminotransferase II
  JOURNAL   Biosci Rep 28 (4), 205-215 (2008)
   PUBMED   18620547
REFERENCE   4  (bases 1 to 1828)
  AUTHORS   Rossi,F., Garavaglia,S., Montalbano,V., Walsh,M.A. and Rizzi,M.
  TITLE     Crystal structure of human kynurenine aminotransferase II, a drug
            target for the treatment of schizophrenia
  JOURNAL   J Biol Chem 283 (6), 3559-3566 (2008)
   PUBMED   18056996
REFERENCE   5  (bases 1 to 1828)
  AUTHORS   Han,Q., Robinson,H. and Li,J.
  TITLE     Crystal structure of human kynurenine aminotransferase II
  JOURNAL   J Biol Chem 283 (6), 3567-3573 (2008)
   PUBMED   18056995
REFERENCE   6  (bases 1 to 1828)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1828)
  AUTHORS   Buchli,R., Alberati-Giani,D., Malherbe,P., Kohler,C., Broger,C. and
            Cesura,A.M.
  TITLE     Cloning and functional expression of a soluble form of
            kynurenine/alpha-aminoadipate aminotransferase from rat kidney
  JOURNAL   J Biol Chem 270 (49), 29330-29335 (1995)
   PUBMED   7493966
REFERENCE   8  (bases 1 to 1828)
  AUTHORS   Okayama,A., Ogawa,Y., Goto,S., Yamatodani,A., Wada,H., Okuno,E.,
            Takikawa,O. and Kido,R.
  TITLE     Enzymatic studies on tryptophan metabolism disorder in rats
            chronically exposed to carbon disulfide
  JOURNAL   Toxicol Appl Pharmacol 94 (3), 356-361 (1988)
   PUBMED   3400092
REFERENCE   9  (bases 1 to 1828)
  AUTHORS   Takeuchi,F. and Shibata,Y.
  TITLE     Kynurenine metabolism in vitamin-B-6-deficient rat liver after
            tryptophan injection
  JOURNAL   Biochem J 220 (3), 693-699 (1984)
   PUBMED   6466295
REFERENCE   10 (bases 1 to 1828)
  AUTHORS   Tobes,M.C. and Mason,M.
  TITLE     L-kynurenine aminotransferase and L-alpha-aminoadipate
            aminotransferase. I. Evidence for identity
  JOURNAL   Biochem Biophys Res Commun 62 (2), 390-397 (1975)
   PUBMED   1111529
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Z50144.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z50144.1, BC078864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1828
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p12"
     gene            1..1828
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /note="aminoadipate aminotransferase"
                     /db_xref="GeneID:29416"
                     /db_xref="RGD:2948"
     exon            1..179
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1390
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /EC_number="2.6.1.7"
                     /EC_number="2.6.1.39"
                     /EC_number="2.6.1.63"
                     /EC_number="2.6.1.4"
                     /EC_number="2.6.1.73"
                     /note="KAT/AadAT; 2-aminoadipate transaminase;
                     2-aminoadipate aminotransferase; alpha-aminoadipate
                     aminotransferase; kynurenine--oxoglutarate transaminase
                     II; kynurenine--oxoglutarate aminotransferase II;
                     kynurenine aminotransferase II; kynurenine
                     aminotransferase 2; kynurenine--oxoglutarate transaminase
                     2; glycine transaminase AADAT; kynurenine--glyoxylate
                     transaminase AADAT; methionine--glyoxylate transaminase
                     AADAT"
                     /codon_start=1
                     /product="kynurenine/alpha-aminoadipate aminotransferase,
                     mitochondrial"
                     /protein_id="NP_058889.1"
                     /db_xref="GeneID:29416"
                     /db_xref="RGD:2948"
                     /translation="MNYSRFLTATSLARKTSPIRATVEIMSRAPKDIISLAPGSPNPK
                     VFPFKSAVFTVENGSTIRFEGEMFQRALQYSSSYGIPELLSWLKQLQIKLHNPPTVNY
                     SPNEGQMDLCITSGCQDGLCKVFEMLINPGDTVLVNEPLYSGALFAMKPLGCNFISVP
                     SDDCGIIPEGLKKVLSQWKPEDSKDPTKRTPKFLYTIPNGNNPTGNSLTGDRKKEIYE
                     LARKYDFLIIEDDPYYFLQFTKPWEPTFLSMDVDGRVIRADSLSKVISSGLRVGFITG
                     PKSLIQRIVLHTQISSLHPCTLSQLMISELLYQWGEEGFLAHVDRAIDFYKNQRDFIL
                     AAADKWLRGLAEWHVPKAGMFLWIKVNGISDAKKLIEEKAIEREILLVPGNSFFVDNS
                     APSSFFRASFSQVTPAQMDLVFQRLAQLIKDVS"
     exon            180..348
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..481
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..556
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
     exon            557..766
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..832
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..915
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1012
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1074
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1139
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1246
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1348
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1809
                     /gene="Aadat"
                     /gene_synonym="Kat2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcactcc gcagcactac ccggagacag ctaacagtgc agcccgagtg atctgggaag
       61 ccgttctcag tgaccgactt ttctagtcct gttccacgcg accagcagag acatgaatta
      121 ctcaaggttc ctcactgcaa cgagcctggc cagaaagaca tcccctatca gagctacagt
      181 ggagataatg agtagagcac ccaaagacat catctccctg gctcctggat ctccgaaccc
      241 gaaagtgttc ccctttaagt cagctgtctt cactgtggag aacggaagca ccatccggtt
      301 tgaaggagag atgtttcaaa gggccctcca atattcctca agctatggaa ttccagaact
      361 tctgtcctgg ctaaaacagt tgcaaataaa attgcataat cctccgactg tcaactactc
      421 acccaacgaa ggacagatgg acctctgcat cacatctggc tgtcaagacg gtctctgtaa
      481 ggtgtttgaa atgctcatca atcctggaga cactgttctg gtcaatgaac cactgtattc
      541 aggagccctt tttgcaatga aaccactggg ctgcaatttt attagtgtcc ccagtgatga
      601 ctgtgggatt attccagagg gtctcaaaaa agtactttcc cagtggaaac cagaagattc
      661 caaggatccc acaaaaagga ctccaaaatt tctgtatact attccgaatg gcaacaaccc
      721 tacaggcaac tcgttgactg gtgaccgcaa gaaagaaatc tatgagcttg caagaaaata
      781 tgacttcctc ataatagaag acgatcctta ctattttctc cagttcacca agccttggga
      841 accaaccttt ctctccatgg atgttgatgg gagagttatc agagctgact ccctttcaaa
      901 agttatctcc tcagggctga gagtggggtt tataactggc cccaagtcct tgatacagag
      961 gattgttctc cacacacaaa tctcatcact gcatccctgt actttatcac agctcatgat
     1021 atcggagctt ctataccagt ggggagaaga gggtttcctg gcccatgttg acagagctat
     1081 tgatttctac aagaaccaga gggattttat attggcagct gcagacaagt ggttacgtgg
     1141 tttggcagag tggcatgttc ccaaagctgg catgtttcta tggattaaag ttaacggaat
     1201 ctctgatgca aaaaaactaa ttgaagaaaa ggctattgaa agagagatct tgttagttcc
     1261 tggaaatagt ttcttcgtcg ataattcagc cccctcctcc ttcttcagag catccttctc
     1321 tcaggttact ccagcgcaga tggacttagt cttccagaga ttggcccaac tcataaaaga
     1381 cgtttcataa agaaatcaaa ctcagcattg aacttataat tttaaaataa atttcctata
     1441 ctttgctgaa gaaatggctg acaggatgga tccagtttgt gaaatatctg tggcaatttc
     1501 actgaacaac tttgaagccc cttaaaatcc accgcattgc caaaataact ttctgatata
     1561 cttttgccct ttgattaatt atgaactaac aaaacatcaa atttcattgt taaagacctc
     1621 tgtagctgct taataatgtc caataaattt ttttgagcct aacatagact aactaacata
     1681 gtaaattgca agggaattag ttaaaatggc ctataatatg caggtttttt tctactttaa
     1741 ggaaatttca tgagcattta ctgcaaaaat tgttgtaatt tgacaattat aaattacttt
     1801 gtaaccgaaa aaaaaaaaaa aaaaaaaa
//
