LOCUS       NM_020538               1645 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus arylacetamide deacetylase (Aadac), mRNA.
ACCESSION   NM_020538
VERSION     NM_020538.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1645)
  AUTHORS   Lo,V., Erickson,B., Thomason-Hughes,M., Ko,K.W., Dolinsky,V.W.,
            Nelson,R. and Lehner,R.
  TITLE     Arylacetamide deacetylase attenuates fatty-acid-induced
            triacylglycerol accumulation in rat hepatoma cells
  JOURNAL   J Lipid Res 51 (2), 368-377 (2010)
   PUBMED   19654421
REFERENCE   2  (bases 1 to 1645)
  AUTHORS   Watanabe,A., Fukami,T., Nakajima,M., Takamiya,M., Aoki,Y. and
            Yokoi,T.
  TITLE     Human arylacetamide deacetylase is a principal enzyme in flutamide
            hydrolysis
  JOURNAL   Drug Metab Dispos 37 (7), 1513-1520 (2009)
   PUBMED   19339378
  REMARK    Erratum:[Drug Metab Dispos. 2014 Jun;42(6):1066]
REFERENCE   3  (bases 1 to 1645)
  AUTHORS   Ross,M.K. and Crow,J.A.
  TITLE     Human carboxylesterases and their role in xenobiotic and endobiotic
            metabolism
  JOURNAL   J Biochem Mol Toxicol 21 (4), 187-196 (2007)
   PUBMED   17936933
  REMARK    Review article
REFERENCE   4  (bases 1 to 1645)
  AUTHORS   Frick,C., Atanasov,A.G., Arnold,P., Ozols,J. and Odermatt,A.
  TITLE     Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1
            in the endoplasmic reticulum lumen is dependent on its N-terminal
            region sharing similar topological determinants with 50-kDa
            esterase
  JOURNAL   J Biol Chem 279 (30), 31131-31138 (2004)
   PUBMED   15152005
REFERENCE   5  (bases 1 to 1645)
  AUTHORS   Trickett,J.I., Patel,D.D., Knight,B.L., Saggerson,E.D.,
            Gibbons,G.F. and Pease,R.J.
  TITLE     Characterization of the rodent genes for arylacetamide deacetylase,
            a putative microsomal lipase, and evidence for transcriptional
            regulation
  JOURNAL   J Biol Chem 276 (43), 39522-39532 (2001)
   PUBMED   11481320
REFERENCE   6  (bases 1 to 1645)
  AUTHORS   Mziaut,H., Korza,G., Hand,A.R., Gerard,C. and Ozols,J.
  TITLE     Targeting proteins to the lumen of endoplasmic reticulum using
            N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the
            50-kDa esterase
  JOURNAL   J Biol Chem 274 (20), 14122-14129 (1999)
   PUBMED   10318829
REFERENCE   7  (bases 1 to 1645)
  AUTHORS   Ozols,J.
  TITLE     Determination of lumenal orientation of microsomal 50-kDa
            esterase/N-deacetylase
  JOURNAL   Biochemistry 37 (28), 10336-10344 (1998)
   PUBMED   9665742
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF182426.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF182426.1, BC088143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1645
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..1645
                     /gene="Aadac"
                     /gene_synonym="Aada"
                     /note="arylacetamide deacetylase"
                     /db_xref="GeneID:57300"
                     /db_xref="RGD:631440"
     exon            1..160
                     /gene="Aadac"
                     /gene_synonym="Aada"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1222
                     /gene="Aadac"
                     /gene_synonym="Aada"
                     /EC_number="3.1.1.3"
                     /note="arylacetamide deacetylase (esterase)"
                     /codon_start=1
                     /product="arylacetamide deacetylase"
                     /protein_id="NP_065413.1"
                     /db_xref="GeneID:57300"
                     /db_xref="RGD:631440"
                     /translation="MGRTIFLLISVVLVAYYIYIPLPDDIEEPWKIILGNTLLKLGGD
                     LASFGELLGLNHFMDTVQLFMRFQVVPPTSDENVTVMETDFNSVPVRIYIPKRKSTTL
                     RRGLFFIHGGGWCLGSAAYFMYDTLSRRTAHRLDAVVVSTDYGLAPKYHFPKQFEDVY
                     HSLRWFLQEDILEKYGVDPRRVGVSGDSAGGNLTAAVTQQILQDPDVKIKLKVQALIY
                     PALQALDMNVPSQQENSQYPLLTRSLLIRFWSEYFTTDRDLEKAMLLNQHVPVEFSHL
                     LQFVNWSSLLPQRYKKGYFYKTPTPGSLELAQKYPGFTDVKACPLLANDSILHHLPMT
                     YIITCQYDVLRDDGLMYVKRLQNTGVHVTHHHIEDGFHGALTLPGLKITYRMQNQYLN
                     WLHKNL"
     exon            161..383
                     /gene="Aadac"
                     /gene_synonym="Aada"
                     /inference="alignment:Splign:2.1.0"
     exon            384..453
                     /gene="Aadac"
                     /gene_synonym="Aada"
                     /inference="alignment:Splign:2.1.0"
     exon            454..625
                     /gene="Aadac"
                     /gene_synonym="Aada"
                     /inference="alignment:Splign:2.1.0"
     exon            626..1645
                     /gene="Aadac"
                     /gene_synonym="Aada"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaagtagaa agagcagaag gaaacatggg aagaactatt tttcttctca tctctgtggt
       61 gcttgtagct tattatattt atatacctct cccagatgat attgaagagc cttggaaaat
      121 aatattggga aatacacttc taaaacttgg aggagatttg gcttcttttg gtgaactttt
      181 gggactcaat catttcatgg acacggtaca gttatttatg agatttcaag ttgtcccacc
      241 cacttctgat gagaatgtca ctgtgatgga gacagatttc aacagtgttc ctgttcgcat
      301 atatataccc aaaaggaagt caacgacgct caggaggggc ttgtttttta ttcatggtgg
      361 tggctggtgt ctggggagtg ctgcttactt catgtatgac actctgtcaa gacggactgc
      421 ccatagactt gatgccgttg ttgtgtcaac tgactatggc ttagccccaa aataccattt
      481 tccaaaacag tttgaagatg tatatcatag tttacgatgg ttcttacaag aggacattct
      541 tgaaaaatat ggtgtagatc ctagaagagt tggtgtgtct ggggacagtg ctggtggaaa
      601 cttaactgca gctgtgacac aacagattct acaggatcca gatgtcaaga tcaaactcaa
      661 ggtccaagct ttaatatatc ctgcccttca ggctcttgat atgaatgtac catcacaaca
      721 agaaaattca caatacccac ttttaaccag gtcattattg atccgtttct ggagtgaata
      781 ctttactaca gaccgagacc ttgagaaagc catgcttctc aaccaacatg tacctgtgga
      841 attcagccat ttgttacaat ttgtgaattg gagttccttg ctccctcaga gatataagaa
      901 aggttacttt tataaaactc ccactcctgg tagtttggag ctggctcaaa agtacccagg
      961 gttcacagat gtaaaggcat gccctctgtt ggccaatgac agtatattac atcatttacc
     1021 tatgacctat attatcactt gtcagtatga tgttctaaga gatgacggac tcatgtatgt
     1081 caagcggctt cagaatactg gagttcatgt gactcatcac catattgaag atggattcca
     1141 tggagcactt accttacctg gtttgaaaat tacatacagg atgcaaaatc agtacttgaa
     1201 ttggcttcac aaaaatctgt agcaaaatct ataaaatggt ttattgaaga tatataaaca
     1261 ccaaaataag aaataaacta gtaaacatgg ttttgaggtt tcacataaat catttgttgt
     1321 ttctaatgag ctgatagctt ccacattttg ttacttttat tattagcaaa catttttttt
     1381 cattccttat tccgcattta cctacagact catcttccaa acaagagttt tatgtgggta
     1441 ctgacaatcc aaattcatgt gtgcatgctt atgaaatggg cactttatca attatcacca
     1501 tgtacaaatt ccataacaat tctgtagtgc acttttatta cccattatta ttttacacat
     1561 aagaaaaagt gaacttaaat aagtgaagta ataaaatatg tcctaaatct agtactgttg
     1621 gaataaacat tcattgtaag tttct
//
