LOCUS       NM_001106795            1911 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus aladin WD repeat nucleoporin (Aaas), mRNA.
ACCESSION   NM_001106795 XM_001067255 XM_217063
VERSION     NM_001106795.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1911)
  AUTHORS   Juhlen,R., Landgraf,D., Huebner,A. and Koehler,K.
  TITLE     Identification of a novel putative interaction partner of the
            nucleoporin ALADIN
  JOURNAL   Biol Open 5 (11), 1697-1705 (2016)
   PUBMED   27754849
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1911)
  AUTHORS   Carvalhal,S., Ribeiro,S.A., Arocena,M., Kasciukovic,T., Temme,A.,
            Koehler,K., Huebner,A. and Griffis,E.R.
  TITLE     The nucleoporin ALADIN regulates Aurora A localization to ensure
            robust mitotic spindle formation
  JOURNAL   Mol Biol Cell 26 (19), 3424-3438 (2015)
   PUBMED   26246606
REFERENCE   3  (bases 1 to 1911)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 1911)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1911)
  AUTHORS   Huebner,A., Mann,P., Rohde,E., Kaindl,A.M., Witt,M., Verkade,P.,
            Jakubiczka,S., Menschikowski,M., Stoltenburg-Didinger,G. and
            Koehler,K.
  TITLE     Mice lacking the nuclear pore complex protein ALADIN show female
            infertility but fail to develop a phenotype resembling human triple
            A syndrome
  JOURNAL   Mol Cell Biol 26 (5), 1879-1887 (2006)
   PUBMED   16479006
REFERENCE   6  (bases 1 to 1911)
  AUTHORS   Brooks,B.P., Kleta,R., Stuart,C., Tuchman,M., Jeong,A.,
            Stergiopoulos,S.G., Bei,T., Bjornson,B., Russell,L., Chanoine,J.P.,
            Tsagarakis,S., Kalsner,L. and Stratakis,C.
  TITLE     Genotypic heterogeneity and clinical phenotype in triple A
            syndrome: a review of the NIH experience 2000-2005
  JOURNAL   Clin Genet 68 (3), 215-221 (2005)
   PUBMED   16098009
REFERENCE   7  (bases 1 to 1911)
  AUTHORS   Storr,H.L., Clark,A.J., Priestley,J.V. and Michael,G.J.
  TITLE     Identification of the sites of expression of triple A syndrome mRNA
            in the rat using in situ hybridisation
  JOURNAL   Neuroscience 131 (1), 113-123 (2005)
   PUBMED   15680696
REFERENCE   8  (bases 1 to 1911)
  AUTHORS   Cronshaw,J.M. and Matunis,M.J.
  TITLE     The nuclear pore complex protein ALADIN is mislocalized in triple A
            syndrome
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 5823-5827 (2003)
   PUBMED   12730363
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474035.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217063.4, XM_001067255.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1911
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1911
                     /gene="Aaas"
                     /note="aladin WD repeat nucleoporin"
                     /db_xref="GeneID:300259"
                     /db_xref="RGD:1308701"
     exon            1..108
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            109..359
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1877
                     /gene="Aaas"
                     /note="achalasia, adrenocortical insufficiency, alacrimia
                     (Allgrove, triple-A)"
                     /codon_start=1
                     /product="aladin"
                     /protein_id="NP_001100265.1"
                     /db_xref="GeneID:300259"
                     /db_xref="RGD:1308701"
                     /translation="MCSLGLFPPPPPRGQVTLYEHNNELVTGNSYESPPPDFRGQWIN
                     LPVLHLTKDPLKAPGRLDHGTRAAFIHHREQVWKRCINVWHDVGLFGVLNEIANSEEE
                     VFEWVKTASSWALALCGRASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWH
                     PHTNKFAVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPLSASVLAVACQSCIL
                     IWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPNGGWLLSASPVDAVILVWDVST
                     ETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWEARMWTCEGWPTLSGRCQTG
                     CWSPDGKRLLFTVLGEALIYSLSFPEPCGTEKGHVGGAKSATIVADLSETTIQTPDGE
                     ERLGGEAHAMVWDPSGERLAVLMKGNPRVQDGNPVILLFRTRNSPVFELLPCGVIQGE
                     PGAQAQLVSFHPAFNKGALLSVCWSTGRITHIPLYFVNAQFPRFSPVLGRAQEPPAGG
                     GGSVHEVPLFTETSPTSAPWDPLPGLPSAQPHSPHSHL"
     exon            360..487
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            488..543
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            544..635
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            636..682
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            683..781
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            782..925
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1046
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1171
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1232
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1323
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1417
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1485
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1567
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1652
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1911
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcaagatc ctaagccttc tggcccggcg cgcggcttca aaggcgcttt gaagaaatct
       61 gagttccgaa gaagtgtaaa ggagacccgg aggagtgggc aggacctgct tcacgcagta
      121 gtttgtcctg tacggctacc cgtccgcata cgaatctagc ccgggaacta agattcaaga
      181 gagcgcagtc accagccggg agcctgtcgg ttccagacac cctccggact gacaagatgt
      241 gctccctggg gttgtttccc ccgccgccgc ctagaggtca agtcaccctg tatgagcaca
      301 ataacgagct ggtgaccggc aacagctatg agagcccgcc tcccgacttc cggggccagt
      361 ggatcaatct tcctgtccta cacctgacca aggatcccct aaaagctcct gggaggctgg
      421 accatggtac aagagctgcc ttcatccatc atcgggagca agtgtggaag aggtgcatca
      481 atgtttggca cgatgtgggt ctttttggag tcctgaatga aattgcaaat tcagaggaag
      541 aagtgtttga gtgggtaaag acagcctcca gctgggccct ggctctctgt ggccgggcct
      601 cctccctcca tggctccttg ttcccacacc tctcactcag gagtgaggat ctgattgctg
      661 aatttgccca agtcactaac tggtccagct gctgcttacg ggtctttgcc tggcatcctc
      721 acaccaacaa gtttgcagtg gccctgctgg atgactccat ccgtgtttat aatgccaaca
      781 gcactatagt tccctccctg aagcaccgtc tacagcgaaa tgtggcagca ctggcctgga
      841 agcccctcag tgcctctgtc ttggctgtgg cctgccagag ctgtattctc atctggaccc
      901 tggaccccac ttccttatct acgagaccct cctctggctg cgcccaggtc ttgtctcacc
      961 ctgggcacac accagtcacc agcttggctt gggcccccaa tggggggtgg ctgctctcag
     1021 cctcaccggt agatgctgtt attctggtat gggacgtttc aacagaaacc tgtgtccccc
     1081 ttccttggtt ccgaggagga ggggttacca acttgctgtg gtccccagat ggcagcaaag
     1141 tcctggctac aactccttcc gctgtctttc gagtctggga ggcccggatg tggacttgtg
     1201 aggggtggcc aactctctca gggcgctgcc agactggctg ctggagtcca gacggaaaac
     1261 gattgttgtt cactgtattg ggggaagcat taatttattc cttgtcattc ccagaaccat
     1321 gtggaacaga gaaaggacat gttggaggtg caaagtcagc caccatcgta gcagatcttt
     1381 ctgagacaac aattcagacc ccagatggag aggagagact cgggggagag gctcacgcca
     1441 tggtttggga ccctagtggt gaacgactgg ctgtgctcat gaaaggaaac ccacgggttc
     1501 aggatgggaa tcctgtcatc ctcctttttc gaactcgaaa cagccccgtg tttgagctgc
     1561 ttccctgtgg tgttattcag ggggagccgg gagcccaagc ccagctcgtc agcttccatc
     1621 ctgctttcaa caaaggggcc ttgctcagtg tgtgctggtc cacaggccga atcacccaca
     1681 tccctctgta ctttgtcaac gcccaatttc cacgctttag cccagtgctt ggtcgggccc
     1741 aggagccccc agctggaggt ggaggctctg ttcatgaagt accactattt actgagacat
     1801 caccaacctc tgccccttgg gaccctcttc caggactacc atctgctcaa ccccactccc
     1861 ctcactccca cttgtaaata aagtttttct tgtttccact catttaccag g
//
