LOCUS       NM_022240               1676 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus alpha 1,4-galactosyltransferase (A4galt), mRNA.
ACCESSION   NM_022240
VERSION     NM_022240.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1676)
  AUTHORS   Porubsky,S., Speak,A.O., Salio,M., Jennemann,R., Bonrouhi,M.,
            Zafarulla,R., Singh,Y., Dyson,J., Luckow,B., Lehuen,A., Malle,E.,
            Muthing,J., Platt,F.M., Cerundolo,V. and Grone,H.J.
  TITLE     Globosides but not isoglobosides can impact the development of
            invariant NKT cells and their interaction with dendritic cells
  JOURNAL   J Immunol 189 (6), 3007-3017 (2012)
   PUBMED   22875802
REFERENCE   2  (bases 1 to 1676)
  AUTHORS   Okuda,T., Tokuda,N., Numata,S., Ito,M., Ohta,M., Kawamura,K.,
            Wiels,J., Urano,T., Tajima,O., Furukawa,K. and Furukawa,K.
  TITLE     Targeted disruption of Gb3/CD77 synthase gene resulted in the
            complete deletion of globo-series glycosphingolipids and loss of
            sensitivity to verotoxins
  JOURNAL   J Biol Chem 281 (15), 10230-10235 (2006)
   PUBMED   16476743
REFERENCE   3  (bases 1 to 1676)
  AUTHORS   Keusch,J.J., Manzella,S.M., Nyame,K.A., Cummings,R.D. and
            Baenziger,J.U.
  TITLE     Cloning of Gb3 synthase, the key enzyme in globo-series
            glycosphingolipid synthesis, predicts a family of alpha 1,
            4-glycosyltransferases conserved in plants, insects, and mammals
  JOURNAL   J Biol Chem 275 (33), 25315-25321 (2000)
   PUBMED   10854428
REFERENCE   4  (bases 1 to 1676)
  AUTHORS   Steffensen,R., Carlier,K., Wiels,J., Levery,S.B., Stroud,M.,
            Cedergren,B., Nilsson Sojka,B., Bennett,E.P., Jersild,C. and
            Clausen,H.
  TITLE     Cloning and expression of the histo-blood group Pk UDP-galactose:
            Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular
            genetic basis of the p phenotype
  JOURNAL   J Biol Chem 275 (22), 16723-16729 (2000)
   PUBMED   10747952
REFERENCE   5  (bases 1 to 1676)
  AUTHORS   Kojima,Y., Fukumoto,S., Furukawa,K., Okajima,T., Wiels,J.,
            Yokoyama,K., Suzuki,Y., Urano,T., Ohta,M. and Furukawa,K.
  TITLE     Molecular cloning of globotriaosylceramide/CD77 synthase, a
            glycosyltransferase that initiates the synthesis of globo series
            glycosphingolipids
  JOURNAL   J Biol Chem 275 (20), 15152-15156 (2000)
   PUBMED   10748143
REFERENCE   6  (bases 1 to 1676)
  AUTHORS   Spitalnik,P.F. and Spitalnik,S.L.
  TITLE     The P blood group system: biochemical, serological, and clinical
            aspects
  JOURNAL   Transfus Med Rev 9 (2), 110-122 (1995)
   PUBMED   7795329
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097323.1.
            
            On Jun 19, 2005 this sequence version replaced NM_022240.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097323.1, AF248544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1676
                     /gene="A4galt"
                     /gene_synonym="Gb3"
                     /note="alpha 1,4-galactosyltransferase"
                     /db_xref="GeneID:63888"
                     /db_xref="RGD:621583"
     exon            1..15
                     /gene="A4galt"
                     /gene_synonym="Gb3"
                     /inference="alignment:Splign:2.1.0"
     exon            16..1652
                     /gene="A4galt"
                     /gene_synonym="Gb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1112
                     /gene="A4galt"
                     /gene_synonym="Gb3"
                     /EC_number="2.4.1.228"
                     /note="alpha4Gal-T1; globotriaosylceramide synthase;
                     alpha-1,4-N-acetylglucosaminyltransferase; alpha
                     1,4-galactosyltransferase (P blood group);
                     UDP-galactose:beta-D-galactosyl-beta1-R
                     4-alpha-D-galactosyltransferase; Gb3 synthase"
                     /codon_start=1
                     /product="lactosylceramide 4-alpha-galactosyltransferase"
                     /protein_id="NP_071576.1"
                     /db_xref="GeneID:63888"
                     /db_xref="RGD:621583"
                     /translation="MGISRSDLEETMSKPPDCLPRMLRGTPRQRVFTLFIISFKFTFL
                     VSILIYWHTVGAPKDQRRQYSLPVDFPCPQLAFPRVSAPGNIFFLETSDRTNPSFLFM
                     CSVESAARAHPESQVVVLMKGLPRDTTAWPRNLGISLLSCFPNVQIRPLDLQELFEDT
                     PLAAWYLEAQHRWEPYLLPVLSDASRIALLWKFGGIYLDTDFIVLKNLRNLTNMLGIQ
                     SRYVLNGAFLAFERKHEFLALCIRDFVAHYNGWIWGHQGPQLLTRVFKKWCSIHSLKE
                     SRACRGVTALPPEAFYPIPWQNWKKYFEDVSPEELAQLLNATYAVHVWNKKSQGTHLE
                     ATSRALLAQLHARYCPTTHRAMTMYL"
ORIGIN      
        1 ggactgccca ggctgacaag tcaatcctta tgggcatctc ccgttcggat ctggaggaga
       61 ccatgtccaa gccccccgac tgcctgcctc ggatgctcag gggcacgccc agacagcggg
      121 tcttcaccct cttcattatc agcttcaagt tcaccttctt ggtctccatc ctgatctatt
      181 ggcacacagt gggtgcaccc aaggaccaaa gacgacagta cagcctgcca gtggacttcc
      241 cctgccccca gctggccttt cctagagtct ctgccccagg caacatcttc ttcctagaga
      301 cctccgacag gaccaacccc agctttctgt ttatgtgttc tgtggaatca gctgccaggg
      361 cacaccctga gtcccaggtg gtggtgctca tgaaagggct gcctagggac actaccgcat
      421 ggccccggaa ccttggcatc tctctcctga gctgctttcc caatgtccag atacgacctt
      481 tggacctgca agaactgttt gaggacacgc cactggcagc ctggtacttg gaggcacagc
      541 acaggtggga accctacctg ttgccggtgc tgtctgacgc ttccaggatc gcactcctct
      601 ggaagtttgg tggcatctac ttggacacag acttcatcgt cctcaagaac ttacgcaacc
      661 tgaccaacat gctgggcatc cagtcccgct acgtcctcaa tggcgccttc ctagccttcg
      721 agcgtaagca cgagttcctg gcactgtgca tacgtgactt tgtggcccat tacaatggtt
      781 ggatttgggg ccaccagggc ccccaactgc ttacccgagt cttcaagaag tggtgttcca
      841 tccacagcct gaaggagagc cgagcttgcc gcggggtcac tgccctgcct cccgaggcct
      901 tttaccccat cccctggcag aactggaaga aatactttga agacgtcagc cccgaggagc
      961 tagcccagct gctcaatgcc acctatgctg ttcatgtgtg gaacaagaaa agtcagggta
     1021 cacatctaga ggccacatcc agggctctgc tggctcagct acatgcccgc tactgcccta
     1081 cgacgcacag agccatgacg atgtacttgt gacggccctc caggcacaag tgatgtcata
     1141 tcaacattgt taccagagag gcaagatgag cagccaggaa aagagggccc tgagatgctt
     1201 ctgttgacca gaggagaccg agctggcccg gggaacatgt gccacttcca cacctgcccc
     1261 tccaggccag agggggactg gtggatacac tttgtccagt gttctaggct gaccagtgat
     1321 tccagaatca cagcatctgg gaccttcacg ggctagatca caagaatgcc aaagagctct
     1381 aaggtagctg gaagacagtt ggttagaggt ggggtcattt gcggagctct ggaaaacctg
     1441 tgttgaaatg ctagtgggag aggatctagc tccatcagac tcctgagccc aaggagagga
     1501 gcagagctct caggaaacac catcttccct cccctgggac actgcattga agctttgtca
     1561 cagcccgttc cagcgctcag ggatggggaa attctttagg ttcctgttgt agacactggg
     1621 ggctgtaata aaagtgactc aggagcatgt aaaaaaaaaa aaaaaaaaaa aaaaaa
//
