LOCUS       NM_138524               1936 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus alpha 1,3-galactosyltransferase 2 (A3galt2),
            mRNA.
ACCESSION   NM_138524
VERSION     NM_138524.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1936)
  AUTHORS   Porubsky,S., Speak,A.O., Salio,M., Jennemann,R., Bonrouhi,M.,
            Zafarulla,R., Singh,Y., Dyson,J., Luckow,B., Lehuen,A., Malle,E.,
            Muthing,J., Platt,F.M., Cerundolo,V. and Grone,H.J.
  TITLE     Globosides but not isoglobosides can impact the development of
            invariant NKT cells and their interaction with dendritic cells
  JOURNAL   J Immunol 189 (6), 3007-3017 (2012)
   PUBMED   22875802
REFERENCE   2  (bases 1 to 1936)
  AUTHORS   Christiansen,D., Milland,J., Mouhtouris,E., Vaughan,H.,
            Pellicci,D.G., McConville,M.J., Godfrey,D.I. and Sandrin,M.S.
  TITLE     Humans lack iGb3 due to the absence of functional iGb3-synthase:
            implications for NKT cell development and transplantation
  JOURNAL   PLoS Biol 6 (7), e172 (2008)
   PUBMED   18630988
REFERENCE   3  (bases 1 to 1936)
  AUTHORS   Fullmer,J.M., Riedl,M., Williams,F.G., Sandrin,M. and Elde,R.
  TITLE     Enzymes that synthesize the IB4 epitope are not sufficient to
            impart IB4 binding in dorsal root ganglia of rat
  JOURNAL   J Comp Neurol 501 (1), 70-82 (2007)
   PUBMED   17206613
REFERENCE   4  (bases 1 to 1936)
  AUTHORS   Taylor,S.G., McKenzie,I.F. and Sandrin,M.S.
  TITLE     Characterization of the rat alpha(1,3)galactosyltransferase:
            evidence for two independent genes encoding glycosyltransferases
            that synthesize Galalpha(1,3)Gal by two separate glycosylation
            pathways
  JOURNAL   Glycobiology 13 (5), 327-337 (2003)
   PUBMED   12626403
REFERENCE   5  (bases 1 to 1936)
  AUTHORS   Keusch,J.J., Manzella,S.M., Nyame,K.A., Cummings,R.D. and
            Baenziger,J.U.
  TITLE     Expression cloning of a new member of the ABO blood group
            glycosyltransferases, iGb3 synthase, that directs the synthesis of
            isoglobo-glycosphingolipids
  JOURNAL   J Biol Chem 275 (33), 25308-25314 (2000)
   PUBMED   10854427
REFERENCE   6  (bases 1 to 1936)
  AUTHORS   Pal,S., Saito,M., Ariga,T. and Yu,R.K.
  TITLE     UDP-galactose:globotriaosylceramide alpha-galactosyltransferase
            activity in rat pheochromocytoma (PC12h) cells
  JOURNAL   J Lipid Res 33 (3), 411-417 (1992)
   PUBMED   1569388
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061714.1.
            
            On Dec 20, 2003 this sequence version replaced NM_138524.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061714.1, AF248543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1936
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1936
                     /gene="A3galt2"
                     /note="alpha 1,3-galactosyltransferase 2"
                     /db_xref="GeneID:171553"
                     /db_xref="RGD:727913"
     exon            1..97
                     /gene="A3galt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1097
                     /gene="A3galt2"
                     /EC_number="2.4.1.87"
                     /note="iGb3S; isoglobotriaosylceramide synthase; iGb3
                     synthase"
                     /codon_start=1
                     /product="alpha-1,3-galactosyltransferase 2"
                     /protein_id="NP_612533.1"
                     /db_xref="GeneID:171553"
                     /db_xref="RGD:727913"
                     /translation="MALEGLRAKKRLLWRLFLSAFGLLGLYHYWFKIFRLFEVFIPMG
                     ICPMAIMPLLKDNFTGVLRHWARPEVLTCTSWGAPIIWDETFDPHVAEREARRQNLTI
                     GLTVFAVGRYLEKYLEHFLVSAEQYFMVGQNVVYYVFTDRPEAVPHVALGQGRLLRVK
                     PVRREKRWQDVSMARMLTLHEALGGQLGREADYVFCLDVDQYFSGNFGPEVLADLVAQ
                     LHAWHFRWPRWMLPYERDKRSAAALSLSEGDFYYHAAVFGGSVAALLKLTAHCATGQQ
                     LDREHGIEARWHDESHLNKFFWLSKPTKLLSPEFCWAEEIGWRPEIHHPRLIWAPKEY
                     ALVRT"
     exon            98..181
                     /gene="A3galt2"
                     /inference="alignment:Splign:2.1.0"
     exon            182..271
                     /gene="A3galt2"
                     /inference="alignment:Splign:2.1.0"
     exon            272..409
                     /gene="A3galt2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..1911
                     /gene="A3galt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttcgagcag gtcatttctt ctatctctct gggctggaaa aaactgcatg gcaggttttc
       61 accactgact tctccccatg gctctggagg gactcagggc caagaagaga ctcctgtggc
      121 gactcttcct gtctgcgttt ggtctcctag gcctgtacca ttactggttc aagattttca
      181 ggctctttga agtgttcatc cccatgggca tctgccctat ggccatcatg cctctgctaa
      241 aggacaattt caccggagtg ctgcgtcact gggcccggcc tgaagtcctg acctgtacct
      301 cttggggagc cccaattatc tgggatgaga ccttcgaccc acacgtagct gagcgagagg
      361 cgagacggca gaaccttacc attggactga ctgtctttgc ggtaggcagg tacctggaga
      421 agtacctgga gcacttcctg gtatcggcag agcagtactt catggtcggc cagaacgtgg
      481 tgtattatgt gtttaccgac cgaccggaag cagtgcccca cgtggctcta ggccagggtc
      541 gcctgctgcg ggtgaaacca gtgagaagag agaagcgctg gcaggacgtg tcaatggctc
      601 gcatgctcac gctacacgag gctctgggag ggcagctggg ccgagaagct gactatgtgt
      661 tctgcctgga cgtggaccag tacttcagcg gtaacttcgg acccgaggtg ctggcagatt
      721 tggtggcaca gctgcacgcc tggcacttcc gctggcctcg gtggatgctg ccctacgaga
      781 gggacaagcg gtcggctgcc gcgctgtcgt taagcgaagg cgatttctac taccacgccg
      841 cggtgttcgg gggcagtgtg gcggctctgc tcaagctgac ggctcactgt gcgactggcc
      901 aacagctgga ccgtgagcat ggcattgagg cacgctggca cgacgagagc cacctcaaca
      961 agttcttctg gctgagcaag cccaccaagc tgctgtcgcc agagttttgc tgggcagagg
     1021 aaattggctg gaggccagag atccaccacc ctcgtctgat ctgggcaccc aaggagtacg
     1081 cactggtgcg aacctagcag gccaccctgg ccaggcgggc acaggaacgt ctttggcact
     1141 gcgagtgttg aatggaattg caaaatgttt caaaagcacg aagtcagagc cagttacact
     1201 gcctttggaa gggggacttc ggaactcaga ggtactgtgc ctggggccgt acacccttgt
     1261 cagctggcca gagagccttt ttgctccaac cagatgcaaa ttatggaaag gcaagagttt
     1321 gtcagcttac tttgcctaca aggccttcct tagcccttgg taatggttgg tgtctcagct
     1381 tctgtccgga ccttaggttt gacagctgtc tggagccatt cctgtgacca ggacctgcag
     1441 attctcttct cttgctcttc acggtcttct gttctacttc agcccccagc tctccattct
     1501 ctgcctgtgc taacatgcag ctccctgtct gcatttgttc aactgcttct tcctccgtca
     1561 tcaggaaggt ttccattcct gcagctgggc tggcttcctg acccaatgag cacttcccct
     1621 tcagctccca agcagctggc tgccttgctg ctgttgtagt gtggctggca gaccactcgg
     1681 ttgtcacggc ctctgccacc accacggctg tctcttcatg ttcctagaca gccctcagcc
     1741 ttggcaaggc cattcaaggg aagcctcttg tgggaccctt cagctcggtc ggtgtcatgt
     1801 aggagcacgg gagagtgttg gctctcctcc ccaaccccat ccctgcatgc tagctcacta
     1861 agggcagctg atcatctagt tttacagcca taaaagaggt gtttaagcca aaaaaaaaaa
     1921 aaaaaaaaaa aaaaaa
//
