LOCUS       NM_012488               4614 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus alpha-2-macroglobulin (A2m), mRNA.
ACCESSION   NM_012488
VERSION     NM_012488.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4614)
  AUTHORS   Wang,J., Zhang,P., Liu,M., Huang,Z., Yang,X., Ding,Y., Liu,J.,
            Cheng,X., Xu,S., He,M., Zhang,F., Wang,G., Li,R. and Yang,X.
  TITLE     Alpha-2-macroglobulin is involved in the occurrence of early-onset
            pre-eclampsia via its negative impact on uterine spiral artery
            remodeling and placental angiogenesis
  JOURNAL   BMC Med 21 (1), 90 (2023)
   PUBMED   36894970
  REMARK    GeneRIF: Alpha-2-macroglobulin is involved in the occurrence of
            early-onset pre-eclampsia via its negative impact on uterine spiral
            artery remodeling and placental angiogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4614)
  AUTHORS   Ramlall,V., Thangaraj,P.M., Meydan,C., Foox,J., Butler,D., Kim,J.,
            May,B., De Freitas,J.K., Glicksberg,B.S., Mason,C.E.,
            Tatonetti,N.P. and Shapira,S.D.
  TITLE     Immune complement and coagulation dysfunction in adverse outcomes
            of SARS-CoV-2 infection
  JOURNAL   Nat Med 26 (10), 1609-1615 (2020)
   PUBMED   32747830
REFERENCE   3  (bases 1 to 4614)
  AUTHORS   Gori,A.M., Giusti,B., Piccardi,B., Nencini,P., Palumbo,V., Nesi,M.,
            Nucera,A., Pracucci,G., Tonelli,P., Innocenti,E., Sereni,A.,
            Sticchi,E., Toni,D., Bovi,P., Guidotti,M., Tola,M.R., Consoli,D.,
            Micieli,G., Tassi,R., Orlandi,G., Sessa,M., Perini,F.,
            Delodovici,M.L., Zedde,M.L., Massaro,F., Abbate,R. and Inzitari,D.
  TITLE     Inflammatory and metalloproteinases profiles predict three-month
            poor outcomes in ischemic stroke treated with thrombolysis
  JOURNAL   J Cereb Blood Flow Metab 37 (9), 3253-3261 (2017)
   PUBMED   28266892
REFERENCE   4  (bases 1 to 4614)
  AUTHORS   Carli,A.V., Harvey,E.J., Azeddine,B., Gao,C., Li,Y., Li,A.,
            Sayegh,M., Wang,H., Nahal,A., Michel,R.P., Henderson,J.E. and
            Seguin,C.
  TITLE     Substrain-specific differences in bone parameters,
            alpha-2-macroglobulin circulating levels, and osteonecrosis
            incidence in a rat model
  JOURNAL   J Orthop Res 35 (6), 1183-1194 (2017)
   PUBMED   26895739
  REMARK    GeneRIF: elevated serum level correlated to glucocorticoid
            treatment and may represent a form of reparative response to
            glucocorticoid-associated damage of bone
REFERENCE   5  (bases 1 to 4614)
  AUTHORS   Ayala,P., Meneses,M., Olmos,P., Montalva,R., Droguett,K., Rios,M.
            and Borzone,G.
  TITLE     Acute lung injury induced by whole gastric fluid: hepatic acute
            phase response contributes to increase lung antiprotease protection
  JOURNAL   Respir Res 17 (1), 71 (2016)
   PUBMED   27301375
  REMARK    GeneRIF: Gastric contents-induced acute lung injury elicits a liver
            acute phase response characterized by increased mRNA expression of
            alpha 2 macroglobulin and alpha1-antitrypsin.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4614)
  AUTHORS   Hunter,N., Weston,K.M. and Bowern,N.A.
  TITLE     Suppression of experimental allergic encephalomyelitis by alpha
            2-macroglobulin
  JOURNAL   Immunology 73 (1), 58-63 (1991)
   PUBMED   1710603
REFERENCE   7  (bases 1 to 4614)
  AUTHORS   Eggertsen,G., Hudson,G., Shiels,B., Reed,D. and Fey,G.H.
  TITLE     Sequence of rat alpha 1-macroglobulin, a broad-range proteinase
            inhibitor from the alpha-macroglobulin-complement family
  JOURNAL   Mol Biol Med 8 (2), 287-302 (1991)
   PUBMED   1725450
REFERENCE   8  (bases 1 to 4614)
  AUTHORS   van Vugt,H., van Gool,J. and de Ridder,L.
  TITLE     Alpha 2 macroglobulin of the rat, an acute phase protein, mitigates
            the early course of endotoxin shock
  JOURNAL   Br J Exp Pathol 67 (3), 313-319 (1986)
   PUBMED   2424486
REFERENCE   9  (bases 1 to 4614)
  AUTHORS   Hayashida,K., Okubo,H., Noguchi,M., Yoshida,H., Kangawa,K.,
            Matsuo,H. and Sakaki,Y.
  TITLE     Molecular cloning of DNA complementary to rat alpha 2-macroglobulin
            mRNA
  JOURNAL   J Biol Chem 260 (26), 14224-14229 (1985)
   PUBMED   2414291
REFERENCE   10 (bases 1 to 4614)
  AUTHORS   Nieuwenhuizen,W., Emeis,J.J. and Hemmink,J.
  TITLE     Purification and properties of rat alpha 2 acute-phase
            macroglobulin
  JOURNAL   Biochim Biophys Acta 580 (1), 129-139 (1979)
   PUBMED   94834
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098922.1.
            
            On Oct 11, 2007 this sequence version replaced NM_012488.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098922.1, FQ223246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..4614
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /note="alpha-2-macroglobulin"
                     /db_xref="GeneID:24153"
                     /db_xref="RGD:2004"
     exon            1..139
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..4460
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /note="alpha-2-M; alpha-2-macroglobulin-P"
                     /codon_start=1
                     /product="alpha-2-macroglobulin precursor"
                     /protein_id="NP_036620.2"
                     /db_xref="GeneID:24153"
                     /db_xref="RGD:2004"
                     /translation="MGKHRLRSLALLPLLLRLLLLLLPTDASAPQKPIYMVMVPSLLH
                     AGTPEKACFLFSHLNETVAVRVSLESVRGNQSLFTDLVVDKDLFHCTSFTVPQSSSDE
                     VMFFTVQVKGATHEFRRRSTVLVKKKESLVFAQTDKPIYKPGQTVRFRVVSLDESFHP
                     LNELIPLLYIQDPKNNRIAQWQNFNLEGGLKQLSFPLSSEPTQGSYKVVIRTESGRTV
                     EHPFSVEEFVLPKFEVRVTVPETITILEEEMNVSVCGIYTYGKPVPGRVTVNICRKYS
                     NPSNCFGEESVAFCEKLSQQLDGRGCFSQLVKTKSFQLKRQEYEMQLDVHAKIQEEGT
                     GVEETGKGLTKITRTITKLSFVNVDSHFRQGIPFVGQVLLVDGRGTPIPYETIFIGAD
                     EANLYINTTTDKHGLARFSINTDDIMGTSLTVRAKYKDSNACYGFRWLTEENVEAWHT
                     AYAVFSPSRSFLHLESLPDKLRCDQTLEVQAHYILNGEAMQELKELVFYYLMMAKGGI
                     VRAGTHVLPLKQGQMRGHFSILISMETDLAPVARLVLYAILPNGEVVGDTAKYEIENC
                     LANKVDLVFRPNSGLPATRALLSVMASPQSLCGLRAVDQSVLLMKPETELSASLIYDL
                     LPVKDLTGFPQGADQREEDTNGCVKQNDTYINGILYSPVQNTNEEDMYGFLKDMGLKV
                     FTNSNIRKPKVCERLRDNKGIPAAYHLVSQSHMDAFLESSESPTETRRSYFPETWIWD
                     LVVVDSAGVAEVEVTVPDTITEWKAGAFCLSNDTGLGLSPVVQFQAFQPFFVELTMPY
                     SVIRGEAFTLKATVLNYLPTCIRVAVQLEASPDFLAAPEEKEQRSHCICMNQRHTASW
                     AVIPKSLGNVNFTVSAEALNSKELCGNEVPVVPEQGKKDTIIKSLLVEPEGLENEVTF
                     NSLLCPMGAEVSELIALKLPSDVVEESARASVTVLGDILGSAMQNTQDLLKMPYGCGE
                     QNMVLFAPNIYVLDYLNETQQLTQEIKTKAIAYLNTGYQRQLNYKHRDGSYSTFGDKP
                     GRNHANTWLTAFVLKSFAQARKYIFIDEVHITQALLWLSQQQKDNGCFRSSGSLLNNA
                     MKGGVEDEVTLSAYITIALLEMSLPVTHPVVRNALFCLDTAWKSARGGAGGSHVYTKA
                     LLAYAFALAGNQDTKKEILKSLDEEAVKEEDSVHWTRPQKPSVSVALWYQPQAPSAEV
                     EMTAYVLLAYLTTEPAPTQEDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKY
                     GSATFTRAKKAAQVTIHSSGTFSTKFQVNNNNQLLLQRVTLPTVPGDYTVKVTGEGCV
                     YLQTSLKYSVLPREEEFPFTVVVQTLPGTCEDPKAHTSFQISLNISYTGSRSESNMAI
                     ADVKMVSGFIPLKPTVKMLERSVHVSRTEVSNNHVLIYLDKVSNQTVNLSFTVQQDIP
                     IRDLKPAVVKVYDYYEKDEFAVAKYSAPCSTDYGNA"
     exon            140..323
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            324..480
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            481..533
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            534..554
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            555..723
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            724..808
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            809..929
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1044
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1154
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1316
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1544
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1608
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1751
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1901
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2069
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2148
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2275
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2504
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2631
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2753
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2805
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2889
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3066
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3154
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3311
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3386
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3567
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..3791
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            3792..4010
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4138
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            4139..4229
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            4230..4298
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            4299..4401
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..4443
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
     exon            4444..4574
                     /gene="A2m"
                     /gene_synonym="A2m1; A2maa; A2MAC1; A2mb; Mam"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagggtgca aggcagccag gtctccgatc ctttccgcag catggggaag cacaggctcc
       61 ggagcctggc cctgctgcca ctgctgctgc ggctgctgct gctgctgctg cccaccgatg
      121 cctcagctcc acaaaaacca atctacatgg tgatggttcc ctccctgctc cacgcaggca
      181 cccccgagaa ggcctgcttc ctgttcagcc atctaaacga gacagtggct gtgagagtgt
      241 ccttggagtc tgtccgtggg aaccaaagcc tcttcactga ccttgtagtt gacaaggacc
      301 tattccactg tacctccttc accgtcccac agtcttcatc cgatgaggtg atgtttttca
      361 ctgtccaagt aaaaggagca actcatgagt tcaggaggcg gagcacggtg ctggttaaga
      421 agaaagagag cctggtcttt gctcagactg acaagcccat ctacaaacca ggacagacag
      481 tgagatttcg tgttgtctca ttggacgaaa gtttccatcc ccttaatgaa ttgattcctc
      541 tactgtacat tcaggatccc aaaaacaatc gcattgcaca atggcagaat ttcaatttag
      601 agggtggcct caaacagctg tccttccccc tctcctcaga gcccactcag ggctcctaca
      661 aggtggtgat acgtacagaa tcaggcagga ccgtcgagca ccctttctct gtggaggaat
      721 tcgtgcttcc caagttcgaa gtgagagtga cagttccaga aacaatcacc atcctggagg
      781 aagagatgaa tgtgtccgtg tgtggaatat acacctatgg gaagcctgtt ccaggacgtg
      841 tgactgtaaa catttgcaga aagtacagta atccttctaa ctgcttcggc gaagagtccg
      901 tggctttctg tgagaaactc agccaacagt tagacggccg tggctgcttc tcacagctag
      961 tgaaaaccaa gtccttccag ctaaagagac aagagtatga gatgcagctc gatgtacatg
     1021 ccaagatcca agaagaagga acaggtgtgg aagaaactgg aaaggggctc actaagatca
     1081 caagaaccat aaccaaacta tcatttgtga acgtggattc acatttcaga caaggaattc
     1141 ctttcgttgg acaggtgctc ctggtggatg ggagaggcac ccctattccg tatgaaacga
     1201 tcttcattgg ggcggatgaa gcaaacctgt acataaatac aaccactgat aagcacggcc
     1261 tggcgaggtt ctccatcaac accgatgaca tcatgggcac gtccctaact gtcagggcca
     1321 aatacaagga tagcaacgcc tgctatggat tcagatggtt gacagaagag aatgtagagg
     1381 cttggcacac tgcctacgct gttttctcac caagcagaag cttcctgcac ctggaatccc
     1441 tgcctgataa actgcgctgt gaccaaaccc tggaggtcca ggcacattac attctaaatg
     1501 gcgaggccat gcaggagctg aaggagctcg tcttctacta tctgatgatg gccaagggag
     1561 gcatcgtacg ggcggggact cacgttctgc ccctgaagca gggacaaatg agaggtcact
     1621 tttccatact catctcgatg gagacagacc tggctcccgt ggctcgactg gtcctctatg
     1681 ccatcctacc caatggagaa gtggttggag acactgctaa atatgagatt gagaactgcc
     1741 tggctaacaa ggtggatttg gtcttccgcc cgaatagcgg tcttccagct acccgtgccc
     1801 tccttagtgt catggcttct cctcagtccc tttgtggcct gcgagctgtg gaccaaagcg
     1861 tgctgctcat gaaacctgag actgagctct ccgcatccct gatttatgac ctgctaccag
     1921 tgaaagacct cactggcttc cctcagggtg cggatcaacg ggaagaagac actaatggct
     1981 gcgttaagca aaatgacact tacattaatg gaatcctgta ctcgccagtg cagaatacaa
     2041 atgaagagga catgtacggc ttcctaaagg atatgggctt aaaggtattt accaactcga
     2101 acatccgtaa acccaaagtc tgcgaacggc tcagagacaa taaaggaata ccagctgcgt
     2161 accacctcgt aagccaaagc cacatggacg cttttctaga gtcttcagag tctcccacag
     2221 agactaggcg aagctacttc cctgagacgt ggatctggga cttggtggtg gtggactcag
     2281 caggagtggc tgaagtggaa gtgacagtcc ctgacaccat cactgaatgg aaggccgggg
     2341 ccttctgcct gtctaatgac actggtctgg gcctgtctcc tgtggtccaa ttccaagcct
     2401 tccagccctt cttcgtggag ctcacaatgc cctactccgt gatccgtgga gaagccttca
     2461 cgctcaaggc cactgtgctg aactacctcc ctacatgcat ccgggttgcc gtgcagctgg
     2521 aggcctctcc cgattttctg gctgccccag aggagaagga acaaaggtct cactgcatct
     2581 gtatgaacca gcggcacacc gcgtcctggg cagtgatccc caagtcatta ggaaatgtga
     2641 atttcacagt tagtgcagag gcactgaact ctaaggagct gtgtgggaat gaggtaccgg
     2701 tggtccctga acagggcaaa aaagacacga tcatcaagtc cctgctggtt gaacccgaag
     2761 gtctagagaa cgaagtgaca tttaacagtc tgctttgtcc aatgggtgct gaggtatctg
     2821 aactgatagc cctgaagctg ccatcagacg tggtagagga atctgccaga gcctctgtca
     2881 cagttttggg agatatattg ggttctgcca tgcagaatac acaggatctc ctcaagatgc
     2941 cctatggctg tggagaacag aacatggttc tatttgctcc taatatctat gtcctggact
     3001 atctgaatga aacacagcag ctgacacagg agatcaagac caaggccatt gcctatctca
     3061 atacgggcta ccaaagacaa ttaaactaca agcaccggga tggctcctac agcacctttg
     3121 gggataaacc tggcaggaat catgccaata cctggctcac agcctttgta ctgaagagtt
     3181 ttgctcaggc tcgaaaatat atcttcatcg atgaagtaca catcacccaa gccctcttat
     3241 ggctctctca gcagcagaag gacaatggtt gtttcaggag ctccgggtca ctgctcaaca
     3301 atgccatgaa gggaggagta gaagatgaag tcaccttgtc tgcctacatc accatagctc
     3361 tcctggagat gtctcttcct gtcactcatc ctgttgtccg caatgccctc ttttgcctgg
     3421 acacagcctg gaagtcagca aggggaggag ctggtggcag ccatgtctac actaaggcgc
     3481 tgttggccta tgcatttgcc cttgctggta accaggacac gaagaaggag atcctgaaat
     3541 cactcgatga ggaggctgta aaagaagaag attctgtcca ctggaccaga cctcagaaac
     3601 ccagcgtgtc agtggccctc tggtaccaac cccaggctcc ctcggctgag gtagagatga
     3661 ctgcatatgt gctcctggct tatcttacca ctgagccagc tccaacccaa gaggacctaa
     3721 cggctgccat gctcatcgtg aagtggctca caaagcagca gaattcccac ggtggcttct
     3781 cttccaccca ggacactgta gtggctctcc acgctttgtc caaatacggg tccgccactt
     3841 tcacaagagc taagaaagct gcacaggtga ccatccattc ttcgggcaca ttttctacaa
     3901 aattccaagt caacaacaac aaccaattat tactccagag agtcacattg ccgactgtgc
     3961 ctggggatta caccgtgaag gtgacaggag aaggctgtgt ctatctccag acatccttga
     4021 aatacagtgt tctcccgaga gaggaggagt tccccttcac tgtggtggtg cagactctgc
     4081 ctgggacatg tgaggatccc aaagctcaca ccagcttcca gatctcactc aacatcagtt
     4141 acactggaag ccgttctgaa tccaacatgg caattgctga cgtgaagatg gtgtccggct
     4201 tcatcccctt gaaaccaaca gtgaaaatgc ttgaaagatc tgtgcatgtg agccgaacag
     4261 aagtcagcaa taaccatgtc ttgatttacc tggataaggt gtcaaatcag acggtgaact
     4321 tgtccttcac ggttcagcaa gatattccaa taagagacct gaagccagcc gtagtgaaag
     4381 tctacgatta ctatgagaaa gatgagtttg cagttgcaaa atacagcgct ccctgcagca
     4441 cagattatgg aaatgcctga ggacgcagtg aataagaagt gtttcgccag agccctgacc
     4501 tcaggacttc ccaagaaaaa cagtgtattt gtatttccag agatttgatc aataaaccat
     4561 ttttttcata tctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
