LOCUS       NM_133400               1863 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Rattus norvegicus APOBEC1 complementation factor (A1cf), mRNA.
ACCESSION   NM_133400 XM_346579
VERSION     NM_133400.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1863)
  AUTHORS   Rasheed,H., Stamp,L.K., Dalbeth,N. and Merriman,T.R.
  TITLE     Interaction of the GCKR and A1CF loci with alcohol consumption to
            influence the risk of gout
  JOURNAL   Arthritis Res Ther 19 (1), 161 (2017)
   PUBMED   28679452
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1863)
  AUTHORS   Dong,Z., Zhou,J., Jiang,S., Li,Y., Zhao,D., Yang,C., Ma,Y.,
            Wang,Y., He,H., Ji,H., Yang,Y., Wang,X., Xu,X., Pang,Y., Zou,H.,
            Jin,L. and Wang,J.
  TITLE     Effects of multiple genetic loci on the pathogenesis from serum
            urate to gout
  JOURNAL   Sci Rep 7, 43614 (2017)
   PUBMED   28252667
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1863)
  AUTHORS   Fossat,N., Tourle,K., Radziewic,T., Barratt,K., Liebhold,D.,
            Studdert,J.B., Power,M., Jones,V., Loebel,D.A. and Tam,P.P.
  TITLE     C to U RNA editing mediated by APOBEC1 requires RNA-binding protein
            RBM47
  JOURNAL   EMBO Rep 15 (8), 903-910 (2014)
   PUBMED   24916387
REFERENCE   4  (bases 1 to 1863)
  AUTHORS   Galloway,C.A., Ashton,J., Sparks,J.D., Mooney,R.A. and Smith,H.C.
  TITLE     Metabolic regulation of APOBEC-1 complementation factor trafficking
            in mouse models of obesity and its positive correlation with the
            expression of ApoB protein in hepatocytes
  JOURNAL   Biochim Biophys Acta 1802 (11), 976-985 (2010)
   PUBMED   20541607
REFERENCE   5  (bases 1 to 1863)
  AUTHORS   Galloway,C.A., Kumar,A., Krucinska,J. and Smith,H.C.
  TITLE     APOBEC-1 complementation factor (ACF) forms RNA-dependent multimers
  JOURNAL   Biochem Biophys Res Commun 398 (1), 38-43 (2010)
   PUBMED   20541536
  REMARK    GeneRIF: N-terminal 320 amino acids of ACF retained RNA-binding
            selectivity and supported complementation of editing activity and
            in addition demonstrate a novel RNA-bridged multimerization of ACF.
REFERENCE   6  (bases 1 to 1863)
  AUTHORS   Sowden,M.P., Ballatori,N., Jensen,K.L., Reed,L.H. and Smith,H.C.
  TITLE     The editosome for cytidine to uridine mRNA editing has a native
            complexity of 27S: identification of intracellular domains
            containing active and inactive editing factors
  JOURNAL   J Cell Sci 115 (Pt 5), 1027-1039 (2002)
   PUBMED   11870221
REFERENCE   7  (bases 1 to 1863)
  AUTHORS   Lellek,H., Kirsten,R., Diehl,I., Apostel,F., Buck,F. and Greeve,J.
  TITLE     Purification and molecular cloning of a novel essential component
            of the apolipoprotein B mRNA editing enzyme-complex
  JOURNAL   J Biol Chem 275 (26), 19848-19856 (2000)
   PUBMED   10781591
REFERENCE   8  (bases 1 to 1863)
  AUTHORS   Mehta,A., Kinter,M.T., Sherman,N.E. and Driscoll,D.M.
  TITLE     Molecular cloning of apobec-1 complementation factor, a novel
            RNA-binding protein involved in the editing of apolipoprotein B
            mRNA
  JOURNAL   Mol Cell Biol 20 (5), 1846-1854 (2000)
   PUBMED   10669759
REFERENCE   9  (bases 1 to 1863)
  AUTHORS   Romanenko,A.V.
  TITLE     [Experience in the certification of veterinary specialists]
  JOURNAL   Veterinariia (12), 47-48 (1978)
   PUBMED   734901
REFERENCE   10 (bases 1 to 1863)
  AUTHORS   Dabrowski,Z., Gregorczyk,J., Samochowiec,L., Wojcicki,J.,
            Lawczynski,L., Antoszczyk,M., Chrzanowska-Ansilewska,K., Jurek,D.
            and Sych,Z.
  TITLE     [Effect of truncal vagotomy on the exocrine function of the
            pancreas in the dog]
  JOURNAL   Pol Tyg Lek 33 (28), 1093-1095 (1978)
   PUBMED   704405
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF290984.1.
            
            On Dec 17, 2003 this sequence version replaced XM_346579.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF290984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..1863
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /note="APOBEC1 complementation factor"
                     /db_xref="GeneID:170912"
                     /db_xref="RGD:619834"
     exon            1..57
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..201
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1863
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /note="APOBEC1-stimulating protein; APOBEC1
                     complementation factort; Apobec-1 complementation factor,
                     APOBEC-1 stimulating protein"
                     /codon_start=1
                     /product="APOBEC1 complementation factor"
                     /protein_id="NP_596891.1"
                     /db_xref="GeneID:170912"
                     /db_xref="RGD:619834"
                     /translation="MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPP
                     PGWDTTPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVT
                     FSNKQEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVT
                     EGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRRLLPGRIQLWGHPIAVDWAEP
                     EVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNSIKPGAVERVKKIRDYAFVHFSNR
                     EDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRNTMLQEYTYPLSHVY
                     DPTTTYLGAPVFYTPQAYAAIPSLHFPATKGHLSNRALIRTPSVRGAAGVRGLGGRGY
                     LAYTGLGRGYQVKGDKRQDKLYDLLPGMELTPMNTISLKPQGVKLAPQILEEICQKNN
                     WGQPVYQLHSAIGQDQRQLFLYKVTIPALASQNPAIHPFTPPKLSAYVDEAKRYAAEH
                     TLQTLGIPTEGGDAGTTAPTATSATVFPGYAVPSATAPVSTAQLKQAVTLGQDLAAYT
                     TYEVYPTFAVTTRGDGYGTF"
     exon            202..336
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            337..467
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..706
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..871
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..969
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1240
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1422
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1559
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1711
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1863
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaattcacca taatcaagaa accttttccg ggtgggggaa cctcagaaat tactcagtga
       61 gcaaccctaa ttaacctgat tttttgctga taatcactct caatggaatc aaatcacaaa
      121 tccggggatg gattgagcgg cacccagaag gaagcagcac tccgcgcact ggtccagcgc
      181 acaggatata gcttggtcca ggaaaatgga caaagaaaat atggtggtcc tccaccaggc
      241 tgggatacta cacccccaga aaggggctgc gagattttca ttgggaaact tccccgggac
      301 ctttttgagg atgaactcat accattgtgt gaaaaaattg gtaaaattta tgaaatgaga
      361 atgatgatgg atttcaatgg gaacaacaga ggctatgcat ttgtaacctt ctcaaataag
      421 caggaagcca agaatgcaat caagcaactt aataattatg aaattcggaa tggccgtctc
      481 ctgggcgtct gtgccagtgt ggacaactgc cggttgtttg tggggggaat ccccaaaacc
      541 aaaaagagag aagaaatctt gtcagagatg aaaaaggtca ctgaaggagt tgttgatgtc
      601 attgtctacc caagcgctgc cgataaaacc aaaaaccggg ggtttgcctt tgtggaatat
      661 gagagtcacc gcgcagccgc catggctagg cggaggctgc tgccaggaag aattcagttg
      721 tggggacatc ctatcgcagt agactgggca gagccagaag tcgaagttga cgaagacaca
      781 atgtcttccg tgaaaatcct gtacgtaagg aaccttatgc tgtctacctc ggaagagatg
      841 attgagaagg aattcaacag tattaaacca ggtgctgtgg aacgggtgaa gaagatccga
      901 gactatgctt ttgtgcattt cagtaaccga gaagatgcag ttgaagccat gaaggctttg
      961 aatggcaagg tgctggatgg ttccccaata gaagtgacct tggccaagcc agtggacaag
     1021 gacagttacg ttaggtacac ccggggcacc gggggcagga acaccatgct gcaagaatac
     1081 acctaccctc tgagccatgt ttatgaccct accacaacct accttggagc tcctgtcttc
     1141 tatactcccc aagcctacgc agccattcca agtcttcatt tcccagctac caaaggacat
     1201 ctcagcaaca gagctctcat ccggacccct tctgtcagag gggctgcggg cgtgagagga
     1261 ctgggcggcc gtgggtattt ggcatataca ggcctgggtc gaggatacca ggtcaaagga
     1321 gacaagagac aagacaaact ctatgacctt ctgcctggga tggagctcac cccgatgaat
     1381 actatctctt taaaaccaca aggagttaaa cttgctcctc agatattaga agaaatctgt
     1441 cagaaaaata actggggaca gccagtgtac cagctgcact ctgccattgg acaagaccaa
     1501 agacagttat tcctatacaa agtaactatc ccagcgctgg ccagccagaa tcctgcgatc
     1561 caccctttca cacccccaaa gctaagcgcc tacgtggatg aagcaaagag gtacgccgca
     1621 gagcacaccc tacagacact aggcatcccc acagaaggag gggacgctgg gactacagca
     1681 cccactgcca catccgccac tgtgtttcca ggatacgctg tccccagtgc caccgctcct
     1741 gtgtctacag cccagctcaa gcaagcagtg acacttggac aagacttagc agcatataca
     1801 acctatgagg tctaccctac ttttgcagtg accacccgag gtgatggata tggcaccttc
     1861 tga
//
