LOCUS       NP_596891                586 aa            linear   ROD 03-DEC-2024
DEFINITION  APOBEC1 complementation factor [Rattus norvegicus].
ACCESSION   NP_596891 XP_346580
VERSION     NP_596891.1
DBSOURCE    REFSEQ: accession NM_133400.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 586)
  AUTHORS   Rasheed,H., Stamp,L.K., Dalbeth,N. and Merriman,T.R.
  TITLE     Interaction of the GCKR and A1CF loci with alcohol consumption to
            influence the risk of gout
  JOURNAL   Arthritis Res Ther 19 (1), 161 (2017)
   PUBMED   28679452
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 586)
  AUTHORS   Dong,Z., Zhou,J., Jiang,S., Li,Y., Zhao,D., Yang,C., Ma,Y.,
            Wang,Y., He,H., Ji,H., Yang,Y., Wang,X., Xu,X., Pang,Y., Zou,H.,
            Jin,L. and Wang,J.
  TITLE     Effects of multiple genetic loci on the pathogenesis from serum
            urate to gout
  JOURNAL   Sci Rep 7, 43614 (2017)
   PUBMED   28252667
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 586)
  AUTHORS   Fossat,N., Tourle,K., Radziewic,T., Barratt,K., Liebhold,D.,
            Studdert,J.B., Power,M., Jones,V., Loebel,D.A. and Tam,P.P.
  TITLE     C to U RNA editing mediated by APOBEC1 requires RNA-binding protein
            RBM47
  JOURNAL   EMBO Rep 15 (8), 903-910 (2014)
   PUBMED   24916387
REFERENCE   4  (residues 1 to 586)
  AUTHORS   Galloway,C.A., Ashton,J., Sparks,J.D., Mooney,R.A. and Smith,H.C.
  TITLE     Metabolic regulation of APOBEC-1 complementation factor trafficking
            in mouse models of obesity and its positive correlation with the
            expression of ApoB protein in hepatocytes
  JOURNAL   Biochim Biophys Acta 1802 (11), 976-985 (2010)
   PUBMED   20541607
REFERENCE   5  (residues 1 to 586)
  AUTHORS   Galloway,C.A., Kumar,A., Krucinska,J. and Smith,H.C.
  TITLE     APOBEC-1 complementation factor (ACF) forms RNA-dependent multimers
  JOURNAL   Biochem Biophys Res Commun 398 (1), 38-43 (2010)
   PUBMED   20541536
  REMARK    GeneRIF: N-terminal 320 amino acids of ACF retained RNA-binding
            selectivity and supported complementation of editing activity and
            in addition demonstrate a novel RNA-bridged multimerization of ACF.
REFERENCE   6  (residues 1 to 586)
  AUTHORS   Sowden,M.P., Ballatori,N., Jensen,K.L., Reed,L.H. and Smith,H.C.
  TITLE     The editosome for cytidine to uridine mRNA editing has a native
            complexity of 27S: identification of intracellular domains
            containing active and inactive editing factors
  JOURNAL   J Cell Sci 115 (Pt 5), 1027-1039 (2002)
   PUBMED   11870221
REFERENCE   7  (residues 1 to 586)
  AUTHORS   Lellek,H., Kirsten,R., Diehl,I., Apostel,F., Buck,F. and Greeve,J.
  TITLE     Purification and molecular cloning of a novel essential component
            of the apolipoprotein B mRNA editing enzyme-complex
  JOURNAL   J Biol Chem 275 (26), 19848-19856 (2000)
   PUBMED   10781591
REFERENCE   8  (residues 1 to 586)
  AUTHORS   Mehta,A., Kinter,M.T., Sherman,N.E. and Driscoll,D.M.
  TITLE     Molecular cloning of apobec-1 complementation factor, a novel
            RNA-binding protein involved in the editing of apolipoprotein B
            mRNA
  JOURNAL   Mol Cell Biol 20 (5), 1846-1854 (2000)
   PUBMED   10669759
REFERENCE   9  (residues 1 to 586)
  AUTHORS   Romanenko,A.V.
  TITLE     [Experience in the certification of veterinary specialists]
  JOURNAL   Veterinariia (12), 47-48 (1978)
   PUBMED   734901
REFERENCE   10 (residues 1 to 586)
  AUTHORS   Dabrowski,Z., Gregorczyk,J., Samochowiec,L., Wojcicki,J.,
            Lawczynski,L., Antoszczyk,M., Chrzanowska-Ansilewska,K., Jurek,D.
            and Sych,Z.
  TITLE     [Effect of truncal vagotomy on the exocrine function of the
            pancreas in the dog]
  JOURNAL   Pol Tyg Lek 33 (28), 1093-1095 (1978)
   PUBMED   704405
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF290984.1.
            
            On Dec 17, 2003 this sequence version replaced XP_346580.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF290984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     Protein         1..586
                     /product="APOBEC1 complementation factor"
                     /note="APOBEC1-stimulating protein; APOBEC1
                     complementation factort; Apobec-1 complementation factor,
                     APOBEC-1 stimulating protein"
                     /calculated_mol_wt=64543
     Region          2..586
                     /region_name="hnRNP-R-Q"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; TIGR01648"
                     /db_xref="CDD:273732"
     Site            490
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9NQ94; propagated from
                     UniProtKB/Swiss-Prot (Q923K9.1)"
     CDS             1..586
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /coded_by="NM_133400.1:103..1863"
                     /db_xref="GeneID:170912"
                     /db_xref="RGD:619834"
ORIGIN      
        1 mesnhksgdg lsgtqkeaal ralvqrtgys lvqengqrky ggpppgwdtt ppergceifi
       61 gklprdlfed eliplcekig kiyemrmmmd fngnnrgyaf vtfsnkqeak naikqlnnye
      121 irngrllgvc asvdncrlfv ggipktkkre eilsemkkvt egvvdvivyp saadktknrg
      181 fafveyeshr aaamarrrll pgriqlwghp iavdwaepev evdedtmssv kilyvrnlml
      241 stseemieke fnsikpgave rvkkirdyaf vhfsnredav eamkalngkv ldgspievtl
      301 akpvdkdsyv rytrgtggrn tmlqeytypl shvydpttty lgapvfytpq ayaaipslhf
      361 patkghlsnr alirtpsvrg aagvrglggr gylaytglgr gyqvkgdkrq dklydllpgm
      421 eltpmntisl kpqgvklapq ileeicqknn wgqpvyqlhs aigqdqrqlf lykvtipala
      481 sqnpaihpft ppklsayvde akryaaehtl qtlgiptegg dagttaptat satvfpgyav
      541 psatapvsta qlkqavtlgq dlaayttyev yptfavttrg dgygtf
//
