LOCUS       NM_022258               2136 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus alpha-1-B glycoprotein (A1bg), mRNA.
ACCESSION   NM_022258
VERSION     NM_022258.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2136)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 2136)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 2136)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 2136)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2136)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   6  (bases 1 to 2136)
  AUTHORS   Gardmo,C., Persson,B. and Mode,A.
  TITLE     Cloning of a novel growth hormone-regulated rat complementary
            deoxyribonucleic acid with homology to the human
            alpha1B-glycoprotein, characterizing a new protein family
  JOURNAL   Endocrinology 142 (6), 2695-2701 (2001)
   PUBMED   11356721
REFERENCE   7  (bases 1 to 2136)
  AUTHORS   Xu,W., Wang,S., Wang,G., Wei,H., He,F. and Yang,X.
  TITLE     Identification and characterization of differentially expressed
            genes in the early response phase during liver regeneration
  JOURNAL   Biochem Biophys Res Commun 278 (2), 318-325 (2000)
   PUBMED   11097837
REFERENCE   8  (bases 1 to 2136)
  AUTHORS   Ishioka,N., Takahashi,N. and Putnam,F.W.
  TITLE     Amino acid sequence of human plasma alpha 1B-glycoprotein: homology
            to the immunoglobulin supergene family
  JOURNAL   Proc Natl Acad Sci U S A 83 (8), 2363-2367 (1986)
   PUBMED   3458201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 18, 2021 this sequence version replaced NM_022258.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ302031.1, BC089771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000007.1  94387434-94387496   c
            64-99               JAXUCZ010000007.1  94387323-94387358   c
            100-408             JAXUCZ010000007.1  94386913-94387221   c
            409-681             JAXUCZ010000007.1  94386304-94386576   c
            682-978             JAXUCZ010000007.1  94385815-94386111   c
            979-1275            JAXUCZ010000007.1  94385056-94385352   c
            1276-1563           JAXUCZ010000007.1  94384044-94384331   c
            1564-2136           JAXUCZ010000007.1  94383333-94383905   c
FEATURES             Location/Qualifiers
     source          1..2136
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2136
                     /gene="A1bg"
                     /gene_synonym="C44"
                     /note="alpha-1-B glycoprotein"
                     /db_xref="GeneID:140656"
                     /db_xref="RGD:69417"
     exon            1..63
                     /gene="A1bg"
                     /gene_synonym="C44"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1571
                     /gene="A1bg"
                     /gene_synonym="C44"
                     /note="alpha-1B-glycoprotein; liver regeneration-related
                     protein 1"
                     /codon_start=1
                     /product="alpha-1B-glycoprotein precursor"
                     /protein_id="NP_071594.3"
                     /db_xref="GeneID:140656"
                     /db_xref="RGD:69417"
                     /translation="MSLLTTVLLLWGFTLGPGNALWLDSGSEPELRAEPQSLLEPWAN
                     LTLVCAVDLPTKVFELIMNGWFLSQVRLETPVLSYRFSLGAITSNNSGVYRCRCGVEP
                     PVDIQLPALSKWTMLSNALEVTGKEPLPPPSAHADPVSWITPGGLPVYIMCRVAMRGV
                     TYLLRKEGVDGTQKPDVQHKGTAGFLIYKPGNYSCSYLTHAGGKPSEPSAIVTIKMSA
                     TQLPPSLCLMGSYLTIYPQKTHETLACKAPRNAAEFQLRQGERVLNIQGFSPTRDATI
                     YYVNLKELDNQSPFTCRYRMHKYMHVWSEDSKPVELMWSDEKLPAPVLTAEPSSHNLE
                     PGSTVQLRCTAHKAGLRFGLQRQGKPDLVVVQMLNSSGTEAVFELHNISTIDSGNYSC
                     IYMEQAPPFSGSASSEPLELRINGPAPKPRLEALWKGKVPLGHEAIFQCHGHVPRVSM
                     ELVREGFKTPFWMASTTSTSAFLKLSFVGPQHTGNYSCRYTALSPFTFESGISDPVEV
                     VVEGS"
     exon            64..99
                     /gene="A1bg"
                     /gene_synonym="C44"
                     /inference="alignment:Splign:2.1.0"
     exon            100..408
                     /gene="A1bg"
                     /gene_synonym="C44"
                     /inference="alignment:Splign:2.1.0"
     exon            409..681
                     /gene="A1bg"
                     /gene_synonym="C44"
                     /inference="alignment:Splign:2.1.0"
     exon            682..978
                     /gene="A1bg"
                     /gene_synonym="C44"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1275
                     /gene="A1bg"
                     /gene_synonym="C44"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1563
                     /gene="A1bg"
                     /gene_synonym="C44"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..2136
                     /gene="A1bg"
                     /gene_synonym="C44"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacactcct gctggactga agacccacca tgtctctgtt gactactgta ctacttctct
       61 ggggtttcac tctgggccca ggaaatgctc tttggcttga ttctggcagt gaacctgaac
      121 tacgggcaga gcctcaatcc ttgctggaac cctgggcaaa cctcacactg gtctgtgcag
      181 ttgatttgcc taccaaggtc ttcgagctga tcatgaatgg gtggttcctg agtcaagtcc
      241 gactggagac accggtgttg tcatatcgct tttccctggg ggccattaca agtaacaaca
      301 gtggcgtcta ccgctgccga tgtggcgtgg aaccccctgt tgacattcaa ctgccagcgc
      361 tgagcaagtg gacaatgcta agcaatgctt tggaggtgac agggaaagag cccttgcctc
      421 caccctcagc tcacgctgat ccagtctcct ggatcacacc tggtggcctg cctgtctaca
      481 tcatgtgccg ggttgccatg cgaggtgtaa cctacctgct gaggaaggaa ggggtggatg
      541 gtacccagaa acctgatgtc cagcacaagg gaacggctgg ctttctaatc tacaagcctg
      601 gtaactacag ctgcagctac ctaacccatg caggaggcaa accctctgag cccagtgcta
      661 ttgtgaccat caagatgtct gccacacagc ttccacccag tctgtgttta atgggaagtt
      721 acctaacgat ctacccccag aagacacatg agacgcttgc ttgcaaagct cctcggaatg
      781 cagccgaatt ccaactcaga caaggagaga gggtgctgaa tattcaaggg ttcagcccca
      841 ccagagatgc taccatatac tatgtgaact tgaaggaact ggataaccaa agtcctttta
      901 cctgccgcta ccgtatgcac aaatacatgc atgtttggtc ggaggacagc aagcccgtag
      961 agctgatgtg gagtgacgag aaactaccag ccccggtact cactgcagag ccatcaagtc
     1021 acaacctgga gcctggttca acagtgcagc ttcgatgtac tgcacacaag gctggcctgc
     1081 gctttggcct gcaacgccag ggcaaaccag atttagttgt ggtgcagatg ctgaattcgt
     1141 ctgggaccga agctgtcttt gagctgcaca atatctcaac aatcgactct ggcaactaca
     1201 gttgtatcta catggaacaa gcaccaccct tctcaggatc tgcttccagt gagcccttag
     1261 agctgcggat aaatgggcca gcacccaagc caaggctgga agctctgtgg aaaggcaagg
     1321 ttcctctggg ccatgaagcc atctttcaat gccatggcca tgtgcccagg gtcagcatgg
     1381 agctggtacg tgagggcttt aaaacaccct tctggatggc ttcaacaaca agcacctcag
     1441 cttttctgaa gctgtccttc gtcggtcccc aacatacagg caactacagc tgccgctata
     1501 ctgccctgtc acccttcaca tttgaatcag ggatcagtga ccctgtggaa gttgtagtag
     1561 aaggtagcta acatcgctgc agacacagga aagtgccctt ggaaagggtt gaagacagac
     1621 ataatacaca ttcttcgtgt aagatgactt cattttctca ggacttaata aaggtcaagt
     1681 aaattgttgt ttaaaacatg tctttcattt gtgggtctaa ggtacctgca gatggaggag
     1741 gatgttcttc caggtctggg atcctgggtc tgtaaaaaga agaagctcag ggttcaatct
     1801 taaggacatg agggtaaaag cctggtcttt gcccacatct ctcaagatcc ctttttcttg
     1861 ttgacctgtg tctggctgtc tcatagctcc ccaaacttac ttcttcccct tccagcactt
     1921 gtataaataa agcttaaagc tctaacccca cctctcagct tggaagggtt tgtccctgac
     1981 ctatcagtaa gttagaaaac accacattaa gagttctggc tgtgttttca atttttacaa
     2041 atatgctatg atggatggca tcagagattg tctcaatcaa ttcattgtct gaagtaactc
     2101 aactgtaaaa aaataaaaca gcaaaatatc ttcaga
//
