LOCUS       NP_071594                513 aa            linear   ROD 27-MAR-2024
DEFINITION  alpha-1B-glycoprotein precursor [Rattus norvegicus].
ACCESSION   NP_071594
VERSION     NP_071594.3
DBSOURCE    REFSEQ: accession NM_022258.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 513)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (residues 1 to 513)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (residues 1 to 513)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (residues 1 to 513)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (residues 1 to 513)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   6  (residues 1 to 513)
  AUTHORS   Gardmo,C., Persson,B. and Mode,A.
  TITLE     Cloning of a novel growth hormone-regulated rat complementary
            deoxyribonucleic acid with homology to the human
            alpha1B-glycoprotein, characterizing a new protein family
  JOURNAL   Endocrinology 142 (6), 2695-2701 (2001)
   PUBMED   11356721
REFERENCE   7  (residues 1 to 513)
  AUTHORS   Xu,W., Wang,S., Wang,G., Wei,H., He,F. and Yang,X.
  TITLE     Identification and characterization of differentially expressed
            genes in the early response phase during liver regeneration
  JOURNAL   Biochem Biophys Res Commun 278 (2), 318-325 (2000)
   PUBMED   11097837
REFERENCE   8  (residues 1 to 513)
  AUTHORS   Ishioka,N., Takahashi,N. and Putnam,F.W.
  TITLE     Amino acid sequence of human plasma alpha 1B-glycoprotein: homology
            to the immunoglobulin supergene family
  JOURNAL   Proc Natl Acad Sci U S A 83 (8), 2363-2367 (1986)
   PUBMED   3458201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 18, 2021 this sequence version replaced NP_071594.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ302031.1, BC089771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     Protein         1..513
                     /product="alpha-1B-glycoprotein precursor"
                     /note="alpha-1B-glycoprotein; liver regeneration-related
                     protein 1"
                     /calculated_mol_wt=54393
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2105
     mat_peptide     21..513
                     /product="Alpha-1B-glycoprotein. /evidence=ECO:0000255.
                     /id=PRO_0000014503"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH1.2)"
                     /calculated_mol_wt=54393
     Region          29..125
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Site            44
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EPH1.2)"
     Region          45..49
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409518"
     Region          57..61
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409518"
     Region          79..83
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409518"
     Site            89
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EPH1.2)"
     Region          93..98
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409518"
     Region          118..121
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409518"
     Region          131..214
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          149..153
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409518"
     Region          161..165
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409518"
     Region          183..187
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409518"
     Region          192..197
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409518"
     Site            192
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EPH1.2)"
     Region          209..212
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409518"
     Region          233..314
                     /region_name="Ig_2"
                     /note="Immunoglobulin domain; pfam13895"
                     /db_xref="CDD:464026"
     Region          322..412
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          339..343
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409518"
     Region          351..355
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409518"
     Site            369
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EPH1.2)"
     Region          375..379
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409518"
     Site            381
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EPH1.2)"
     Region          389..394
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409518"
     Site            389
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EPH1.2)"
     Region          407..410
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409518"
     Region          420..510
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          437..441
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409518"
     Region          449..453
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409518"
     Region          471..475
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409518"
     Region          485..490
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409518"
     Site            485
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EPH1.2)"
     Region          503..506
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409518"
     CDS             1..513
                     /gene="A1bg"
                     /gene_synonym="C44"
                     /coded_by="NM_022258.3:30..1571"
                     /db_xref="GeneID:140656"
                     /db_xref="RGD:69417"
ORIGIN      
        1 msllttvlll wgftlgpgna lwldsgsepe lraepqslle pwanltlvca vdlptkvfel
       61 imngwflsqv rletpvlsyr fslgaitsnn sgvyrcrcgv eppvdiqlpa lskwtmlsna
      121 levtgkeplp ppsahadpvs witpgglpvy imcrvamrgv tyllrkegvd gtqkpdvqhk
      181 gtagfliykp gnyscsylth aggkpsepsa ivtikmsatq lppslclmgs yltiypqkth
      241 etlackaprn aaefqlrqge rvlniqgfsp trdatiyyvn lkeldnqspf tcryrmhkym
      301 hvwsedskpv elmwsdeklp apvltaepss hnlepgstvq lrctahkagl rfglqrqgkp
      361 dlvvvqmlns sgteavfelh nistidsgny sciymeqapp fsgsassepl elringpapk
      421 prlealwkgk vplgheaifq chghvprvsm elvregfktp fwmasttsts aflklsfvgp
      481 qhtgnyscry talspftfes gisdpvevvv egs
//
