LOCUS       NM_015770                692 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus nonagouti (a), mRNA.
ACCESSION   NM_015770
VERSION     NM_015770.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 692)
  AUTHORS   Komleva,P.D., Alhalabi,G., Izyurov,A.E., Khotskin,N.V. and
            Kulikov,A.V.
  TITLE     Effects of the Combination of the C1473G Mutation in the Tph2 Gene
            and Lethal Yellow Mutations in the Raly-Agouti Locus on Behavior,
            Brain 5-HT and Melanocortin Systems in Mice
  JOURNAL   Biomolecules 13 (6), 963 (2023)
   PUBMED   37371543
  REMARK    GeneRIF: Effects of the Combination of the C1473G Mutation in the
            Tph2 Gene and Lethal Yellow Mutations in the Raly-Agouti Locus on
            Behavior, Brain 5-HT and Melanocortin Systems in Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 692)
  AUTHORS   Steiger,L.J., Tsintsadze,T., Mattheisen,G.B. and Smith,S.M.
  TITLE     Somatic and terminal CB1 receptors are differentially coupled to
            voltage-gated sodium channels in neocortical neurons
  JOURNAL   Cell Rep 42 (3), 112247 (2023)
   PUBMED   36933217
REFERENCE   3  (bases 1 to 692)
  AUTHORS   Blech-Hermoni,Y., Subedi,K., Silver,M., Jensen,L., Coscia,S.,
            Kates,M.M., Zhao,Y., Raley,C., Edwards,N., Tran,B.,
            Ray-Chaudhary,A., Pathak,P. and Mankodi,A.
  TITLE     Expression of LIM domain-binding 3 (LDB3), a striated muscle Z-band
            alternatively spliced PDZ-motif protein in the nervous system
  JOURNAL   Sci Rep 13 (1), 270 (2023)
   PUBMED   36609526
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 692)
  AUTHORS   Takeishi,T., Fujiwara,K., Osada,N., Mita,A., Takada,T.,
            Shiroishi,T. and Suzuki,H.
  TITLE     Phylogeographic study using nuclear genome sequences of Asip to
            infer the origins of ventral fur color variation in the house mouse
            Mus musculus
  JOURNAL   Genes Genet Syst 96 (6), 271-284 (2022)
   PUBMED   35283410
  REMARK    GeneRIF: Phylogeographic study using nuclear genome sequences of
            Asip to infer the origins of ventral fur color variation in the
            house mouse Mus musculus.
REFERENCE   5  (bases 1 to 692)
  AUTHORS   Gunasekar,S.K., Xie,L., Kumar,A., Hong,J., Chheda,P.R., Kang,C.,
            Kern,D.M., My-Ta,C., Maurer,J., Heebink,J., Gerber,E.E.,
            Grzesik,W.J., Elliot-Hudson,M., Zhang,Y., Key,P., Kulkarni,C.A.,
            Beals,J.W., Smith,G.I., Samuel,I., Smith,J.K., Nau,P., Imai,Y.,
            Sheldon,R.D., Taylor,E.B., Lerner,D.J., Norris,A.W., Klein,S.,
            Brohawn,S.G., Kerns,R. and Sah,R.
  TITLE     Small molecule SWELL1 complex induction improves glycemic control
            and nonalcoholic fatty liver disease in murine Type 2 diabetes
  JOURNAL   Nat Commun 13 (1), 784 (2022)
   PUBMED   35145074
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 692)
  AUTHORS   Summerhayes,I.C. and Franks,L.M.
  TITLE     Effects of donor age on neoplastic transformation of adult mouse
            bladder epithelium in vitro
  JOURNAL   J Natl Cancer Inst 62 (4), 1017-1023 (1979)
   PUBMED   107359
REFERENCE   7  (bases 1 to 692)
  AUTHORS   Theiler,K., Varnum,D.S. and Stevens,L.C.
  TITLE     Development of Dickie's small eye, a mutation in the house mouse
  JOURNAL   Anat Embryol (Berl) 155 (1), 81-86 (1978)
   PUBMED   103464
REFERENCE   8  (bases 1 to 692)
  AUTHORS   LaVail,J.H., Nixon,R.A. and Sidman,R.L.
  TITLE     Genetic control of retinal ganglion cell projections
  JOURNAL   J Comp Neurol 182 (3), 399-421 (1978)
   PUBMED   102659
REFERENCE   9  (bases 1 to 692)
  AUTHORS   Green,M.C., Sweet,H.O. and Bunker,L.E.
  TITLE     Tight-skin, a new mutation of the mouse causing excessive growth of
            connective tissue and skeleton
  JOURNAL   Am J Pathol 82 (3), 493-512 (1976)
   PUBMED   176891
REFERENCE   10 (bases 1 to 692)
  AUTHORS   Cohen,P.L., Scher,I. and Mosier,D.E.
  TITLE     In vitro studies of the genetically determined unresponsiveness to
            thymus-independent antigens in CBA/N mice
  JOURNAL   J Immunol 116 (2), 301-304 (1976)
   PUBMED   55435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L06941.1 and AL805955.26.
            
            On Mar 23, 2007 this sequence version replaced NM_015770.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L06941.1, L06451.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                L06941.1           1-55
            56-56               AL805955.26        114053-114053
            57-118              L06941.1           57-118
            119-119             AL805955.26        146086-146086
            120-692             L06941.1           120-692
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 76.83 cM"
     gene            1..692
                     /gene="a"
                     /gene_synonym="A<y>; As; ASIP; ASP"
                     /note="nonagouti"
                     /db_xref="GeneID:50518"
                     /db_xref="MGI:MGI:87853"
     exon            1..72
                     /gene="a"
                     /gene_synonym="A<y>; As; ASIP; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            73..242
                     /gene="a"
                     /gene_synonym="A<y>; As; ASIP; ASP"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..478
                     /gene="a"
                     /gene_synonym="A<y>; As; ASIP; ASP"
                     /note="non-agouti; agouti-signaling protein; agouti switch
                     protein; agouti coat color protein; agouti signal protein"
                     /codon_start=1
                     /product="agouti-signaling protein precursor"
                     /protein_id="NP_056585.2"
                     /db_xref="CCDS:CCDS16941.1"
                     /db_xref="GeneID:50518"
                     /db_xref="MGI:MGI:87853"
                     /translation="MDVTRLLLATLVGFLCFFTVHSHLALEETLGDDRSLRSNSSMNS
                     LDFSSVSIVALNKKSKKISRKEAEKRKRSSKKKASMKKVARPPPPSPCVATRDSCKPP
                     APACCDPCASCQCRFFGSACTCRVLNPNC"
     exon            243..307
                     /gene="a"
                     /gene_synonym="A<y>; As; ASIP; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            308..692
                     /gene="a"
                     /gene_synonym="A<y>; As; ASIP; ASP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      668..673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="a"
                     /gene_synonym="A<y>; As; ASIP; ASP"
                     /note="hexamer: AATACA"
     polyA_site      692
                     /gene="a"
                     /gene_synonym="A<y>; As; ASIP; ASP"
                     /note="major polyA site"
ORIGIN      
        1 ttcaaggaca ggaaagacat tctggcctgg cttcccttag gggagctgat gcggagtaga
       61 gtcacttgtg ctgcttctca ggatggatgt cacccgccta ctcctggcca ccctagtggg
      121 cttcctgtgc ttcttcaccg tccacagcca cctggcactc gaggagacgc ttggagatga
      181 caggagtctg cggagtaact cctccatgaa ctcgctggat ttctcctctg tttctatcgt
      241 ggcactgaac aagaaatcca agaagatcag cagaaaagaa gccgagaagc ggaagaggtc
      301 ttccaagaaa aaggcttcga tgaagaaggt ggcaaggccc ccgccacctt cgccctgcgt
      361 ggccacccgc gacagctgca agccacccgc acccgcctgc tgcgacccgt gcgcctcctg
      421 ccagtgccgt ttcttcggca gcgcctgcac ctgtcgagta ctcaacccca actgctgacg
      481 cagcttcttc gctgcgcgcg cagcttcggg aacgggtgat tgggcggggc ttcagggtcc
      541 cgcgcttcta ggctgagggg cgggtctctg tgggtggggc ttgtgggtgg gcgtggtcag
      601 tggttgtgac ttgtgggcgc tttcaaaaaa ccggttttct aggaaaccta gtggaagcta
      661 aaatcagaat acaataatat ttttaggctg cc
//
