LOCUS       NM_001289619            2286 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus zyxin (Zyx), transcript variant 3, mRNA.
ACCESSION   NM_001289619 XM_006505937
VERSION     NM_001289619.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2286)
  AUTHORS   Kliewe,F., Siegerist,F., Hammer,E., Al-Hasani,J., Amling,T.R.J.,
            Hollemann,J.Z.E., Schindler,M., Drenic,V., Simm,S., Amann,K.,
            Daniel,C., Lindenmeyer,M., Hecker,M., Volker,U. and Endlich,N.
  TITLE     Zyxin is important for the stability and function of podocytes,
            especially during mechanical stretch
  JOURNAL   Commun Biol 7 (1), 446 (2024)
   PUBMED   38605154
  REMARK    GeneRIF: Zyxin is important for the stability and function of
            podocytes, especially during mechanical stretch.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2286)
  AUTHORS   Zhang,S., Chong,L.H., Woon,J.Y.X., Chua,T.X., Cheruba,E., Yip,A.K.,
            Li,H.Y., Chiam,K.H. and Koh,C.G.
  TITLE     Zyxin regulates embryonic stem cell fate by modulating mechanical
            and biochemical signaling interface
  JOURNAL   Commun Biol 6 (1), 62 (2023)
   PUBMED   36653484
  REMARK    GeneRIF: Zyxin regulates embryonic stem cell fate by modulating
            mechanical and biochemical signaling interface.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2286)
  AUTHORS   Al-Hasani,J., Sens-Albert,C., Ghosh,S., Trogisch,F.A., Nahar,T.,
            Friede,P.A.P., Reil,J.C. and Hecker,M.
  TITLE     Zyxin protects from hypertension-induced cardiac dysfunction
  JOURNAL   Cell Mol Life Sci 79 (2), 93 (2022)
   PUBMED   35075545
  REMARK    GeneRIF: Zyxin protects from hypertension-induced cardiac
            dysfunction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2286)
  AUTHORS   Yan,R., Ge,X., Pang,N., Ye,H., Yuan,L., Cheng,B., Zhou,K., Yang,M.,
            Sun,Y., Zhang,S., Ding,Z., Luo,J., Ruan,C. and Dai,K.
  TITLE     Essential role of zyxin in platelet biogenesis and glycoprotein
            Ib-IX surface expression
  JOURNAL   Cell Death Dis 12 (11), 955 (2021)
   PUBMED   34657146
  REMARK    GeneRIF: Essential role of zyxin in platelet biogenesis and
            glycoprotein Ib-IX surface expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2286)
  AUTHORS   Kang,X., Deng,Y., Cao,Y., Huo,Y. and Luo,J.
  TITLE     Zyxin Mediates Vascular Repair via Endothelial Migration Promoted
            by Forskolin in Mice
  JOURNAL   Front Physiol 12, 741699 (2021)
   PUBMED   34690814
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2286)
  AUTHORS   Tani,K., Sato,S., Sukezane,T., Kojima,H., Hirose,H., Hanafusa,H.
            and Shishido,T.
  TITLE     Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian
            enabled (Mena) by c-Abl kinase
  JOURNAL   J Biol Chem 278 (24), 21685-21692 (2003)
   PUBMED   12672821
REFERENCE   7  (bases 1 to 2286)
  AUTHORS   Hoffman,L.M., Nix,D.A., Benson,B., Boot-Hanford,R., Gustafsson,E.,
            Jamora,C., Menzies,A.S., Goh,K.L., Jensen,C.C., Gertler,F.B.,
            Fuchs,E., Fassler,R. and Beckerle,M.C.
  TITLE     Targeted disruption of the murine zyxin gene
  JOURNAL   Mol Cell Biol 23 (1), 70-79 (2003)
   PUBMED   12482962
  REMARK    GeneRIF: Mice that lack zyxin function are viable and fertile and
            display no obvious histological abnormalities in any of the organs
            examined.Specifically, we evaluated blood platelet function,
            nervous system development, and skin architecture
REFERENCE   8  (bases 1 to 2286)
  AUTHORS   Macalma,T., Otte,J., Hensler,M.E., Bockholt,S.M., Louis,H.A.,
            Kalff-Suske,M., Grzeschik,K.H., von der Ahe,D. and Beckerle,M.C.
  TITLE     Molecular characterization of human zyxin
  JOURNAL   J Biol Chem 271 (49), 31470-31478 (1996)
   PUBMED   8940160
REFERENCE   9  (bases 1 to 2286)
  AUTHORS   Gertler,F.B., Niebuhr,K., Reinhard,M., Wehland,J. and Soriano,P.
  TITLE     Mena, a relative of VASP and Drosophila Enabled, is implicated in
            the control of microfilament dynamics
  JOURNAL   Cell 87 (2), 227-239 (1996)
   PUBMED   8861907
REFERENCE   10 (bases 1 to 2286)
  AUTHORS   Sadler,I., Crawford,A.W., Michelsen,J.W. and Beckerle,M.C.
  TITLE     Zyxin and cCRP: two interactive LIM domain proteins associated with
            the cytoskeleton
  JOURNAL   J Cell Biol 119 (6), 1573-1587 (1992)
   PUBMED   1469049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153915.5.
            
            On Dec 30, 2022 this sequence version replaced NM_001289619.1.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon, compared to variant 1. The encoded isoform (b) is shorter
            than isoform a. Variants 3 and 4 encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054775.1, SRR13861890.40882.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC153915.5         35147-35211         c
            66-285              AC153915.5         34790-35009         c
            286-488             AC153915.5         34118-34320         c
            489-983             AC153915.5         33297-33791         c
            984-1104            AC153915.5         29229-29349         c
            1105-1274           AC153915.5         28935-29104         c
            1275-1453           AC153915.5         28656-28834         c
            1454-1574           AC153915.5         27833-27953         c
            1575-2286           AC153915.5         26703-27414         c
FEATURES             Location/Qualifiers
     source          1..2286
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 20.64 cM"
     gene            1..2286
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /note="zyxin"
                     /db_xref="GeneID:22793"
                     /db_xref="MGI:MGI:103072"
     exon            1..65
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            66..285
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1679
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /note="isoform b is encoded by transcript variant 3"
                     /codon_start=1
                     /product="zyxin isoform b"
                     /protein_id="NP_001276548.1"
                     /db_xref="CCDS:CCDS85034.1"
                     /db_xref="GeneID:22793"
                     /db_xref="MGI:MGI:103072"
                     /translation="MAAPRPPPAISVSVSAPAFYAPQKKFAPVVAPKPKVNPFRPGDS
                     EPPVAAGAQRAQMGRVGEIPPPPPEDFPLPPPPLIGEGDDSEGALGGAFPPPPPPMIE
                     EPFPPAPLEEDIFPSPPPPLEEEGGPEAPTQLPPQVSSGYVPPPVATPFVPKPSTKPA
                     PGGTAPLPPWKTPSSSQPPPQPQAKPQVQLHVQPQAKPHVQPQPVSSANTQPRGPLSQ
                     APTPAPKFAPVAPKFTPVVSKFSPGAPSGPGPQPNQKMVPPDAPSSVSTGSPQPPSFT
                     YAQQKEKPLVQEKQHPQPPPAQNQNQVRSPGGPGPLTLKEVEELEQLTQQLMQDMEHP
                     QRQSVAVNESCGKCNQPLARAQPAVRALGQLFHITCFTCHQCQQQLQGQQFYSLEGAP
                     YCEGCYTDTLEKCNTCGQPITDRMLRATGKAYHPQCFTCVVCACPLEGTSFIVDQANQ
                     PHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIE
                     ADDNGCFPLDGHVLCRKCHSARAQT"
     exon            286..488
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            489..983
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1104
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1274
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1453
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1574
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..2286
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2098..2103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /note="hexamer: TATAAA"
     polyA_site      2118
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /note="major polyA site"
     regulatory      2148..2153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /note="hexamer: AATGAA"
     polyA_site      2168
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
     regulatory      2264..2269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2286
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
ORIGIN      
        1 gcagagtccg cggactcggc gccgaggcgg tcatccgaga cgcgcctctc acgctcctgc
       61 gcgcgcccgg cctggccatg gcggcccccc gcccgcctcc cgcgatctcc gtctccgtct
      121 cggcccccgc gttttacgcc ccgcagaaga agttcgcccc ggttgtggcc ccaaagccca
      181 aagtgaatcc tttccggcct ggggacagcg agcctcctgt agcagccggg gcccaaagag
      241 cgcagatggg tcgggtgggc gagatcccac caccaccccc ggaagacttt cctttgcccc
      301 ctcctcccct tattggggag ggcgacgact cagagggtgc cctgggaggt gccttcccac
      361 ctccacctcc cccgatgatc gaggaaccat tcccccctgc tcctctggag gaggacatct
      421 tcccctcccc tccacctcca ctggaggagg agggagggcc tgaggcccct acccagctcc
      481 caccgcaggt atcatccgga tatgtacccc caccagttgc cactccattt gttcccaagc
      541 ctagtaccaa acctgcccct gggggcacag cacccttgcc tccttggaag accccttcta
      601 gctcccagcc accacctcag ccgcaggcca agcctcaggt ccagctccat gtccagcctc
      661 aggccaagcc ccatgtccaa ccccagcctg tgtcttctgc taatacacag ccccggggtc
      721 ccctttctca ggcaccaact ccagcaccta agtttgctcc agtggctcct aaatttactc
      781 ccgtggtttc caagttcagc cctggtgctc caagtggacc tgggccacag cccaatcaaa
      841 aaatggtgcc tccggatgct ccttcttctg tgagcacagg ctcccctcag ccccctagct
      901 tcacctatgc tcagcagaag gagaagcccc tagttcaaga gaagcagcac ccacagcctc
      961 caccagctca aaaccaaaac caggtacgct ctcctggagg cccaggcccc ttgaccctga
     1021 aggaggtaga ggagttggag cagctgaccc agcagctgat gcaggacatg gaacaccctc
     1081 agaggcagag cgtggcagtg aatgagtcct gtggcaaatg caatcagcca ctggcccgtg
     1141 cacagcctgc ggttcgtgca ctgggacaac tgttccacat cacctgcttc acttgccatc
     1201 agtgtcagca gcagctgcag ggacagcagt tctatagcct ggagggagca ccatattgtg
     1261 agggctgcta caccgacact ttggagaagt gcaacacctg tgggcagccc atcactgacc
     1321 gcatgctgag ggccactggc aaagcctacc acccacagtg cttcacctgt gtggtctgcg
     1381 cctgtcccct ggagggcacc tccttcattg tggaccaggc caatcagccc cactgtgtcc
     1441 ctgactatca caagcaatac gctccaaggt gctccgtctg ctcggagcca atcatgcctg
     1501 agcctggccg agacgagact gtgcgagtag tggcgctgga taagaacttt catatgaagt
     1561 gttacaagtg tgaggactgt gggaaacctc tgtccattga ggcagatgac aacggctgtt
     1621 tccctctgga tggccacgtc ctttgtcgga agtgccactc cgctagagcc cagacctgag
     1681 ttgagatgga cctccttcca gaccacaggt ccgtccccca ccgtggacca cccacactga
     1741 ggccagtcct tgcctctacc ctccctgcat tccaatcccc tcccgagtct caagtgccct
     1801 gacccagggc ctcagcatgg cctacaagta ttgaggctcc ctcctggtgc tgaggcccag
     1861 ccctgggctc caacccttgc ctcttctgca gggatcaccc atcattctga ggtccccaac
     1921 ccaagggtca catatagtgc tgctgctttc actgctgcac caatgccctt ggctggcctg
     1981 agcagcctat gcaatgtgct tgctgagggt agaagcccta accctccagg agcgtggctt
     2041 cagcagcctg gacacccacc ttgctctgtg ctgctaggtt gtggccacag ctaagattat
     2101 aaaacctcat tttccagagt tgctagtact tgattttttt gataataaat gaacgattgg
     2161 agttgaaata gagggaatca acggggaaaa acatcaaggg aagagatgaa aactcaactc
     2221 ttgtttattt acaaaaatag ataatgcata tgtaagtgta tatattaaac cctcccccag
     2281 aaccca
//
