LOCUS       NM_001289617            3183 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus zyxin (Zyx), transcript variant 2, mRNA.
ACCESSION   NM_001289617
VERSION     NM_001289617.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3183)
  AUTHORS   Kliewe,F., Siegerist,F., Hammer,E., Al-Hasani,J., Amling,T.R.J.,
            Hollemann,J.Z.E., Schindler,M., Drenic,V., Simm,S., Amann,K.,
            Daniel,C., Lindenmeyer,M., Hecker,M., Volker,U. and Endlich,N.
  TITLE     Zyxin is important for the stability and function of podocytes,
            especially during mechanical stretch
  JOURNAL   Commun Biol 7 (1), 446 (2024)
   PUBMED   38605154
  REMARK    GeneRIF: Zyxin is important for the stability and function of
            podocytes, especially during mechanical stretch.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3183)
  AUTHORS   Zhang,S., Chong,L.H., Woon,J.Y.X., Chua,T.X., Cheruba,E., Yip,A.K.,
            Li,H.Y., Chiam,K.H. and Koh,C.G.
  TITLE     Zyxin regulates embryonic stem cell fate by modulating mechanical
            and biochemical signaling interface
  JOURNAL   Commun Biol 6 (1), 62 (2023)
   PUBMED   36653484
  REMARK    GeneRIF: Zyxin regulates embryonic stem cell fate by modulating
            mechanical and biochemical signaling interface.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3183)
  AUTHORS   Al-Hasani,J., Sens-Albert,C., Ghosh,S., Trogisch,F.A., Nahar,T.,
            Friede,P.A.P., Reil,J.C. and Hecker,M.
  TITLE     Zyxin protects from hypertension-induced cardiac dysfunction
  JOURNAL   Cell Mol Life Sci 79 (2), 93 (2022)
   PUBMED   35075545
  REMARK    GeneRIF: Zyxin protects from hypertension-induced cardiac
            dysfunction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3183)
  AUTHORS   Yan,R., Ge,X., Pang,N., Ye,H., Yuan,L., Cheng,B., Zhou,K., Yang,M.,
            Sun,Y., Zhang,S., Ding,Z., Luo,J., Ruan,C. and Dai,K.
  TITLE     Essential role of zyxin in platelet biogenesis and glycoprotein
            Ib-IX surface expression
  JOURNAL   Cell Death Dis 12 (11), 955 (2021)
   PUBMED   34657146
  REMARK    GeneRIF: Essential role of zyxin in platelet biogenesis and
            glycoprotein Ib-IX surface expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3183)
  AUTHORS   Kang,X., Deng,Y., Cao,Y., Huo,Y. and Luo,J.
  TITLE     Zyxin Mediates Vascular Repair via Endothelial Migration Promoted
            by Forskolin in Mice
  JOURNAL   Front Physiol 12, 741699 (2021)
   PUBMED   34690814
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3183)
  AUTHORS   Tani,K., Sato,S., Sukezane,T., Kojima,H., Hirose,H., Hanafusa,H.
            and Shishido,T.
  TITLE     Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian
            enabled (Mena) by c-Abl kinase
  JOURNAL   J Biol Chem 278 (24), 21685-21692 (2003)
   PUBMED   12672821
REFERENCE   7  (bases 1 to 3183)
  AUTHORS   Hoffman,L.M., Nix,D.A., Benson,B., Boot-Hanford,R., Gustafsson,E.,
            Jamora,C., Menzies,A.S., Goh,K.L., Jensen,C.C., Gertler,F.B.,
            Fuchs,E., Fassler,R. and Beckerle,M.C.
  TITLE     Targeted disruption of the murine zyxin gene
  JOURNAL   Mol Cell Biol 23 (1), 70-79 (2003)
   PUBMED   12482962
  REMARK    GeneRIF: Mice that lack zyxin function are viable and fertile and
            display no obvious histological abnormalities in any of the organs
            examined.Specifically, we evaluated blood platelet function,
            nervous system development, and skin architecture
REFERENCE   8  (bases 1 to 3183)
  AUTHORS   Macalma,T., Otte,J., Hensler,M.E., Bockholt,S.M., Louis,H.A.,
            Kalff-Suske,M., Grzeschik,K.H., von der Ahe,D. and Beckerle,M.C.
  TITLE     Molecular characterization of human zyxin
  JOURNAL   J Biol Chem 271 (49), 31470-31478 (1996)
   PUBMED   8940160
REFERENCE   9  (bases 1 to 3183)
  AUTHORS   Gertler,F.B., Niebuhr,K., Reinhard,M., Wehland,J. and Soriano,P.
  TITLE     Mena, a relative of VASP and Drosophila Enabled, is implicated in
            the control of microfilament dynamics
  JOURNAL   Cell 87 (2), 227-239 (1996)
   PUBMED   8861907
REFERENCE   10 (bases 1 to 3183)
  AUTHORS   Sadler,I., Crawford,A.W., Michelsen,J.W. and Beckerle,M.C.
  TITLE     Zyxin and cCRP: two interactive LIM domain proteins associated with
            the cytoskeleton
  JOURNAL   J Cell Biol 119 (6), 1573-1587 (1992)
   PUBMED   1469049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153915.5.
            
            On Dec 30, 2022 this sequence version replaced NM_001289617.1.
            
            Transcript Variant: This variant (2) differs in the 3' UTR,
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035743.1, AK031415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC153915.5         35147-35211         c
            66-285              AC153915.5         34790-35009         c
            286-488             AC153915.5         34118-34320         c
            489-581             AC153915.5         33904-33996         c
            582-1076            AC153915.5         33297-33791         c
            1077-1197           AC153915.5         29229-29349         c
            1198-1367           AC153915.5         28935-29104         c
            1368-1546           AC153915.5         28656-28834         c
            1547-1667           AC153915.5         27833-27953         c
            1668-1801           AC153915.5         27281-27414         c
            1802-3183           AC153915.5         25042-26423         c
FEATURES             Location/Qualifiers
     source          1..3183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 20.64 cM"
     gene            1..3183
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /note="zyxin"
                     /db_xref="GeneID:22793"
                     /db_xref="MGI:MGI:103072"
     exon            1..65
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            66..285
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1772
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zyxin isoform a"
                     /protein_id="NP_001276546.1"
                     /db_xref="CCDS:CCDS20066.1"
                     /db_xref="GeneID:22793"
                     /db_xref="MGI:MGI:103072"
                     /translation="MAAPRPPPAISVSVSAPAFYAPQKKFAPVVAPKPKVNPFRPGDS
                     EPPVAAGAQRAQMGRVGEIPPPPPEDFPLPPPPLIGEGDDSEGALGGAFPPPPPPMIE
                     EPFPPAPLEEDIFPSPPPPLEEEGGPEAPTQLPPQPREKVCSIDLEIDSLSSLLDDMT
                     KNDPFKARVSSGYVPPPVATPFVPKPSTKPAPGGTAPLPPWKTPSSSQPPPQPQAKPQ
                     VQLHVQPQAKPHVQPQPVSSANTQPRGPLSQAPTPAPKFAPVAPKFTPVVSKFSPGAP
                     SGPGPQPNQKMVPPDAPSSVSTGSPQPPSFTYAQQKEKPLVQEKQHPQPPPAQNQNQV
                     RSPGGPGPLTLKEVEELEQLTQQLMQDMEHPQRQSVAVNESCGKCNQPLARAQPAVRA
                     LGQLFHITCFTCHQCQQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGQPITDRMLRA
                     TGKAYHPQCFTCVVCACPLEGTSFIVDQANQPHCVPDYHKQYAPRCSVCSEPIMPEPG
                     RDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHSARAQT"
     exon            286..488
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            489..581
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            582..1076
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1197
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1367
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1546
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1667
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1801
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..3183
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2168..2173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /note="hexamer: CATAAA"
     polyA_site      2188
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /note="major polyA site"
     regulatory      3149..3154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /note="hexamer: AATATA"
     polyA_site      3183
                     /gene="Zyx"
                     /gene_synonym="9530098H06Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcagagtccg cggactcggc gccgaggcgg tcatccgaga cgcgcctctc acgctcctgc
       61 gcgcgcccgg cctggccatg gcggcccccc gcccgcctcc cgcgatctcc gtctccgtct
      121 cggcccccgc gttttacgcc ccgcagaaga agttcgcccc ggttgtggcc ccaaagccca
      181 aagtgaatcc tttccggcct ggggacagcg agcctcctgt agcagccggg gcccaaagag
      241 cgcagatggg tcgggtgggc gagatcccac caccaccccc ggaagacttt cctttgcccc
      301 ctcctcccct tattggggag ggcgacgact cagagggtgc cctgggaggt gccttcccac
      361 ctccacctcc cccgatgatc gaggaaccat tcccccctgc tcctctggag gaggacatct
      421 tcccctcccc tccacctcca ctggaggagg agggagggcc tgaggcccct acccagctcc
      481 caccgcagcc cagggagaaa gtgtgcagta ttgacctgga gattgactct ctgtcctcac
      541 tgctggacga catgaccaag aacgatccct tcaaagcccg ggtatcatcc ggatatgtac
      601 ccccaccagt tgccactcca tttgttccca agcctagtac caaacctgcc cctgggggca
      661 cagcaccctt gcctccttgg aagacccctt ctagctccca gccaccacct cagccgcagg
      721 ccaagcctca ggtccagctc catgtccagc ctcaggccaa gccccatgtc caaccccagc
      781 ctgtgtcttc tgctaataca cagccccggg gtcccctttc tcaggcacca actccagcac
      841 ctaagtttgc tccagtggct cctaaattta ctcccgtggt ttccaagttc agccctggtg
      901 ctccaagtgg acctgggcca cagcccaatc aaaaaatggt gcctccggat gctccttctt
      961 ctgtgagcac aggctcccct cagcccccta gcttcaccta tgctcagcag aaggagaagc
     1021 ccctagttca agagaagcag cacccacagc ctccaccagc tcaaaaccaa aaccaggtac
     1081 gctctcctgg aggcccaggc cccttgaccc tgaaggaggt agaggagttg gagcagctga
     1141 cccagcagct gatgcaggac atggaacacc ctcagaggca gagcgtggca gtgaatgagt
     1201 cctgtggcaa atgcaatcag ccactggccc gtgcacagcc tgcggttcgt gcactgggac
     1261 aactgttcca catcacctgc ttcacttgcc atcagtgtca gcagcagctg cagggacagc
     1321 agttctatag cctggaggga gcaccatatt gtgagggctg ctacaccgac actttggaga
     1381 agtgcaacac ctgtgggcag cccatcactg accgcatgct gagggccact ggcaaagcct
     1441 accacccaca gtgcttcacc tgtgtggtct gcgcctgtcc cctggagggc acctccttca
     1501 ttgtggacca ggccaatcag ccccactgtg tccctgacta tcacaagcaa tacgctccaa
     1561 ggtgctccgt ctgctcggag ccaatcatgc ctgagcctgg ccgagacgag actgtgcgag
     1621 tagtggcgct ggataagaac tttcatatga agtgttacaa gtgtgaggac tgtgggaaac
     1681 ctctgtccat tgaggcagat gacaacggct gtttccctct ggatggccac gtcctttgtc
     1741 ggaagtgcca ctccgctaga gcccagacct gagttgagat ggacctcctt ccagaccaca
     1801 ggtccctgtg gaaaaggaaa ggaagccgtg agtctagagg ctcagacctc agccaccctc
     1861 ccgtgcccgt gctgcctggc cccggagttc tcactcagcc gtcagctcca gcacacactc
     1921 catggtgtcc agcccagccg aacggaagtg caggatgtag cgcttcatgc gtatggattc
     1981 aagccactca gagacacttc gataagggat cccatcagag ccactcaggc tgggcaggcg
     2041 taaggtcacc ctgtgggaaa cagggtaccc tgtttgtacc ccttaagtag aggagctggt
     2101 tggcccgggc caccacattg cagccagcac ggagtcagat gcttacatac agctcatcta
     2161 ggctgcacat aaactggctg ttacctgagc tgacttcctg gcctgttttc ctggtatgct
     2221 caaagtggca ggcaggcagc agactgacct gttccatggg tagatctaga gagtgtggtt
     2281 gccctggcca tccctagtga agcaaaccct ttagtcatga atgcttcttg actgagataa
     2341 atcagaaggg gccaacagca aggtgctccc ttctcctaag atggccacct aggagcagcc
     2401 ctcacttgcc atattcgacc ctgactgtta ttcttacact ctgataacca caatacaatg
     2461 agtgttcctg taggaaagcc agccagagcc aaaaaccatt agcaaagtaa atctgctggg
     2521 ggaaaaaata tccagcattc cagaaagatt agcacacaca gtctccagcg tccgagggag
     2581 ttgtgctcca aaagatagtc tcaaaagttg gaacatggaa aacagtttct tccagaaaca
     2641 aggttatata tggtgggttt gataaacggg ccagtacact gtgctgcctt acccgataaa
     2701 gcacctcaag tccagcctcg cctggctccc aggcttgact ccctccttcc acttcattct
     2761 ctaaattctg gccatggttt tgaacaaata acagttttgg gaaactggtc accatctctt
     2821 gttctcacaa agtgctccct tctcagcagg gctggtcctt tgtcttgacc ttggctgcct
     2881 ccctcccgtt ctcaggagtg cagcctctga cctggatgct gccattgttc tgtactgtct
     2941 gatctgtcgt ctctcagccc tggccgactg gccatgtagt cagaggcctc ctcagactcc
     3001 ttcctgttcc taccctaatc tagctgccta tgctctcagg agtaggttcc aggctgtagc
     3061 caaaagcttg tactagtagg tcctccaaga tatgtgacat ctgtgaatct ttccttcatg
     3121 tttgaaaata tatatgtggg ggaaggaaaa tataccaaat tctagatggt cagaggaaca
     3181 cca
//
