LOCUS       NM_026507               2761 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zwilch kinetochore protein (Zwilch), transcript
            variant 1, mRNA.
ACCESSION   NM_026507
VERSION     NM_026507.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2761)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2761)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2761)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2761)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   5  (bases 1 to 2761)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 2761)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160118.2 and AC114674.10.
            
            On Jun 7, 2022 this sequence version replaced NM_026507.4.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus. The use of an alternative upstream start codon, which
            appears to be rodent-specific, would result in a protein that is 7
            aa longer. This uAUG also has a strong Kozak signal and has a good
            chance of being used in these species.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027435.1, AK019825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC160118.2         74693-74783         c
            92-143              AC160118.2         70488-70539         c
            144-239             AC160118.2         67238-67333         c
            240-358             AC160118.2         66222-66340         c
            359-558             AC160118.2         64439-64638         c
            559-629             AC160118.2         63246-63316         c
            630-785             AC160118.2         62696-62851         c
            786-857             AC160118.2         60570-60641         c
            858-951             AC114674.10        202469-202562       c
            952-1007            AC114674.10        201620-201675       c
            1008-1107           AC114674.10        200007-200106       c
            1108-1187           AC114674.10        199341-199420       c
            1188-1344           AC114674.10        196612-196768       c
            1345-1373           AC114674.10        195855-195883       c
            1374-1510           AC114674.10        193726-193862       c
            1511-1606           AC114674.10        193281-193376       c
            1607-1719           AC114674.10        190536-190648       c
            1720-1845           AC114674.10        186347-186472       c
            1846-2761           AC114674.10        183600-184515       c
FEATURES             Location/Qualifiers
     source          1..2761
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 34.52 cM"
     gene            1..2761
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /note="zwilch kinetochore protein"
                     /db_xref="GeneID:68014"
                     /db_xref="MGI:MGI:1915264"
     exon            1..91
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1808
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein zwilch homolog; Zwilch, kinetochore associated,
                     homolog"
                     /codon_start=1
                     /product="protein zwilch homolog isoform 1"
                     /protein_id="NP_080783.4"
                     /db_xref="CCDS:CCDS23275.2"
                     /db_xref="GeneID:68014"
                     /db_xref="MGI:MGI:1915264"
                     /translation="MWSRMNRAAEEFYARLRQEFNEEKKGASKDPFIYEADVQVQLIS
                     KGQPSLLKTILNENDSVFLVEKVVLEKEETSQVEELQSEETAISDLSAGENIRPLALP
                     VGRARQLIGLYTMAHNPNMTHLKIKQPVTALPPLWVRCDGSDPEGTCWLGAELITTND
                     IIAGVILYVLTCKADKNYSEDLENLKTSHKKRHHVSAVTARGFAQYELFKSDDLDDTV
                     APSQTTVTLDLSWSPVDEMLQTPPLSSTAALNIRVQSGESRGCLSHLHRELKFLLVLA
                     DGIRTGVTEWLEPLETKSALEFVQEFLNDLNKLDEFDDSTKKDKQKEAVNHDAAAVVR
                     SMLLTVRGDLDFAEQLWCRMSSSVVSYQDLVKCFTLILQSLQRGDIQPWLHSGSNSLL
                     SKLIHQSYHGAMDSVPLSGTTPLQMLLEIGLDKLKKDYISFFVSQELASLNHLEYFIS
                     PSVSTQEQVCRVQKLHHILEILVICMLFIKPQHELLFSLTQSCIKYYKQNPLDEQHIF
                     QLPVRPAAVKNLYQSEKPQKWRVELSNSQKRVKTVWQLSDSSPVDHSSFHRPEFPELT
                     LNGSLEERTAFVNMLTCSQVHFK"
     exon            92..143
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            144..239
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            240..358
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            359..558
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            559..629
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            630..785
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            786..857
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            858..951
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1007
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1107
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1187
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1344
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1373
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1510
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1606
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1719
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1845
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2761
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2209..2214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2232
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
     regulatory      2737..2742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      2761
                     /gene="Zwilch"
                     /gene_synonym="2310031L18Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtttaactt cttagcaatg gacggaggcc acggcggtat gtggtcgcga atgaaccgcg
       61 cggcggagga gttttatgct cgtctccggc aggaatttaa tgaagagaag aaaggagcct
      121 ctaaagaccc attcatctat gaggctgatg tacaagtgca gttgatcagc aaaggccaac
      181 caagtcttct gaaaactatt ctaaatgaaa atgactcagt gtttctcgtg gaaaaagtgg
      241 ttttggagaa ggaagaaaca agtcaagttg aagaactgca gtctgaagaa actgctattt
      301 ctgatctctc tgctggtgaa aatattaggc cactggcctt acctgttggg agagcaaggc
      361 agttaattgg gctctatacc atggctcaca atcctaatat gactcatctg aagattaagc
      421 agccagtgac agcccttcct cctctttggg tgagatgtga cggttcagat cctgaaggta
      481 cctgttggct aggagctgag cttatcacaa caaatgacat cattgcaggc gttatcctgt
      541 atgtgctcac ttgtaaagct gataaaaatt actctgaaga tctggaaaat ttaaaaactt
      601 cacacaagaa aagacatcac gtgtctgctg tgacagccag aggctttgcc cagtatgagc
      661 tctttaagtc tgacgacttg gatgacactg ttgccccatc acaaactaca gtcacgctgg
      721 acctttcctg gagccctgtg gatgagatgc tccaaacccc tcccctgtct tcaactgcag
      781 ctctgaatat cagagtacaa tcaggagagt ccagaggttg tctgagtcat cttcacagag
      841 aactgaaatt tctccttgtt ttagctgatg gcatcaggac tggtgtaact gaatggcttg
      901 agcctctgga aacaaaatct gctcttgaat ttgttcagga atttctgaat gacttaaata
      961 aactggatga atttgatgat tctacaaaaa aagataaaca aaaagaggca gtgaaccatg
     1021 acgcagctgc agttgtcagg tccatgcttc tcaccgtgcg gggggatctc gattttgctg
     1081 aacagctttg gtgtagaatg agcagcagtg tggtttccta tcaagacttg gtgaagtgtt
     1141 tcacactcat cctgcagagt cttcagcgtg gtgatataca gccatggttg cacagtggaa
     1201 gtaacagttt actaagtaaa ctcattcatc agtcttacca tggagctatg gacagtgtcc
     1261 ctctctctgg aactacccca ctgcagatgc ttttggaaat tggtttggac aaactgaaga
     1321 aagattatat cagctttttt gtcagtcagg aacttgcatc tttgaatcat ttggaatact
     1381 tcatttctcc ctcagtatcg acacaggaac aggtttgccg tgttcagaaa ctccatcata
     1441 ttcttgaaat cttagtcatc tgcatgcttt tcattaaacc tcagcatgag cttctcttct
     1501 ctttaacaca atcctgcata aaatattata aacaaaatcc tcttgatgag caacacattt
     1561 ttcagttgcc agtcagacca gctgctgtca agaatttgta tcaaagtgag aagccgcaga
     1621 aatggagagt ggagctcagc aatagtcaga agagggtgaa aacagtgtgg caactgagtg
     1681 acagctcccc tgtagaccat tccagtttcc acaggcctga gtttcctgag ctgacactga
     1741 atggtagtct ggaagaaagg acagccttcg ttaacatgct tacctgcagc caggtgcact
     1801 tcaagtaatg cgcactgcgg gcccttgcaa agggtcttct ctccgcacaa aacaaaaagg
     1861 gggaaaagag tgagttaatt ttcagagcct gaaaaataga catcacgtga acttctgcag
     1921 cagaaaagaa gagtgatcct gaagagatgc tttgacagat gaaggtggag aggagatccc
     1981 gtctcagcca cgtctcctga ggagaagtgt cagcatcagg gcagcagtga ggatggagag
     2041 ggcgcagact gtggggacca caatctctga agccacgtgc atgtgcctaa gcaagggctc
     2101 tgaaagggac agatacatcc accagaagtg agctgtgttt tgaaacaaaa gctaaaggag
     2161 atgggccact gcgtttctaa tttttcttat ttgttgtaaa agtgaaccag taaatcaaac
     2221 attattttga aatggagttt tggagccatg ggacaaaggc atcatgttca cttggtatgc
     2281 acacagcttt tgggaatcct taccatcaca caaaacttac atcagtgctg gaaatgtaac
     2341 agaaaatctg gggatgcctg actttggtta tttccctggt attttattaa gcttgagtat
     2401 ggttaatatt tatgctggcg ttgcattaat ctcaaaagat tagcacctat attccatgga
     2461 ttctctcggc tttagtccaa atatttttaa ctgggcatgg cagtacacac ctttaatccc
     2521 agcactgagg aggcagaggc ggcctggtct acagagcaag ttccagaaaa accacagcta
     2581 cacagagaaa ccctgtctca aaaggaaaga caaaaagaat ccctgggaaa cattttcagc
     2641 tttttcagtt tgttattctc aatatactta tatcctcata tattacaatt tctaatggta
     2701 attctaatac ttatttcttt gtaaacacaa aaattcacta aaatgttaaa ttatttgata
     2761 a
//
