LOCUS       NP_001346384             577 aa            linear   ROD 27-APR-2025
DEFINITION  zinc finger-containing ubiquitin peptidase 1 isoform 1 [Mus
            musculus].
ACCESSION   NP_001346384 XP_006512930
VERSION     NP_001346384.1
DBSOURCE    REFSEQ: accession NM_001359455.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 577)
  AUTHORS   Li,T. and Li,S.
  TITLE     MAVS promotes interferon signaling in RNA virus infection by
            ZUFSP-mediated chromatin regulation
  JOURNAL   Int Immunopharmacol 131, 111819 (2024)
   PUBMED   38460305
  REMARK    GeneRIF: MAVS promotes interferon signaling in RNA virus infection
            by ZUFSP-mediated chromatin regulation.
REFERENCE   2  (residues 1 to 577)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077304.1, AK077730.1 and AV316666.1.
            
            On Jan 4, 2018 this sequence version replaced XP_006512930.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089514.1, AK077304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..577
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 18.85 cM"
     Protein         1..577
                     /product="zinc finger-containing ubiquitin peptidase 1
                     isoform 1"
                     /EC_number="3.4.19.12"
                     /note="zinc finger with UFM1-specific peptidase domain
                     protein; lys-63-specific deubiquitinase ZUFSP; ubiquitin
                     carboxyl-terminal hydrolase ZUFSP"
                     /calculated_mol_wt=65462
     Region          124..145
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3T9Z9.2)"
     Region          225..247
                     /region_name="MIU. /evidence=ECO:0000250|UniProtKB:Q96AP4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3T9Z9.2)"
     Region          238..260
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3T9Z9.2)"
     Region          248..273
                     /region_name="zUBD/ZHA.
                     /evidence=ECO:0000250|UniProtKB:Q96AP4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3T9Z9.2)"
     Site            261
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96AP4; propagated from
                     UniProtKB/Swiss-Prot (Q3T9Z9.2)"
     Region          335..550
                     /region_name="Peptidase_C78"
                     /note="Peptidase family C78; pfam07910"
                     /db_xref="CDD:400318"
     Site            486
                     /site_type="other"
                     /note="Involved in the stabilization of negative charge on
                     the oxyanion by the formation of the oxyanion hole.
                     /evidence=ECO:0000250|UniProtKB:Q96AP4; propagated from
                     UniProtKB/Swiss-Prot (Q3T9Z9.2)"
     CDS             1..577
                     /gene="Zup1"
                     /gene_synonym="2700019D07Rik; DUB; Zufsp"
                     /coded_by="NM_001359455.1:261..1994"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS87987.1"
                     /db_xref="GeneID:72580"
                     /db_xref="MGI:MGI:1919830"
ORIGIN      
        1 mlscnicget vnsepdmkah livhmeneii cpfcklsgin yneicfhiet vhfeqnapek
       61 nseklaavqy ghsdrkntnl qstaevtsgi hsacassfpk esseslpkdr tvkheafyte
      121 nitesrkyqk srekkpglse aqgsiyetty sppecpfcgk iegcsqdmei hvktkhasll
      181 esplkdchqp lydcpmcglv ctnyhilqeh vdlhleessf qqgmdrvqcs sdrelahrlq
      241 qeedrkrkse esrqereefq klqrqygldn sggykqqqlr hmelevnrgr mhpsefhsrk
      301 admlesiaig iddgktktsg iiealhryyq ntatdvrcvw lstvvdhfhs sfgdkgwgcg
      361 yrnfqmllss llqsdvygdc lkgmavpcip kiqsmiedaw negfdpqgas qlnnklqgtk
      421 awigaceiyt lltslrvkcr iidfhkstgp lgthprlfew ilnyyssete gtpkivctsk
      481 ppiylqhqgh srtvvgieek knrtlcllvf dpgcpsremq kllkqdmeas slrqlrksvg
      541 nlkhkqyqiv avegvlspee kvarkqasqv ftaekip
//
