LOCUS       NM_001408318            6085 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus zinc finger SWIM-type containing 8 (Zswim8),
            transcript variant 4, mRNA.
ACCESSION   NM_001408318 XM_006519038
VERSION     NM_001408318.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6085)
  AUTHORS   Shi,C.Y., Elcavage,L.E., Chivukula,R.R., Stefano,J., Kleaveland,B.
            and Bartel,D.P.
  TITLE     ZSWIM8 destabilizes many murine microRNAs and is required for
            proper embryonic growth and development
  JOURNAL   Genome Res 33 (9), 1482-1496 (2023)
   PUBMED   37532519
  REMARK    GeneRIF: ZSWIM8 destabilizes many murine microRNAs and is required
            for proper embryonic growth and development.
REFERENCE   2  (bases 1 to 6085)
  AUTHORS   Jones,B.T., Han,J., Zhang,H., Hammer,R.E., Evers,B.M., Rakheja,D.,
            Acharya,A. and Mendell,J.T.
  TITLE     Target-directed microRNA degradation regulates developmental
            microRNA expression and embryonic growth in mammals
  JOURNAL   Genes Dev 37 (13-14), 661-674 (2023)
   PUBMED   37553261
REFERENCE   3  (bases 1 to 6085)
  AUTHORS   Shi,C.Y., Kingston,E.R., Kleaveland,B., Lin,D.H., Stubna,M.W. and
            Bartel,D.P.
  TITLE     The ZSWIM8 ubiquitin ligase mediates target-directed microRNA
            degradation
  JOURNAL   Science 370 (6523) (2020)
   PUBMED   33184237
REFERENCE   4  (bases 1 to 6085)
  AUTHORS   Wang,Z., Hou,Y., Guo,X., van der Voet,M., Boxem,M., Dixon,J.E.,
            Chisholm,A.D. and Jin,Y.
  TITLE     The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein
            quality of the SAX-3/Robo receptor in developing neurons
  JOURNAL   Neuron 79 (5), 903-916 (2013)
   PUBMED   24012004
REFERENCE   5  (bases 1 to 6085)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121599.3.
            
            On Jun 15, 2022 this sequence version replaced XM_006519038.5.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               AC121599.3         78149-78641
            494-647             AC121599.3         81222-81375
            648-742             AC121599.3         81613-81707
            743-915             AC121599.3         82043-82215
            916-1023            AC121599.3         82376-82483
            1024-1105           AC121599.3         82622-82703
            1106-1226           AC121599.3         82827-82947
            1227-1428           AC121599.3         83561-83762
            1429-1604           AC121599.3         83915-84090
            1605-2589           AC121599.3         84468-85452
            2590-2721           AC121599.3         86537-86668
            2722-2901           AC121599.3         86807-86986
            2902-3085           AC121599.3         87084-87267
            3086-3184           AC121599.3         87495-87593
            3185-3309           AC121599.3         88453-88577
            3310-3550           AC121599.3         89012-89252
            3551-3709           AC121599.3         89345-89503
            3710-3938           AC121599.3         89582-89810
            3939-4231           AC121599.3         89965-90257
            4232-4455           AC121599.3         90398-90621
            4456-4944           AC121599.3         91756-92244
            4945-5128           AC121599.3         92455-92638
            5129-5305           AC121599.3         92728-92904
            5306-5425           AC121599.3         93045-93164
            5426-5604           AC121599.3         93413-93591
            5605-6085           AC121599.3         93724-94204
FEATURES             Location/Qualifiers
     source          1..6085
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.53 cM"
     gene            1..6085
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /note="zinc finger SWIM-type containing 8"
                     /db_xref="GeneID:268721"
                     /db_xref="MGI:MGI:1919156"
     exon            1..493
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            494..647
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            648..742
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            743..915
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1023
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1105
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1226
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1428
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1604
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..2589
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2721
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2901
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3085
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3184
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3309
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3550
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3709
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3938
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            3939..4231
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4455
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            4456..4944
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            4945..5128
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            5129..5305
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            5306..5425
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            5426..5604
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     exon            5605..6085
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6064..6069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /note="hexamer: TATAAA"
     polyA_site      6085
                     /gene="Zswim8"
                     /gene_synonym="2310021P13Rik; 4832404P21Rik; Kiaa0913;
                     mKIAA0913"
                     /note="major polyA site"
ORIGIN      
        1 aggcggcgcc gcagccgcct agaggccctg gccgcccagc gcttcgtccc ggcctcgagt
       61 ctcgcaggct ggccacaatc cccgctcgca cctcgctgtt gggtgaggcc cggcccggtg
      121 tccctcccag gcccgagatc cttgcccggc acggccgccc tgagcgcccc ggccaccccc
      181 agccccggct cgcccctcag gccccgggcc tcccctcagt ccccggccgg cggcccaggc
      241 cccggatccg cggggggaga cccggccccg gggggtgcgg gccccatgga gctgatgttc
      301 gcggagtggg aggacggcga gcgcttctcg tttgaggatt ccgaccgctt tgaggaggat
      361 tcactctgtt cgttcatttc cgaggccgag agcctttgcc agaactggcg aggatggcgc
      421 aaacagtcag cggggcccaa ttcccccact ggaggcggtg gcggaggtgg cagtggcggt
      481 accagaacgc gagatggatt ggtaatccca ttggtggagc tgtcagcaaa gcaggtggca
      541 tttcacatcc catttgaagt ggtagagaaa gtttatcctc cagtgccaga acaactccaa
      601 ctccgaattg ctttttggag cttccctgag aatgaagagg acattcgtct gtattcatgc
      661 ctagccaatg gcagtgcgga tgagtttcag cgaggggatc agctgttccg aatgagggct
      721 gtgaaagacc cgctgcagat agggttccat ctgagcgcca cagtggtacc accgcaaatg
      781 gtcccaccca agggggccta caatgtagct gtgatgtttg accgctgccg ggtcacttct
      841 tgtagctgta cctgtggggc cggggccaaa tggtgcaccc atgtcgtggc actctgcctc
      901 ttccgcattc acaacgcatc tgcagtctgc ctgcgggctc cagtctcaga gtccctgtct
      961 cggctacaaa gggaccagct tcaaaaattt gctcagtacc ttatcagtga gcttcctcag
     1021 cagattctcc ccacagccca gcgtcttcta gacgagctcc tttcctccca gtccacagcc
     1081 atcaacacag tgtgtggggc tccggaccct acagcagggc cctcagcttc agaccagagc
     1141 acttggtatt tggatgagtc aacactcact gacaacataa agaagacact acataagttc
     1201 tgtggcccct cccctgtggt cttcagtgat gtaaactcta tgtatctctc ttccacggaa
     1261 cctcctgctg ctgctgagtg ggcatgtctg ctgcggcctc tgaggggtcg agagcctgag
     1321 ggtgtctgga acctgcttag cattgttcga gagatgttca agcgaaggga cagcaatgct
     1381 gcccccttgc tggaaatact cactgaccag tgcctcacct atgaacagat aacaggctgg
     1441 tggtatagtg tgcgcacctc agcttcacac agcagtgcca gtggtcacac aggccgtagc
     1501 aatgggcagt cagaggtagc agcccatgca tgtgcaagta tgtgcgacga gatggttacc
     1561 ctctggaggc tggctgtgct ggaccctgcc ctcagccctc agcgccgccg ggaactgtgt
     1621 gcacagctgc gtcagtggca actgaaggtg attgagaatg tcaagcgggg ccagcacaag
     1681 aagaccctag agaggctctt ccctggcttc cggccagctg tggaggcctg ctactttaac
     1741 tgggaagagg cttatcctct tcctggtgtt acctacagtg gcactgaccg gaagctagcc
     1801 ctgtgctggg cccgggccct gcctgccagg ccaggagcct ctagatctgg gggcctggaa
     1861 gagtcccggc cccgacctct tcctactgag ccagctgtga ggcccaagga acctggggcc
     1921 aaacgcaaag gattgggtga ggggatctcc tcacagcggg gcccccgccg cctctctgcc
     1981 gaaggaggag ataaggctct gcataagatg ggtccaagtg ggggcaaagc caaggtactg
     2041 ggtgggactg gcagcggggg caagagctca gcaggcagtg ggagcaaacg gcggctaagc
     2101 agtgaagaca gctccctgga accagacctg gcagagatga gcctggatga cagcagcctg
     2161 gccctgggtg cagaggccag cacctttggt ggattccctg agagccctcc accctgtcct
     2221 tcctcggttg gctccagagg accttccacc ttccttcctg agcccccaga tacttatgag
     2281 gaagatgctg gtgtgtactt ttcagaagga cctgagcctc ccacagcctc tgcagaccac
     2341 cctggtctgc tgcctgggga ggtctgtacc cgagatgacc tcccttccac agacgacagt
     2401 ggcagtgggc tacacaaaac caaagaagca gctcctgcag ttggagagga ggatgacgac
     2461 taccaagcat attacctgaa tgcccaggat ggggctggag gcgaggagga gaaggcggag
     2521 ggcgggactg gggaggagca tgacctgttt gctggtttga agccactgga acaggagagc
     2581 cgaatggagg tgttgtttgc ctgcgctgag gccctgcatg cccatggcta cagcaatgag
     2641 gcctcccgcc tcactgtgga gcttgcccag gacctgctag ccaacccacc tgacctcaag
     2701 gtagagccgc cccctgccaa gggcaagaaa aacaaggtgt ccacaagccg tcagacctgg
     2761 gtggctacca acactctgac caaagcagcc ttcctgttga cagtgcttag tgagcgccct
     2821 gagcaccaca gcctggcctt ccgagttggc atgtttgcgc tggagctaca gcggcctcct
     2881 gcttcaacca aggccttgga ggtaaaattg gcatatcagg aatctgaggt agctgctctg
     2941 ctcaagaaga tccctcgggg ccccagtgaa atgagtacca ttcgatgccg ggcagaagaa
     3001 cttcgggagg gtacactgtg tgactatcgg cctgtcttgc ccctcatgtt ggccagtttc
     3061 atctttgatg ttctctgtgc tccagtggtt tctctcacgg gttcccggcc cccaagtcga
     3121 aactggacta acgagatgcc tggagatgag gagctaggat ttgaagcagc agttgctgcc
     3181 ttgggcatga agacaacagt gagtgaggca gaacatcccc tcctatgtga aggcacacgt
     3241 cgggagaagg gtgacctggc cttagcactc atgatcacct acaaggatga ccaggccaag
     3301 ctcaagaaga tcctagacaa actcttggac cgagaaagcc agacacataa gccacagacc
     3361 ctgagttctt tctactcatc cagccggccg gccacagcca accagagatc tccttcaaag
     3421 cacggggccc catctgctcc cggggccctg cagccactga cttcaagctc tgcagggcct
     3481 gctcagccag ggaatgtggc aggggctggg ccaggtccca ctgagggctt cacagagaag
     3541 aatgtacccg aaagttcccc acattccccc tgtgaaggtc tcccacctga ggcagctttg
     3601 actccacggc cggaggggaa ggttcctagc cgcctagcac ttggcagtcg tggaggttat
     3661 aatggtcgag gttggggctc tccagggcgg cccaaaaaga aacacacagg catggccagc
     3721 attgacagca gtgcccctga aaccacatcg gacagctctc ctaccttaag ccgacggcca
     3781 cttcgagggg gctgggcccc tacttcttgg ggtcgaggac aagacagtga cagcattagc
     3841 agctcttcct cagactctct gggctcttca tcctccagtg gaagccgccg ggctagtgcc
     3901 agtggagggg cccgggcaaa gacagttgac gttggcaggt gttacaaagg ccgccgccct
     3961 gagagtcatg ccccccacgt acccaatcag ccgtcagagg cagctgcaca cttctacttc
     4021 gaattggcga agacagttct gatcaaggca gggggcaaca gcagcacctc cattttcaca
     4081 catccatctt cctcaggagg ccaccagggt cctcaccgca acctgcacct ttgcgccttt
     4141 gagattgggc tttatgccct aggcctgcat aactttgttt ctcctaactg gctctctcgt
     4201 acctattctt cccatgtatc ctggattaca gggcaggcca tggagattgg cagtgcagcc
     4261 ttgactatac tggtagaatg ctgggatggg cacctgacac cccctgaggt tgcatcgctg
     4321 gccgacagag cgtcacgggc acgagactcc aacatggtga gggcagcggc agagctggct
     4381 ctaagctgcc tgcctcatgc ccacgcactg aaccccaatg agattcagcg ggccttggtg
     4441 cagtgcaagg aacaggataa cctgatgttg gagaaggcct gcatggccgt ggaagaggca
     4501 gccaagggtg ggggcgtata ccctgaagtg ctgtttgagg ttgctcatca gtggttctgg
     4561 ctttatgagg agacagcagg cggctcgtcc acagctcgtg aaggggctac aagctgtagt
     4621 ggcagtggga tgagggccgc tggggaggct gggcggggac tccctgaggg taggggtgcc
     4681 ccagggactg aacctgttac agtggctgcg gcagcagtga cagcagcagc cacagtggtt
     4741 ccggtcatct cagtggggtc cagtttatat ccaggtccag gactggggca tggccactcc
     4801 cctggcctgc acccctacac tgctctccag ccccacttgc cctgcagccc tcagtacctc
     4861 acccacccag ctcaccctgc ccaccctatg cctcatatgc cccggcctgc cgtcttccct
     4921 gtgcccagct ctgcataccc acagggtgtg catcctgcat tcctgggggc gcaataccct
     4981 tactcagtga ctcctccctc gcttgctgcc acagctgtat ctttccctgt cccttccatg
     5041 gctcccatca cagtccatcc ttaccacaca gaaccagggc tcccactgcc caccagtgtg
     5101 gcctgtgagt ttcggggaca gggagcagtg agcagtgtcc atccagcatc tacgtttcca
     5161 gccatccagg gtgcctcact gcctgctctg accacacagc ccagccctct ggtaagcggg
     5221 ggttttccac cacccgaaga ggagacacac agtcaaccgg tcaatccaca tagcctgcac
     5281 catctgcatg ctgcttaccg tgttgggatg ctggcactgg agatgctagg tcgccgggca
     5341 cacaacgatc accccaacaa cttttcccgc tccccccctt acactgatga tgtcaaatgg
     5401 ttgctggggc tggcagcaaa gctgggagtg aactacgtgc accagttctg tgtgggggca
     5461 gccaaggggg tgctgagccc gtttgtgctg caggagatcg tcatggagac gctgcagcgg
     5521 ctgaacccca ttcatgccca caaccacctt cgagccccgg ccttccacca actggtgcag
     5581 cgctgtcagc aggcatacat gcagtacatc catcaccgct taattcacct gactcctgcc
     5641 gactacgacg actttgtgaa tgcaatccgc agcgctcgca gcgccttctg cctgacaccc
     5701 atgggcatga tgcagttcaa cgacatccta cagaacctca aacgcagcaa acagaccaag
     5761 gagttgtggc agcgggtctc tctggagata accaccttct ccccctgagt ctggtccctg
     5821 gagggcccta tttagggaca caggcctgtg gctatgggga gccctcacac agagggtcag
     5881 gcgactcttg gctggacaga tcatccccac tcaattccct tgtagcccag actggcagct
     5941 gctcttgggc tgtagcttgg ggccaagatg tctcagacct tagaagtcta gggttggggg
     6001 agacagcttt gtctgggaga gggcgttggg tggcctctgg tatttatttg gcatttataa
     6061 atatataaac tcctttttta ctcta
//
