LOCUS       NM_178375               2711 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger SWIM-type containing 3 (Zswim3), mRNA.
ACCESSION   NM_178375
VERSION     NM_178375.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2711)
  AUTHORS   Li,H.D., Chen,X., Xu,J.J., Du,X.S., Yang,Y., Li,J.J., Yang,X.J.,
            Huang,H.M., Li,X.F., Wu,M.F., Zhang,C., Zhang,C., Li,Z., Wang,H.,
            Meng,X.M., Huang,C. and Li,J.
  TITLE     DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in
            alcohol-induced liver injury via regulating TRAF2-mediated
            NF-kappaB pathway
  JOURNAL   Clin Sci (Lond) 134 (14), 1935-1956 (2020)
   PUBMED   32639005
  REMARK    GeneRIF: DNMT3b-mediated methylation of ZSWIM3 enhances
            inflammation in alcohol-induced liver injury via regulating
            TRAF2-mediated NF-kappaB pathway.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC023287.1.
            
            On Jun 3, 2003 this sequence version replaced NM_178375.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023287.1, SRR1660819.95645.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.27 cM"
     gene            1..2711
                     /gene="Zswim3"
                     /gene_synonym="4921517A06Rik"
                     /note="zinc finger SWIM-type containing 3"
                     /db_xref="GeneID:67538"
                     /db_xref="MGI:MGI:1914788"
     exon            1..318
                     /gene="Zswim3"
                     /gene_synonym="4921517A06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2251
                     /gene="Zswim3"
                     /gene_synonym="4921517A06Rik"
                     /note="zinc finger, SWIM domain containing 3"
                     /codon_start=1
                     /product="zinc finger SWIM domain-containing protein 3"
                     /protein_id="NP_848462.1"
                     /db_xref="CCDS:CCDS17058.1"
                     /db_xref="GeneID:67538"
                     /db_xref="MGI:MGI:1914788"
                     /translation="MELGSCFKTYEDFKECFSAYKKETRCSFIVRDCISVRFHNLNNG
                     TSFREDILYVQVKFVCIRTQSNRKKTRKVDRCPAYLLLQYNETLDRLFISELNTQHIH
                     ADSNASGGIPASKPQAICLHKLPPVQLSIRKDLDTAEKPSVEPSFCLDKIHKPSNPEQ
                     EGISPSDMAKIAKVMKNFLTVDEGSMASFSVGTSQDLDRLSFQSSKMSDLFARFPETL
                     LLHRVENSQGHILYAFLVENKERESRVVHFAVLKAETAPSVAKMLNIFTEFNSDWPKV
                     KMVFVDPSFPHRAILQEIFPSARTLLSIYHTTRLLEKKLHQSSVNASFKRLMKEALRE
                     AVFVSSDASLKNLCEMSQVLLDEELFSFLQAHWFSCELLWYIHVRKGLHACNTYMDSL
                     DIVTSKVSSLFREQRSLLDCILHFVDYIDFFNTKGLKSLPTNAPKLRRTRLPSTPPRP
                     KKPFRICGGGDTRLPVEEVEETKADSAQSQLPQPQDQSSKAGMLDILHQSGSELAYKL
                     CHNEWEVVQNSTHLVDEAGSSVAVQLLENSHQVSKDGCSCSCSFQQCYHLPCRHILAL
                     LHTSQQPVGEAMVCCRWQKKYQHLLDPNGELQDRGIIPNTDQPEKQGQNHMIRDLSRE
                     LANLLMQTEGPELEERCSTLRKIVDIWADPYQLPESSQQPVDFRDVGCLPFLWGKLEE
                     ADSPPLAEAMVHD"
     exon            319..2689
                     /gene="Zswim3"
                     /gene_synonym="4921517A06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2666..2671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zswim3"
                     /gene_synonym="4921517A06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2689
                     /gene="Zswim3"
                     /gene_synonym="4921517A06Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcgccccta ggttgctgtt accggtctcc tcctgttctg ggctcctccc aagcgccctg
       61 taagccactc actcgggacc gcagctgggc ccgtgccagc cgttacccag tgacctctga
      121 cccctgccgt ggttctaggt tctaggaggg ccagtccccg gccatggagc taggcagctg
      181 ctttaagacc tacgaggact tcaaggagtg tttcagcgcc tacaaaaagg agaccaggtg
      241 ctccttcatt gtcagggact gcatctccgt ccgcttccat aacctcaaca acggcacctc
      301 tttccgcgag gatatcctat atgtgcaggt gaaatttgtc tgtattcgga cgcagtcaaa
      361 caggaagaaa actcggaagg tggacaggtg tccagcgtat ctgctgctgc aatacaacga
      421 gactctagat agactgttta tcagtgagtt gaatacccag cacattcatg ctgactctaa
      481 tgcttctgga ggaatccctg ctagcaagcc tcaggcaata tgtctacaca aactcccgcc
      541 ggtgcagctc agcatcagga aagaccttga tacagcagag aagccctcag tagagccgtc
      601 attttgcctc gataagatac acaagccctc aaatccagaa caggagggca tcagtccttc
      661 tgatatggcc aagatagcaa aagtgatgaa gaactttctt accgtggacg agggctcaat
      721 ggcctccttc agtgtgggca ccagccaaga cctagaccga ctcagcttcc agagcagcaa
      781 gatgagtgac ctgttcgccc gattcccaga gacactcttg ctgcaccggg tggaaaacag
      841 ccagggccat attctgtatg ctttcttggt ggagaacaag gagcgagaga gtcgagtggt
      901 gcacttcgct gtgctcaagg ctgagacagc gccttctgtg gccaagatgc tcaatatctt
      961 tacagaattc aactctgatt ggcccaaggt caagatggtc tttgtggacc cttcattccc
     1021 tcaccgagcg atcttacagg agatcttccc ctctgcccgc actctcctct ctatctacca
     1081 caccactcgt ctcttggaga agaagttaca ccagagttca gtaaatgcgt cttttaaaag
     1141 gctcatgaaa gaagctctgc gggaagctgt gtttgtctct tctgatgcaa gcctaaaaaa
     1201 tctctgtgag atgtcccaag tcctactaga tgaggaactc ttcagtttcc tccaggccca
     1261 ttggttctcc tgtgaactgc tgtggtacat acatgtgagg aagggcctgc atgcatgtaa
     1321 cacctacatg gacagcctag acatagtcac cagcaaggtg tcaagcctct ttcgggaaca
     1381 gcggtctctg ctggactgca tccttcactt tgtggattac atagacttct ttaataccaa
     1441 aggtctgaag agcttgccca caaatgctcc caagttaagg agaactcggc tcccaagcac
     1501 gcctccaagg cccaagaagc cttttagaat ttgtggtggg ggtgacacca ggctccctgt
     1561 ggaagaggta gaagagacaa aggcagactc agcacagtct cagttgccac agccccagga
     1621 tcagtcctcc aaggctggca tgctagacat cttgcaccag agtggctctg aactagccta
     1681 caagttgtgt cataatgagt gggaggtggt acagaattcc acccacctgg tagacgaggc
     1741 cggctcctca gtggctgttc agctgctaga gaactcacac caggtgagca aagatggctg
     1801 tagctgcagc tgctcctttc aacagtgcta ccatctgcca tgccgccaca ttttggctct
     1861 gttgcatacc agccagcagc cagtagggga agccatggtg tgctgccggt ggcagaagaa
     1921 ataccagcac ctccttgacc ccaatgggga gctgcaagac cgtggaatca tcccaaacac
     1981 agatcagcct gaaaagcaag gtcagaacca catgattcgg gacctaagca gggagctggc
     2041 aaacctgctg atgcagaccg aggggccaga gctggaggag cgctgctcca ccctgcgcaa
     2101 gattgtggac atctgggcag acccctatca gctgcctgag tccagtcagc agccagttga
     2161 cttcagagac gtgggctgcc tccctttcct ctggggaaag ctagaggaag cagacagccc
     2221 ccctcttgct gaagccatgg ttcatgattg aagtgtttgt actagtgaac ccatctcaga
     2281 accaccttgg gacagttcaa agtggtgggt cagactgtag gtcagtattt ttatcagtgt
     2341 cttcctaggt aagggctaag aagatcttaa aactcggggg agagggactc cactgtgaca
     2401 atcctttgac cctgcctcat ttcagcccta cctttggcgt tctgtagaca ccttgttcat
     2461 tgttcaaagc caaagttatt ccatatgaaa gggcatgctc ctttcttccc agcctacaca
     2521 gacgaaccct tgcccaggtt aggataaaca caatgggccc ggaaaggagc tttgtgtcca
     2581 gagacagagg gggaggaggg tagcccttga ttgtcaactg ttgctgctct ttagaaaata
     2641 cctgttacgt atttttattc acactaataa agtcggtttt tgttttgtta aaaaaaaaaa
     2701 aaaaaaaaaa a
//
