LOCUS       NM_011757               2321 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger and SCAN domain containing 21 (Zscan21),
            transcript variant 1, mRNA.
ACCESSION   NM_011757
VERSION     NM_011757.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2321)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2321)
  AUTHORS   Yan,Z., Fan,D., Meng,Q., Yang,J., Zhao,W., Guo,F., Song,D., Guo,R.,
            Sun,K. and Wang,J.
  TITLE     Transcription factor ZFP38 is essential for meiosis prophase I in
            male mice
  JOURNAL   Reproduction 152 (5), 431-437 (2016)
   PUBMED   27492080
REFERENCE   3  (bases 1 to 2321)
  AUTHORS   Lessard,J.C., Kalinin,A., Bible,P.W. and Morasso,M.I.
  TITLE     Calmodulin 4 is dispensable for epidermal barrier formation and
            wound healing in mice
  JOURNAL   Exp Dermatol 24 (1), 55-57 (2015)
   PUBMED   25316000
REFERENCE   4  (bases 1 to 2321)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2321)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2321)
  AUTHORS   Przyborski,S.A., Knowles,B.B. and Ackerman,S.L.
  TITLE     Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion
            during the formation of the rostral cerebellar boundary
  JOURNAL   Development 125 (1), 41-50 (1998)
   PUBMED   9389662
REFERENCE   7  (bases 1 to 2321)
  AUTHORS   Yang,X.W., Zhong,R. and Heintz,N.
  TITLE     Granule cell specification in the developing mouse brain as defined
            by expression of the zinc finger transcription factor RU49
  JOURNAL   Development 122 (2), 555-566 (1996)
   PUBMED   8625807
REFERENCE   8  (bases 1 to 2321)
  AUTHORS   Noce,T., Fujiwara,Y., Ito,M., Takeuchi,T., Hashimoto,N.,
            Yamanouchi,M., Higashinakagawa,T. and Fujimoto,H.
  TITLE     A novel murine zinc finger gene mapped within the tw18 deletion
            region expresses in germ cells and embryonic nervous system
  JOURNAL   Dev Biol 155 (2), 409-422 (1993)
   PUBMED   8432396
REFERENCE   9  (bases 1 to 2321)
  AUTHORS   Chowdhury,K., Goulding,M., Walther,C., Imai,K. and Fickenscher,H.
  TITLE     The ubiquitous transactivator Zfp-38 is upregulated during
            spermatogenesis with differential transcription
  JOURNAL   Mech Dev 39 (3), 129-142 (1992)
   PUBMED   1284028
REFERENCE   10 (bases 1 to 2321)
  AUTHORS   Noce,T., Fujiwara,Y., Sezaki,M., Fujimoto,H. and Higashinakagawa,T.
  TITLE     Expression of a mouse zinc finger protein gene in both
            spermatocytes and oocytes during meiosis
  JOURNAL   Dev Biol 153 (2), 356-367 (1992)
   PUBMED   1397691
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY293243.1, DV651309.1, AK146875.1, BY654936.1 and AI326272.1.
            
            On Oct 2, 2013 this sequence version replaced NM_011757.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1,2,3 and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146875.1, SRR3224856.2472.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY293243.1         1-11
            12-40               DV651309.1         25-53
            41-2269             AK146875.1         2-2230
            2270-2317           BY654936.1         372-419
            2318-2321           AI326272.1         4-7                 c
FEATURES             Location/Qualifiers
     source          1..2321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.96 cM"
     gene            1..2321
                     /gene="Zscan21"
                     /gene_synonym="CTfin51; RU49; Zfp-38; Zfp38; Zipro1"
                     /note="zinc finger and SCAN domain containing 21"
                     /db_xref="GeneID:22697"
                     /db_xref="MGI:MGI:99182"
     exon            1..103
                     /gene="Zscan21"
                     /gene_synonym="CTfin51; RU49; Zfp-38; Zfp38; Zipro1"
                     /inference="alignment:Splign:2.1.0"
     exon            104..188
                     /gene="Zscan21"
                     /gene_synonym="CTfin51; RU49; Zfp-38; Zfp38; Zipro1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..901
                     /gene="Zscan21"
                     /gene_synonym="CTfin51; RU49; Zfp-38; Zfp38; Zipro1"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1939
                     /gene="Zscan21"
                     /gene_synonym="CTfin51; RU49; Zfp-38; Zfp38; Zipro1"
                     /note="transcription factor RU49; zinc finger protein 38;
                     zinc finger proliferation 1"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein
                     21"
                     /protein_id="NP_035887.2"
                     /db_xref="CCDS:CCDS19790.1"
                     /db_xref="GeneID:22697"
                     /db_xref="MGI:MGI:99182"
                     /translation="MTKVVGMATVLGPRPPQESMGPSPIKVEEDEEKDKCCPTLELSH
                     KHFRQSGNQDTLEPMGPSTIKAEEDESKDKCRPNLEISRKSFKQFGYQDTLEQLGPST
                     IKAEEDDEKDKGHPSPEISRQRFRQFGYHDTPGPREALSQLRVLCCEWLQPEIHTKEQ
                     ILELLVLEQFLTILPRELQTWVQQHCPESAEEAVTLLEDLEQELDEPGLQVSSPPNEQ
                     KQSWEKMSTSGTAMESLSSTETQHVDASPKYEFWGPLYIQETGEEEVFTQDPRKRQGF
                     KSNPQKEDSADEHRSSEEESHADGLKRTVIPMIPANKYGSRSERQWANNLERERGTKA
                     SLQDTGSRKGAEPASTRPAPGEKRYICAECGKAFSNSSNLTKHRRTHTGEKPYVCTKC
                     GKAFSHSSNLTLHYRTHLVDRPYDCKCGKAFGQSSDLLKHQRMHTEEAPYQCKDCGKA
                     FSGKGSLIRHYRIHTGEKPYQCNECGKSFSQHAGLSSHQRLHTGEKPYKCKECGKAFN
                     HSSNFNKHHRIHTGEKPYWCSHCGKTFCSKSNLSKHQRVHTGEGEVQ"
     exon            902..1094
                     /gene="Zscan21"
                     /gene_synonym="CTfin51; RU49; Zfp-38; Zfp38; Zipro1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..2321
                     /gene="Zscan21"
                     /gene_synonym="CTfin51; RU49; Zfp-38; Zfp38; Zipro1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2253..2258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zscan21"
                     /gene_synonym="CTfin51; RU49; Zfp-38; Zfp38; Zipro1"
                     /note="hexamer: AATAAA"
     polyA_site      2270
                     /gene="Zscan21"
                     /gene_synonym="CTfin51; RU49; Zfp-38; Zfp38; Zipro1"
                     /note="major polyA site"
     regulatory      2296..2301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zscan21"
                     /gene_synonym="CTfin51; RU49; Zfp-38; Zfp38; Zipro1"
                     /note="hexamer: GATAAA"
     polyA_site      2317
                     /gene="Zscan21"
                     /gene_synonym="CTfin51; RU49; Zfp-38; Zfp38; Zipro1"
ORIGIN      
        1 ggggcggggc tctgacgcgc ttccggtggt gctgtcgttc agccgctgtg aggattccag
       61 actccaaagc ggttctgagt cacggtgagc ctgcgagtcc cagtgctgta attacaggta
      121 tgcaccacca cgacttcagc ttggagtttc caagtgcaga gtgtcttaag ggcattatct
      181 actacaaggt ttgaagagtg gcactttaag aaccagaaac ccaaaggtac caggtctact
      241 cctaaaagtc ctgctggctc gggaatctgt gatgactaag gtggtgggca tggccacagt
      301 tctgggcccc aggccacctc aggaatctat gggaccttcg cccattaaag tagaagagga
      361 tgaagagaaa gacaagtgct gccctaccct agagctatcc cataagcact tcagacagtc
      421 tgggaaccaa gatacccttg agccaatggg tccttcgacc attaaagctg aagaggatga
      481 aagcaaagac aagtgccgcc ctaacctaga gatatcccgt aagagcttca agcagtttgg
      541 gtaccaagac actcttgagc agttgggacc ttcgaccatt aaagctgaag aggatgatga
      601 gaaggataag ggccacccta gcccagagat atctcgacag cgcttcaggc aatttgggta
      661 ccatgacact cctgggcccc gagaggcact gagccagctt cgggtgctct gctgtgagtg
      721 gctacagccc gagatccaca ccaaagagca gattctagag ctactggttc tggagcagtt
      781 cctgaccatc ctgccccgag agctccagac ctgggtacag cagcactgcc ctgaaagtgc
      841 agaggaggcc gtcactctcc tggaagacct ggagcaagaa cttgatgagc caggactgca
      901 ggtctcatct cctccaaatg aacagaagca gtcttgggag aaaatgtcaa cttcaggaac
      961 ggcaatggag tccttaagca gtactgagac ccaacatgtg gatgccagcc ctaaatatga
     1021 gttttggggg cccctgtaca tccaagagac tggtgaggag gaggttttta ctcaggatcc
     1081 aagaaagcgc caaggtttta aatcgaatcc ccagaaggag gactcagcag atgagcacag
     1141 aagttctgaa gaagagtctc atgcagacgg actcaaaaga accgtcatcc ccatgattcc
     1201 tgccaataag tatgggtcac ggtcagaaag gcagtgggcc aacaacctgg agagggagag
     1261 agggacaaaa gcctctcttc aagacacagg ttccaggaaa ggggcagagc cagcgtctac
     1321 taggcctgcc ccaggagaga aacgttacat atgtgcagag tgtgggaagg cctttagcaa
     1381 tagctcaaac ctcactaagc accggagaac acacactggg gagaagcctt atgtgtgtac
     1441 aaagtgtggg aaggctttca gccacagctc caaccttacc cttcattacc gaactcacct
     1501 ggtggaccgg ccctatgact gtaagtgtgg gaaagccttt gggcagagct cagacctcct
     1561 taaacatcaa aggatgcaca cggaagaggc gccctatcag tgtaaagact gtgggaaagc
     1621 ctttagtggg aagggcagcc tcattcgaca ctatcgcatc cacacagggg agaagcccta
     1681 tcagtgtaat gagtgtggaa agagttttag tcagcatgca ggtctcagtt ctcatcagcg
     1741 tctgcataca ggggagaaac cctataagtg taaggagtgt ggcaaagcct tcaaccatag
     1801 ttcaaatttt aataagcatc atagaatcca tactggcgaa aagccctatt ggtgtagcca
     1861 ctgtgggaaa accttctgta gcaagtccaa tctgtccaag catcagagag ttcacactgg
     1921 agagggagaa gtccagtaac ggtccattct cgtctgttgt tctcgttgta aacgttagaa
     1981 tgcgaatgct aggaagaagc tctgtaatgc atttgatgtt tgatagtagg ttttgctgta
     2041 gtcatcaagg gtgccttgga gggagagcta cacagtgata gagcagacag gaggtctaca
     2101 gaggagcagg gagctccaca cactccaggc cccagtgtac tgtgtgtcca gtatagttaa
     2161 ggaagaaaca ttaaaattgt ttaactgttt taacatgtat cccacagttg tagtttgtaa
     2221 agaattgagc caccttgaac agtctgattc agaataaacg tatagcatca tgtagcgtct
     2281 caggactgtt attgtgataa acaatgttgc tataaaactt g
//
