LOCUS       NM_001289481            2639 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus zinc finger and SCAN domain containing 10 (Zscan10),
            transcript variant 2, mRNA.
ACCESSION   NM_001289481 XM_006524446
VERSION     NM_001289481.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2639)
  AUTHORS   Laugwitz,L., Cheng,F., Collins,S.C., Hustinx,A., Navarro,N.,
            Welsch,S., Cox,H., Hsieh,T.C., Vijayananth,A., Buchert,R.,
            Bender,B., Efthymiou,S., Murphy,D., Zafar,F., Rana,N.,
            Grasshoff,U., Falb,R.J., Grimmel,M., Seibt,A., Zheng,W., Ghaedi,H.,
            Thirion,M., Couette,S., Azizimalamiri,R., Sadeghian,S.,
            Galehdari,H., Zamani,M., Zeighami,J., Sedaghat,A., Ramshe,S.M.,
            Zare,A., Alipoor,B., Klee,D., Sturm,M., Ossowski,S., Houlden,H.,
            Riess,O., Wieczorek,D., Gavin,R., Maroofian,R., Krawitz,P.,
            Yalcin,B., Distelmaier,F. and Haack,T.B.
  TITLE     ZSCAN10 deficiency causes a neurodevelopmental disorder with
            characteristic oto-facial malformations
  JOURNAL   Brain 147 (7), 2471-2482 (2024)
   PUBMED   38386308
  REMARK    GeneRIF: ZSCAN10 deficiency causes a neurodevelopmental disorder
            with characteristic oto-facial malformations.
REFERENCE   2  (bases 1 to 2639)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2639)
  AUTHORS   Yanagihara,Y., Inoue,K., Saeki,N., Sawada,Y., Yoshida,S., Lee,J.,
            Iimura,T. and Imai,Y.
  TITLE     Zscan10 suppresses osteoclast differentiation by regulating
            expression of Haptoglobin
  JOURNAL   Bone 122, 93-100 (2019)
   PUBMED   30771488
  REMARK    GeneRIF: Zscan10 negatively regulates osteoclast differentiation
            through transcription of Hp.
REFERENCE   4  (bases 1 to 2639)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2639)
  AUTHORS   Skamagki,M., Correia,C., Yeung,P., Baslan,T., Beck,S., Zhang,C.,
            Ross,C.A., Dang,L., Liu,Z., Giunta,S., Chang,T.P., Wang,J.,
            Ananthanarayanan,A., Bohndorf,M., Bosbach,B., Adjaye,J.,
            Funabiki,H., Kim,J., Lowe,S., Collins,J.J., Lu,C.W., Li,H., Zhao,R.
            and Kim,K.
  TITLE     ZSCAN10 expression corrects the genomic instability of iPSCs from
            aged donors
  JOURNAL   Nat Cell Biol 19 (9), 1037-1048 (2017)
   PUBMED   28846095
  REMARK    GeneRIF: The pluripotency factor ZSCAN10 is poorly expressed in
            A-iPSCs and addition of ZSCAN10 to the four Yamanaka factors (OCT4,
            SOX2, KLF4 and c-MYC) during A-iPSC reprogramming normalizes
            ROS-glutathione homeostasis and the DNA damage response, and
            recovers genomic stability.
            Erratum:[Nat Cell Biol. 2019 Apr;21(4):531-532. doi:
            10.1038/s41556-018-0269-y.. PMID: 30643186]
REFERENCE   6  (bases 1 to 2639)
  AUTHORS   Pettitt,S.J., Liang,Q., Rairdan,X.Y., Moran,J.L., Prosser,H.M.,
            Beier,D.R., Lloyd,K.C., Bradley,A. and Skarnes,W.C.
  TITLE     Agouti C57BL/6N embryonic stem cells for mouse genetic resources
  JOURNAL   Nat Methods 6 (7), 493-495 (2009)
   PUBMED   19525957
REFERENCE   7  (bases 1 to 2639)
  AUTHORS   Wang,Z.X., Kueh,J.L., Teh,C.H., Rossbach,M., Lim,L., Li,P.,
            Wong,K.Y., Lufkin,T., Robson,P. and Stanton,L.W.
  TITLE     Zfp206 is a transcription factor that controls pluripotency of
            embryonic stem cells
  JOURNAL   Stem Cells 25 (9), 2173-2182 (2007)
   PUBMED   17628018
  REMARK    GeneRIF: Zfp206 is an embryonic transcription factor that plays a
            role in regulating pluripotency of embryonic stem cells.
REFERENCE   8  (bases 1 to 2639)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   9  (bases 1 to 2639)
  AUTHORS   Zhang,W., Walker,E., Tamplin,O.J., Rossant,J., Stanford,W.L. and
            Hughes,T.R.
  TITLE     Zfp206 regulates ES cell gene expression and differentiation
  JOURNAL   Nucleic Acids Res 34 (17), 4780-4790 (2006)
   PUBMED   16971461
  REMARK    GeneRIF: Zfp206 is a regulator of embryonic stem cell
            differentiation that controls a set of genes expressed very early
            in development, most of which themselves appear to be regulators.
REFERENCE   10 (bases 1 to 2639)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154766.2, AK141259.1, CF896527.1, CD539380.1, BM933809.1 and
            BX526901.1.
            
            On Jan 23, 2014 this sequence version replaced XM_006524446.1.
            
            Transcript Variant: This variant (2) uses alternate in-frame splice
            sites in the 3' coding region, compared to variant 1. This results
            in an isoform (2) that is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ323930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC154766.2         92265-92294         c
            31-144              AK141259.1         2-115
            145-166             CF896527.1         46-67
            167-1117            AK141259.1         138-1088
            1118-1312           CD539380.1         2-196               c
            1313-1740           AK141259.1         1380-1807
            1741-2151           BM933809.1         1-411               c
            2152-2632           AK141259.1         2219-2699
            2633-2639           BX526901.1         14-20               c
FEATURES             Location/Qualifiers
     source          1..2639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 11.79 cM"
     gene            1..2639
                     /gene="Zscan10"
                     /gene_synonym="Zfp206; Zkscan10; Znf206"
                     /note="zinc finger and SCAN domain containing 10"
                     /db_xref="GeneID:332221"
                     /db_xref="MGI:MGI:3040700"
     exon            1..134
                     /gene="Zscan10"
                     /gene_synonym="Zfp206; Zkscan10; Znf206"
                     /inference="alignment:Splign:2.1.0"
     exon            135..594
                     /gene="Zscan10"
                     /gene_synonym="Zfp206; Zkscan10; Znf206"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2454
                     /gene="Zscan10"
                     /gene_synonym="Zfp206; Zkscan10; Znf206"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger and SCAN domain-containing protein 10; zinc finger
                     protein 206; zinc finger with KRAB and SCAN domains 10;
                     zinc finger and SCAN domains 10"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein
                     10 isoform 2"
                     /protein_id="NP_001276410.1"
                     /db_xref="CCDS:CCDS70766.1"
                     /db_xref="GeneID:332221"
                     /db_xref="MGI:MGI:3040700"
                     /translation="MLAEPVPDALEQEHPGAVKLEEDEVGEEDPRLAESRPRPEVAHQ
                     LFRCFQYQEDMGPRASLGRLRELCNHWLRPALHTKKQILELLVLEQFLSVLPPHVLSR
                     LHGQPLRDGEEVVQLLEGVPRDISHMGPLDFSFSAGKNAPADIISEEQNSPSQVPSHS
                     PQTELPSEEIPALHPLNELPPPQPAPIRPAEPEEWRLAPSSNWPMSPEPQEILQDPRE
                     SNPSQGPSWLEENSRDQELAAVLESLTFEDTSEKRAWPANPLGFGSRMPDNEELKVEE
                     PKVTTWPVVIGAESQTEKPEVAGEPLTQTVGQETSSTGWGGTPADGSEVVKAHQLQSH
                     PNLQPHPSSRSFRCLWCGKTFGRSSILKLHMRTHTDERPHACHLCNRRFRQSSHLTKH
                     LLTHSSEPAFRCAECNQGFQRRSSLMQHLLAHAQGKNLTPNPEGKTKVPEMAAVLCSH
                     CGQTFKRRSSLKRHLRNHAKDKDHLSSEDPGSLSSSQESNPYVCSDCGKAFRQSEQLM
                     IHTRRVHTRERPFSCQVCGRCFTQNSQLISHQQIHTGEKPHACPQCSKRFVRRAGLAR
                     HLLTHGSLRPYHCAQCGKSFRQMRDLTRHVRCHTGEKPCRCNECGEGFTQNAHLARHQ
                     RIHTGEKPHACDICGHRFRNSSNLARHRRSHTGERPYSCPTCGRSFRRNAHLQRHLIT
                     HTGSKQEKEVPQECPECGKSFNRSCNLLRHLLVHTGARPYSCALCGRSFSRNSHLLRH
                     LRTHARESLY"
     exon            595..859
                     /gene="Zscan10"
                     /gene_synonym="Zfp206; Zkscan10; Znf206"
                     /inference="alignment:Splign:2.1.0"
     exon            860..924
                     /gene="Zscan10"
                     /gene_synonym="Zfp206; Zkscan10; Znf206"
                     /inference="alignment:Splign:2.1.0"
     exon            925..982
                     /gene="Zscan10"
                     /gene_synonym="Zfp206; Zkscan10; Znf206"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1182
                     /gene="Zscan10"
                     /gene_synonym="Zfp206; Zkscan10; Znf206"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..2639
                     /gene="Zscan10"
                     /gene_synonym="Zfp206; Zkscan10; Znf206"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2616..2621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zscan10"
                     /gene_synonym="Zfp206; Zkscan10; Znf206"
                     /note="hexamer: AGTAAA"
     polyA_site      2639
                     /gene="Zscan10"
                     /gene_synonym="Zfp206; Zkscan10; Znf206"
                     /note="major polyA site"
ORIGIN      
        1 gggatgggtc aggcagggaa cttcctgttc catttcccgg gattcctttc ccaaactagg
       61 ctacgctgcc tcttaccctg aattctccca aggatcccca aacatctcgg cctcaggcgt
      121 cggtacctgg agtgctccac aggtgcagga ggagctgaag aaagggattt aagagcggcc
      181 caggtgtggg agttgtgaaa gatgctggcg gaaccagtcc ctgatgccct ggaacaagag
      241 catcccggag cagtgaagtt ggaggaggat gaagttggcg aggaggatcc caggctcgca
      301 gagtccaggc ctaggcctga ggtggcccac cagcttttca gatgcttcca gtatcaggaa
      361 gatatggggc cacgggcatc cctgggccgg ctccgggaac tctgcaacca ctggctgcga
      421 ccggctctgc acaccaagaa gcagatcctg gagctgctgg tactggagca gttcctgagt
      481 gtcctgcccc cgcatgtgct gagccggctg cacggccaac cgctccggga cggagaggag
      541 gtggtacagc tattggaggg cgtgcccaga gacatcagcc acatggggcc actggatttt
      601 agcttcagtg ctggcaagaa tgcccctgca gacatcatct cagaggaaca aaatagccct
      661 tcccaggtcc ccagccacag cccccagacg gagttgccct cagaagagat tccagcccta
      721 catccactga atgagttacc tccacctcag ccagcaccca taaggcctgc tgagcctgag
      781 gagtggagac tggcccccag ttcaaattgg ccaatgagcc cagagcccca ggagatactc
      841 caggacccac gagaaagcaa cccttcccag ggcccttcat ggcttgagga aaattccaga
      901 gaccaagagc tggcggctgt gttggagtcc ctcacctttg aggatacctc agagaagaga
      961 gcttggcctg caaaccctct tggatttgga agcagaatgc ctgacaatga ggaacttaaa
     1021 gttgaagagc ctaaagtgac tacttggcct gtcgtcattg gagcagagtc ccagacagag
     1081 aaacctgaag ttgcaggaga gcctcttacg caaactgtag ggcaggagac cagcagcact
     1141 ggttggggag gtactcctgc tgacggcagt gaagttgtga aggcccacca gttacaatct
     1201 caccccaact tgcaacctca cccaagctct cgatccttcc gatgtctgtg gtgtgggaag
     1261 acttttggac gcagctcgat cctcaagctg cacatgcgca ctcacacaga cgagcggccg
     1321 cacgcctgtc atctctgcaa ccgccgcttc cgccagagct cacacctgac gaagcacttg
     1381 ctaacgcatt cctctgagcc tgccttccga tgcgccgagt gtaaccaggg ttttcagcgt
     1441 cgctccagcc tcatgcagca cctgctggca catgcccagg gaaagaatct cacgccaaat
     1501 ccagaaggca agacaaaagt gccagagatg gcagctgtcc tctgttccca ctgcgggcag
     1561 accttcaagc ggcgctctag cttaaagcgt cacctgcgta accatgccaa ggacaaggac
     1621 catctgtcct ctgaagaccc tggcagcctt agctctagcc aggagagtaa cccctatgtg
     1681 tgtagtgact gtggcaaggc cttccgacaa agcgagcaac taatgatcca cactaggcga
     1741 gtccataccc gtgaacgacc cttctcctgc caggtctgtg gccgctgctt tacccaaaat
     1801 tcccagctga tcagccacca gcagattcat acgggtgaga agcctcacgc ctgtcctcag
     1861 tgcagcaaac gctttgtgag acgagctggc cttgctcggc atctgttgac ccacggtagc
     1921 ctccggcctt accactgtgc ccaatgtggc aaaagctttc gccaaatgcg agacctaacc
     1981 cgccacgtac gctgccacac gggggagaag ccctgccgat gcaacgaatg tggagagggg
     2041 ttcacccaga atgcccacct ggcacgccac caacgcatcc acacggggga gaagccccac
     2101 gcctgtgaca tctgtggtca ccgctttcgt aacagctcca acttggcccg ccaccgccgc
     2161 agccacactg gcgaacggcc ctatagctgt ccaacctgtg gccgcagttt ccggcgcaat
     2221 gcgcacctgc agcgccacct gatcacacac acagggtcaa agcaagaaaa ggaagttcct
     2281 caggagtgcc ctgagtgtgg caagagcttc aatcgcagct gcaacttgct gcgccacctg
     2341 ctggttcaca ccggtgcaag gccttactcc tgtgcactgt gtggccgcag cttcagccgt
     2401 aattcacacc tgctgcgcca cctgcgaacc catgcccggg aatcgctgta ctaactgctt
     2461 cacccatgtt ccagcaacct tgtcccatgt gcacctccct gcatgaataa gattccctat
     2521 ggtgtcccct tcacacatat ctctcctccc agttcctcca ccttcgacct cccccacagt
     2581 ttacctcttc ccttgactcc aagaatttgt ttttaagtaa agctgccttc tcaaaatta
//
