LOCUS       NM_009453               2812 bp    mRNA    linear   ROD 31-JAN-2023
DEFINITION  Mus musculus zinc finger (CCCH type), RNA binding motif and
            serine/arginine rich 2 (Zrsr2), transcript variant 1, mRNA.
ACCESSION   NM_009453
VERSION     NM_009453.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2812)
  AUTHORS   Garcia-Ruiz C, Martinez-Valiente C, Cordon L, Liquori A,
            Fernandez-Gonzalez R, Pericuesta E, Sandoval J, Cervera J,
            Gutierrez-Adan A and Sanjuan-Pla A.
  TITLE     Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic
            neoplasm in mice
  JOURNAL   Leukemia 36 (10), 2509-2518 (2022)
   PUBMED   36030305
  REMARK    GeneRIF: Concurrent Zrsr2 mutation and Tet2 loss promote
            myelodysplastic neoplasm in mice.
REFERENCE   2  (bases 1 to 2812)
  AUTHORS   Madan V, Cao Z, Teoh WW, Dakle P, Han L, Shyamsunder P, Jeitany M,
            Zhou S, Li J, Nordin HBM, Shi J, Yu S, Yang H, Hossain MZ, Chng WJ
            and Koeffler HP.
  TITLE     ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type
            introns in murine hematopoietic cells
  JOURNAL   Haematologica 107 (3), 680-689 (2022)
   PUBMED   33691379
  REMARK    GeneRIF: ZRSR1 co-operates with ZRSR2 in regulating splicing of
            U12-type introns in murine hematopoietic cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2812)
  AUTHORS   Gomez-Redondo I, Pericuesta E, Navarrete-Lopez P, Ramos-Ibeas P,
            Planells B, Fonseca-Balvis N, Vaquero-Rey A, Fernandez-Gonzalez R,
            Laguna-Barraza R, Horiuchi K and Gutierrez-Adan A.
  TITLE     Zrsr2 and functional U12-dependent spliceosome are necessary for
            follicular development
  JOURNAL   iScience 25 (2), 103860 (2022)
   PUBMED   35198906
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2812)
  AUTHORS   Inoue D, Polaski JT, Taylor J, Castel P, Chen S, Kobayashi S, Hogg
            SJ, Hayashi Y, Pineda JMB, El Marabti E, Erickson C, Knorr K,
            Fukumoto M, Yamazaki H, Tanaka A, Fukui C, Lu SX, Durham BH, Liu B,
            Wang E, Mehta S, Zakheim D, Garippa R, Penson A, Chew GL, McCormick
            F, Bradley RK and Abdel-Wahab O.
  TITLE     Minor intron retention drives clonal hematopoietic disorders and
            diverse cancer predisposition
  JOURNAL   Nat Genet 53 (5), 707-718 (2021)
   PUBMED   33846634
REFERENCE   5  (bases 1 to 2812)
  AUTHORS   Gomez-Redondo I, Ramos-Ibeas P, Pericuesta E, Fernandez-Gonzalez R,
            Laguna-Barraza R and Gutierrez-Adan A.
  TITLE     Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early
            Embryo Development and 2-Cell-Like Conversion
  JOURNAL   Int J Mol Sci 21 (11), 4115 (2020)
   PUBMED   32527007
  REMARK    GeneRIF: Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for
            Early Embryo Development and 2-Cell-Like Conversion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2812)
  AUTHORS   Gan P, Patterson M, Watanabe H, Wang K, Edmonds RA, Reinholdt LG
            and Sucov HM.
  TITLE     Allelic variants between mouse substrains BALB/cJ and BALB/cByJ
            influence mononuclear cardiomyocyte composition and cardiomyocyte
            nuclear ploidy
  JOURNAL   Sci Rep 10 (1), 7605 (2020)
   PUBMED   32371981
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2812)
  AUTHORS   Horiuchi K, Perez-Cerezales S, Papasaikas P, Ramos-Ibeas P,
            Lopez-Cardona AP, Laguna-Barraza R, Fonseca Balvis N, Pericuesta E,
            Fernandez-Gonzalez R, Planells B, Viera A, Suja JA, Ross PJ, Alen
            F, Orio L, Rodriguez de Fonseca F, Pintado B, Valcarcel J and
            Gutierrez-Adan A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   8  (bases 1 to 2812)
  AUTHORS   Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco
            G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T,
            Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T,
            Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ,
            Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A,
            Vescovi AL, Rossant J, Kunath T, Hogan BL, Curci A, D'Urso M, Kelso
            J, Hide W and Ko MS.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 2812)
  AUTHORS   Kitagawa K, Wang X, Hatada I, Yamaoka T, Nojima H, Inazawa J, Abe
            T, Mitsuya K, Oshimura M, Murata A et al.
  TITLE     Isolation and mapping of human homologues of an imprinted mouse
            gene U2af1-rs1
  JOURNAL   Genomics 30 (2), 257-263 (1995)
   PUBMED   8586425
REFERENCE   10 (bases 1 to 2812)
  AUTHORS   Yamaoka T, Hatada I, Kitagawa K, Wang X and Mukai T.
  TITLE     Cloning and mapping of the U2af1-rs2 gene with a high transmission
            distortion in interspecific backcross progeny
  JOURNAL   Genomics 27 (2), 337-340 (1995)
   PUBMED   7558001
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX469932.7.
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_009453.4.
            
            On Jun 18, 2010 this sequence version replaced NM_009453.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D45205.1, SRR11927937.3296600.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               BX469932.7         64436-64828         c
            394-473             BX469932.7         64078-64157         c
            474-555             BX469932.7         62634-62715         c
            556-664             BX469932.7         60536-60644         c
            665-751             BX469932.7         59732-59818         c
            752-790             BX469932.7         56349-56387         c
            791-909             BX469932.7         55422-55540         c
            910-1123            BX469932.7         49262-49475         c
            1124-1179           BX469932.7         46281-46336         c
            1180-1289           BX469932.7         45468-45577         c
            1290-2812           BX469932.7         41605-43127         c
FEATURES             Location/Qualifiers
     source          1..2812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 75.99 cM"
     gene            1..2812
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /note="zinc finger (CCCH type), RNA binding motif and
                     serine/arginine rich 2"
                     /db_xref="GeneID:22184"
                     /db_xref="MGI:MGI:103287"
     exon            1..393
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..1966
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /note="isoform 1 is encoded by transcript variant 1; U2
                     small nuclear ribonucleoprotein auxiliary factor 35 kDa
                     subunit-related protein 2; U2(RNU2) small nuclear RNA
                     auxiliary factor 1-like 2; U2AF35-related protein; U2
                     small nuclear ribonucleoprotein auxiliary factor (U2AF),
                     35 kDa, related sequence 2"
                     /codon_start=1
                     /product="U2 small nuclear ribonucleoprotein auxiliary
                     factor 35 kDa subunit-related protein 2 isoform 1"
                     /protein_id="NP_033479.2"
                     /db_xref="CCDS:CCDS41204.1"
                     /db_xref="GeneID:22184"
                     /db_xref="MGI:MGI:103287"
                     /translation="METAGATADATAGPQKLSRKKYLALRKKERRKRRRQALARLREA
                     ELAQKEEEEDPLAEEKRLEEERLLEEERQRLHEEWLLREEKAQEEFRAKKKKEEEARK
                     RKEELERKLKAEWEEQQRKEREEEEQKRQEKREREEAVQKMLDQAENELENGGTWQNP
                     EPPMDIRVLEKDRANCPFYSKTGACRFGDRCSRKHNFPTSSPTLLIKGMFTTFGMEQC
                     RRDDYDPDSSLEFSEEEIYQQFLDFYYDVLPEFKSVGKVIQFKVSCNLEPHLRGNVYV
                     QYQSEEDCQAAFSVFNGRWYAGRQLQCEFCPVTRWKMAICGLFEVQQCPRGKHCNFLH
                     VFRNPNNEYRDANRDLYPSPDWTSSSFGKNSERRERASHYDEYYGRSRRRRRSPSPDF
                     YKRNGESDRKSSSRHRVKKSHRYGMKSRERRSSPSRRRKDHSPGPWSQSRRSHRSRSR
                     SRSRSRSRSRTRSRSRGRGRSRSRSRSRSRGRSRSRGRGSGRGRGRGRGRGRNQSRSW
                     SQSRSRSSSSSRSRSRGRRSGSRDKTTQSPKSK"
     exon            394..473
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /inference="alignment:Splign:2.1.0"
     exon            474..555
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /inference="alignment:Splign:2.1.0"
     exon            556..664
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /inference="alignment:Splign:2.1.0"
     exon            665..751
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /inference="alignment:Splign:2.1.0"
     exon            752..790
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /inference="alignment:Splign:2.1.0"
     exon            791..909
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1123
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1179
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1289
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..2812
                     /gene="Zrsr2"
                     /gene_synonym="35kDa; 5031411E02Rik; A230052C13Rik;
                     U2af1-rs2; URP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgctaagg cccccgcgag gccccgagga gctggggcac gagtttccgg gggtggaaga
       61 tctccggggg gcggcttcgg tgaggagaca ttttctcagc ccgcgatgcc tggctgactg
      121 gccgagggag gaaaactcag gtctgccgcg gtggctgcgg cggcctcttt gagggtctgt
      181 tttctcaggc cgcggcgcct ggctgaccag ctgcgggaag aaagccgtct ccttccgtct
      241 tgggcaggta ccggttggtg gccgcgcgga gtgggcgacc gaggacctgg gtggctgctt
      301 ccgctgagac cttgccgtgg gagaacacag cgacagcagt atggaaacgg cgggggctac
      361 ggcggacgct acggcggggc cgcagaaact gagccgtaag aagtacttgg ccctccggaa
      421 gaaggagaga cgtaagaggc gacggcaggc gctcgctcgg ctcagagagg cagaattggc
      481 acagaaagag gaggaagaag atcctcttgc tgaagaaaaa cgactagaag aagaaaggtt
      541 gttagaggaa gagaggcaga gactgcatga agaatggtta ctgagggaag aaaaggcaca
      601 agaagaattc agggcaaaga agaaaaaaga agaggaagct cgaaaacgga aggaagaact
      661 agagagaaag ttaaaggcag aatgggaaga acagcagaga aaagagcgag aggaagagga
      721 gcagaaacga caagagaaga gagaaagaga ggaagctgtg cagaagatgc tggatcaggc
      781 tgaaaatgag ctggaaaatg gtggcacctg gcagaaccca gaaccgccca tggatataag
      841 agtactggag aaagatcgag ccaactgtcc gttctacagc aaaacgggag cttgcagatt
      901 tggagatagg tgttcacgta aacacaactt ccccacatca agtcccacct tgctgattaa
      961 gggcatgttt acaacatttg gaatggagca gtgtcggagg gatgactatg accctgactc
     1021 aagcctagaa ttcagtgaag aagagatcta ccaacagttc ctagacttct attatgatgt
     1081 cctgcctgaa ttcaagagtg tgggaaaagt gattcagttt aaggtcagct gcaacctgga
     1141 acctcatctg aggggcaatg tgtatgttca gtaccagtcg gaagaagact gtcaagcagc
     1201 cttttctgtt tttaatggac gatggtatgc aggacgacag ctccagtgtg aattctgccc
     1261 agtgacccgg tggaaaatgg caatttgtgg cttatttgaa gtccagcagt gtccaagagg
     1321 aaagcactgc aactttcttc acgtgttcag aaatcccaac aatgaatata gggacgctaa
     1381 tagagacctc tacccgtctc cagattggac tagctcctcc ttcggtaaga attcagagag
     1441 gagggaaagg gccagtcact atgatgaata ctatggcagg tcaaggagga ggaggaggag
     1501 cccgagtccc gacttctaca agagaaatgg cgagtctgac aggaagagca gtagcagaca
     1561 cagggtgaag aaatctcaca gatatggaat gaagagtcgt gagaggcgca gttcacccag
     1621 tagaagaaga aaggaccaca gtccgggccc ctggagccag agcaggagga gccaccgcag
     1681 caggagtcgc agtcgcagcc gcagccgcag ccgcagtcgg acccgtagcc gaagccgggg
     1741 ccggggccgg agcaggagcc ggagccggag caggagcagg ggccggagca ggagcagggg
     1801 ccggggcagc ggcaggggca ggggcagggg caggggcagg ggcaggaacc agagcaggag
     1861 ttggagtcaa agccggagcc ggagtagtag ctcgtcaagg tccagaagtc gtggcaggag
     1921 gtcaggtagt agagacaaaa ccacccagag tcccaaatct aaataaactt ggttgttttt
     1981 aaatatgtct gtctttttat agcagctact cacctgtata gatagatgat gctagctaat
     2041 gctatcatgt aaatcatact ttttgagaaa ttatacacac acacacacac acacacacac
     2101 acacacacat gaaattactt gtaataataa cctcgagagc atcagttaat gctggagtga
     2161 tgctttacta ttttttcctg ttttctgcct gtgcacctct ccccctccct ccatctctcc
     2221 tttcctcctc tttcccttcc tccctcttcc tcttcctctt cctctctgtc tctctgtgta
     2281 tgtgtgtgca tatgtgtgtt cagaggacaa cttttagggg tcatttatac aatgtgatcc
     2341 aggaattgaa ccgaggtgaa gcttttacac caaggacctt tactcacgga gccatcttct
     2401 cagcccgcct tttttcttgt taggggtcca caccctttat ttctgcttaa tgtatatggg
     2461 tgttttgcct gcatgtatct atgtgcaaca tttgggagcc cagtgtccgt ggaggccaaa
     2521 gagtatgcca gatccgcctg gagcagaatt atagatgatt gtgaactgtc atgtgggtcc
     2581 tgagaattga acccagatcc tctaaaagta cacttaacca ctgagccatc tttgcagccc
     2641 tacacacttt attttttaat tcaaaggcca tattgctttg atggttttca ctcaattgtc
     2701 tcatttcatc aatctgatgc tcaagtccca taattcttat ttttactcac tacatagagt
     2761 atatctgcca atagacttga caacattcct attgttggat tttaaaggtg gc
//
