LOCUS       NM_001410610            2720 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zinc finger, RAN-binding domain containing 2 (Zranb2),
            transcript variant 4, mRNA.
ACCESSION   NM_001410610
VERSION     NM_001410610.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2720)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2720)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2720)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   4  (bases 1 to 2720)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2720)
  AUTHORS   Ohte,S., Kokabu,S., Iemura,S., Sasanuma,H., Yoneyama,K., Shin,M.,
            Suzuki,S., Fukuda,T., Nakamura,Y., Jimi,E., Natsume,T. and
            Katagiri,T.
  TITLE     Identification and functional analysis of Zranb2 as a novel
            Smad-binding protein that suppresses BMP signaling
  JOURNAL   J Cell Biochem 113 (3), 808-814 (2012)
   PUBMED   22021003
  REMARK    GeneRIF: Findings suggested that Zranb2 is a novel BMP suppressor
            that forms a complex with Smads in the nucleus.
REFERENCE   6  (bases 1 to 2720)
  AUTHORS   Nguyen,C.D., Mansfield,R.E., Leung,W., Vaz,P.M., Loughlin,F.E.,
            Grant,R.P. and Mackay,J.P.
  TITLE     Characterization of a family of RanBP2-type zinc fingers that can
            recognize single-stranded RNA
  JOURNAL   J Mol Biol 407 (2), 273-283 (2011)
   PUBMED   21256132
REFERENCE   7  (bases 1 to 2720)
  AUTHORS   Li,J., Chen,X.H., Xiao,P.J., Li,L., Lin,W.M., Huang,J. and Xu,P.
  TITLE     Expression pattern and splicing function of mouse ZNF265
  JOURNAL   Neurochem Res 33 (3), 483-489 (2008)
   PUBMED   17805964
  REMARK    GeneRIF: regulation of GluR-B and SMN2 pre-mRNA splicing by ZNF265
            implies this newly identified SR protein may play important roles
            in maintaining normal neuronal function and SMA pathogenesis
REFERENCE   8  (bases 1 to 2720)
  AUTHORS   Mangs,A.H. and Morris,B.J.
  TITLE     ZRANB2: structural and functional insights into a novel splicing
            protein
  JOURNAL   Int J Biochem Cell Biol 40 (11), 2353-2357 (2008)
   PUBMED   17905639
  REMARK    Review article
REFERENCE   9  (bases 1 to 2720)
  AUTHORS   Adams,D.J., van der Weyden,L., Kovacic,A., Lovicu,F.J.,
            Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Ioannou,P.A. and
            Morris,B.J.
  TITLE     Chromosome localization and characterization of the mouse and human
            zinc finger protein 265 gene
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 68-73 (2000)
   PUBMED   10773668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141480.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.105084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC141480.4         79709-79807         c
            100-152             AC141480.4         77797-77849         c
            153-291             AC141480.4         77597-77735         c
            292-374             AC141480.4         76514-76596         c
            375-451             AC141480.4         73474-73550         c
            452-586             AC141480.4         72994-73128         c
            587-756             AC141480.4         72314-72483         c
            757-843             AC141480.4         70939-71025         c
            844-1002            AC141480.4         69061-69219         c
            1003-2720           AC141480.4         65791-67508         c
FEATURES             Location/Qualifiers
     source          1..2720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 81.29 cM"
     gene            1..2720
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /note="zinc finger, RAN-binding domain containing 2"
                     /db_xref="GeneID:53861"
                     /db_xref="MGI:MGI:1858211"
     exon            1..99
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1066
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /note="isoform 4 is encoded by transcript variant 4; zinc
                     finger Ran-binding domain-containing protein 2; zinc
                     finger, splicing; zinc finger protein 265"
                     /codon_start=1
                     /product="zinc finger Ran-binding domain-containing
                     protein 2 isoform 4"
                     /protein_id="NP_001397539.1"
                     /db_xref="GeneID:53861"
                     /db_xref="MGI:MGI:1858211"
                     /translation="MSTKNFRVSDGDWICPDKKCGNVNFARRTSCNRCGRGFISSSCL
                     FAEKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCSNVNWARRSECNMCNTPK
                     YAKLEERTGYGGGFNERENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVED
                     KESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRS
                     SHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSHSGSREHSRSRGSKSRSSSRSHRGS
                     SSPRKRSYSSSSSSPERDRKRSRSRPSSPAVRKKRRTRSRSPERHHRSSSGSTHSGSR
                     SSSKKK"
     exon            100..152
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /inference="alignment:Splign:2.1.0"
     exon            153..291
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /inference="alignment:Splign:2.1.0"
     exon            292..374
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /inference="alignment:Splign:2.1.0"
     exon            375..451
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /inference="alignment:Splign:2.1.0"
     exon            452..586
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /inference="alignment:Splign:2.1.0"
     exon            587..756
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /inference="alignment:Splign:2.1.0"
     exon            757..843
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1002
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..2720
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2648..2653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /note="hexamer: AATAAA"
     polyA_site      2669
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /note="major polyA site"
     regulatory      2689..2694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /note="hexamer: AATAAA"
     regulatory      2694..2699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
                     /note="hexamer: AATAGA"
     polyA_site      2708
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
     polyA_site      2720
                     /gene="Zranb2"
                     /gene_synonym="Zfp265; Zis; Znf265"
ORIGIN      
        1 ggtggggacg tcgctgcggg cggcactgct gctggcgtcc aagatgtcga ccaagaattt
       61 ccgagtcagt gacggggact ggatctgccc tgacaagaag tgtggaaatg taaactttgc
      121 taggagaacc agctgtaaca gatgtggtcg aggatttata tcgagttctt gtctgtttgc
      181 agaaaagaca actgaggcca agatgatgaa agctggggga acagaaatag gaaagacact
      241 ggcagagaag agccggggct tatttagtgc caatgattgg caatgcaaaa cttgcagtaa
      301 tgtgaattgg gctagaagat cagagtgtaa catgtgtaat actccaaagt atgctaaatt
      361 agaagaaaga acaggatatg gaggtggttt taatgaaaga gagaatgttg aatacataga
      421 aagagaagaa tctgatgggg aatatgatga gtttggacgt aaaaagaaaa aatacagggg
      481 gaaagcagtt ggccctgcat ctatattaaa ggaagttgaa gataaagagt cagagggaga
      541 agaagaggat gaggatgaag atctatctaa gtataagcta gatgaggacg aggatgaaga
      601 tgatgctgat ctctcaaaat ataatcttga tgccagcgaa gaagaagata gtaacaaaaa
      661 gaaaagcaat aggcggagcc gctcaaagtc acgatcgtct cactcaaggt cttcatcacg
      721 ctcatcctcc ccctcaagtt caaggtccag gtccaggtcc cgttcaagaa gctcttccag
      781 ttcgcagtcc aggtctcact ccggttccag agaacattcc agatcccgtg gttcgaaatc
      841 aagatccagc tccaggtccc acaggggctc ttcttcccca agaaaaagat cttattcgag
      901 ttcttcgtca tctcctgaaa gagacaggaa gaggagtcgc tctagacctt cttcaccagc
      961 tgttcgcaaa aaaagacgaa cgagatcacg gtcacccgaa aggcaccaca ggtcgtcctc
     1021 cggatcaaca cattctggtt cccgttcaag ttcaaaaaag aaataatgta ttaaaattta
     1081 catctttaaa aaacattgag tacagtgcat gaagcatatt ttttaggaag ttgatgtctc
     1141 atttggtcag aagtactaca tctgctagta gaggtgcatg cctttattgc ttttcaaaac
     1201 aatacaactg tgtttatttg tgaaactgaa agtaaattgc attttaagcc atatactgtt
     1261 ccccagataa atgctctgtt cattatttac aaccatttgc ttcatttaaa accatcctag
     1321 caataacaga gtacttttgt ttcctacttt aaatccttgt ccttttcatt tctaaatgtt
     1381 ctattgacag agacagggtt gcctgggctt gcctggactt cagacacatg ggcaaagcta
     1441 ataagctagt tggaattacc aatttatgtt catatggggt tagtagtcaa cctggttatg
     1501 ttatttacct ctgccagtaa tttcttacca gcagttaact acgttgcaaa gctgacaact
     1561 gggaacaagc tgagggtgcc ttagaatcat tgtctcttaa cagctttaca cctcttaatg
     1621 caagaggatt gtagaaatta tagaagaaaa aggttaatca catcatttca gaatgtttct
     1681 caaagtttaa gaaatgcgga tatcctttta ccaaatccta gttaccaaat attgtacttg
     1741 atcgataaag gatttttaaa aaaggctaaa tcatagttaa tgagcaaatt gaagaaagct
     1801 tttgaaacct gtttctcagt ggcaggctga cagggacatg aatttaagtg aacatttgcc
     1861 ttgtgatgtc tgattttgaa cattgcagat acctaagtaa cagaagaatt cttatttctg
     1921 cacaatttaa gcaaaatcat ttttctccac atctgaaaaa gaaaaccata tggcttaaaa
     1981 tgcttttgga gttttatttc tcaaattaaa atctggtcac ttgagatcca ttttgttctc
     2041 tggtttaaaa gttaaaaggt ttctctttaa cagtctcttc agcagcaaaa gcaaggtaag
     2101 tatataaggg acaacagttg tgctggggct ccttgtgagg gaattatttt tcctgtttct
     2161 cctttagtat ttgtctgctg cagtttaaat aagtaaagcc ttctaagatg tttagtagac
     2221 agatcaaaca aaatgttttt attttaaagt gagtgtttct cttctcaact gatctaaaga
     2281 tgaaaacaaa gtatcgtacg tagaaatatt ttggtaatat ttttacaagc tttcctgtgt
     2341 ttttttgtct tattttcctt gctgcattta ctgtaggttg cacacgaact cttactctct
     2401 tgtaattgtg cctcagactt ctcgaaagtc gactttctga gttgcccaga tcttctagat
     2461 ccaacgtgtt agccttggtt tgtttttgtg ctttctgtat ttaaaacttg aactgtacta
     2521 ggcaaatgca agattataaa tttagctaat aggagtttac aaacagttca gatgattatg
     2581 atttgatttg gtttaattga gctgtactag ttcatttcat aaggaaatga tactgtagac
     2641 aaatgtaaat aaaatccgtg agtcaactat caagtgttgt ttattagaaa taaaatagaa
     2701 agttgtaagc tctgactgaa
//
