LOCUS       NM_207302               4974 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zinc finger, RAN-binding domain containing 1 (Zranb1),
            transcript variant 1, mRNA.
ACCESSION   NM_207302 XM_006507967 XM_355951
VERSION     NM_207302.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4974)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4974)
  AUTHORS   Chen,Y.H., Chen,H.H., Wang,W.J., Chen,H.Y., Huang,W.S., Kao,C.H.,
            Lee,S.R., Yeat,N.Y., Yan,R.L., Chan,S.J., Wu,K.P. and Chen,R.H.
  TITLE     TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity
            through mitosis and autophagy dysregulation
  JOURNAL   Nat Commun 14 (1), 3050 (2023)
   PUBMED   37237031
  REMARK    GeneRIF: TRABID inhibition activates cGAS/STING-mediated anti-tumor
            immunity through mitosis and autophagy dysregulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4974)
  AUTHORS   Tamura,A., Ito,G., Matsuda,H., Nibe-Shirakihara,Y., Hiraoka,Y.,
            Kitagawa,S., Hiraguri,Y., Nagata,S., Aonuma,E., Otsubo,K.,
            Nemoto,Y., Nagaishi,T., Watanabe,M., Okamoto,R. and Oshima,S.
  TITLE     Zranb1-mutant mice display abnormal colonic mucus production and
            exacerbation of DSS-induced colitis
  JOURNAL   Biochem Biophys Res Commun 628, 147-154 (2022)
   PUBMED   36087511
  REMARK    GeneRIF: Zranb1-mutant mice display abnormal colonic mucus
            production and exacerbation of DSS-induced colitis.
REFERENCE   4  (bases 1 to 4974)
  AUTHORS   Harris,L.D., Le Pen,J., Scholz,N., Mieszczanek,J., Vaughan,N.,
            Davis,S., Berridge,G., Kessler,B.M., Bienz,M. and Licchesi,J.D.F.
  TITLE     The deubiquitinase TRABID stabilizes the K29/K48-specific E3
            ubiquitin ligase HECTD1
  JOURNAL   J Biol Chem 296, 100246 (2021)
   PUBMED   33853758
REFERENCE   5  (bases 1 to 4974)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4974)
  AUTHORS   Jin,J., Xie,X., Xiao,Y., Hu,H., Zou,Q., Cheng,X. and Sun,S.C.
  TITLE     Epigenetic regulation of the expression of Il12 and Il23 and
            autoimmune inflammation by the deubiquitinase Trabid
  JOURNAL   Nat Immunol 17 (3), 259-268 (2016)
   PUBMED   26808229
  REMARK    GeneRIF: Trabid regulates inflammatory T cell responses via
            facilitation of histone modifications at the promoters of Il12 and
            Il23, which involved deubiqutination and stabilization of the
            histone demethylase Jmjd2d.
REFERENCE   7  (bases 1 to 4974)
  AUTHORS   Somma,G., Alger,H.M., McGuire,R.M., Kretlow,J.D., Ruiz,F.R.,
            Yatsenko,S.A., Stankiewicz,P., Harrison,W., Funk,E.,
            Bergamaschi,A., Oghalai,J.S., Mikos,A.G., Overbeek,P.A. and
            Pereira,F.A.
  TITLE     Head bobber: an insertional mutation causes inner ear defects,
            hyperactive circling, and deafness
  JOURNAL   J Assoc Res Otolaryngol 13 (3), 335-349 (2012)
   PUBMED   22383091
REFERENCE   8  (bases 1 to 4974)
  AUTHORS   Tran,H., Hamada,F., Schwarz-Romond,T. and Bienz,M.
  TITLE     Trabid, a new positive regulator of Wnt-induced transcription with
            preference for binding and cleaving K63-linked ubiquitin chains
  JOURNAL   Genes Dev 22 (4), 528-542 (2008)
   PUBMED   18281465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119806.6.
            
            On Jun 17, 2019 this sequence version replaced NM_207302.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.4484.1,
                                           SRR7652917.591195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               AC119806.6         167043-167412       c
            371-1221            AC119806.6         148153-149003       c
            1222-1409           AC119806.6         131894-132081       c
            1410-1563           AC119806.6         127249-127402       c
            1564-1635           AC119806.6         125827-125898       c
            1636-1834           AC119806.6         124965-125163       c
            1835-1955           AC119806.6         117187-117307       c
            1956-2085           AC119806.6         116088-116217       c
            2086-2315           AC119806.6         115676-115905       c
            2316-4974           AC119806.6         112197-114855       c
FEATURES             Location/Qualifiers
     source          1..4974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 76.32 cM"
     gene            1..4974
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /note="zinc finger, RAN-binding domain containing 1"
                     /db_xref="GeneID:360216"
                     /db_xref="MGI:MGI:106441"
     exon            1..370
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /inference="alignment:Splign:2.1.0"
     exon            371..1221
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..2534
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin thioesterase Zranb1; zinc finger Ran-binding
                     domain-containing protein 1; TRAF-binding protein"
                     /codon_start=1
                     /product="ubiquitin thioesterase Zranb1 isoform 1"
                     /protein_id="NP_997185.1"
                     /db_xref="CCDS:CCDS21929.1"
                     /db_xref="GeneID:360216"
                     /db_xref="MGI:MGI:106441"
                     /translation="MSEHGIKWACEYCTYENWPSAIKCTMCRAQRPSGTIITEDPFKS
                     GSSDVGRDWDPSSTEGGSSPLICPDSSARPRVKSSYSMENANKWSCHMCTYLNWPRAI
                     RCTQCLSQRRTRSPTESPQSSGSGSRPVAFSVDPCEEYNDRNKLNTRTQHWTCSVCTY
                     ENWAKAKKCVVCDHPRPNNIEAIELAETEEASSIINEQDRARWRGGCSSGNSQRRSPP
                     TTKRDSEVKMDFQRIELAGAVGTKEELEVDFKKLKQIKNRMKKTDWLFLNACVGVVEG
                     DLAAIEAYKSSGGDIARQLTADEVRLLNRPSAFDVGYTLVHLAIRFQRQDMLAILLTE
                     VSQQAAKCIPAMVCPELTEQIRREIAASLHQRKGDFACYFLTDLVTFTLPADIEDLPP
                     TVQEKLFDEVLDRDVQKELEEESPIINWSLELATRLDSRLYALWNRTAGDCLLDSVLQ
                     ATWGIYDKDSVLRKALHDSLHDCSHWFYTRWKDWESWYSQSFGLHFSLREEQWQEDWA
                     FILSLASQPGASLEQTHIFVLAHILRRPIIVYGVKYYKSFRGETLGYTRFQGVYLPLL
                     WEQSFCWKSPIALGYTRGHFSALVAMENDGYGNRGAGANLNTDDDVTITFLPLVDSER
                     KLLHVHFLSAQELGNEEQQEKLLREWLDCCVTEGGVLVAMQKSSRRRNHPLVTQMVEK
                     WLDRYRQIRPCTSLSDGEEDEDDEDE"
     exon            1222..1409
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1563
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1635
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1834
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1955
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2085
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2315
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..4974
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3982..3987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /note="hexamer: AAGAAA"
     polyA_site      3994
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /note="major polyA site"
     regulatory      4954..4959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /note="hexamer: ATTAAA"
     polyA_site      4974
                     /gene="Zranb1"
                     /gene_synonym="9330160G10Rik; D7Wsu87e; Gm1956; Trabid"
                     /note="major polyA site"
ORIGIN      
        1 agttcctgac gttgtgcggc cgccgcgggg tttatttagc tctagggtcc tgaccgccgc
       61 cattcggagt cctctgcgcc cgaggctgtc cccagaccgc tccgcccctg tccccgagcc
      121 tcggcccccg cctccgcgca gcctctccgc ccctcgggcc gctgggagcc gcgcgcgggc
      181 ccgcggagaa catgtcctga ctgaggcggg agggcggagg cggcagcagc ggggtgggcg
      241 gcggcgccga gggaggcgga gaggggccgg gctcggctcg tcgccgctgg ccgtgcggga
      301 gtcgccgccg ccgccgcggc cgccgggcgc cgcgcgtcag acggggagga ggaggatccg
      361 cggccgccag cttcctgcct gacataactc acttcaagaa gtacacaatg tcagaacatg
      421 ggattaagtg ggcctgtgaa tattgtacgt atgaaaactg gccgtctgca atcaagtgta
      481 ctatgtgtcg tgcccagaga cccagtggaa caattattac agaagatcca tttaaaagtg
      541 gttcaagtga tgttggtaga gattgggatc cttccagtac tgaaggtgga agtagtcctt
      601 tgatatgtcc agactctagt gcaagaccaa gggttaagtc ttcatacagc atggaaaatg
      661 caaataaatg gtcatgccac atgtgtacat atttgaactg gccaagagca atcagatgta
      721 cccagtgctt atcccagcgt aggaccagga gtcccacaga atctcctcaa tcctcaggat
      781 ctggttcaag accagttgct ttttctgttg atccttgtga agaatacaat gatagaaata
      841 aattgaatac aaggacccag cattggactt gttctgtttg cacatatgaa aactgggcta
      901 aggctaaaaa atgtgttgtt tgtgaccatc ccagacctaa taacattgaa gcaatagagt
      961 tggcagagac tgaagaggct tcttcaataa ttaatgagca agacagagct cgatggaggg
     1021 gaggctgcag tagtggtaat agccaaagaa gatcacctcc aactacaaaa cgggactcgg
     1081 aagtgaagat ggattttcag aggatcgaat tggctggtgc tgttggtacc aaggaggaac
     1141 ttgaagtgga ctttaaaaaa ctaaagcaga ttaaaaatag gatgaaaaag actgattggc
     1201 tattcctcaa tgcctgtgtg ggtgttgtgg aaggtgactt agcagccata gaagcataca
     1261 agtcatcggg aggagacatt gcacgccagc ttactgcaga tgaagtacgc ttgctgaacc
     1321 gtccttctgc ttttgatgtt ggctacactc tggtacatct ggccatacgc tttcagaggc
     1381 aggacatgtt agcgatattg cttacagagg tatctcagca agcagcaaag tgtattccag
     1441 ccatggtgtg tcctgaactg acagagcaaa tccggagaga aatagctgct tctcttcacc
     1501 agagaaaggg ggattttgct tgctattttc tgactgacct tgtaacattt acattaccag
     1561 cagatattga agatttgcct ccaacagttc aagaaaaatt atttgatgag gtgcttgata
     1621 gagatgttca aaaagagcta gaggaagaat ctcccattat aaactggtct ttggagttgg
     1681 ctacacgtct ggacagtaga ctatatgcac tttggaaccg gactgccgga gattgtttac
     1741 ttgactcagt actacaagct acatggggca tttatgacaa agactcggtg cttcggaaag
     1801 ccctgcatga cagcctgcat gactgttcac attggtttta cacacgctgg aaagactggg
     1861 aatcgtggta ttcccagagc tttggtttac atttttcact gagggaagaa caatggcaag
     1921 aagactgggc attcatactc tctctagcta gtcagcctgg agcaagtttg gaacagacac
     1981 acatttttgt acttgcacat attcttagac gaccaattat agtttatgga gtaaaatatt
     2041 ataagagttt ccggggagaa actttaggat atactcggtt tcaaggagtt tatctgcctt
     2101 tgttgtggga acagagtttt tgttggaaaa gtccaatcgc actgggctat acaaggggcc
     2161 acttctctgc tttggttgcc atggagaacg atggctatgg caaccgaggt gctggtgcta
     2221 atctgaacac tgatgatgat gtcaccatca catttttgcc tctggttgac agtgaaagga
     2281 agctcctcca tgtgcacttc ctgtctgctc aggagctagg taatgaggag cagcaagaga
     2341 aactgctcag agagtggctg gactgctgtg tgactgaagg gggagttcta gtggccatgc
     2401 agaaaagctc tcggcggaga aaccacccct tggtcacaca aatggtagaa aaatggcttg
     2461 accgctacag acagatccgg ccttgtacat ccctgtctga tggagaggaa gatgaggatg
     2521 atgaggatga atgacaacaa acctaaggaa agaaaaagac caaggcatca ggtctgaggt
     2581 ggcctcaaag ttagtgtggt atcctaaaca gaatatgcag catggagcga gccataccct
     2641 gccggatctg ctcccaagtt atctttctgt tccacactca caggagagaa ttgactgcat
     2701 ctgcatgagg agatggagaa ctttggttga actacagttt gtaaaaaaga aaaaaaaaaa
     2761 aaaaaaagaa aagaaaaaaa aagaaaaaag aaaaaaaata acctaatttt attgacagaa
     2821 cttttttttc ctttcaaatt gtaaatctgt ctatgaatgt aacgcatgtg gttgtttgag
     2881 aagttgtgta ctaggaaaag tgcaccagca tcttcatgtt actgagacca ttttcccagc
     2941 atgggcactc ataaacagca catagcagac agaccagtga gatgctctct ctctcattag
     3001 cacctgacat cctgctccca ccacaccaga cccatttccc attgttttag agatttggaa
     3061 actttgtaca aattatccac ggcaagataa aaataaacaa gcctttattt tattaataat
     3121 ttagttcctg ttgtgcccaa taaaagtaaa aaaaaaaaaa aaaaaaaaaa atcaaaccct
     3181 taggaacaaa ctacaagaaa aactagcaag tttttggagt gaacttaaca taaacattgt
     3241 ctcttgtttt ttgaagaggg ttttagtttc tgttgttttc aatttttccg atttgcccct
     3301 ttcattattt aggtatttgt ttggaagagt gccctgtaaa gggggttctt actcgactct
     3361 gggcggtgca tttgtgcact tctaccctgg atggatggat ggatggaaag ggagcaggct
     3421 cactcatccc tgggtgggtt atgtgacagt tacttggact caacctgttc tgttcccagg
     3481 cggccatgca gacagtcttc agctacttcc tgtctttgtc acctctgctc taagcagacc
     3541 ctgtattagg ggcaggcctt tggttaggct gattgggaat acagttcagt acagaataaa
     3601 gatttttaaa atgcagtaag gtggtcaatg cattgtatga tcagtttctg tgtagtctga
     3661 gaatttttgc atgttggtta gttgtagcat tatttaaagt taaaaccata ctttttagaa
     3721 aaaaaattta tggagagtgt taattgacca cttcaggtat atgttagtac tgggtaaaca
     3781 tttctgacct cctcaggcac acaacatgta gtgtcctgat aagcacttag actgatgtgg
     3841 caagcagttg caaagtagca aatacacaca tttcctcttc tcctcccctt taatgaaaag
     3901 gctgtgaaac ctttaaatct tgtttttctg atgagatggt attgaagtgt atacaacttt
     3961 taagtttgct ggaatactaa aaagaaaaaa cttatgagct gttatgtctt tagttctctc
     4021 tcttgtgaac acttaataaa aaggtgttct caggatgaaa gatcatttat gctgcatgct
     4081 aaaaccagaa agtaattttc acagtaggtg actccatata aatgaattgt ggtaacaata
     4141 ctggtaaatg ttactgttcc agtagttagt gtttttctac aaattgacta tttcgttttc
     4201 attttgatca gtgaatgata accaagtcaa tagaaggctg tcattctaag tacttagcat
     4261 ccatagcatc tagaatagct gatctccatg tgtagagttg atttttcagg aggcagagat
     4321 ccagttaagc aaaaccttcc tcccaaataa gccacagaga gctgagaggg taacactggt
     4381 ctctaggtgc atctgtgttg tacccaaacc ttgtggtaca gagtcaggct caggattgag
     4441 ccttgttctg catattgtca attcttgagt gtcctttcct gagttccctc tgtatttata
     4501 ttatttattt atttatttat gaccagtgac cctgaccaca cataatttga taggtaccca
     4561 ttcttccctg tgggaaagaa ttaaagaagg ctccatttct tggactctta agataggaat
     4621 ggggctttca ttagtttctc tagcagactg ctggctgtga aatggccaac ccctttggga
     4681 aatcagcgct atgttaagct cttgaactaa accaacagcc ataattattg tcccaagaaa
     4741 gtgtaatgcc gtcctttgta aaagatgata catggctggg tggcaggtat agggattttc
     4801 agatggactg gacagtaata cttttataac tacgtggact ttatggttct ttttctaggg
     4861 tgaaaccagt actttgtttt tatcctgatg ttgtcgttct ttggagtcag tttataatca
     4921 tttctaaagg actgtttgag caaccacaat ctaattaaac aaaacctagg caca
//
