LOCUS       NM_011752               2984 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ZPR1 zinc finger (Zpr1), mRNA.
ACCESSION   NM_011752
VERSION     NM_011752.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2984)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2984)
  AUTHORS   Kannan,A., Jiang,X., He,L., Ahmad,S. and Gangwani,L.
  TITLE     ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and
            rescues spinal muscular atrophy
  JOURNAL   Brain 143 (1), 69-93 (2020)
   PUBMED   31828288
  REMARK    GeneRIF: ZPR1 prevents R-loop accumulation, upregulates SMN2
            expression and rescues spinal muscular atrophy.
            Erratum:[Brain. 2020 Mar 1;143(3):e24. doi: 10.1093/brain/awaa007..
            PMID: 32333675]
REFERENCE   3  (bases 1 to 2984)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   4  (bases 1 to 2984)
  AUTHORS   Genabai,N.K., Kannan,A., Ahmad,S., Jiang,X., Bhatia,K. and
            Gangwani,L.
  TITLE     Deregulation of ZPR1 causes respiratory failure in spinal muscular
            atrophy
  JOURNAL   Sci Rep 7 (1), 8295 (2017)
   PUBMED   28811488
  REMARK    GeneRIF: these findings provide insight into the molecular basis of
            respiratory failure associated with SMA pathogenesis and identify
            ZPR1 and HoxA5 as potential targets that lay a foundation for
            developing therapeutic strategies to treat respiratory distress in
            SMA.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2984)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2984)
  AUTHORS   Gangwani,L., Flavell,R.A. and Davis,R.J.
  TITLE     ZPR1 is essential for survival and is required for localization of
            the survival motor neurons (SMN) protein to Cajal bodies
  JOURNAL   Mol Cell Biol 25 (7), 2744-2756 (2005)
   PUBMED   15767679
  REMARK    GeneRIF: ZPR1 contributes to the regulation of survival motor
            neurons complexes and that it is essential for cell survival
REFERENCE   7  (bases 1 to 2984)
  AUTHORS   Hemberger,M., Himmelbauer,H., Ruschmann,J., Zeitz,C. and Fundele,R.
  TITLE     cDNA subtraction cloning reveals novel genes whose temporal and
            spatial expression indicates association with trophoblast invasion
  JOURNAL   Dev Biol 222 (1), 158-169 (2000)
   PUBMED   10885754
REFERENCE   8  (bases 1 to 2984)
  AUTHORS   Gangwani,L., Mikrut,M., Galcheva-Gargova,Z. and Davis,R.J.
  TITLE     Interaction of ZPR1 with translation elongation factor-1alpha in
            proliferating cells
  JOURNAL   J Cell Biol 143 (6), 1471-1484 (1998)
   PUBMED   9852145
REFERENCE   9  (bases 1 to 2984)
  AUTHORS   Galcheva-Gargova,Z., Gangwani,L., Konstantinov,K.N., Mikrut,M.,
            Theroux,S.J., Enoch,T. and Davis,R.J.
  TITLE     The cytoplasmic zinc finger protein ZPR1 accumulates in the
            nucleolus of proliferating cells
  JOURNAL   Mol Biol Cell 9 (10), 2963-2971 (1998)
   PUBMED   9763455
REFERENCE   10 (bases 1 to 2984)
  AUTHORS   Galcheva-Gargova,Z., Konstantinov,K.N., Wu,I.H., Klier,F.G.,
            Barrett,T. and Davis,R.J.
  TITLE     Binding of zinc finger protein ZPR1 to the epidermal growth factor
            receptor
  JOURNAL   Science 272 (5269), 1797-1802 (1996)
   PUBMED   8650580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164105.4.
            
            On Mar 20, 2007 this sequence version replaced NM_011752.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.42068.1, AK168061.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AC164105.4         171705-172008       c
            305-466             AC164105.4         171433-171594       c
            467-557             AC164105.4         170926-171016       c
            558-628             AC164105.4         170345-170415       c
            629-715             AC164105.4         169622-169708       c
            716-838             AC164105.4         169219-169341       c
            839-886             AC164105.4         168825-168872       c
            887-953             AC164105.4         168594-168660       c
            954-1024            AC164105.4         168210-168280       c
            1025-1114           AC164105.4         167337-167426       c
            1115-1225           AC164105.4         166658-166768       c
            1226-1312           AC164105.4         165317-165403       c
            1313-1378           AC164105.4         165091-165156       c
            1379-2984           AC164105.4         162429-164034       c
FEATURES             Location/Qualifiers
     source          1..2984
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.38 cM"
     gene            1..2984
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /note="ZPR1 zinc finger"
                     /db_xref="GeneID:22687"
                     /db_xref="MGI:MGI:1330262"
     exon            1..304
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1513
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /note="zinc finger protein 259"
                     /codon_start=1
                     /product="zinc finger protein ZPR1"
                     /protein_id="NP_035882.1"
                     /db_xref="CCDS:CCDS23144.1"
                     /db_xref="GeneID:22687"
                     /db_xref="MGI:MGI:1330262"
                     /translation="MSASGAVQPGHPGAAVGPSPAAAASPATGPLFRPLSAEDEEQQP
                     TEIESLCMNCYRNGTTRLLLTKIPFFREIIVSSFSCEHCGWNNTEIQSAGRIQDQGVR
                     YTLTVRSQEDMNREVVKTDSATTRIPELDFEIPAFSQKGALTTVEGLISRAISGLEQD
                     QPTRRAVEGAIAERIDEFIGKLKDLKQMASPFTLVIDDPSGNSFVENPHAPQKDNALV
                     ITYYDRTPQQAEMLGLQAEAPEEKAEEEDLRNEVLQFNTNCPECNAPAQTNMKLVQIP
                     HFKEVIIMATNCENCGHRTNEVKSGGAVEPLGTRITLHITDPSDMTRDLLKSETCSVE
                     IPELEFELGMAVLGGKFTTLEGLLKDIRELVTKNPFTLGDSSNPDQSEKLQEFSQKLG
                     QIIEGKMKAHFIMNDPAGNSYLQNVYAPEDDPEMKVERYKRTFDQNEELGLNDMKTEG
                     YEAGLAPQR"
     exon            305..466
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     exon            467..557
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     exon            558..628
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     exon            629..715
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     exon            716..838
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     exon            839..886
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     exon            887..953
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1024
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1114
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1225
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1312
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1378
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..2984
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1920..1925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /note="hexamer: ATTAAA"
     polyA_site      1943
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /note="major polyA site"
     regulatory      2962..2967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
                     /note="hexamer: AATAAA"
     polyA_site      2984
                     /gene="Zpr1"
                     /gene_synonym="Zfp259; Znf259"
ORIGIN      
        1 ctttgtcaga gactgaccta ggaaacgcag ggtctgcggc ctctttaaga aggggcggga
       61 acaggggctg gaggaagtga ggtcgcaggg gccgcggaag ccggaagccg ccgcgggagc
      121 aacgcgtggg gagatgtctg ccagcggggc tgtgcagccg ggacacccgg gggccgccgt
      181 cgggccctcg cccgctgcgg ctgcgtcacc agccaccggg cctttgttcc ggcccctcag
      241 cgccgaggat gaggagcaac agcccaccga gatcgagtca ctgtgcatga actgttaccg
      301 gaacggcacg acgcgacttc tgctcaccaa gatccccttc tttagagaaa tcatcgtgag
      361 ctccttttcc tgcgaacact gtggctggaa caacacggag atccagtctg caggcaggat
      421 ccaggaccag ggagtgcgct acaccttgac cgtgagaagc caagaggaca tgaacagaga
      481 agtggtaaag acagactctg ccaccacaag gatccccgag ctggattttg agattccagc
      541 cttcagccag aagggagctc tgaccactgt tgaaggactc atcagccgtg cgatctctgg
      601 cctggaacag gatcagccca cacgacgggc agtggaaggt gccatcgcag agagaattga
      661 tgagttcatt ggcaaactga aggacctaaa gcaaatggct tcccctttca cactggtcat
      721 tgatgatccc tcgggaaaca gctttgtaga aaacccacat gctccccaga aagataatgc
      781 cttggtgatc acatactatg accgaacccc acagcaagct gagatgctgg ggctccaagc
      841 agaagcacca gaggagaagg cggaagagga agaccttaga aacgaagtgc tccagttcaa
      901 cactaactgc ccagagtgca acgctccggc tcagaccaac atgaagcttg tccaaatccc
      961 ccactttaaa gaggttatca tcatggccac caactgtgag aattgtgggc atcggactaa
     1021 tgaggtgaag tccggaggag ctgtagaacc tttgggtacc aggatcaccc tccacatcac
     1081 agatccctca gacatgacca gagacctcct caagtctgag acctgtagtg tggaaatccc
     1141 agagcttgag tttgaactgg gaatggctgt acttgggggc aagttcacca ctctagaagg
     1201 actgctgaaa gacatccgag aactggtaac caagaaccca ttcacactgg gcgacagctc
     1261 taatcctgac cagtcagaga aactgcagga gtttagccag aagttgggcc agatcatcga
     1321 gggcaagatg aaggcccact ttatcatgaa tgatccagca ggaaacagtt atctgcagaa
     1381 tgtgtatgca cctgaagacg atccagagat gaaggtcgag cggtacaaac gcacctttga
     1441 ccaaaatgag gagctcgggc tcaatgacat gaagacagag ggctatgagg cgggcctggc
     1501 cccacagcgg tagcagtggc cagctcactg gccagctaca gtgccactca cactgcaggg
     1561 ttatctgtta ctgtggggaa ctgacgagga gtgctcaagc cctcgtccat ggtgaagagg
     1621 ttaccacttg agttagaaat gtaagcaccc aagattagca gctgacggac gaggcagctg
     1681 cagccctact gtgctccttg accttctttt ggaggtttta aagtcggcgt gagaagaatc
     1741 ccagaaacac caggcggtct gccatcaccg tttgcctgtc agctctctga cctccagtgc
     1801 tggacctttg aagtctgggg aagtgaaata caagtttctg ctggctctgg gcatgtgaag
     1861 tactgactca gcagggaagg atgtcggagg ggccgagcag gcacaggtga agacgccaca
     1921 ttaaagtgat ggcctttaaa cgacacccgc ctctgcgttc atgtccttac tgattaccat
     1981 gtgctagact aagctgggtc acactgagtc acactcagct ccgaggagac tgaggacagc
     2041 ttgggccatg cagtgagagt ccgtcttcat gaaaagaaat gaggaaggaa aaaccagttt
     2101 agtttcctaa gcaaatcttt cttgaggtgg ctgctgtaga ggcagcattt gattcactcc
     2161 aataggccat cctgtctgct ctgagccagg tacacctgtg tggagtctag ctgttctcat
     2221 gcagcttaaa gcagtctgga aaagcagggt ggcacacacc tttaatccca gcagaggcag
     2281 gtggttctat gagtttgaag ccgatttggt ctacagagga agttccagga cagcctgggc
     2341 tacacagaaa aaccctgatt caagacaaaa cgaattcaaa ctggataacc agcaccatcc
     2401 ttgtttggcc tctgctagca aaaattagag ccaggcagta tgaagatgtg tgggttcctg
     2461 tacttacccg aaagttctta ttatctataa aggaggctaa taaaactgaa gggtaggtca
     2521 tggtgtccag ccacttgaga ggctgaggag gaaggctaac aaattcaggg gcagcttagg
     2581 caatttagat cttcaacatt caaaagagtg gggatgtagt tctatagaac tcctgcatac
     2641 catgtgcaaa aggccttggg tttaatcctc ggtgctggat gaaagaaaaa aaaattgtga
     2701 gggttaagtg agaagtcata aaacacttaa ccctttatag aagaaactcc agaatcttcc
     2761 tggtttcttt gccacactga ccacgaatcc atttcactgg gaagagttta tatcattttt
     2821 tagaaagaca tatcaaaggt gagaaggtca gtacaggttt gataaaaacc tatcaaactt
     2881 ttatagtcac aagtttgact tcccctaaat ggtacccgga agcctcttcc agcagacttc
     2941 ccaccaaaag gtatttatag caataaaagt gattgaaatt gaaa
//
