LOCUS       NM_027061               1519 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zona pellucida binding protein 2 (Zpbp2), transcript
            variant 1, mRNA.
ACCESSION   NM_027061 XM_126496
VERSION     NM_027061.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1519)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1519)
  AUTHORS   Youssef,M., De Sanctis,J.B., Shah,J., Dumut,D.C., Hajduch,M.,
            Naumova,A.K. and Radzioch,D.
  TITLE     Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b)
            Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (Ormdl3)
            Expression and Normalizes Ceramide Imbalance
  JOURNAL   J Pharmacol Exp Ther 373 (3), 476-487 (2020)
   PUBMED   32273303
REFERENCE   3  (bases 1 to 1519)
  AUTHORS   Chang,M.L., Moussette,S., Gamero-Estevez,E., Galvez,J.H.,
            Chiwara,V., Gupta,I.R., Ryan,A.K. and Naumova,A.K.
  TITLE     Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region
            and the circadian clock
  JOURNAL   PLoS One 14 (9), e0223212 (2019)
   PUBMED   31560728
  REMARK    GeneRIF: Study of diurnal expression profiles of ZPBP2/Zpbp2,
            gasdermin B, and ORMDL3/Ormdl3 in human and mouse tissues revealed
            that Ormdl3 and Zpbp2 were controlled by the circadian clock in a
            tissue-specific fashion provided the first evidence that
            disease-associated genes Zpbp2 and Ormdl3 are regulated by
            circadian rhythms and the Zpbp2 region influences expression of the
            core clock gene Nr1d1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1519)
  AUTHORS   Kanagaratham,C., Chiwara,V., Ho,B., Moussette,S., Youssef,M.,
            Venuto,D., Jeannotte,L., Bourque,G., de Sanctis,J.B., Radzioch,D.
            and Naumova,A.K.
  TITLE     Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice
            impacts airway hypersensitivity and lung lipid metabolism in a
            sex-dependent fashion
  JOURNAL   Mamm Genome 29 (3-4), 281-298 (2018)
   PUBMED   29536159
  REMARK    GeneRIF: the mouse ortholog of ZPBP2 has a role in controlling
            airway hypersensitivity in female mice.
REFERENCE   5  (bases 1 to 1519)
  AUTHORS   Dun,M.D., Smith,N.D., Baker,M.A., Lin,M., Aitken,R.J. and Nixon,B.
  TITLE     The chaperonin containing TCP1 complex (CCT/TRiC) is involved in
            mediating sperm-oocyte interaction
  JOURNAL   J Biol Chem 286 (42), 36875-36887 (2011)
   PUBMED   21880732
REFERENCE   6  (bases 1 to 1519)
  AUTHORS   Lin,Y.N., Roy,A., Yan,W., Burns,K.H. and Matzuk,M.M.
  TITLE     Loss of zona pellucida binding proteins in the acrosomal matrix
            disrupts acrosome biogenesis and sperm morphogenesis
  JOURNAL   Mol Cell Biol 27 (19), 6794-6805 (2007)
   PUBMED   17664285
  REMARK    Erratum:[Mol Cell Biol. 2008 Apr;28(7):2495]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089476.1, AK006058.1 and AL591125.20.
            
            On Oct 27, 2009 this sequence version replaced NM_027061.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY251601.1, SRR5189685.121288.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-580               BC089476.1         1-580
            581-848             AK006058.1         649-916
            849-1512            BC089476.1         630-1293
            1513-1519           AL591125.20        105188-105194       c
FEATURES             Location/Qualifiers
     source          1..1519
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.97 cM"
     gene            1..1519
                     /gene="Zpbp2"
                     /gene_synonym="1700017D11Rik; 2610022C02Rik; ZPBPL"
                     /note="zona pellucida binding protein 2"
                     /db_xref="GeneID:69376"
                     /db_xref="MGI:MGI:1916626"
     exon            1..226
                     /gene="Zpbp2"
                     /gene_synonym="1700017D11Rik; 2610022C02Rik; ZPBPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1158
                     /gene="Zpbp2"
                     /gene_synonym="1700017D11Rik; 2610022C02Rik; ZPBPL"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="zona pellucida-binding protein 2 isoform 1
                     precursor"
                     /protein_id="NP_081337.2"
                     /db_xref="CCDS:CCDS25353.1"
                     /db_xref="GeneID:69376"
                     /db_xref="MGI:MGI:1916626"
                     /translation="MLAWALLYAVLWSLAGVGSQRSSLFNIKGFVYGTVGHPVKIYVK
                     LHQASPVLICMDIDRANKETVDPTYLWTGPNENTLKGNSQINITNTGELVLKDFLEPL
                     SGLYSCMLSYKTIKAETQEETMIKKKYDFLVFAYREPDYSYHMAVRFTTGSCVGRHND
                     LLFRVLKKILDNLISDLLCHVIEPSYKCHFVKLPERDFLYELFIAFQVNPFAPGWRSL
                     CNRSADCEDITNHNVLKARDRMEEFFRKQAHILHHHFNRTVPAMHFVDHSFQVTRIDN
                     CRPGFGKNEGLHSNCATCCVVCSPGTFSPDVDVTCQICVSVHIYGAKACP"
     exon            227..292
                     /gene="Zpbp2"
                     /gene_synonym="1700017D11Rik; 2610022C02Rik; ZPBPL"
                     /inference="alignment:Splign:2.1.0"
     exon            293..418
                     /gene="Zpbp2"
                     /gene_synonym="1700017D11Rik; 2610022C02Rik; ZPBPL"
                     /inference="alignment:Splign:2.1.0"
     exon            419..580
                     /gene="Zpbp2"
                     /gene_synonym="1700017D11Rik; 2610022C02Rik; ZPBPL"
                     /inference="alignment:Splign:2.1.0"
     exon            581..799
                     /gene="Zpbp2"
                     /gene_synonym="1700017D11Rik; 2610022C02Rik; ZPBPL"
                     /inference="alignment:Splign:2.1.0"
     exon            800..882
                     /gene="Zpbp2"
                     /gene_synonym="1700017D11Rik; 2610022C02Rik; ZPBPL"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1063
                     /gene="Zpbp2"
                     /gene_synonym="1700017D11Rik; 2610022C02Rik; ZPBPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1519
                     /gene="Zpbp2"
                     /gene_synonym="1700017D11Rik; 2610022C02Rik; ZPBPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1489..1494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zpbp2"
                     /gene_synonym="1700017D11Rik; 2610022C02Rik; ZPBPL"
                     /note="hexamer: AATAAA"
     polyA_site      1519
                     /gene="Zpbp2"
                     /gene_synonym="1700017D11Rik; 2610022C02Rik; ZPBPL"
                     /note="major polyA site"
ORIGIN      
        1 gtgccaagcc ggaacacgca ggcgctctcg ggcacagccg cccccgtgat agcctgggac
       61 cggtagggaa gatgcccttg gcggtttgct tcgctctgta gaggagcgat ggggaggcgt
      121 tgggcctggc ctgaggtagg agggcaccca gccgtcgcca ctagtgcctg agccgtgatg
      181 cttgcgtggg ccctactcta cgcggtgctc tggtctctcg caggagttgg atcgcaacgt
      241 tcttccttat tcaatatcaa aggctttgtt tacggcacgg tagggcaccc agtaaaaata
      301 tatgtaaagt tacatcaggc tagtcctgtc cttatttgta tggatattga tcgtgccaat
      361 aaagaaacag tggaccccac ctatttatgg actgggccaa atgaaaacac attaaaaggg
      421 aatagccaga taaatataac aaacacagga gaactggtac tgaaggattt cctggagccg
      481 ttatctggac tttactcatg tatgctttcc tataagacta tcaaagcaga aacccaagaa
      541 gaaactatga taaagaagaa atatgacttt ctggtctttg catatcggga acctgattat
      601 tcttaccaca tggccgtgcg ttttaccaca ggatcttgtg taggaagaca caatgacctg
      661 ctctttagag tgctgaagaa aatcttggat aacttaatct ctgatttatt gtgccatgtc
      721 atagagccat catacaaatg ccattttgtt aaacttccag agagggactt cctgtatgag
      781 ctgttcatag cctttcaagt gaatcctttc gcaccgggct ggagaagttt gtgcaaccgc
      841 tctgctgact gtgaagacat cacgaatcac aacgtcctca aggcgagaga tcggatggaa
      901 gaattttttc ggaaacaagc acacattcta caccatcact tcaacagaac ggtcccagct
      961 atgcactttg tggaccacag ttttcaagta acacggatag acaattgtcg accaggcttt
     1021 gggaaaaacg aaggtctgca cagcaattgt gctacctgtt gcgtggtctg tagtcctgga
     1081 acgttcagtc ccgatgtgga tgtcacctgt cagatctgtg tttctgtcca tatctatgga
     1141 gctaaagctt gcccataaac tccaagagca gaggtggaag catggctgtt tgcccttgaa
     1201 ggtgggggcc aagatctgct ggcatcagag agcatcgtag gtacctcggg aaagtaagat
     1261 cagtaagggc aaagctttgg aagtccgcac tctagaaaca acagcagaaa gtagctgaca
     1321 tggaccagag aagttgcttc tgagaaggca tttatctctg tgcctccggt gtacgagagg
     1381 aagttcaagt gctactggat gctttaaatg aatacgttct gttttctaca aactgaaaca
     1441 tgctttgtac ctgatattaa ggtcaaaaag agtagcaaag tataatataa taaaacattg
     1501 tctattttcc aaatattaa
//
