LOCUS       NM_011775               2229 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus zona pellucida glycoprotein 2 (Zp2), transcript
            variant 1, mRNA.
ACCESSION   NM_011775
VERSION     NM_011775.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2229)
  AUTHORS   Yao,X., Wang,C., Yu,W., Sun,L., Lv,Z., Xie,X., Tian,S., Yan,L.,
            Li,L. and Liu,J.
  TITLE     BCAS2 regulates oocyte meiotic prophase I by participating in mRNA
            alternative splicing
  JOURNAL   FASEB J 38 (1), e23361 (2024)
   PUBMED   38085152
REFERENCE   2  (bases 1 to 2229)
  AUTHORS   Liu,S.L., Zuo,H.Y., Zhao,B.W., Guo,J.N., Liu,W.B., Lei,W.L.,
            Li,Y.Y., Ouyang,Y.C., Hou,Y., Han,Z.M., Wang,W.Z., Sun,Q.Y. and
            Wang,Z.B.
  TITLE     A heterozygous ZP2 mutation causes zona pellucida defects and
            female infertility in mouse and human
  JOURNAL   iScience 26 (10), 107828 (2023)
   PUBMED   37736051
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2229)
  AUTHORS   Shen,Y., Guo,J., Zhang,X., Wang,X., Zhu,S., Chen,D., Xiong,W.,
            Lu,G., Liu,X., Dai,C., Gong,F., Wang,Y., Lin,G., Wang,Z. and Xu,W.
  TITLE     Identification of a heterozygous variant of ZP2 as a novel cause of
            empty follicle syndrome in humans and mice
  JOURNAL   Hum Reprod 37 (4), 859-872 (2022)
   PUBMED   35211729
  REMARK    GeneRIF: Identification of a heterozygous variant of ZP2 as a novel
            cause of empty follicle syndrome in humans and mice.
REFERENCE   4  (bases 1 to 2229)
  AUTHORS   Zhao,L.W., Zhu,Y.Z., Chen,H., Wu,Y.W., Pi,S.B., Chen,L., Shen,L.
            and Fan,H.Y.
  TITLE     PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the
            maternal-to-zygotic transition
  JOURNAL   EMBO Rep 21 (8), e49956 (2020)
   PUBMED   32558204
REFERENCE   5  (bases 1 to 2229)
  AUTHORS   Boja,E.S., Hoodbhoy,T., Fales,H.M. and Dean,J.
  TITLE     Structural characterization of native mouse zona pellucida proteins
            using mass spectrometry
  JOURNAL   J Biol Chem 278 (36), 34189-34202 (2003)
   PUBMED   12799386
  REMARK    GeneRIF: characterization of native mouse zona pellucida proteins
            by mass spectrometry
REFERENCE   6  (bases 1 to 2229)
  AUTHORS   Shekels,L.L., Lyftogt,C., Kieliszewski,M., Filie,J.D., Kozak,C.A.
            and Ho,S.B.
  TITLE     Mouse gastric mucin: cloning and chromosomal localization
  JOURNAL   Biochem J 311 (Pt 3) (Pt 3), 775-785 (1995)
   PUBMED   7487932
REFERENCE   7  (bases 1 to 2229)
  AUTHORS   Siracusa,L.D., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification and applications of repetitive probes for gene
            mapping in the mouse
  JOURNAL   Genetics 127 (1), 169-179 (1991)
   PUBMED   1673105
REFERENCE   8  (bases 1 to 2229)
  AUTHORS   Lyon,M.F., Peters,J., Glenister,P.H., Ball,S. and Wright,E.
  TITLE     The scurfy mouse mutant has previously unrecognized hematological
            abnormalities and resembles Wiskott-Aldrich syndrome
  JOURNAL   Proc Natl Acad Sci U S A 87 (7), 2433-2437 (1990)
   PUBMED   2320565
REFERENCE   9  (bases 1 to 2229)
  AUTHORS   Liang,L.F., Chamow,S.M. and Dean,J.
  TITLE     Oocyte-specific expression of mouse Zp-2: developmental regulation
            of the zona pellucida genes
  JOURNAL   Mol Cell Biol 10 (4), 1507-1515 (1990)
   PUBMED   1690843
REFERENCE   10 (bases 1 to 2229)
  AUTHORS   Lunsford,R.D., Jenkins,N.A., Kozak,C.A., Liang,L.F., Silan,C.M.,
            Copeland,N.G. and Dean,J.
  TITLE     Genomic mapping of murine Zp-2 and Zp-3, two oocyte-specific loci
            encoding zona pellucida proteins
  JOURNAL   Genomics 6 (1), 184-187 (1990)
   PUBMED   1968044
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK138699.1, AK135903.1 and
            DV657934.1.
            
            On Sep 13, 2016 this sequence version replaced NM_011775.6.
            
            Summary: This gene encodes a member of the zona pellucida family of
            glycoproteins that play an important role in the survival of
            growing oocytes, successful fertilization and the passage of early
            embryos through the oviduct. The encoded preproprotein undergoes
            proteolytic processing to generate the mature polypeptide that is
            incorporated into the extracellular matrix surrounding mouse
            oocytes. Mice lacking the encoded protein develop defective zonae
            pellucidae that disrupt folliculogenesis, fertility and
            development. [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071183.1, M34148.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK138699.1         1-2
            3-2015              AK135903.1         2-2014
            2016-2229           DV657934.1         59-272
FEATURES             Location/Qualifiers
     source          1..2229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 64.38 cM"
     gene            1..2229
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /note="zona pellucida glycoprotein 2"
                     /db_xref="GeneID:22787"
                     /db_xref="MGI:MGI:99214"
     exon            1..81
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2173
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; zona pellucida sperm-binding protein 2; zona
                     pellucida protein A; zona pellucida glycoprotein ZP2"
                     /codon_start=1
                     /product="zona pellucida sperm-binding protein 2 isoform 1
                     preproprotein"
                     /protein_id="NP_035905.1"
                     /db_xref="CCDS:CCDS21792.1"
                     /db_xref="GeneID:22787"
                     /db_xref="MGI:MGI:99214"
                     /translation="MARWQRKASVSSPCGRSIYRFLSLLFTLVTSVNSVSLPQSENPA
                     FPGTLICDKDEVRIEFSSRFDMEKWNPSVVDTLGSEILNCTYALDLERFVLKFPYETC
                     TIKVVGGYQVNIRVGDTTTDVRYKDDMYHFFCPAIQAETHEISEIVVCRRDLISFSFP
                     QLFSRLADENQNVSEMGWIVKIGNGTRAHILPLKDAIVQGFNLLIDSQKVTLHVPANA
                     TGIVHYVQESSYLYTVQLELLFSTTGQKIVFSSHAICAPDLSVACNATHMTLTIPEFP
                     GKLESVDFGQWSIPEDQWHANGIDKEATNGLRLNFRKSLLKTKPSEKCPFYQFYLSSL
                     KLTFYFQGNMLSTVIDPECHCESPVSIDELCAQDGFMDFEVYSHQTKPALNLDTLLVG
                     NSSCQPIFKVQSVGLARFHIPLNGCGTRQKFEGDKVIYENEIHALWENPPSNIVFRNS
                     EFRMTVRCYYIRDSMLLNAHVKGHPSPEAFVKPGPLVLVLQTYPDQSYQRPYRKDEYP
                     LVRYLRQPIYMEVKVLSRNDPNIKLVLDDCWATSSEDPASAPQWQIVMDGCEYELDNY
                     RTTFHPAGSSAAHSGHYQRFDVKTFAFVSEARGLSSLIYFHCSALICNQVSLDSPLCS
                     VTCPASLRSKREANKEDTMTVSLPGPILLLSDVSSSKGVDPSSSEITKDIIAKDIASK
                     TLGAVAALVGSAVILGFICYLYKKRTIRFNH"
     exon            82..170
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            171..254
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            255..349
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            350..499
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..544
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            545..706
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..803
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..988
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1115
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1297
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1389
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1514
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1704
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1840
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1937
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2015
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2205
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /note="hexamer: AATAAA"
     polyA_site      2205
                     /gene="Zp2"
                     /gene_synonym="Zp-2"
                     /note="major polyA site"
ORIGIN      
        1 tcacctcggc gctttggtgg taccttccaa catggcgagg tggcagagga aagcatctgt
       61 aagctctccg tgcggcagga gcatctacag gtttctttcc ctcttattca cccttgtgac
      121 ttcagtgaac tcagtaagcc ttcctcagtc cgagaatcct gccttcccag gcactctcat
      181 ttgtgacaaa gacgaagtga gaattgaatt ttcaagcaga tttgacatgg aaaaatggaa
      241 tccttctgtg gtggataccc ttggtagtga aattttgaac tgcacttatg ctctggactt
      301 ggaaaggttc gtcctgaagt tcccttacga gacctgcact ataaaagtgg ttggtggata
      361 ccaggtgaac atcagagtgg gggacaccac cactgatgtg agatataaag atgacatgta
      421 tcatttcttc tgtccagcta ttcaagcaga gacccatgag atttcagaaa ttgttgtctg
      481 caggagagat ctaatatctt tttctttccc acaacttttc tctaggcttg ctgatgaaaa
      541 ccagaatgta tctgagatgg gatggattgt taagattggc aatggtacaa gagcccacat
      601 tctgcccttg aaggatgcca tagtacaagg atttaatctt ctgattgaca gccagaaagt
      661 aactctccac gtgccagcca atgctactgg aatagttcac tatgtgcaag agagcagcta
      721 tctctatact gtgcagctgg agctcttgtt ctcaaccact gggcagaaga tcgtcttctc
      781 atcacacgct atctgcgcac cagatctttc tgtggcttgt aatgctacac acatgactct
      841 cactatacca gaatttcctg ggaagctaga gtctgtggac tttggacaat ggagcatccc
      901 tgaggaccaa tggcatgcca atggaattga caaagaagca acaaatggct tgagattgaa
      961 tttcagaaaa tctctcctga aaactaaacc ctctgaaaaa tgtccattct accagttcta
     1021 cctctcttca ctcaagctga ccttctactt ccaagggaac atgctatcca cagtgataga
     1081 tcctgagtgc cactgtgagt caccagtctc tatagatgaa ctgtgtgcac aggatgggtt
     1141 tatggacttt gaggtctaca gccaccaaac aaaacccgca ctgaacctgg acaccctcct
     1201 ggtgggaaat tcctcttgcc agcctatttt caaggtgcag tctgtggggc ttgcaaggtt
     1261 tcacatacct ctgaatggat gtggaacaag gcagaaattt gaaggtgata aagtcatcta
     1321 tgagaatgaa atacatgctc tctgggaaaa cccaccctcc aacattgtat tcagaaacag
     1381 cgagttcagg atgacagtaa gatgctatta catcagagac agtatgctac taaatgccca
     1441 tgtcaaagga catccttctc cagaggcctt tgtaaagcca ggcccactgg tgttggtcct
     1501 acaaacatac ccagaccaat cctaccaacg gccttacagg aaggatgagt accctctagt
     1561 gaggtacctc cgccagccaa tctacatgga agtgaaggtc ttgagcagga acgatcccaa
     1621 catcaagctg gtcttagatg actgctgggc aacttcttct gaggacccgg cctctgcgcc
     1681 tcagtggcag attgtcatgg atggctgtga atatgaactg gacaactacc gcactacttt
     1741 ccacccagct ggctcctctg cagcccattc cggtcactac cagaggtttg atgtgaagac
     1801 ttttgccttt gtatcagagg cacgggggct ctccagcctg atctacttcc actgcagtgc
     1861 cttgatctgt aaccaagtct ctcttgactc ccctctgtgc tctgtgactt gccctgcatc
     1921 actgaggagc aaacgagagg ccaacaaaga agacacaatg acggttagcc ttccaggacc
     1981 tattctcttg ctgtcagatg tctcttcatc caaaggtgtt gaccccagca gctctgagat
     2041 taccaaggat attattgcca aggatattgc ttctaaaaca ttgggtgctg tggctgcact
     2101 agtgggctca gctgtcattc taggcttcat ctgttacctg tataagaaaa gaactataag
     2161 gttcaatcac tgattggact tgcaaataaa gagactgcag ttaaaaaaaa aaaaaaaaaa
     2221 aaaaaaaaa
//
