LOCUS       NP_033606                623 aa            linear   ROD 27-APR-2025
DEFINITION  zona pellucida sperm-binding protein 1 precursor [Mus musculus].
ACCESSION   NP_033606 XP_986786 XP_989500 XP_991598
VERSION     NP_033606.2
DBSOURCE    REFSEQ: accession NM_009580.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 623)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 623)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   3  (residues 1 to 623)
  AUTHORS   Kato,Y., Iwamori,T., Ninomiya,Y., Kohda,T., Miyashita,J., Sato,M.
            and Saga,Y.
  TITLE     ELAVL2-directed RNA regulatory network drives the formation of
            quiescent primordial follicles
  JOURNAL   EMBO Rep 20 (12), e48251 (2019)
   PUBMED   31657143
REFERENCE   4  (residues 1 to 623)
  AUTHORS   Wang,Y., Lv,C., Huang,H.L., Zeng,M.H., Yi,D.J., Tan,H.J.,
            Peng,T.L., Yu,W.X., Deng,H.W. and Xiao,H.M.
  TITLE     Influence of mouse defective zona pellucida in folliculogenesis on
            apoptosis of granulosa cells and developmental competence of
            oocytesdagger
  JOURNAL   Biol Reprod 101 (2), 457-465 (2019)
   PUBMED   31162612
  REMARK    GeneRIF: Influence of mouse defective zona pellucida in
            folliculogenesis on apoptosis of granulosa cells and developmental
            competence of oocytesdagger.
REFERENCE   5  (residues 1 to 623)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 623)
  AUTHORS   Rowe,L.B., Janaswami,P.M., Barter,M.E. and Birkenmeier,E.H.
  TITLE     Genetic mapping of 18S ribosomal RNA-related loci to mouse
            chromosomes 5, 6, 9, 12, 17, 18, 19, and X
  JOURNAL   Mamm Genome 7 (12), 886-889 (1996)
   PUBMED   8995758
REFERENCE   7  (residues 1 to 623)
  AUTHORS   Epifano,O., Liang,L.F. and Dean,J.
  TITLE     Mouse Zp1 encodes a zona pellucida protein homologous to egg
            envelope proteins in mammals and fish
  JOURNAL   J Biol Chem 270 (45), 27254-27258 (1995)
   PUBMED   7592984
REFERENCE   8  (residues 1 to 623)
  AUTHORS   Epifano,O., Liang,L.F., Familari,M., Moos,M.C. Jr. and Dean,J.
  TITLE     Coordinate expression of the three zona pellucida genes during
            mouse oogenesis
  JOURNAL   Development 121 (7), 1947-1956 (1995)
   PUBMED   7635043
REFERENCE   9  (residues 1 to 623)
  AUTHORS   Tong,Z.B., Nelson,L.M. and Dean,J.
  TITLE     Inhibition of zona pellucida gene expression by antisense
            oligonucleotides injected into mouse oocytes
  JOURNAL   J Biol Chem 270 (2), 849-853 (1995)
   PUBMED   7822321
REFERENCE   10 (residues 1 to 623)
  AUTHORS   Harris,J.D., Hibler,D.W., Fontenot,G.K., Hsu,K.T., Yurewicz,E.C.
            and Sacco,A.G.
  TITLE     Cloning and characterization of zona pellucida genes and cDNAs from
            a variety of mammalian species: the ZPA, ZPB and ZPC gene families
  JOURNAL   DNA Seq 4 (6), 361-393 (1994)
   PUBMED   7841460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC125613.1.
            
            On or before Jan 29, 2007 this sequence version replaced
            XP_991598.1, XP_986786.1, XP_989500.1, NP_033606.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC125613.1, BC100347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 7.36 cM"
     Protein         1..623
                     /product="zona pellucida sperm-binding protein 1
                     precursor"
                     /note="zona pellucida sperm-binding protein 1; zp-1"
                     /calculated_mol_wt=66627
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2115
     mat_peptide     21..546
                     /product="Zona pellucida sperm-binding protein 1.
                     /id=PRO_0000041679"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62005.1)"
                     /calculated_mol_wt=58326
     Site            21
                     /site_type="pyrrolidone-carboxylic-acid"
                     /note="Pyrrolidone carboxylic acid.
                     /evidence=ECO:0000269|PubMed:12799386; propagated from
                     UniProtKB/Swiss-Prot (Q62005.1)"
     Site            49
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12799386; propagated from
                     UniProtKB/Swiss-Prot (Q62005.1)"
     Site            68
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12799386; propagated from
                     UniProtKB/Swiss-Prot (Q62005.1)"
     Region          182..201
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62005.1)"
     Region          226..268
                     /region_name="PD"
                     /note="P or trefoil or TFF domain; smart00018"
                     /db_xref="CDD:197472"
     Site            order(240,260..261)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:238059"
     Site            240
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12799386; propagated from
                     UniProtKB/Swiss-Prot (Q62005.1)"
     Site            order(255,260)
                     /site_type="active"
                     /note="putative binding specificity loop [active]"
                     /db_xref="CDD:238059"
     Region          271..541
                     /region_name="ZP"
                     /note="Zona pellucida (ZP) domain; smart00241"
                     /db_xref="CDD:214579"
     Site            371
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12799386; propagated from
                     UniProtKB/Swiss-Prot (Q62005.1)"
     Site            554
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62005.1)"
     Site            585
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62005.1)"
     Site            591..611
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62005.1)"
     CDS             1..623
                     /gene="Zp1"
                     /coded_by="NM_009580.2:27..1898"
                     /db_xref="CCDS:CCDS37918.1"
                     /db_xref="GeneID:22786"
                     /db_xref="MGI:MGI:103073"
ORIGIN      
        1 mawgcfvvll llaaaplrlg qrlhlepgfe ysydcgvrgm qllvfprpnq tvqfkvldef
       61 gnrfevnncs icyhwvtsea qehtvfsady kgchvlekdg rfhlrvfiqa vlpngrvdia
      121 qdvtlicpkp dhtvtpdpyl appttpepft phafalhpip dhtlagsght glttlypeqs
      181 fihptpapps lgpgpagstv phsqwgtlep welteldsvg thlpqercqv asghipcmvn
      241 gssketcqqa gccydstkee pcyygntvtl qcfksgyftl vmsqetalth gvlldnvhla
      301 yapngcpptq ktsafvvfhv pltlcgtaiq vvgeqliyen qlvsdidvqk gpqgsitrds
      361 afrlhvrcif nasdflpiqa sifspqppap vtqsgplrle lriatdktfs syyqgsdypl
      421 vrllrepvyv evrllqrtdp slvlvlhqcw atpttspfeq pqwpilsdgc pfkgdnyrtq
      481 vvaadrealp fwshyqrfti ttfmlldsss qnalrgqvyf fcsasachpl gsdtcsttcd
      541 sgiarrrrss ghhnitlral divsspgavg fedaakleps gssrnsssrm lllllaitla
      601 laagifvgli wawaqklweg iry
//
