LOCUS       NM_001080924            6306 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus zinc and ring finger 3 (Znrf3), transcript variant 1,
            mRNA.
ACCESSION   NM_001080924 XM_893176 XM_988545
VERSION     NM_001080924.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6306)
  AUTHORS   Kay,R.G.G., Reeves,R., Siggers,P., Greenaway,S., Mallon,A.M.,
            Wells,S., Koo,B.K., Mayere,C., Nef,S., Greenfield,A. and Simon,M.M.
  TITLE     Gonadal sex reversal at single-cell resolution in Znrf3-deficient
            mice
  JOURNAL   Development 151 (23) (2024)
   PUBMED   39629665
REFERENCE   2  (bases 1 to 6306)
  AUTHORS   Wilmouth,J.J. Jr., Olabe,J., Garcia-Garcia,D., Lucas,C., Guiton,R.,
            Roucher-Boulez,F., Dufour,D., Damon-Soubeyrand,C.,
            Sahut-Barnola,I., Pointud,J.C., Renaud,Y., Levasseur,A.,
            Tauveron,I., Lefrancois-Martinez,A.M., Martinez,A. and Val,P.
  TITLE     Sexually dimorphic activation of innate antitumor immunity prevents
            adrenocortical carcinoma development
  JOURNAL   Sci Adv 8 (41), eadd0422 (2022)
   PUBMED   36240276
REFERENCE   3  (bases 1 to 6306)
  AUTHORS   Lu,C., Lin,X., Yamashita,J., Xi,R., Zhou,M., Zhang,Y.V., Wang,H.,
            Margolskee,R.F., Koo,B.K., Clevers,H., Matsumoto,I. and Jiang,P.
  TITLE     RNF43/ZNRF3 negatively regulates taste tissue homeostasis and
            positively regulates dorsal lingual epithelial tissue homeostasis
  JOURNAL   Stem Cell Reports 17 (2), 369-383 (2022)
   PUBMED   34995498
  REMARK    GeneRIF: RNF43/ZNRF3 negatively regulates taste tissue homeostasis
            and positively regulates dorsal lingual epithelial tissue
            homeostasis.
REFERENCE   4  (bases 1 to 6306)
  AUTHORS   Sun,T., Annunziato,S., Bergling,S., Sheng,C., Orsini,V.,
            Forcella,P., Pikiolek,M., Kancherla,V., Holwerda,S., Imanci,D.,
            Wu,F., Meylan,L.C., Puehringer,L.F., Waldt,A., Oertli,M.,
            Schuierer,S., Terracciano,L.M., Reinker,S., Ruffner,H.,
            Bouwmeester,T., Sailer,A.W., George,E., Roma,G., de Weck,A.,
            Piscuoglio,S., Lohmann,F., Naumann,U., Liberali,P., Cong,F. and
            Tchorz,J.S.
  TITLE     ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and
            hepatocyte proliferation
  JOURNAL   Cell Stem Cell 28 (10), 1822-1837 (2021)
   PUBMED   34129813
  REMARK    GeneRIF: ZNRF3 and RNF43 cooperate to safeguard metabolic liver
            zonation and hepatocyte proliferation.
REFERENCE   5  (bases 1 to 6306)
  AUTHORS   Le Rolle,M., Massa,F., Siggers,P., Turchi,L., Loubat,A., Koo,B.K.,
            Clevers,H., Greenfield,A., Schedl,A., Chaboissier,M.C. and
            Chassot,A.A.
  TITLE     Arrest of WNT/beta-catenin signaling enables the transition from
            pluripotent to differentiated germ cells in mouse ovaries
  JOURNAL   Proc Natl Acad Sci U S A 118 (30) (2021)
   PUBMED   34301885
REFERENCE   6  (bases 1 to 6306)
  AUTHORS   Peng,W.C., de Lau,W., Madoori,P.K., Forneris,F., Granneman,J.C.,
            Clevers,H. and Gros,P.
  TITLE     Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1
            and implications for signaling
  JOURNAL   PLoS One 8 (12), e83110 (2013)
   PUBMED   24349440
  REMARK    GeneRIF: ZNRF3 binds RSPO1 and LGR5-RSPO1 with micromolar affinity
            via RSPO1 furin-like 1 (Fu1) domain.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6306)
  AUTHORS   Koo,B.K., Spit,M., Jordens,I., Low,T.Y., Stange,D.E., van de
            Wetering,M., van Es,J.H., Mohammed,S., Heck,A.J., Maurice,M.M. and
            Clevers,H.
  TITLE     Tumour suppressor RNF43 is a stem-cell E3 ligase that induces
            endocytosis of Wnt receptors
  JOURNAL   Nature 488 (7413), 665-669 (2012)
   PUBMED   22895187
REFERENCE   8  (bases 1 to 6306)
  AUTHORS   Hao,H.X., Xie,Y., Zhang,Y., Charlat,O., Oster,E., Avello,M.,
            Lei,H., Mickanin,C., Liu,D., Ruffner,H., Mao,X., Ma,Q., Zamponi,R.,
            Bouwmeester,T., Finan,P.M., Kirschner,M.W., Porter,J.A.,
            Serluca,F.C. and Cong,F.
  TITLE     ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive
            manner
  JOURNAL   Nature 485 (7397), 195-200 (2012)
   PUBMED   22575959
  REMARK    GeneRIF: data suggest that R-spondin enhances Wnt signalling by
            inhibiting ZNRF3
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6306)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   10 (bases 1 to 6306)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662876.23 and AL662853.16.
            
            On Feb 15, 2008 this sequence version replaced NM_001080924.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR15390195.278315.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               AL662876.23        72745-73204         c
            461-586             AL662853.16        163698-163823       c
            587-661             AL662853.16        114723-114797       c
            662-793             AL662853.16        114086-114217       c
            794-904             AL662853.16        112433-112543       c
            905-1072            AL662853.16        111154-111321       c
            1073-1175           AL662853.16        108398-108500       c
            1176-2873           AL662853.16        105868-107565       c
            2874-6306           AL662853.16        101389-104821       c
FEATURES             Location/Qualifiers
     source          1..6306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.46 cM"
     gene            1..6306
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /note="zinc and ring finger 3"
                     /db_xref="GeneID:407821"
                     /db_xref="MGI:MGI:3039616"
     exon            1..460
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2911
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; zinc/RING finger protein 3; E3
                     ubiquitin-protein ligase ZNRF3; RING-type E3 ubiquitin
                     transferase ZNRF3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ZNRF3 isoform 1
                     precursor"
                     /protein_id="NP_001074393.1"
                     /db_xref="CCDS:CCDS36102.1"
                     /db_xref="GeneID:407821"
                     /db_xref="MGI:MGI:3039616"
                     /translation="MRPRSGGRPGAPGRRRRRLRRGPRGRRLPPPPPLPLLLGLLLAA
                     AGPGAARAKETAFVEVVLFESSPSGDYTTHTTGLTGRFSRAGAMLSAEGEIVQMHPLG
                     LCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPE
                     AIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHLPPRQPTEYFDMGI
                     FLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSC
                     GALDTLSSGSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNI
                     IEQKGNPGAVCVETSNLTRGRQPRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
                     LLTMDRHGEQNLYSPQTPTYVRGYPPLHLDHTLAPHRCSLEHRAYSPAHPFRRPKFSS
                     RSFSKAACFSQYETMYQHYYFQGLSYPEQEGQTIPSVTPRGQSRAFPPSGASSLLFPT
                     MVHVAPPTHVESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSNSSGQCRCSSSDSVVD
                     CTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRGPAVHLEGSPPPEELPAGHSQSAGRG
                     EPWLGPASPSGDQLSTCSLEMNYSSNSSLEPRGPNSSTSEVGLEVSPGAALDLRRTWK
                     GGPEGPSCACCFEPQPFPPGSGIETSAGGSSLFLGPRLLEDCNPPSGEPQLGSSQGLY
                     GLHSDHYPRTDGVKYEGLPCCFYEEKQVAHSAGRGNGCYTEDYSVSVQYTLTEEPPPS
                     CYAGPRDLSQRIPIIPEDVDCDLGLPQDCHGMHNHSPWGGALSLDVPRLHWSLGTTRE
                     EEQAPCYQAEVQPGCSPEEAGASRASLSSAPQDTQESHALAAEASGPGSGPGIGTGA"
     exon            461..586
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /inference="alignment:Splign:2.1.0"
     exon            587..661
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /inference="alignment:Splign:2.1.0"
     exon            662..793
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /inference="alignment:Splign:2.1.0"
     exon            794..904
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1072
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1175
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..2873
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..6306
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6288..6293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /note="hexamer: AATACA"
     polyA_site      6306
                     /gene="Znrf3"
                     /gene_synonym="Gm1167"
                     /note="major polyA site"
ORIGIN      
        1 agatgaaagg gccgcggcgc gacggccggg ggagcggagc agagcctgcg acccacaaag
       61 ccgccgccgc cgcgatggtg ctgtgaggcg accgcccgcg ctcggtcctc cgccggcccg
      121 cgactatgcc cggccgcgcc cgccctccgc gccctcccgc cgcaggacca tgaggccacg
      181 ctcgggcggg cgcccagggg ccccgggccg ccgccgccgc cgcctccgcc gcggcccccg
      241 cggtcgtcgc ctgccgccgc cgccgccgct gccgctgctt ctcgggctgc tgctggcggc
      301 cgcggggccc ggcgcggcgc gggccaagga gacggcgttc gtggaggtgg tgctgttcga
      361 gtcgagcccg agcggcgact ataccaccca caccaccggc ctcacgggcc gcttctcgcg
      421 ggccggggcc atgctcagcg ccgagggcga gatcgtgcag atgcacccac taggcctatg
      481 taataacaat gacgaagagg acttgtatga atatggctgg gtaggagtgg tgaagcttga
      541 acagccagaa ttggacccca aaccatgtct cactgtcctg ggcaaggcca agagagcagt
      601 tcagcgggga gctactgcag ttatctttga tgtatctgaa aatccagaag ccatcgacca
      661 gctaaaccaa ggctcagaag accctcttaa gaggccagtg gtgtatgtga agggtgcaga
      721 tgctatcaag ctgatgaaca ttgtcaacaa gcagaaagta gctcgagcaa ggatccagca
      781 cctccctcct cgacaaccca ccgagtactt tgacatggga attttcctgg ccttcttcgt
      841 cgtggtctcc ttggtctgcc tcattctcct tgtcaaaatc aagctgaagc aacgtcgtag
      901 tcagaattcc atgaacaggc tggctgtgca ggctctggag aagatggaaa ccagaaagtt
      961 caactccaag agcaaggggc gccgggaagg aagctgtggg gccctggaca cactgagcag
     1021 cggctccaca tccgactgtg ccatctgtct ggagaagtac attgacggag aggagcttcg
     1081 ggtcatccct tgtactcatc ggttccacag gaagtgtgtg gatccatggc tactgcagca
     1141 ccacacctgc ccccactgtc ggcacaacat catagaacaa aagggaaatc caggtgctgt
     1201 ttgtgtggag acaagcaacc ttacacgtgg tcggcagcca agagtgaccc taccggtaca
     1261 ttacccaggc cgtgtgcata ggaccaatgc catcccagcc taccctacta ggacaagtat
     1321 ggactcccat ggcaaccctg tcacactgct aaccatggac cggcatgggg agcagaacct
     1381 ctattctcca caaacaccca cctatgtccg tggctaccca cccctgcacc tggaccacac
     1441 tctggcccct catcgctgca gcctggaaca ccgggcctac tcaccagccc atcccttccg
     1501 caggcccaag ttcagcagcc gcagcttctc caaggcagct tgcttctccc agtatgagac
     1561 catgtaccaa cactactact tccagggtct cagctaccca gagcaggagg gccagacaat
     1621 acccagcgtc acacccaggg gccaatcccg tgccttccca ccaagtggtg ccagcagcct
     1681 gctcttcccc acaatggtac atgtggcccc tccaacccac gtggagagtg gcagcacatc
     1741 tagcttcagt tgctatcatg ggcaccgttc tgtgtgtagc ggctacctgg ctgactgtcc
     1801 tggcagcgat agcagcagca acagctctgg ccagtgccgc tgctcttcca gtgactccgt
     1861 ggtggactgc acagaagtca gcaaccaagg tgtgtatggg agctgttcca ccttccgaag
     1921 ctccctcagc agcgactatg accccttcat ctaccgcagc cgggggcctg ctgtgcacct
     1981 tgagggctcc cctccaccag aggagctccc agcaggacac agtcaaagtg ctgggagggg
     2041 cgagccatgg ctaggccctg cctctccctc aggggaccag ctgtccacct gcagcctgga
     2101 gatgaactac agcagcaact cctcgctgga acccagaggg cccaacagct ctacctcaga
     2161 agtggggctc gaggtttctc ctggggctgc cctggacctc aggaggacct ggaaaggggg
     2221 tccagaggga ccatcatgtg cttgctgctt cgagccccag cccttcccgc cgggctctgg
     2281 gatagaaaca agtgcaggtg gcagcagttt attcctgggt cctcggctcc tcgaggactg
     2341 caaccctcca agtggggagc cacagctggg gagctcccag ggcctgtatg gtcttcactc
     2401 agaccattat cctaggacag atggggtgaa atatgagggc ttgccctgct gcttctatga
     2461 agagaagcag gtggcccaca gtgctggcag gggcaatggc tgctacactg aggactattc
     2521 agtgagtgta cagtacacac tcaccgagga acccccaccc agctgttatg cagggccccg
     2581 ggacctgagc cagcgcatcc ccattattcc agaggatgta gactgtgact tgggcttgcc
     2641 ccaagactgc cacgggatgc acaaccacag cccctggggt ggggcactga gcttggacgt
     2701 tccccgactc cactggagtc taggcacaac ccgggaagag gaacaggctc catgttacca
     2761 agctgaggtg cagcctggct gctctccaga ggaggcaggt gcttccaggg ctagcctctc
     2821 cagtgccccc caggacactc aggagtctca tgccctggct gctgaggctt caggaccagg
     2881 atctggccca ggcatcggta cgggagcttg agctcaaaag gaactcttat gtagaaatcg
     2941 tgaactgtac ggagacttca aagtctggct tccttcaaaa ctactataca cacacacaca
     3001 cacacacaca cacacacaca cacacacaca cacacacata tatatatttt agctttgaca
     3061 aacacaaaag tggtaataaa gagagccctc ctcaacccaa aatgtgagcc acctgtggca
     3121 tcccttcctc tttaacaaac caacagacaa aaatctcttg agtcctttgc ctctttaata
     3181 atgtgttgtt ctgttttgta atgtgtgctt gggtttctga ggtgtgtggg attgagttct
     3241 ctgctttttt tctaaaatat tatatgtaaa tgtaaaaagt tatttaaata tatattttaa
     3301 agaaccctaa ctaccaactt ctgttgaaaa aaaaaatcac tgctgcatta aatgaaccac
     3361 atcatgtgtc aatactgttg tctccctgga gggacctcag gcctttgaaa agctcagggt
     3421 tacacctgcc ttattgaaaa tgaaccagaa acttgaagta aaaagctcca aggaacaata
     3481 caaagctgcc tcatcctttt tccctttttt gaggcaaatc tgaacttctg ggcttctggg
     3541 aagccacacc tctcctgccc acacctgtag gcagcaatgg aacaggaggg aagtgggggc
     3601 agtgtcaagc tattactgcc taggccaact ttattggaga cagttctgcc cattctcttc
     3661 tgttcctttg gtaggtcttt atcccagcag aggctgtggc tgtgaccagc cctgttacta
     3721 gggtctctcc tgcactctga ccaccagtca agggaagaga cgctctcacc ctgtggcctt
     3781 ggagtctttt gtaaaatcat tttgggcttc atgccatcaa ttgcaggggt aatttaaatg
     3841 gggtgtgcag ggtggacacc caggaggaat gttgatttat ggccttggtg tcctgtggga
     3901 ctagaggaac aagctctcct ctcagtagca gtgcaccgct ccttgaaagg catgctgagg
     3961 cacacttgtg cccatgggtc tagggcagcc acacccctca gctgttgccc ccttaggttg
     4021 ccttcttggg ggacatatgc ttgaaccaca agagtgtact aagctccaat tggaccagtc
     4081 ccccatcccc agaaacaggc ctctgcctgg tggctgcagc ggttcacctt gccagcagat
     4141 gtctgctagc ctgtctgcct gatgcactat tatgtactga ttctccacga gacagactat
     4201 cagatagttc agacccaaag ggtaggcttt tgtatatttt ttccagcctc ttttttttta
     4261 aggggaagag ttttttaaac ccaaaccact tttggttgtt tttgttattg tttttaagat
     4321 gttttgttta tttttaaaag ggagagagaa ttatttaaaa tcacttcagg gattgtaatc
     4381 ctttttattc aaaatagtcc ttgttcttaa aagtattttc ttttccttag aggaaactaa
     4441 tcggcttggc cctgtgtttg ctaactcttc tggtcacttt tagtcattca tttagcagat
     4501 gtctttttcc atcaggaaga gtttggccga gtgggtctga aaactcggtt acagaatggg
     4561 gaccacctgg gttgccagag acagaaatga cccttcttcc cagtcaggct cccaggaagt
     4621 catcccaggg tccagattgc acatttgaga tgatcagaat actttgttct ttaaaacctc
     4681 gtcctaggat gagggcattt gcttatttct atccagaatc taacaaaaga agtcccacgt
     4741 cagatggccc agttatttgc cctttaggaa gtggccatag tgaaatttgt tcttctgccg
     4801 gactctggag gtcggtccct tgaggctatg cccagtgcac ctgttgctga gggtgtgaga
     4861 agggcctaaa ctgttgacat gtaatcgggg ctgcctttct ttctggggcc aggagtagca
     4921 gctgctaaga acagcagctt tccttactgt gcaagggggg gggtggaggc acagctttta
     4981 acatgaactg caaagcacag cttctcattg ttgagatgtt tgttgtttct ggttttcctt
     5041 tttttttttt tttttttttt ttttttttgt gtgtgtgtgt ctgtatgtgc atatttctcc
     5101 attggctgaa acaaacccca gaaagatttt gcctttgtcc tgcctggcta gaaaaccatt
     5161 tctcagtact catagatgag tagagaattt gaatgccact aggcagagtt aaaaaaacaa
     5221 gttcaactct cctttgaaaa aatgctacta gtgggtgaca ggcacttgta attgttgtag
     5281 ttttggacta gtagaaacaa aagatttaga gacaattatc atctttgtgt tgccacatca
     5341 gaccagaata aaacctatct tatgcaccat ttaaatcaga agaaatagtg tctatgaagt
     5401 tctgagagcc acagtgctct cttctgtgcc ctcttctggg gaggggaagt ggaaagggag
     5461 tgtcagtagt gtgtggtgat tgtatagcca tggacaagga gcaccccact gtccactggg
     5521 agcctgtgtg tggaatagca agtgtgggct tgataccagc cctgggtgta agacagccat
     5581 gccaacccaa aatctagaac cagatgaaaa tggaagttaa gtcattgtgt accttgaggt
     5641 gcctctgtgg tcgtagctcc agaagctgac catccatccc ctctccccca ggcccagacc
     5701 gctgtatccg tgtccctctt tagtcccgtg gttcaggcct ttccctatgt gcttctgctc
     5761 tcaaagtcca cacaggactg atgcttttaa aatgtggtct gtaaaagaat ttgaaagtat
     5821 catcttttaa actgacctgc atttttctat tccttacata aactttttgt atcgtgttgg
     5881 tctaatgaca ctattttaat ttttttttta tttctcccat agcacttaat attttgtaaa
     5941 gatttttttg tgataaaatg gtctaagggc tctttttcca cattaccatt ttaaaaactt
     6001 ttaaaagcta gaaaacaact tatgtatatt ctgtatatgt atagcagcac atttcattta
     6061 tggaaatatg ttctcagaat atttatttac taatatattt atcttaagcc atgtcttatg
     6121 ttgagagtgt gacattgttg aaataatcat tgaaaatgac taacaaggcc ctgtaaatac
     6181 atgataattg cacacagatt ttacatattt gcagaccaaa aatgatttaa agcaagttgt
     6241 agtcgtctat gattttgtaa caaattgtac aaatgactgt aaaaaaaaat acaattttat
     6301 caagta
//
