LOCUS       NM_199143               2610 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus zinc and ring finger 2 (Znrf2), mRNA.
ACCESSION   NM_199143
VERSION     NM_199143.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Hoxhaj,G., Najafov,A., Toth,R., Campbell,D.G., Prescott,A.R. and
            MacKintosh,C.
  TITLE     ZNRF2 is released from membranes by growth factors and, together
            with ZNRF1, regulates the Na+/K+ATPase
  JOURNAL   J Cell Sci 125 (Pt 19), 4662-4675 (2012)
   PUBMED   22797923
  REMARK    Erratum:[J Cell Sci. 2022 Mar 15;135(6):jcs259936. doi:
            10.1242/jcs.259936.. PMID: 35267011]
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Araki,T. and Milbrandt,J.
  TITLE     ZNRF proteins constitute a family of presynaptic E3 ubiquitin
            ligases
  JOURNAL   J Neurosci 23 (28), 9385-9394 (2003)
   PUBMED   14561866
REFERENCE   4  (bases 1 to 2610)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF513708.1, AK078666.1 and AC079183.5.
            
            On Apr 22, 2010 this sequence version replaced NM_199143.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF513708.1, BC104317.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1202              AF513708.1         1-1202
            1203-2122           AF513708.1         1204-2123
            2123-2455           AK078666.1         585-917
            2456-2456           AC079183.5         21732-21732
            2457-2610           AK078666.1         919-1072
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.15 cM"
     gene            1..2610
                     /gene="Znrf2"
                     /gene_synonym="1190002C14Rik; D6Ertd365e"
                     /note="zinc and ring finger 2"
                     /db_xref="GeneID:387524"
                     /db_xref="MGI:MGI:1196246"
     exon            1..557
                     /gene="Znrf2"
                     /gene_synonym="1190002C14Rik; D6Ertd365e"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..817
                     /gene="Znrf2"
                     /gene_synonym="1190002C14Rik; D6Ertd365e"
                     /EC_number="2.3.2.27"
                     /note="zinc/RING finger protein 2; zinc finger/RING finger
                     2; RING-type E3 ubiquitin transferase ZNRF2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ZNRF2"
                     /protein_id="NP_954594.1"
                     /db_xref="CCDS:CCDS20159.1"
                     /db_xref="GeneID:387524"
                     /db_xref="MGI:MGI:1196246"
                     /translation="MGAKQSGPAANGRTRAYSGSDLPSGTGSGGGGADGARAARFAAP
                     VSGAQQPSASAGAAAAAAAAASAPAAPRSRSLGGAVGSASGGRAAQSAFSIPSAGGGG
                     GPYGSQDSVHSSPEDSVGARDRDRPAGGGPGGPRLVIGSLPAHLSPHLFGGFKCPVCS
                     KFVPSDEMDLHLVMCLTKPRITYNEDVLSKDTGECAICLEELQQGDTIARLPCLCIYH
                     KGCIDEWFEVNRSCPEHPSD"
     exon            558..653
                     /gene="Znrf2"
                     /gene_synonym="1190002C14Rik; D6Ertd365e"
                     /inference="alignment:Splign:2.1.0"
     exon            654..759
                     /gene="Znrf2"
                     /gene_synonym="1190002C14Rik; D6Ertd365e"
                     /inference="alignment:Splign:2.1.0"
     exon            760..841
                     /gene="Znrf2"
                     /gene_synonym="1190002C14Rik; D6Ertd365e"
                     /inference="alignment:Splign:2.1.0"
     exon            842..2610
                     /gene="Znrf2"
                     /gene_synonym="1190002C14Rik; D6Ertd365e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2100..2105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Znrf2"
                     /gene_synonym="1190002C14Rik; D6Ertd365e"
                     /note="hexamer: AATAAA"
     regulatory      2117..2122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Znrf2"
                     /gene_synonym="1190002C14Rik; D6Ertd365e"
                     /note="hexamer: AATACA"
     polyA_site      2120
                     /gene="Znrf2"
                     /gene_synonym="1190002C14Rik; D6Ertd365e"
                     /note="major polyA site"
     polyA_site      2153
                     /gene="Znrf2"
                     /gene_synonym="1190002C14Rik; D6Ertd365e"
ORIGIN      
        1 accgcgtccg cacggctacc tgagcggcag ccgcgagctg cgtcccgcct ctctcgcttg
       61 ctcgctcgct cgctcgctcg cggcccgggg cggcgcggac atgggcgcca agcagagcgg
      121 ccccgccgcc aacggccgca cccgtgccta ctcgggctcg gacctgccct ccgggaccgg
      181 cagcggcggc ggcggggcgg acggcgctcg ggcggcccgt ttcgcggccc cggtgtccgg
      241 cgcgcagcag cccagcgcct cggccggcgc ggcggctgca gcggcggcgg cggcctcggc
      301 cccggcagcg ccccgtagcc gctcgctcgg cggggcggtg ggcagcgcgt cgggcggccg
      361 cgcggcgcag tcggccttca gcatccccag cgctggcggc ggcggcggcc cgtacggctc
      421 acaggactca gtgcacagca gcccagagga cagcgtcggc gctagggacc gggaccggcc
      481 ggcgggcggg ggccctggcg ggccgcgtct ggtgatcggc tcgctcccgg cccacctctc
      541 cccgcacttg tttggaggat ttaagtgccc ggtatgctca aaatttgtac cctcagatga
      601 aatggatttg catcttgtga tgtgtttaac aaagccaaga ataacgtata atgaggatgt
      661 gctgagtaaa gatacggggg aatgtgcaat atgccttgaa gaactgcagc agggggacac
      721 catagcacgg ctgccttgcc tgtgtatata tcataaaggc tgcatagatg aatggtttga
      781 agtcaataga tcttgtccag agcacccctc agactaagca cagcagaccc ctgtgttacg
      841 ggttttcttg tctttacaag atgcttgaga aatctagaag atttgaagat ctgtctctgg
      901 aagaaaatga gagctgcagg cttattcagc caggatctga gttctgggac acttgggtcc
      961 agagaaggac aggaagaacc acagaactca gcgaaccaaa cttgcatata agggacacac
     1021 agggattttg aaaatgctgc acagcctgta ccagtcactg cgtagatgac actgataaat
     1081 gttttgtatt cagacgccaa agttaactca tttcaaagtt gatttccttt ttagtaagtt
     1141 cttagagctg ctgttttaat gtgtttggtt ttggtttgtt tgttggttgg ggtttttttt
     1201 ttgtttgttt gttttgtttt gttttttagt ttggggactt tttattttcc tgaacataat
     1261 gtttctgcat tcacctattc ttaacttgaa aaccacacaa tttctttctt acaaagtctt
     1321 caacatgaac caagaaaatg taatcaaagc agtataatat tctgtgaatg gagagtataa
     1381 ttgaagttct tccacttcca ggccccacct ccccctaccc ccatgtatga aaagtaggtt
     1441 tctgggttgg aaagctaaac tccgatagta tgaattaaag gttaatatat aaaagtgtca
     1501 tccaaagagt aaatcaaggt acataattac atttagttca ttacatgtag agctgtctac
     1561 tcaactgcag tttctgaaat ccattgtttc ttctaaaagg aaactgtgca atagcttgtt
     1621 agcagtgacc atcttgcagc agctatgcaa ctttgaaaag ttttgctggt ccccgctccg
     1681 gggccacagt gactctgtcc tagcaggtgt cttttgtctt tctgtaatta cttcattgtg
     1741 ctttgcattt ccaggaggtt tccctatgtt tgggtaaaat gtttagcaag ttgtaaaaca
     1801 tcagaccttc tgaaaagggt gaaataaaca cttctgcagt gggacttgga gtaatctgag
     1861 ggacatttta tatactttta aaaatcagaa tttaattggg atgccagatt tctagcaact
     1921 tgcatcttta gttttccaga taatctggaa gttagcattt gataaatgat tttttaagca
     1981 aatataaaga tttttgttaa tttataattt attaatgtgt tgttactgta attgaaaatg
     2041 ttgtggatac ttttaaattc agtctttgta gaaagaactg tattaagcaa aattatgtga
     2101 ataaatattc cccaaaaata catctaatgg ttaagaatac tggaagagag ctatcagggc
     2161 tgcaacagtg aatgtctttt taaataacta tcaaaatgtc aagaagtaga gttcaccttt
     2221 agtctctggg ggggacacag ccctgctgtc ctgctgtgct gcgctgtgct gcactgccct
     2281 gccctgggtg tggaagggga gtctctggtg ctgctctgcc gctcttcact ctgactgtgc
     2341 ccagctctgt tgcttgtacc tctccctgct cacagggcat gagcacctgc tgctatggtg
     2401 ctcacaaggg catgggcagg agcacctgct gctatggtgg ggtcgggtgg ggactgtcct
     2461 gatatgggaa gaacttgcct gctttcctat ggctgtagac tacatagtac ctctgcagtt
     2521 ccactgtgat cgcctgttag ggccagtggt ctgatcctgt gtcacagctg ccagcacagc
     2581 tctgtaggtg tccttcagcc agggctaagg
//
