LOCUS       NM_133206               5387 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus zinc and ring finger 1 (Znrf1), transcript variant 1,
            mRNA.
ACCESSION   NM_133206
VERSION     NM_133206.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5387)
  AUTHORS   Lin,Y.S., Chang,Y.C., Chao,T.L., Tsai,Y.M., Jhuang,S.J., Ho,Y.H.,
            Lai,T.Y., Liu,Y.L., Chen,C.Y., Tsai,C.Y., Hsueh,Y.P., Chang,S.Y.,
            Chuang,T.H., Lee,C.Y. and Hsu,L.C.
  TITLE     The Src-ZNRF1 axis controls TLR3 trafficking and interferon
            responses to limit lung barrier damage
  JOURNAL   J Exp Med 220 (8) (2023)
   PUBMED   37158982
REFERENCE   2  (bases 1 to 5387)
  AUTHORS   Lee,C.Y., Lai,T.Y., Tsai,M.K., Chang,Y.C., Ho,Y.H., Yu,I.S.,
            Yeh,T.W., Chou,C.C., Lin,Y.S., Lawrence,T. and Hsu,L.C.
  TITLE     The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and
            degradation to modulate inflammation
  JOURNAL   Nat Commun 8, 15502 (2017)
   PUBMED   28593998
  REMARK    GeneRIF: This study defines ZNRF1 as a regulator of TLR4-induced
            inflammatory responses and reveals another mechanism for the
            regulation of TLR4 signalling through CAV1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5387)
  AUTHORS   Ye,A., He,H. and Kim,J.
  TITLE     PEG3 binds to H19-ICR as a transcriptional repressor
  JOURNAL   Epigenetics 11 (12), 889-900 (2016)
   PUBMED   27824289
REFERENCE   4  (bases 1 to 5387)
  AUTHORS   Wakatsuki,S., Furuno,A., Ohshima,M. and Araki,T.
  TITLE     Oxidative stress-dependent phosphorylation activates ZNRF1 to
            induce neuronal/axonal degeneration
  JOURNAL   J Cell Biol 211 (4), 881-896 (2015)
   PUBMED   26572622
  REMARK    GeneRIF: up-regulation of ZNRF1 activity by oxidative stress leads
            to neuronal apoptosis and Wallerian degeneration.
REFERENCE   5  (bases 1 to 5387)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5387)
  AUTHORS   Wakatsuki,S., Saitoh,F. and Araki,T.
  TITLE     ZNRF1 promotes Wallerian degeneration by degrading AKT to induce
            GSK3B-dependent CRMP2 phosphorylation
  JOURNAL   Nat Cell Biol 13 (12), 1415-1423 (2011)
   PUBMED   22057101
  REMARK    GeneRIF: The ZNRF1-AKT-GSK3B-CRMP2 pathway plays an important role
            in controlling Wallerian degeneration.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5387)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 5387)
  AUTHORS   Araki,T. and Milbrandt,J.
  TITLE     ZNRF proteins constitute a family of presynaptic E3 ubiquitin
            ligases
  JOURNAL   J Neurosci 23 (28), 9385-9394 (2003)
   PUBMED   14561866
REFERENCE   9  (bases 1 to 5387)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5387)
  AUTHORS   Araki,T., Nagarajan,R. and Milbrandt,J.
  TITLE     Identification of genes induced in peripheral nerve after injury.
            Expression profiling and novel gene discovery
  JOURNAL   J Biol Chem 276 (36), 34131-34141 (2001)
   PUBMED   11427537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127356.4 and AC122364.4.
            
            On Feb 1, 2022 this sequence version replaced NM_133206.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1, 2, and
            5 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086770.1, SRR7652917.1067305.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1060              AC127356.4         117021-118080       c
            1061-1156           AC122364.4         154702-154797       c
            1157-1262           AC122364.4         144779-144884       c
            1263-5387           AC122364.4         138370-142494       c
FEATURES             Location/Qualifiers
     source          1..5387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.98 cM"
     gene            1..5387
                     /gene="Znrf1"
                     /gene_synonym="B830022L21Rik; nin283; Rnf42; Zrfp1"
                     /note="zinc and ring finger 1"
                     /db_xref="GeneID:170737"
                     /db_xref="MGI:MGI:2177308"
     exon            1..1060
                     /gene="Znrf1"
                     /gene_synonym="B830022L21Rik; nin283; Rnf42; Zrfp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             637..1320
                     /gene="Znrf1"
                     /gene_synonym="B830022L21Rik; nin283; Rnf42; Zrfp1"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 1; ring
                     finger protein 42; zinc ring finger protein 1; E3
                     ubiquitin-protein ligase ZNRF1; peripheral nerve injury
                     protein nin283; zinc/RING finger protein 1; nerve
                     injury-induced gene 283 protein; RING-type E3 ubiquitin
                     transferase ZNRF1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ZNRF1 isoform a"
                     /protein_id="NP_573469.1"
                     /db_xref="CCDS:CCDS22676.1"
                     /db_xref="GeneID:170737"
                     /db_xref="MGI:MGI:2177308"
                     /translation="MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAM
                     GLRSRSVSSVAGMGMDPSTAGGVPFSLYTPASRGTGDSERAPGGGGSTSDSTYAHGNG
                     YQETGGGHHRDGMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEMH
                     FIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVN
                     RSCPEHPAD"
     exon            1061..1156
                     /gene="Znrf1"
                     /gene_synonym="B830022L21Rik; nin283; Rnf42; Zrfp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1262
                     /gene="Znrf1"
                     /gene_synonym="B830022L21Rik; nin283; Rnf42; Zrfp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..5387
                     /gene="Znrf1"
                     /gene_synonym="B830022L21Rik; nin283; Rnf42; Zrfp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2732..2737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Znrf1"
                     /gene_synonym="B830022L21Rik; nin283; Rnf42; Zrfp1"
                     /note="hexamer: TATAAA"
     polyA_site      2752
                     /gene="Znrf1"
                     /gene_synonym="B830022L21Rik; nin283; Rnf42; Zrfp1"
                     /note="major polyA site"
     regulatory      3424..3429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Znrf1"
                     /gene_synonym="B830022L21Rik; nin283; Rnf42; Zrfp1"
                     /note="hexamer: ATTAAA"
     polyA_site      3445
                     /gene="Znrf1"
                     /gene_synonym="B830022L21Rik; nin283; Rnf42; Zrfp1"
     regulatory      5371..5376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Znrf1"
                     /gene_synonym="B830022L21Rik; nin283; Rnf42; Zrfp1"
                     /note="hexamer: AAGAAA"
     polyA_site      5387
                     /gene="Znrf1"
                     /gene_synonym="B830022L21Rik; nin283; Rnf42; Zrfp1"
ORIGIN      
        1 attgtctcca cggcggcgag gagcgccggc gagcgcagcc cgggacggag cggggcggtg
       61 cggctggctg gcggggccgg cggcggctgg agccggagcg cgacgccacg cgaccgcggc
      121 ttccagagct ccgcctggct gccccaccgc cgcgagccct cccgaagcct ggaggagtga
      181 gggccgccgg cgcgggctga ggagtcctga gacgggggac gcgaacggcg cggcgcccgg
      241 agcctccgcc gcttcctgct gcgggcgagc ggcctcctcc ggctcctccc tcccttcgct
      301 gcggctcctt aggctccgga gcccgggggc ggcctgtggc gcgaggcgcc ggctctggac
      361 cgcgcttctt cggaccttaa ggggaacatg cattcggctt ggacagtttg aaattcttag
      421 tttggggtcc ccgctcgctt gctttttcca ccccgcggat tttttttgag gattcccccc
      481 ctcacctttt ttcatttttc tcccctcggg gctcttttgt gactctcccc aaccccaacc
      541 ctccgccttt atgttcgccc agacctccac ccgcttctga gtagtggggg agggtttcag
      601 cctccacgtt cccgccccac cggggccccg gcgaacatgg ggggcaagca gagcacggcg
      661 gcccgctctc ggggcccctt cccgggggtc tctacggatg acagcgccgt gccgccgccg
      721 ggaggggcgc cccactttgg gcactaccgg acgggcggcg gggcgatggg gctgcgcagc
      781 cgctcggtca gctcggtggc gggcatgggc atggacccca gcacggccgg aggggtgccc
      841 tttagtctct acacccccgc ctcccgcggg accggcgact ccgagagggc gccgggcggc
      901 ggagggtcca cgtcggactc cacctatgcc cacggcaatg gttaccaaga gaccggcggc
      961 ggtcaccata gagacgggat gctgtacctg ggctcccgag cctcgctggc ggatgctcta
     1021 cctctgcaca tcgcacccag gtggttcagc tcgcacagtg gtttcaagtg ccccatttgt
     1081 tccaagtctg tggcttccga tgagatggaa atgcacttta taatgtgtct gagcaagcct
     1141 cgcctgtcct acaatgatga tgtgctgact aaagatgcgg gtgagtgtgt gatctgcctg
     1201 gaggagctgc ttcaggggga cacgatagcc aggctgcctt gcctgtgcat ctatcacaaa
     1261 agctgcatag actcatggtt tgaagtgaac agatcttgtc cagagcaccc tgctgactga
     1321 ccctgctggg cctgcttgcc gactcctctc aaaggtgagc ccatacttgg cgggagactc
     1381 tgggctaaga gtcaagtttc tgggagctgg gggagaggag ctggcctgcc tgatacacac
     1441 cccaccaagg agaaagcaga agcagaaaga cagaagccat ctcctcagag agcagtcccc
     1501 aggaagtagg gggatgttcc tgggagttgg gggagcatga aagagcgata gtaacctagt
     1561 catgagaact ccatgcaaag atagaaccag gctccttccc ctcaggagag gcagaaggtc
     1621 ccctgcaggg tgcatgggct ggagcagagg cgcccccagc caggctctac agcagcctca
     1681 cctccctcac ctctcagaga ctcggttctg aaagggaaga atcactaagt agtggcctgt
     1741 ggaacagaca ttgtccactg caaagacatg gcctgaggtc tttccactcc tggttcttcc
     1801 accggcctga gaggtccagg ccacactcag tccttgtgtc ccaggcacag tgtcacagca
     1861 gcaggctact ccctcccaca cacgcacttc tggtgctgtg taaccattgg atctgacctt
     1921 catttcttcc ccagggtacc ttgtttaact gcccctatcc cgcccccacc ctgcctgtgc
     1981 ctttgaggac tgtgttgggt gttctctctc ttttgttttg tttagtttgt ttttgtccca
     2041 tccaactgaa aaccatcagc cccttcccac ttgatcccac atccaaaggc ttggggatcc
     2101 cttttcttct ctctcttctt tgttgttttt tcttttgtta ggtttatttt atttattcca
     2161 agtaaatgcc cagaacagct gctggtgtca ggcaaatcag ggacattggc tctttctacc
     2221 ctcacctcaa aacctgatgc caagcgaggg agagtgaggc agagggactg gatcccagct
     2281 ccagagtgca ggtccagaat gccgccgccg gcatgatgtt tggcttccaa tgggcctgcc
     2341 tggactgaac cagatgcccc agccaaccag cctggtctca gggggacaca agctgctgcc
     2401 accgtgcgat ggagcggcaa ctctcagcaa gatgaagcgg gactgacttc ttccgaccca
     2461 cacagggaca gccagcccct gttcctggga ggaggctcct cggacactgg acagagctga
     2521 gcttgggaca ccagagagaa cagggcaccc ttctgcactg acttccagaa aatggtcctc
     2581 cctgaggaca cccagtggat gagagaagaa tgaattgacc tctatccttc ccctcaccct
     2641 cgacccagga gggaaagggc attttctttt tcacctttga aaggcgttgt gggtctgtct
     2701 ttaaaaagtg tttacaaaca acaaaaaatt ctataaaaaa gtcttgtgtc gactggtgtt
     2761 ttcccttgtg atgtttacag cctgctgttt gctgcccagc taaaaaccac tcatgacaga
     2821 agcaagcata gccatgtcct gaccctagcg ctctgatggc aggtgggcag gcgggcacac
     2881 gttagtccct ctgcccagcg ccccagttgg ctctctgcat cactaacctt tctacctttg
     2941 gggattcgtt ttttttttgt tttcttgttc ttctgtccca tttttctggc ttggttttgc
     3001 acttttctcc ccttaaattt ccttgatttc cttgccaaaa aagaggaaga tgaagagccc
     3061 atcgtggaca cttgccctcc cccagccccg agtctcccct gcctttcctc ctggatctga
     3121 tcccatcaga ggatttaata atcacaaata cactgaaaaa aaaaatgcct ggacattttt
     3181 ccaaggcccc tgtgattttt ttttccccct gaggaaattt agacttagct aaaggactgt
     3241 gtgctgcaac ccccattttc aggcgcacgg aaatatttta gccattcaca catgacatca
     3301 gcccatgcag gataggtttc tgtatttata tattaaaatc caaaaaaaaa aaattacaaa
     3361 aatgttttaa aactgttcaa agcttaggag aaaagcttat cagtcaaggt gttttgatat
     3421 ggtattaaaa tagtgtgtaa caaaagatgc accgtgtgat ttattttaat gaagtgttgt
     3481 tacacaatca aggtggaagg caaatgccag ttccctctgt ccacctctca gcccacaccc
     3541 cctccctcag cacctgtaat ggcttagcca ctcctgggca gaggctctac atagtggctc
     3601 ggctgtgtct ttgaagttta taaattctta agcatcatgg agtgattgtc agtcttctgt
     3661 catctctggt tgtgatagga tgctactgga atgatattca ggggcaaagc tcttacagcc
     3721 accagaggat acaggcacct ggagatgcca gcccagtccg tttgcttttc agagcctctg
     3781 cccccctccc taccctctgc ttgcctgttg ctccgtgcag agccaagtgc tgactcatgg
     3841 gcatgcttct ctgaggcccc ggaaaaggcc ctgctctggg cttcttccag ctcacagtcc
     3901 ttgaaccaga accagccact cagcctcata caagttagca aattgcaggc tgggcaggaa
     3961 acctcggggc agagcagcag tgcatacctg cctgtcttct agccaggctc caggagctgc
     4021 atttcagggc ctcctgcaga gccagctaag ggaagctctg gagggagatg gcaccacctc
     4081 tctaccatga ccatttccag acctgcccct tgtactgctg tgtcagggcc cagtcccagc
     4141 aggcccacaa gtttggacta tgctaccacc cttgccctca gatgcgtcct gaagcaattg
     4201 ctctgtgcaa ggacatgtgt tggaggccag tgggcatgtg ggcaccaagg cagggaggca
     4261 agttcagaga actaagagtg ctttatttag agcctgagtg tcagacgcct caggacctga
     4321 actgtaagca ctgtcaatgg ccagaaactg ggctcttgtc tgtactgggg cactttactt
     4381 cttggtggaa ccgtgaactc gatcccttgc atgtgaagtg gggacagggt catgcggctc
     4441 ggttcagttt gtgtcgggga tctgccccaa aggcctggca catgcgcagc aggcttcctt
     4501 gtagctatgt cactgcaaag ggcactgttc tattcccagc acctccagct tctgcctggc
     4561 acctgtgtct ccccgttcta tatataatcc taccagcaga gctggcgggc cagggcccag
     4621 cccgcaaaga gatctccttg tctgaccccc gggcctggag acaggctttg tgtgcccacc
     4681 ttggctgtgt gagctcggct gccctggcag tgctgtggct gagtcccgtg gttgagttgg
     4741 ttggggcggc gctgagcccc acaccgggtg ctattctagg ctctctaggc tggtgctcat
     4801 cccatcccca gtgacttccg cccccacctg gcacaccaaa gccctctgtt ggctgtcatg
     4861 tcctctgaat ttggacccag attgccagtg cctggtgtga ggggtgggtg ggactgggct
     4921 tgtctgggct tcccaaggtg gcacttgtgt gtgtcacctt ttatccagac agccctccag
     4981 aatcctgtgt tgttcgttcc tactctgcct ttctgagaag gaagaaaatc cggaagagcc
     5041 aagggatggg ttcttcccct tagctctgag gagcccagaa agccttctga gagctccagg
     5101 agcccctttt gaaaaccacc catctaagcc atttaatagt attgaaactc ataggagaat
     5161 gtcctcctta ggagacagtg gctgaaatat atagttgaat gatttcaaga aatgtataat
     5221 ctaatcccat atggtctccc ctcccccaaa atatacaaag caaataaggc aaaaatgtcc
     5281 attgttgaat cttcaacgac tgatatttca gtgaatatag tgtatttgtt ctttcaactt
     5341 tttctgtatg tttgggattt tctttaataa aagaaattgt ggggaaa
//
