LOCUS       NM_001310748             869 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus zinc finger, HIT domain containing 1 (Znhit1),
            transcript variant 3, mRNA.
ACCESSION   NM_001310748 XM_006504496
VERSION     NM_001310748.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 869)
  AUTHORS   He,X.D., Taylor,L.F., Miao,X., Shi,Y., Lin,X., Yang,Z., Liu,X.,
            Miao,Y.L., Alfandari,D., Cui,W., Tremblay,K.D. and Mager,J.
  TITLE     Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2
            despite distinct functions during early mouse developmentdagger
  JOURNAL   Biol Reprod 111 (5), 1017-1029 (2024)
   PUBMED   39194072
REFERENCE   2  (bases 1 to 869)
  AUTHORS   Audiger,C., Laabi,Y., Nie,J., Gibson,L., Wilson-Annan,J.,
            Brook-Carter,P., Kueh,A., Harris,A.W., Naik,S., Nutt,S.L.,
            Strasser,A., Adams,J.M., Bouillet,P. and Chopin,M.
  TITLE     Mis-expression of GATA6 re-programs cell fate during early
            hematopoiesis
  JOURNAL   Cell Rep 43 (5), 114159 (2024)
   PUBMED   38676923
REFERENCE   3  (bases 1 to 869)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 869)
  AUTHORS   Wei,W., Tang,X., Jiang,N., Ni,C., He,H., Sun,S., Yu,M., Yu,C.,
            Qiu,M., Yan,D., Zhou,Z., Song,Y., Liu,H., Zhao,B. and Lin,X.
  TITLE     Chromatin remodeler Znhit1 controls bone morphogenetic protein
            signaling in embryonic lung tissue branching
  JOURNAL   J Biol Chem 298 (10), 102490 (2022)
   PUBMED   36115458
  REMARK    GeneRIF: Chromatin remodeler Znhit1 controls bone morphogenetic
            protein signaling in embryonic lung tissue branching.
REFERENCE   5  (bases 1 to 869)
  AUTHORS   Lu,J., An,J., Wang,J., Cao,X., Cao,Y., Huang,C., Jiao,S., Yan,D.,
            Lin,X. and Zhou,X.
  TITLE     Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation
  JOURNAL   Invest Ophthalmol Vis Sci 63 (4), 18 (2022)
   PUBMED   35472217
  REMARK    GeneRIF: Znhit1 Regulates p21Cip1 to Control Mouse Lens
            Differentiation.
REFERENCE   6  (bases 1 to 869)
  AUTHORS   Zhao,B., Chen,Y., Jiang,N., Yang,L., Sun,S., Zhang,Y., Wen,Z.,
            Ray,L., Liu,H., Hou,G. and Lin,X.
  TITLE     Znhit1 controls intestinal stem cell maintenance by regulating
            H2A.Z incorporation
  JOURNAL   Nat Commun 10 (1), 1071 (2019)
   PUBMED   30842416
  REMARK    GeneRIF: Znhit1 promotes the interaction between H2A.Z and YL1
            (H2A.Z chaperone) by controlling YL1 phosphorylation. These results
            demonstrate that Znhit1/H2A.Z is essential for Lgr5+ stem cell
            maintenance and intestinal homeostasis.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 869)
  AUTHORS   Ye,B., Liu,B., Yang,L., Huang,G., Hao,L., Xia,P., Wang,S., Du,Y.,
            Qin,X., Zhu,P., Wu,J., Sakaguchi,N., Zhang,J. and Fan,Z.
  TITLE     Suppression of SRCAP chromatin remodelling complex and restriction
            of lymphoid lineage commitment by Pcid2
  JOURNAL   Nat Commun 8 (1), 1518 (2017)
   PUBMED   29138493
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 869)
  AUTHORS   Cuadrado,A., Corrado,N., Perdiguero,E., Lafarga,V.,
            Munoz-Canoves,P. and Nebreda,A.R.
  TITLE     Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin
            incorporation in muscle differentiation
  JOURNAL   EMBO J 29 (12), 2014-2025 (2010)
   PUBMED   20473270
  REMARK    GeneRIF: These results identify SRCAP/H2A.Z-mediated chromatin
            remodelling as a key early event in muscle differentiation-specific
            gene expression.
REFERENCE   9  (bases 1 to 869)
  AUTHORS   Yang,Z., Cao,Y., Zhu,X., Huang,Y., Ding,Y. and Liu,X.
  TITLE     Znhit1 causes cell cycle arrest and down-regulates CDK6 expression
  JOURNAL   Biochem Biophys Res Commun 386 (1), 146-152 (2009)
   PUBMED   19501046
  REMARK    GeneRIF: These findings identified Znhit1 as a CDK6 regulator that
            plays an important role in cell proliferation.
REFERENCE   10 (bases 1 to 869)
  AUTHORS   Ruhl,D.D., Jin,J., Cai,Y., Swanson,S., Florens,L., Washburn,M.P.,
            Conaway,R.C., Conaway,J.W. and Chrivia,J.C.
  TITLE     Purification of a human SRCAP complex that remodels chromatin by
            incorporating the histone variant H2A.Z into nucleosomes
  JOURNAL   Biochemistry 45 (17), 5671-5677 (2006)
   PUBMED   16634648
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147987.5.
            
            On Jul 18, 2015 this sequence version replaced XM_006504496.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and 5'
            coding region compared to variant 1. The encoded isoform (3) has a
            longer, distinct N-terminus than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR2844020.241029.1,
                                           ERR3363658.1905274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC147987.5         176733-176826       c
            95-224              AC147987.5         176048-176177       c
            225-395             AC147987.5         174801-174971       c
            396-475             AC147987.5         172790-172869       c
            476-645             AC147987.5         172440-172609       c
            646-869             AC147987.5         172116-172339       c
FEATURES             Location/Qualifiers
     source          1..869
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.09 cM"
     gene            1..869
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /note="zinc finger, HIT domain containing 1"
                     /db_xref="GeneID:70103"
                     /db_xref="MGI:MGI:1917353"
     exon            1..94
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     exon            95..224
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..667
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /note="isoform 3 is encoded by transcript variant 3; zinc
                     finger protein, subfamily 4A (HIT domain containing),
                     member 1; zinc finger HIT domain-containing protein 1; p18
                     Hamlet"
                     /codon_start=1
                     /product="zinc finger HIT domain-containing protein 1
                     isoform 3"
                     /protein_id="NP_001297677.1"
                     /db_xref="CCDS:CCDS80437.1"
                     /db_xref="GeneID:70103"
                     /db_xref="MGI:MGI:1917353"
                     /translation="MLWETQHQEWAVRSQDPGQRRVLDRAARQRRINRQLEALENDNF
                     QDDPHAGLPQLGKRLPQFDDDADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSASEG
                     PNYLTACAGPPSRPQRPFCAVCGFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV"
     exon            225..395
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..475
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..645
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..869
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      847..852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /note="hexamer: AATAAA"
     polyA_site      869
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtgctca gagcaagggt cggtggttag tacgcgtgcg cagtaggctc ttctgtcaac
       61 tgtgttgcgc caatggtgga gaagaaaccc gccgcctagg ctgcctatgt aaattaggct
      121 ggacctcagc ctcttggtgt cctgtagtcc tgaagtctgt ggtttggggg agttctggtt
      181 tgagactggc atgttatggg aaacccagca ccaggaatgg gcagttcgct cccaggaccc
      241 tggacagcgg cgggtgctgg acagggcagc caggcagcgg cggatcaacc gacagctgga
      301 ggcattggag aatgacaact tccaggatga cccccatgcc ggcctccccc agctgggcaa
      361 gaggctacct cagtttgatg atgatgcaga cacaggaaag aaaaagaaga aaactcgagg
      421 tgaccacttt aaacttcgct tccggaaaaa cttccaggct ttgctggagg agcagaacct
      481 gagtgcatct gagggcccca actacttgac agcctgtgcc ggccccccat ctcggcccca
      541 gcgtcccttc tgtgctgtgt gtggcttccc atccccgtat acctgtgtga gctgtggtgc
      601 ccggtactgc accgtgcgct gcctgggtac ccatcaggag accaggtgtc tgaagtggac
      661 cgtgtaaacc tggcatcagg gagagaaagt acccccaccc ttcccaaccc accccagctc
      721 attcacaaag gacagagaga gggagaaact acccattcac ccagcaaagc tgtgccctgc
      781 cgaccaagga aggccacagg gacccaggac tgttgtgggg gtggtccatc cacagagtgc
      841 tgtgataata aacggcctgg tgaaaggaa
//
