LOCUS       NM_001310747             754 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus zinc finger, HIT domain containing 1 (Znhit1),
            transcript variant 2, mRNA.
ACCESSION   NM_001310747 XM_006504498
VERSION     NM_001310747.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 754)
  AUTHORS   He,X.D., Taylor,L.F., Miao,X., Shi,Y., Lin,X., Yang,Z., Liu,X.,
            Miao,Y.L., Alfandari,D., Cui,W., Tremblay,K.D. and Mager,J.
  TITLE     Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2
            despite distinct functions during early mouse developmentdagger
  JOURNAL   Biol Reprod 111 (5), 1017-1029 (2024)
   PUBMED   39194072
REFERENCE   2  (bases 1 to 754)
  AUTHORS   Audiger,C., Laabi,Y., Nie,J., Gibson,L., Wilson-Annan,J.,
            Brook-Carter,P., Kueh,A., Harris,A.W., Naik,S., Nutt,S.L.,
            Strasser,A., Adams,J.M., Bouillet,P. and Chopin,M.
  TITLE     Mis-expression of GATA6 re-programs cell fate during early
            hematopoiesis
  JOURNAL   Cell Rep 43 (5), 114159 (2024)
   PUBMED   38676923
REFERENCE   3  (bases 1 to 754)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 754)
  AUTHORS   Wei,W., Tang,X., Jiang,N., Ni,C., He,H., Sun,S., Yu,M., Yu,C.,
            Qiu,M., Yan,D., Zhou,Z., Song,Y., Liu,H., Zhao,B. and Lin,X.
  TITLE     Chromatin remodeler Znhit1 controls bone morphogenetic protein
            signaling in embryonic lung tissue branching
  JOURNAL   J Biol Chem 298 (10), 102490 (2022)
   PUBMED   36115458
  REMARK    GeneRIF: Chromatin remodeler Znhit1 controls bone morphogenetic
            protein signaling in embryonic lung tissue branching.
REFERENCE   5  (bases 1 to 754)
  AUTHORS   Lu,J., An,J., Wang,J., Cao,X., Cao,Y., Huang,C., Jiao,S., Yan,D.,
            Lin,X. and Zhou,X.
  TITLE     Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation
  JOURNAL   Invest Ophthalmol Vis Sci 63 (4), 18 (2022)
   PUBMED   35472217
  REMARK    GeneRIF: Znhit1 Regulates p21Cip1 to Control Mouse Lens
            Differentiation.
REFERENCE   6  (bases 1 to 754)
  AUTHORS   Zhao,B., Chen,Y., Jiang,N., Yang,L., Sun,S., Zhang,Y., Wen,Z.,
            Ray,L., Liu,H., Hou,G. and Lin,X.
  TITLE     Znhit1 controls intestinal stem cell maintenance by regulating
            H2A.Z incorporation
  JOURNAL   Nat Commun 10 (1), 1071 (2019)
   PUBMED   30842416
  REMARK    GeneRIF: Znhit1 promotes the interaction between H2A.Z and YL1
            (H2A.Z chaperone) by controlling YL1 phosphorylation. These results
            demonstrate that Znhit1/H2A.Z is essential for Lgr5+ stem cell
            maintenance and intestinal homeostasis.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 754)
  AUTHORS   Ye,B., Liu,B., Yang,L., Huang,G., Hao,L., Xia,P., Wang,S., Du,Y.,
            Qin,X., Zhu,P., Wu,J., Sakaguchi,N., Zhang,J. and Fan,Z.
  TITLE     Suppression of SRCAP chromatin remodelling complex and restriction
            of lymphoid lineage commitment by Pcid2
  JOURNAL   Nat Commun 8 (1), 1518 (2017)
   PUBMED   29138493
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 754)
  AUTHORS   Cuadrado,A., Corrado,N., Perdiguero,E., Lafarga,V.,
            Munoz-Canoves,P. and Nebreda,A.R.
  TITLE     Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin
            incorporation in muscle differentiation
  JOURNAL   EMBO J 29 (12), 2014-2025 (2010)
   PUBMED   20473270
  REMARK    GeneRIF: These results identify SRCAP/H2A.Z-mediated chromatin
            remodelling as a key early event in muscle differentiation-specific
            gene expression.
REFERENCE   9  (bases 1 to 754)
  AUTHORS   Yang,Z., Cao,Y., Zhu,X., Huang,Y., Ding,Y. and Liu,X.
  TITLE     Znhit1 causes cell cycle arrest and down-regulates CDK6 expression
  JOURNAL   Biochem Biophys Res Commun 386 (1), 146-152 (2009)
   PUBMED   19501046
  REMARK    GeneRIF: These findings identified Znhit1 as a CDK6 regulator that
            plays an important role in cell proliferation.
REFERENCE   10 (bases 1 to 754)
  AUTHORS   Ruhl,D.D., Jin,J., Cai,Y., Swanson,S., Florens,L., Washburn,M.P.,
            Conaway,R.C., Conaway,J.W. and Chrivia,J.C.
  TITLE     Purification of a human SRCAP complex that remodels chromatin by
            incorporating the histone variant H2A.Z into nucleosomes
  JOURNAL   Biochemistry 45 (17), 5671-5677 (2006)
   PUBMED   16634648
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI426440.1, BY084904.1, AA002885.1 and AI841783.1.
            
            On Jul 18, 2015 this sequence version replaced XM_006504498.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region compared to variant 1. The encoded isoform (2) has a
            longer, distinct N-terminus than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU946467.1, CA464501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AI426440.1         360-395             c
            37-74               BY084904.1         35-72
            75-435              AA002885.1         17-377
            436-754             AI841783.1         1-319               c
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.09 cM"
     gene            1..754
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /note="zinc finger, HIT domain containing 1"
                     /db_xref="GeneID:70103"
                     /db_xref="MGI:MGI:1917353"
     exon            1..94
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..537
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein, subfamily 4A (HIT domain containing),
                     member 1; zinc finger HIT domain-containing protein 1; p18
                     Hamlet"
                     /codon_start=1
                     /product="zinc finger HIT domain-containing protein 1
                     isoform 2"
                     /protein_id="NP_001297676.1"
                     /db_xref="CCDS:CCDS80438.1"
                     /db_xref="GeneID:70103"
                     /db_xref="MGI:MGI:1917353"
                     /translation="MVEKKPAVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDP
                     HAGLPQLGKRLPQFDDDADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSASEGPNYL
                     TACAGPPSRPQRPFCAVCGFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV"
     exon            95..265
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..345
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..515
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..739
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      717..722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /note="hexamer: AATAAA"
     polyA_site      739
                     /gene="Znhit1"
                     /gene_synonym="2700001K05Rik; ZNFN4A1"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtgctca gagcaagggt cggtggttag tacgcgtgcg cagtaggctc ttctgtcaac
       61 tgtgttgcgc caatggtgga gaagaaaccc gccgttcgct cccaggaccc tggacagcgg
      121 cgggtgctgg acagggcagc caggcagcgg cggatcaacc gacagctgga ggcattggag
      181 aatgacaact tccaggatga cccccatgcc ggcctccccc agctgggcaa gaggctacct
      241 cagtttgatg atgatgcaga cacaggaaag aaaaagaaga aaactcgagg tgaccacttt
      301 aaacttcgct tccggaaaaa cttccaggct ttgctggagg agcagaacct gagtgcatct
      361 gagggcccca actacttgac agcctgtgcc ggccccccat ctcggcccca gcgtcccttc
      421 tgtgctgtgt gtggcttccc atccccgtat acctgtgtga gctgtggtgc ccggtactgc
      481 accgtgcgct gcctgggtac ccatcaggag accaggtgtc tgaagtggac cgtgtaaacc
      541 tggcatcagg gagagaaagt acccccaccc ttcccaaccc accccagctc attcacaaag
      601 gacagagaga gggagaaact acccattcac ccagcaaagc tgtgccctgc cgaccaagga
      661 aggccacagg gacccaggac tgttgtgggg gtggtccatc cacagagtgc tgtgataata
      721 aacggcctgg tgaaaggaaa aaaaaaaaaa aaaa
//
