LOCUS       NM_146097               1944 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus Zn regulated GTPase metalloprotein activator 1 (Zng1),
            transcript variant 1, mRNA.
ACCESSION   NM_146097
VERSION     NM_146097.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1944)
  AUTHORS   Weiss,A., Murdoch,C.C., Edmonds,K.A., Jordan,M.R., Monteith,A.J.,
            Perera,Y.R., Rodriguez Nassif,A.M., Petoletti,A.M., Beavers,W.N.,
            Munneke,M.J., Drury,S.L., Krystofiak,E.S., Thalluri,K., Wu,H.,
            Kruse,A.R.S., DiMarchi,R.D., Caprioli,R.M., Spraggins,J.M.,
            Chazin,W.J., Giedroc,D.P. and Skaar,E.P.
  TITLE     Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate
            zinc homeostasis
  JOURNAL   Cell 185 (12), 2148-2163 (2022)
   PUBMED   35584702
REFERENCE   2  (bases 1 to 1944)
  AUTHORS   Kanda,S., Ohmuraya,M., Akagawa,H., Horita,S., Yoshida,Y.,
            Kaneko,N., Sugawara,N., Ishizuka,K., Miura,K., Harita,Y.,
            Yamamoto,T., Oka,A., Araki,K., Furukawa,T. and Hattori,M.
  TITLE     Deletion in the Cobalamin Synthetase W Domain-Containing Protein 1
            Gene Is associated with Congenital Anomalies of the Kidney and
            Urinary Tract
  JOURNAL   J Am Soc Nephrol 31 (1), 139-147 (2020)
   PUBMED   31862704
REFERENCE   3  (bases 1 to 1944)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139711.4, AK132291.1 and AC123930.4.
            
            On Jun 17, 2010 this sequence version replaced NM_146097.2.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132291.1, BC018472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC139711.4         209950-209964
            16-1580             AK132291.1         2-1566
            1581-1581           AC123930.4         36240-36240
            1582-1944           AK132291.1         1568-1930
FEATURES             Location/Qualifiers
     source          1..1944
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 19.86 cM"
     gene            1..1944
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /note="Zn regulated GTPase metalloprotein activator 1"
                     /db_xref="GeneID:226043"
                     /db_xref="MGI:MGI:2385089"
     exon            1..233
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1267
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /note="dopamine responsive protein; COBW domain-containing
                     protein 1; cobalamin synthetase W domain-containing
                     protein 1; cobalamin synthase W domain-containing protein
                     1; COBW domain containing 1"
                     /codon_start=1
                     /product="zinc-regulated GTPase metalloprotein activator
                     1"
                     /protein_id="NP_666209.1"
                     /db_xref="CCDS:CCDS37942.1"
                     /db_xref="GeneID:226043"
                     /db_xref="MGI:MGI:2385089"
                     /translation="MLPAVKTVEAEEEYAEDCPELVPIETKNQEEENLDFITKIPVTI
                     VTGYLGAGKTTLLNYILTEQHNRKIAVILNEFGEGSAVEKSLAVSQGGELYEEWLELR
                     NGCLCCSVKDSGLRAIENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDIYL
                     DGIITVVDSKYGLKHLTEEKPDGLVNEATRQVALADMILINKTDLVSEEELNNLRTTI
                     RSINGLGKVLETQRSRVHLSNILDLHAYDILSGISLQKKLQHVSTAPHLDQSIVTVTF
                     EVPGSAKEECLNVFIQNLLWEKNVKNKDGHCMEVIRLKGLVSIKDKPQQMIVQGIHEL
                     YDLEESLVNWKDDAERACQLVFIGRNLDKDVLQQLFLTAVAEAEEQRTAPGRDGVCPS
                     H"
     exon            234..320
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..417
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..509
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..569
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..607
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..654
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..741
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..786
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..843
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..892
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..961
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1027
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1157
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1944
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1407..1412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /note="hexamer: TATAAA"
     polyA_site      1433
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /note="major polyA site"
ORIGIN      
        1 agccccgcgc cgactgaatc ctgtcgcgga aacgcgactg gcggcagctc tttagttctg
       61 gagtcactgg tgtcctgctg gcggcatgtt acctgctgtg aaaactgtgg aggcggaaga
      121 agagtacgcg gaggattgtc ctgaattggt ccccattgag accaagaacc aagaagagga
      181 aaatcttgac ttcatcacta agattccagt cacaattgtc accgggtact taggtgctgg
      241 aaagacaaca cttctgaact acattttgac agaacaacat aatagaaaaa tagcagtgat
      301 tttaaatgaa tttggagaag ggagtgcagt agagaaatcc ttagctgtca gtcaaggtgg
      361 agaactctat gaagaatggc tggaacttag aaatggttgc ctctgctgtt cagtcaagga
      421 cagtggcctt agagctatag agaatctgat gcaaaagaag ggcaagtttg actacatact
      481 cttagagacc actgggctag cagatcctgg tgcagtggct tctatgtttt gggttgatgc
      541 tgagttaggg agtgatattt atcttgatgg tatcataact gttgtagatt caaaatatgg
      601 attaaaacat ttaactgaag aaaaacctga tggccttgtc aatgaagcta ctaggcaagt
      661 tgcattggca gacatgattc tcatcaataa aacagacttg gtttcagaag aggagctaaa
      721 caacttaaga acaactatca gatcaataaa tggactggga aaagttttag aaactcagag
      781 atcaagagtt catctctcaa atatattaga ccttcatgcc tatgatattc tctctggaat
      841 aagtttacag aaaaagctcc agcatgtgtc aacagcaccc caccttgatc agagtattgt
      901 tacagtcaca tttgaagtac caggaagtgc aaaggaagaa tgtctaaatg tatttatcca
      961 gaatctcctg tgggaaaaga acgtgaaaaa caaggacggc cactgcatgg aggtcattcg
     1021 gctaaaggga ctggtgtcta tcaaagacaa accacagcaa atgattgtgc aaggcatcca
     1081 tgagctgtac gacctggaag aaagcctagt gaactggaag gatgatgcgg agagagcgtg
     1141 tcagctggtc ttcattggta gaaatttaga taaggatgtt cttcaacaac tcttcctcac
     1201 tgctgtggca gaggcagaag agcaaaggac agcaccaggc agagatggag tttgtccatc
     1261 gcactagaag ctgtttctta ccggaagaac tgacgagaaa aacaaagatg tatttaaatc
     1321 ctggatccac taccgctgtt gtgatttggg agtatacgta taatagtatt tattttataa
     1381 aaacacataa cattgtagta aattattata aaaaatatct gatattcata aaatatatcc
     1441 tctggaggtt ttttttgagg caagtatttc acaaaagttc cagaattttc tttgaagttt
     1501 aagtatgact gctgacaact tatccatcat tatttgtaaa aatgatggca aacattttca
     1561 ttttctctta aaaacttcag gttattgctg agatacaatg aatacagtga tagtaacaaa
     1621 aaattgctat cattatattt aaaaccagct taacctttat ttttatgcta tgtgtgtgag
     1681 tattttgcct gcatgtatgt ctgtgtactt tgcacattca gtgtctgaag tccagaaggc
     1741 accagatctc ctggagctga agtcacagac ggttgtaagt cttcatgtgg gtgctgtgaa
     1801 ctaaacccag gtcctctgga agaacagcca gcactcttaa ctactgagcc atccatctct
     1861 tcaactctct cactgtgttt ttaggagaat gagtttttaa tgttcctaaa gagtcaaaga
     1921 aattaaacca tctcttacaa tcag
//
