LOCUS       NP_666209                393 aa            linear   ROD 27-APR-2025
DEFINITION  zinc-regulated GTPase metalloprotein activator 1 [Mus musculus].
ACCESSION   NP_666209
VERSION     NP_666209.1
DBSOURCE    REFSEQ: accession NM_146097.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 393)
  AUTHORS   Weiss,A., Murdoch,C.C., Edmonds,K.A., Jordan,M.R., Monteith,A.J.,
            Perera,Y.R., Rodriguez Nassif,A.M., Petoletti,A.M., Beavers,W.N.,
            Munneke,M.J., Drury,S.L., Krystofiak,E.S., Thalluri,K., Wu,H.,
            Kruse,A.R.S., DiMarchi,R.D., Caprioli,R.M., Spraggins,J.M.,
            Chazin,W.J., Giedroc,D.P. and Skaar,E.P.
  TITLE     Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate
            zinc homeostasis
  JOURNAL   Cell 185 (12), 2148-2163 (2022)
   PUBMED   35584702
REFERENCE   2  (residues 1 to 393)
  AUTHORS   Kanda,S., Ohmuraya,M., Akagawa,H., Horita,S., Yoshida,Y.,
            Kaneko,N., Sugawara,N., Ishizuka,K., Miura,K., Harita,Y.,
            Yamamoto,T., Oka,A., Araki,K., Furukawa,T. and Hattori,M.
  TITLE     Deletion in the Cobalamin Synthetase W Domain-Containing Protein 1
            Gene Is associated with Congenital Anomalies of the Kidney and
            Urinary Tract
  JOURNAL   J Am Soc Nephrol 31 (1), 139-147 (2020)
   PUBMED   31862704
REFERENCE   3  (residues 1 to 393)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139711.4, AK132291.1 and AC123930.4.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132291.1, BC018472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..393
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 19.86 cM"
     Protein         1..393
                     /product="zinc-regulated GTPase metalloprotein activator
                     1"
                     /note="dopamine responsive protein; COBW domain-containing
                     protein 1; cobalamin synthetase W domain-containing
                     protein 1; cobalamin synthase W domain-containing protein
                     1; COBW domain containing 1"
                     /calculated_mol_wt=43641
     Region          16..23
                     /region_name="psi-PxLVp motif.
                     /evidence=ECO:0000269|PubMed:35584702"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VEH6.1)"
     Region          41..244
                     /region_name="CobW-like"
                     /note="cobalamin synthesis protein CobW; cd03112"
                     /db_xref="CDD:349766"
     Site            order(50..55,134,201..202)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:349766"
     Site            order(73,78,107)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:349766"
     Region          105..108
                     /region_name="CXCC motif.
                     /evidence=ECO:0000305|PubMed:35584702"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VEH6.1)"
     Region          271..374
                     /region_name="CobW_C"
                     /note="Cobalamin synthesis protein cobW C-terminal domain;
                     pfam07683"
                     /db_xref="CDD:462228"
     CDS             1..393
                     /gene="Zng1"
                     /gene_synonym="Cbwd1"
                     /coded_by="NM_146097.3:86..1267"
                     /db_xref="CCDS:CCDS37942.1"
                     /db_xref="GeneID:226043"
                     /db_xref="MGI:MGI:2385089"
ORIGIN      
        1 mlpavktvea eeeyaedcpe lvpietknqe eenldfitki pvtivtgylg agkttllnyi
       61 lteqhnrkia vilnefgegs avekslavsq ggelyeewle lrngclccsv kdsglraien
      121 lmqkkgkfdy illettglad pgavasmfwv daelgsdiyl dgiitvvdsk yglkhlteek
      181 pdglvneatr qvaladmili nktdlvseee lnnlrttirs inglgkvlet qrsrvhlsni
      241 ldlhaydils gislqkklqh vstaphldqs ivtvtfevpg sakeeclnvf iqnllweknv
      301 knkdghcmev irlkglvsik dkpqqmivqg ihelydlees lvnwkddaer acqlvfigrn
      361 ldkdvlqqlf ltavaeaeeq rtapgrdgvc psh
//
