LOCUS       NM_053253               1761 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zinc finger, MYND domain containing 10 (Zmynd10),
            transcript variant 1, mRNA.
ACCESSION   NM_053253 XM_976421
VERSION     NM_053253.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1761)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1761)
  AUTHORS   Mali,G.R., Yeyati,P.L., Mizuno,S., Dodd,D.O., Tennant,P.A.,
            Keighren,M.A., Zur Lage,P., Shoemark,A., Garcia-Munoz,A.,
            Shimada,A., Takeda,H., Edlich,F., Takahashi,S., von Kreigsheim,A.,
            Jarman,A.P. and Mill,P.
  TITLE     ZMYND10 functions in a chaperone relay during axonemal dynein
            assembly
  JOURNAL   Elife 7, e34389 (2018)
   PUBMED   29916806
  REMARK    GeneRIF: ZMYND10 is a novel co-chaperone that confers specificity
            for the FKBP8-HSP90 chaperone complex towards axonemal dynein
            clients required for cilia motility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1761)
  AUTHORS   Cho,K.J., Noh,S.H., Han,S.M., Choi,W.I., Kim,H.Y., Yu,S., Lee,J.S.,
            Rim,J.H., Lee,M.G., Hildebrandt,F. and Gee,H.Y.
  TITLE     ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic
            pre-assembly of dynein arms
  JOURNAL   PLoS Genet 14 (3), e1007316 (2018)
   PUBMED   29601588
  REMARK    GeneRIF: results demonstrated that ZMYND10 regulated the early
            stage of DA cytoplasmic pre-assembly by stabilizing DNAI1
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1761)
  AUTHORS   Shi,B., Xue,J., Zhou,J., Kasowitz,S.D., Zhang,Y., Liang,G.,
            Guan,Y., Shi,Q., Liu,M., Sha,J., Huang,X. and Wang,P.J.
  TITLE     MORC2B is essential for meiotic progression and fertility
  JOURNAL   PLoS Genet 14 (1), e1007175 (2018)
   PUBMED   29329290
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1761)
  AUTHORS   Moore,D.J., Onoufriadis,A., Shoemark,A., Simpson,M.A., zur
            Lage,P.I., de Castro,S.C., Bartoloni,L., Gallone,G., Petridi,S.,
            Woollard,W.J., Antony,D., Schmidts,M., Didonna,T.,
            Makrythanasis,P., Bevillard,J., Mongan,N.P., Djakow,J., Pals,G.,
            Lucas,J.S., Marthin,J.K., Nielsen,K.G., Santoni,F., Guipponi,M.,
            Hogg,C., Antonarakis,S.E., Emes,R.D., Chung,E.M., Greene,N.D.,
            Blouin,J.L., Jarman,A.P. and Mitchison,H.M.
  TITLE     Mutations in ZMYND10, a gene essential for proper axonemal assembly
            of inner and outer dynein arms in humans and flies, cause primary
            ciliary dyskinesia
  JOURNAL   Am J Hum Genet 93 (2), 346-356 (2013)
   PUBMED   23891471
REFERENCE   6  (bases 1 to 1761)
  AUTHORS   Agathanggelou,A., Dallol,A., Zochbauer-Muller,S., Morrissey,C.,
            Honorio,S., Hesson,L., Martinsson,T., Fong,K.M., Kuo,M.J.,
            Yuen,P.W., Maher,E.R., Minna,J.D. and Latif,F.
  TITLE     Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU
            in human cancers
  JOURNAL   Oncogene 22 (10), 1580-1588 (2003)
   PUBMED   12629521
REFERENCE   7  (bases 1 to 1761)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY284492.1, BC052357.1 and AL672219.7.
            
            On Jun 21, 2018 this sequence version replaced NM_053253.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052357.1, AK132332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BY284492.1         2-7
            7-1759              BC052357.1         1-1753
            1760-1761           AL672219.7         124469-124470
FEATURES             Location/Qualifiers
     source          1..1761
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.12 cM"
     gene            1..1761
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /note="zinc finger, MYND domain containing 10"
                     /db_xref="GeneID:114602"
                     /db_xref="MGI:MGI:2387863"
     exon            1..245
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1476
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger MYND domain-containing protein 10; protein BLu"
                     /codon_start=1
                     /product="zinc finger MYND domain-containing protein 10
                     isoform 1"
                     /protein_id="NP_444483.2"
                     /db_xref="CCDS:CCDS23493.1"
                     /db_xref="GeneID:114602"
                     /db_xref="MGI:MGI:2387863"
                     /translation="MGDLELLLPGEAEVLVRGLRSFQLREMGSEGWNKQHESLEKLNM
                     QAILDATISQAEPIQELLINHGKIPTLVEELIAVEMWKQKVFPVLCRLEDFKPQNTFP
                     IYMVVHHEASIINLLETVFFHKEVCESADDKVLDLVDYCHRKLILLVARKGGGDLSEE
                     EQFQDSTPMQELQKQAEMMEFEISLKALSVLRYITDCVDSLSLSTLNRMLRTHNLPCL
                     LVELLEHSPWSRRVGGKLQHFESGRWQTVAPSEQQKLNKLDGQVWIALYNLLLSPEAR
                     ARYCLTSFAKGQLLKLQAFLTDTLLDQLPNLADLKGFLAHLSLAETQPPKKDLVLEQI
                     PEIWDRLERENKGKWQAIAKHQLQHVFSLSEKDLRQQAQRWAETYRLDVLEAVAPERP
                     RCGYCNAEASKRCSRCQNVWYCCRECQVKHWEKHGKTCVLAAQGDRAK"
     exon            246..354
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /inference="alignment:Splign:2.1.0"
     exon            355..471
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /inference="alignment:Splign:2.1.0"
     exon            472..525
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /inference="alignment:Splign:2.1.0"
     exon            526..663
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /inference="alignment:Splign:2.1.0"
     exon            664..752
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /inference="alignment:Splign:2.1.0"
     exon            753..853
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1026
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1152
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1274
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1400
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1761
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1737..1742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /note="hexamer: AATAAA"
     polyA_site      1761
                     /gene="Zmynd10"
                     /gene_synonym="Blu"
                     /note="major polyA site"
ORIGIN      
        1 gtttccatgg cgacgacgac tcaagcgctt caacggcttg gcaactgccc tgtcccaaga
       61 ctttggtcct accgctggac tctgtagtcc taagtgtttc agttttccct attcgggttg
      121 cttcccaaaa ccaaaggaat cttagcccct ggcatgggtg acctggaact gctgctgcct
      181 ggggaggctg aggtgctggt gcggggcctg cgcagcttcc agcttcggga gatgggctct
      241 gaagggtgga ataagcagca tgagagcctg gagaagctga acatgcaagc catccttgat
      301 gcaactatca gccaggctga gcccatccag gaactgctaa tcaaccatgg gaagatccca
      361 acgctggtgg aggagctgat tgcggtggag atgtggaaac agaaggtttt ccctgtgctg
      421 tgccggctgg aggacttcaa gccccagaat accttcccca tatacatggt ggtacaccat
      481 gaggcctcca tcatcaatct cctagagaca gtgttcttcc acaaggaggt gtgtgagtca
      541 gctgatgaca aggtcttgga cctagtagac tattgccacc gcaagctgat actgctagtg
      601 gcccggaaag gcggtggtga cctgtctgaa gaagaacagt tccaggacag tacccctatg
      661 caagagctgc aaaagcaggc ggagatgatg gaatttgaga tatccctgaa agccctctcg
      721 gtgcttcgct acatcacaga ctgcgtggat agcctttccc tgagcacact gaaccgcatg
      781 ctcaggactc acaacttgcc ctgcctcttg gtggaactgc tggagcacag tccctggagc
      841 cggcgggtag gaggcaagct gcagcatttt gagagtggcc gatggcagac ggtggccccc
      901 tcagagcagc aaaagctgaa taaactggat gggcaagtat ggatcgccct gtacaatcta
      961 ctgctcagcc ctgaggcccg agcccgttac tgccttacaa gctttgccaa gggacagctg
     1021 cttaagcttc aggccttcct cactgacaca ctactcgacc agttgcccaa tcttgccgat
     1081 ctgaagggtt tcctggccca cctgtccctg gctgaaaccc agccccctaa gaaggaccta
     1141 gtgttagaac agatcccaga aatctgggat cgcctggaga gagagaacaa agggaaatgg
     1201 caggctatcg ccaagcacca gcttcagcac gtattcagcc tctcggagaa ggatcttcgt
     1261 caacaagcac agaggtgggc tgaaacctac aggctggatg tcctagaggc agtagctccg
     1321 gagaggcccc gctgcggcta ctgcaacgca gaggcctcca agcgctgctc cagatgccag
     1381 aatgtgtggt attgctgcag ggagtgtcaa gtcaagcact gggagaagca cggaaagaca
     1441 tgtgttctag cagcccaagg tgacagagcc aagtgaaggc cgtagctgcc gagggccgac
     1501 agaagagcgc acccagactg tgactgagct tcagggactc gtggctcgcc cctgtcagac
     1561 ctcaatttcc ctggtgagca cagctgagtc aagtagagct gcaaaccacc acactcttca
     1621 cttcctgccc cacccagcga atacgcagag gaccaggcca cagcatcagc aaactggcag
     1681 acagggttgg ggggtgtaag caagggccgg atgtggagac cctcttcctt tcgcacaata
     1741 aagcagactc atgaaacgca a
//
