LOCUS       NM_029498               6767 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus zinc finger, MYM-type 2 (Zmym2), transcript variant 2,
            mRNA.
ACCESSION   NM_029498 XM_006519665
VERSION     NM_029498.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6767)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6767)
  AUTHORS   Graham-Paquin,A.L., Saini,D., Sirois,J., Hossain,I., Katz,M.S.,
            Zhuang,Q.K., Kwon,S.Y., Yamanaka,Y., Bourque,G., Bouchard,M. and
            Pastor,W.A.
  TITLE     ZMYM2 is essential for methylation of germline genes and active
            transposons in embryonic development
  JOURNAL   Nucleic Acids Res 51 (14), 7314-7329 (2023)
   PUBMED   37395395
  REMARK    GeneRIF: ZMYM2 is essential for methylation of germline genes and
            active transposons in embryonic development.
REFERENCE   3  (bases 1 to 6767)
  AUTHORS   Ludtke,T.H., Kleppa,M.J., Rivera-Reyes,R., Qasrawi,F.,
            Connaughton,D.M., Shril,S., Hildebrandt,F. and Kispert,A.
  TITLE     Proteomic analysis identifies ZMYM2 as endogenous binding partner
            of TBX18 protein in 293 and A549 cells
  JOURNAL   Biochem J 479 (1), 91-109 (2022)
   PUBMED   34935912
REFERENCE   4  (bases 1 to 6767)
  AUTHORS   Connaughton,D.M., Dai,R., Owen,D.J., Marquez,J., Mann,N.,
            Graham-Paquin,A.L., Nakayama,M., Coyaud,E., Laurent,E.M.N.,
            St-Germain,J.R., Blok,L.S., Vino,A., Klambt,V., Deutsch,K.,
            Wu,C.W., Kolvenbach,C.M., Kause,F., Ottlewski,I., Schneider,R.,
            Kitzler,T.M., Majmundar,A.J., Buerger,F., Onuchic-Whitford,A.C.,
            Youying,M., Kolb,A., Salmanullah,D., Chen,E., van der Ven,A.T.,
            Rao,J., Ityel,H., Seltzsam,S., Rieke,J.M., Chen,J., Vivante,A.,
            Hwang,D.Y., Kohl,S., Dworschak,G.C., Hermle,T., Alders,M.,
            Bartolomaeus,T., Bauer,S.B., Baum,M.A., Brilstra,E.H.,
            Challman,T.D., Zyskind,J., Costin,C.E., Dipple,K.M., Duijkers,F.A.,
            Ferguson,M., Fitzpatrick,D.R., Fick,R., Glass,I.A., Hulick,P.J.,
            Kline,A.D., Krey,I., Kumar,S., Lu,W., Marco,E.J., Wentzensen,I.M.,
            Mefford,H.C., Platzer,K., Povolotskaya,I.S., Savatt,J.M.,
            Shcherbakova,N.V., Senguttuvan,P., Squire,A.E., Stein,D.R.,
            Thiffault,I., Voinova,V.Y., Somers,M.J.G., Ferguson,M.A.,
            Traum,A.Z., Daouk,G.H., Daga,A., Rodig,N.M., Terhal,P.A., van
            Binsbergen,E., Eid,L.A., Tasic,V., Rasouly,H.M., Lim,T.Y.,
            Ahram,D.F., Gharavi,A.G., Reutter,H.M., Rehm,H.L., MacArthur,D.G.,
            Lek,M., Laricchia,K.M., Lifton,R.P., Xu,H., Mane,S.M.,
            Sanna-Cherchi,S., Sharrocks,A.D., Raught,B., Fisher,S.E.,
            Bouchard,M., Khokha,M.K., Shril,S. and Hildebrandt,F.
  TITLE     Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic
            Urinary Tract Malformations
  JOURNAL   Am J Hum Genet 107 (4), 727-742 (2020)
   PUBMED   32891193
REFERENCE   5  (bases 1 to 6767)
  AUTHORS   Urra,H., Henriquez,D.R., Canovas,J., Villarroel-Campos,D.,
            Carreras-Sureda,A., Pulgar,E., Molina,E., Hazari,Y.M., Limia,C.M.,
            Alvarez-Rojas,S., Figueroa,R., Vidal,R.L., Rodriguez,D.A.,
            Rivera,C.A., Court,F.A., Couve,A., Qi,L., Chevet,E., Akai,R.,
            Iwawaki,T., Concha,M.L., Glavic,A., Gonzalez-Billault,C. and
            Hetz,C.
  TITLE     IRE1alpha governs cytoskeleton remodelling and cell migration
            through a direct interaction with filamin A
  JOURNAL   Nat Cell Biol 20 (8), 942-953 (2018)
   PUBMED   30013108
  REMARK    Erratum:[Nat Cell Biol. 2018 Oct;20(10):1228. doi:
            10.1038/s41556-018-0186-0.. PMID: 30089843]
REFERENCE   6  (bases 1 to 6767)
  AUTHORS   ZeRuth,G.T., Williams,J.G., Cole,Y.C. and Jetten,A.M.
  TITLE     HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative
            Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity
  JOURNAL   PLoS One 10 (7), e0131303 (2015)
   PUBMED   26147758
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6767)
  AUTHORS   Ren,M. and Cowell,J.K.
  TITLE     Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced
            T-cell lymphomas associated with atypical myeloproliferative
            disease
  JOURNAL   Blood 117 (25), 6837-6847 (2011)
   PUBMED   21527531
  REMARK    GeneRIF: The study demonstrates frequent, constitutive activation
            of Notch1 and its downstream target genes in T-cell lymphomas that
            arose in a murine model of Zmym2-Fgfr1 stem cell leukemia-lymphoma
            syndrome.
REFERENCE   8  (bases 1 to 6767)
  AUTHORS   Campbell,G.R., Baudhuin,A., Vranizan,K. and Ngai,J.
  TITLE     Transcription factors expressed in olfactory bulb local progenitor
            cells revealed by genome-wide transcriptome profiling
  JOURNAL   Mol Cell Neurosci 46 (2), 548-561 (2011)
   PUBMED   21194568
REFERENCE   9  (bases 1 to 6767)
  AUTHORS   Inoue,H., Nobuhisa,I., Okita,K., Takizawa,M., Pebusque,M.J. and
            Taga,T.
  TITLE     Negative regulation of hematopoiesis by the fused in
            myeloproliferative disorders gene product
  JOURNAL   Biochem Biophys Res Commun 313 (1), 125-128 (2004)
   PUBMED   14672707
REFERENCE   10 (bases 1 to 6767)
  AUTHORS   Warner,D.R., Roberts,E.A., Greene,R.M. and Pisano,M.M.
  TITLE     Identification of novel Smad binding proteins
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1185-1190 (2003)
   PUBMED   14651998
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ110016.1, AK135499.1,
            AK137720.1, CA536924.1, CV561457.1, AC154303.2, AV142652.2 and
            BE993957.1.
            
            On or before Feb 8, 2018 this sequence version replaced
            XM_006519665.3, NM_029498.3.
            
            Summary: This gene encodes a protein that contains nine MYM-type
            zinc finger motifs. Expression of this gene may mediate the
            inhibition of hematopoietic cell development during ontogeny, and
            the encoded protein may also play a role in transforming growth
            factor-beta signaling as a Smad binding protein. [provided by
            RefSeq, Feb 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.258645.1,
                                           SRR10223971.14771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                CJ110016.1         3-98
            97-2688             AK135499.1         114-2705
            2689-4936           AK137720.1         355-2602
            4937-5326           CA536924.1         157-546
            5327-5941           CV561457.1         62-676
            5942-6209           AC154303.2         55747-56014         c
            6210-6746           AV142652.2         1-537
            6747-6767           BE993957.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..6767
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.99 cM"
     gene            1..6767
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /note="zinc finger, MYM-type 2"
                     /db_xref="GeneID:76007"
                     /db_xref="MGI:MGI:1923257"
     exon            1..96
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            97..159
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            160..1016
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..4300
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /note="isoform 1 is encoded by transcript variant 2; zinc
                     finger protein 198; zinc finger MYM-type protein 2"
                     /codon_start=1
                     /product="zinc finger MYM-type protein 2 isoform 1"
                     /protein_id="NP_083774.2"
                     /db_xref="CCDS:CCDS49506.1"
                     /db_xref="GeneID:76007"
                     /db_xref="MGI:MGI:1923257"
                     /translation="MDTSSVGTLELTDQTPVLLGSTAMATSLTNVGNSFSGPPNPLVS
                     RSSKFQNSSVEDDDDVVFIEPVQPPPSSAPLVADQRPITFTSSKNEELQGNDPKILPS
                     SKELAPQKGSVSETIVIDDEEDMETNQGQEKSSSNFIERRPSETKNRTNDVDFSSSTF
                     SRSKVNAGVSNSGITTEPDSEIQIANVTTLETGVSSVSDGQLESTDGRDMNLMITHVT
                     SLHNTSLGDGSNGLQSSNFGVNIQTYTPSLTSQTKAGVGPFNPGRMNVAGDVFQNGES
                     APHHNPDSWISQSASFPRNQKQQGVDSLSPVASLPKQIFQPSNQQPTKPVKVTCANCK
                     KPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDS
                     SESFQEFCSTSCLSLYEDKQSPAKGALNKSRCTICGKLTEIRHEVSFKNMTHKLCSDH
                     CFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVVDGQQKRFCCQSCVTEYKQVGSHP
                     SFLKEVRDHMQDSFLMQPEKYGKLTTCTGCRTQCRFFDMTQCIGPNGYMEPYCSTACM
                     NSHKTKYAKSQSLGIICHFCKRNSLPQYQATMPDGKLYNFCNSSCVAKFQALSMQSSP
                     NGQFVAPSDIQLKCNYCKNSFCSKPEILEWENKVHQFCSKTCSDDYKKLHCIVTYCEY
                     CQEEKTLHETVNFSGVKRPFCSEGCKLLYKQDFARRLGLRCVTCNYCSQLCKKGATKE
                     LDGVVRDFCSEDCCKKFQEWYYKAARCDCCKSQGTLKERVQWRGEMKHFCDQHCLLRF
                     YCQQNEPNMTTQKGPENLHYDQGCQTSRTKMTGSAPPPSPTPNKEMKNKAILCKPLTM
                     TKATYCKPHMQTKSCQTDENWKTEYVPVPIPVPVYVPVPMHMYSQNIPVPTTVPVPVP
                     VPVFLPAPLDSSEKIPATVEDLKSKVSSDPLDSELLTMTDMMTEEEGKAEASNINSVI
                     IETDIIGSDLTKNSDPDIQSNMPDVPYEPDLDIEIDFPRAAEELDMENEFLLPPVFGE
                     EYEEQPRPRSKKKGTKRKAVSGYQSHDDSSDNSECSFPFKYTYGVNAWKHWVKTRQLD
                     EDLLVLDELKSSKSVKLKEDLLSHTTAELNYGLAHFVNEIRRPNGENYAPDSIYYLCL
                     GIQEYLCGSNRKDNIFIDPGYQMFEQELNKILRSWQPSILPDGSIFSRVEEDYLWRIK
                     QLGSHSPVALLNTLFYFNTKYFGLKTVEQHLRLSFGTVFRHWKKNPLTMENKACLRYQ
                     VSSLCGTDNEDKIATGKRKHEDDEPVFEQVENTANPSRCPVKMFECYLSKSPQNLNQR
                     MDVFYLQPECSSSTDSPVWYTSTSLDRNTLENMLVRVLLVKDIYDKDNYELDEDTD"
     exon            1017..1299
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1465
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1678
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1750
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1901
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2017
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2134
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2285
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2458
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2624
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2659
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2789
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2905
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3077
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3203
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3298
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3467
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..3619
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3734
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..3986
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            3987..4107
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     exon            4108..6751
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4724..4729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /note="hexamer: AATAAA"
     polyA_site      4742
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /note="major polyA site"
     regulatory      4908..4913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /note="hexamer: ATTAAA"
     polyA_site      4932
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
     regulatory      6730..6735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /note="hexamer: ATTAAA"
     polyA_site      6751
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
ORIGIN      
        1 aagccgggac tggaccgagc ggagttgtgc gtgtcgccga aggggggtgg gccgggggag
       61 gggaggttcg ttccgcggag ctgcagccag aacccggacc agaaatttcg ttcaacccta
      121 tctggtgcat ctttggcaga aagtgaggaa aacaccattg ttctttggca tggacacaag
      181 ttcagtggga acgttagaac tgactgatca aactcctgtc ttattaggaa gtacagccat
      241 ggcaactagt ctcacgaacg taggaaattc atttagtggc ccacctaatc ctttagtgtc
      301 tagatctagt aagtttcaga actcatcagt agaagatgat gatgacgttg tttttattga
      361 acctgtacaa cctcctccat cttctgcacc tttggttgct gatcaaagac ccataacatt
      421 tacatcttca aaaaatgaag aactacaagg aaacgatccc aaaattcttc cttcatcgaa
      481 agagttggcc ccgcaaaagg gcagtgtaag cgagacaatt gttattgatg atgaagagga
      541 catggaaaca aatcaaggac aagagaagag ttcctcaaat tttattgaaa ggagaccttc
      601 tgaaactaaa aacagaacta atgatgtgga tttctccagt tccacttttt caagaagtaa
      661 agtaaacgca ggagtgagta acagtggtat taccacagag ccagactcgg agattcagat
      721 tgctaatgtt acaaccttag aaacaggcgt aagctctgtg agtgatggcc agctagaaag
      781 tactgatggg agagatatga acttaatgat tactcatgtc acatcactgc acaacaccag
      841 cctgggagat ggctccaacg gacttcagtc cagtaacttt ggtgtgaata tacaaacgta
      901 caccccatct ctaacgtcac agaccaaggc tggagttgga ccttttaatc ctggtaggat
      961 gaatgttgca ggagatgtat ttcagaatgg agagtctgca cctcatcaca atcctgattc
     1021 ttggatctcc cagtcagcat catttcctcg taaccagaaa caacaagggg tggattcttt
     1081 atcaccagtg gcctcacttc ctaaacagat attccagccc tcgaaccaac aacccactaa
     1141 accagttaaa gtcacttgtg caaactgcaa aaaacctcta cagaaggggc agacagctta
     1201 ccaacgcaaa ggatcagctc acctcttctg ttcaaccacc tgcctttctt ctttctccca
     1261 taagcctgct ccaaagaaac tctgtgttat gtgtaaaaaa gatataacta caatgaaggg
     1321 aaccattgtt gctcaagtgg actcaagtga gtccttccaa gaattttgta gtacatcttg
     1381 tttgtctctc tatgaggaca aacagagtcc tgctaaagga gctctaaata aatcaagatg
     1441 cacaatctgt ggcaaattaa ctgagattcg ccatgaagtt agttttaaaa acatgactca
     1501 taagctgtgc agtgaccact gctttaacag ataccgaatg gccaatggtc tgataatgaa
     1561 ttgctgtgag cagtgcggag aatatttgcc cagtaaaggt gctgggaata atgttctggt
     1621 ggttgatggt cagcagaaga gattttgttg tcagagttgt gtcactgaat acaaacaggt
     1681 aggtagccat ccaagcttcc tgaaggaagt tcgggatcac atgcaggact ctttcttaat
     1741 gcagcctgag aaatatggaa aactgacaac ttgtactggt tgccgaacac agtgcaggtt
     1801 ttttgatatg actcagtgca taggtcctaa tggatatatg gagccatatt gttcaactgc
     1861 ttgcatgaac agtcacaaga caaaatatgc aaaatcacaa agtttgggaa ttatttgcca
     1921 tttttgtaag cgaaactctt tacctcaata ccaagccaca atgcctgatg gaaaactgta
     1981 taacttttgc aattccagtt gtgtggctaa atttcaggct ctaagcatgc agtcatctcc
     2041 aaatggccag tttgtagcac ccagtgatat tcagctgaaa tgcaactact gtaaaaattc
     2101 cttttgttca aaaccagaaa tcttggaatg ggagaacaaa gtgcatcagt tctgcagcaa
     2161 aacttgctca gatgactata agaagttgca ttgcatagtt acatattgcg aatactgcca
     2221 agaggagaag actctgcatg aaacagtaaa tttctctggc gttaagagac ctttctgtag
     2281 tgaaggctgc aagctattat acaaacaaga ttttgcaaga cgattaggat taagatgtgt
     2341 tacctgcaac tattgttctc agctgtgtaa gaagggagcc actaaagaac ttgatggagt
     2401 tgtcagagac ttctgcagtg aagactgctg taagaaattc caggagtggt actacaaggc
     2461 tgcgaggtgt gactgctgta aatcccaagg cactctgaaa gagcgagtgc agtggcgtgg
     2521 cgaaatgaaa catttctgtg atcagcactg cttactacgt ttctattgtc agcaaaatga
     2581 gcccaacatg acaactcaga aaggacctga aaacctacat tatgatcagg gctgtcagac
     2641 gtcccgaacc aaaatgacag gctcagcacc acccccttct cctacaccaa acaaagagat
     2701 gaagaataaa gcaattcttt gcaaaccttt aacaatgaca aaagcaactt actgtaagcc
     2761 tcacatgcag accaaatctt gtcagacaga tgagaattgg aagacagagt atgtcccagt
     2821 gcctattcct gtccctgtgt atgtccctgt gcctatgcac atgtacagcc agaatattcc
     2881 tgttccgacc acagttcctg ttcctgtgcc cgttcctgtg tttctgcctg ctccattgga
     2941 cagcagtgag aagattcctg ccacagttga ggacctcaaa agcaaagttt cttcagatcc
     3001 tcttgattca gaattgctta cgatgacaga tatgatgact gaagaggagg ggaaagcaga
     3061 ggcatccaac atcaatagtg taattattga gacagacata attggctcag atcttacaaa
     3121 gaactctgac ccagatatac aatccaacat gcccgatgta ccatatgaac cagatttgga
     3181 tattgaaata gatttcccca gagctgcaga ggagcttgat atggaaaatg agtttttatt
     3241 accacctgtt tttggagaag aatacgagga gcagcccaga cctcgatcta aaaaaaaggg
     3301 aaccaagagg aaggctgtat caggatacca gtctcatgat gatagttctg acaattcaga
     3361 atgcagcttt cctttcaagt atacatacgg tgtaaatgcg tggaaacatt gggtcaaaac
     3421 taggcaactt gatgaagatc ttctggtatt agatgagcta aaatcctcta aatcagtaaa
     3481 gttaaaagaa gatctactct ctcataccac agctgagctt aactatgggt tagcccattt
     3541 tgtcaatgag atcagacgac caaatggaga gaattatgca cctgacagca tctattatct
     3601 atgccttggt atacaggagt acttatgtgg tagtaatcga aaggacaaca tatttattga
     3661 tccaggatac cagatgtttg agcaagaact gaataaaata ctccgaagtt ggcaaccaag
     3721 catacttcca gatgggtcaa ttttctctcg agttgaagaa gactatctct ggaggataaa
     3781 acaactagga tcccactctc cagtagcact tttgaatacc ctattctact ttaacactaa
     3841 gtattttggc ctgaaaacag tggaacaaca cttaagactt tcctttggca ctgtgtttag
     3901 gcattggaaa aaaaatcctt taacaatgga aaataaagca tgtcttcgct atcaggtgtc
     3961 ttccttatgt ggaacagaca atgaagataa aattgctact ggaaaacgaa aacatgaaga
     4021 tgatgagcca gtatttgaac aagttgaaaa cacagccaac ccttctagat gtcctgtgaa
     4081 aatgtttgaa tgctacttgt ctaaaagtcc acagaacctt aatcagagaa tggatgtttt
     4141 ttatttacaa ccagaatgtt ctagttctac agatagccct gtctggtaca catctacttc
     4201 cctggaccgg aacaccttgg aaaatatgct tgtacgggtt cttctagtaa aagatattta
     4261 tgataaagac aattatgaac tggatgaaga cacagactaa aaaggaccat ttcagaagca
     4321 atgggataac acagcattag atagtcatgc tgctagatct ttacaggaaa acattttaag
     4381 tttactcctt ctgttctgag ttttgtagca atgtacccac actgggtatt accatgtaaa
     4441 taatctgtgt gtgaaagttg ccattattct atgtagtggt tttaggatac ttaacaaata
     4501 catcaaattc ttttttatta ttatttattt gattaggtat gtttgtaact ttttacatta
     4561 caaataagaa gagaatgtgc catgtataag tttttcttgt tgcactgctc tgctgttgca
     4621 aagctccctg cagagggcgg gctttatgcg ttcctgacca gatggttgtg tatgggtagc
     4681 actactcaag tttagaactt gcggtgtctt tcagaatttt taaaataaac tgtaaactaa
     4741 taggctgggt tttttgtttg tttgttttat gttttagtta ctgaagcctt agcaggttat
     4801 gtagagagat accatcttct gtaccaaaaa tagacaagag aatgctgttg atactggtgt
     4861 tctgtaatgt gaacttatgc tggtgaaaac aactttatgt tccccttatt aaaacttagt
     4921 gtccttttct cacttgtgac tttctgcatc accccatcaa tttaaggaaa aaaagtatgt
     4981 atatatgtgt aagtagagag agagagtgag agagagagag tgactataac ttgaaaacaa
     5041 gattaagaca tttttctttg taaaatgtcc ggcgacagtg taagactctt gtttttcttt
     5101 cccacggcag ccatcagcat ctgaggccct cacctgccag gtgtattaca gcttgcatag
     5161 cactctcgag tgtcaccact ctcgctggag gtcttgtgct gcttccagaa gtgacatgca
     5221 tatgtggggc agaattattt ttagaaatgc cactcttgaa atattcattt tagaaagtca
     5281 ggctacttga agggagacag tgtcacattg ttctatggct attaccaatg gagaatgctg
     5341 actagtccag gagactgaag aaacagaagc tggtggatgg tgccagtgcc agtgtcagag
     5401 gaaatcttgc ttgctactag gttgtttggc tttgaaattt aattacttct tatagaagat
     5461 tacatttaaa atacttttgt gcttctgcat agcagtttat ctgttcataa cttttagatt
     5521 aaggaaatct acttcaaatt atactttcta aagactgagt aaagtggtat ctgaaaatta
     5581 tcagttattt agctgacttt gtatatagca tgtgtgatgt ttccttctta tttctgaatc
     5641 ctgaaatcac catggtgata ctagttttca aaatagttct gagggaaatt gttttccata
     5701 gtgactagac agtatatagc ccttatcaat ttctctcttc tttagcataa attttagcaa
     5761 gtaaagaaat tttctcaatc atgattttga aaatttcaca ggtatagcta ctgctcgttt
     5821 aagcaataac tatctgaaat gtttttggca tgaaaattta tagtgttcta aatttttata
     5881 agtttgaata acttcagtcc cttggttttc tatttgaatc atcagactga tagtggcagc
     5941 tccatacttt actaagacag acctgcccct cgcctgttaa gtgaagctgg aaacacttaa
     6001 caacagaatg cagatgtttc ttggcttttc agcgcgcctt ctgaagcact tttactagaa
     6061 atgcatattg tgattaaaga ctggttaatc ctaaccatct tctattcttc agagtggtgc
     6121 tatagcccat caaaaaaaag caataaattt acccacaaat gtcacatgta tattttacca
     6181 ataccataaa tttctgccgt ggtactacta agcaccgtgt cttgctattt agtttttatt
     6241 gtttgtacat tttagctttt ctaagcagaa atgcctacag aagtttgatc gtacatgata
     6301 gaggatctag agcttgcctt tgtctcatgc aatccaatga ttgatctact tgattctcag
     6361 ggggaaagaa aaacaaacta ttttatgaga attgttctgg gaaatttatt tcacctggaa
     6421 cacatttcct tgattcttgg ctgtctttag tgtgtggcca taactaactg ctgagagaaa
     6481 ggacattgaa atgatagttt atttttattt cttggtgact tctgattata gacagcatcc
     6541 tgtaaatata actttattgt cttgagatgt ctattgaaga tactatattt ttctgttctg
     6601 aacgattttg ccacttaaaa tcgttcaatg aaaaagatga ctagctattc tgaggcaggt
     6661 ggatttccca tgcaaactga atccttaacg catttcaaaa ggcttttact gtattaggta
     6721 acatgagata ttaaaggatt tttctaggca aaaaaaaaaa aaaaaaa
//
