LOCUS       NP_083774               1376 aa            linear   ROD 03-JUN-2025
DEFINITION  zinc finger MYM-type protein 2 isoform 1 [Mus musculus].
ACCESSION   NP_083774 XP_006519728
VERSION     NP_083774.2
DBSOURCE    REFSEQ: accession NM_029498.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1376)
  AUTHORS   Dai,R., Yin,Y., Yu,M., Zhang,Y., Zhang,J., Liu,T., Fang,X., Wu,X.,
            Shen,Q. and Xu,H.
  TITLE     Genitourinary defects, anxiety and aggressive-like behavior and
            glucose metabolism disorders in Zmym2 mutant mice with inserted
            piggyBac transposon
  JOURNAL   Front Cell Dev Biol 13, 1523266 (2025)
   PUBMED   40313719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1376)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 1376)
  AUTHORS   Graham-Paquin,A.L., Saini,D., Sirois,J., Hossain,I., Katz,M.S.,
            Zhuang,Q.K., Kwon,S.Y., Yamanaka,Y., Bourque,G., Bouchard,M. and
            Pastor,W.A.
  TITLE     ZMYM2 is essential for methylation of germline genes and active
            transposons in embryonic development
  JOURNAL   Nucleic Acids Res 51 (14), 7314-7329 (2023)
   PUBMED   37395395
  REMARK    GeneRIF: ZMYM2 is essential for methylation of germline genes and
            active transposons in embryonic development.
REFERENCE   4  (residues 1 to 1376)
  AUTHORS   Ludtke,T.H., Kleppa,M.J., Rivera-Reyes,R., Qasrawi,F.,
            Connaughton,D.M., Shril,S., Hildebrandt,F. and Kispert,A.
  TITLE     Proteomic analysis identifies ZMYM2 as endogenous binding partner
            of TBX18 protein in 293 and A549 cells
  JOURNAL   Biochem J 479 (1), 91-109 (2022)
   PUBMED   34935912
REFERENCE   5  (residues 1 to 1376)
  AUTHORS   Connaughton,D.M., Dai,R., Owen,D.J., Marquez,J., Mann,N.,
            Graham-Paquin,A.L., Nakayama,M., Coyaud,E., Laurent,E.M.N.,
            St-Germain,J.R., Blok,L.S., Vino,A., Klambt,V., Deutsch,K.,
            Wu,C.W., Kolvenbach,C.M., Kause,F., Ottlewski,I., Schneider,R.,
            Kitzler,T.M., Majmundar,A.J., Buerger,F., Onuchic-Whitford,A.C.,
            Youying,M., Kolb,A., Salmanullah,D., Chen,E., van der Ven,A.T.,
            Rao,J., Ityel,H., Seltzsam,S., Rieke,J.M., Chen,J., Vivante,A.,
            Hwang,D.Y., Kohl,S., Dworschak,G.C., Hermle,T., Alders,M.,
            Bartolomaeus,T., Bauer,S.B., Baum,M.A., Brilstra,E.H.,
            Challman,T.D., Zyskind,J., Costin,C.E., Dipple,K.M., Duijkers,F.A.,
            Ferguson,M., Fitzpatrick,D.R., Fick,R., Glass,I.A., Hulick,P.J.,
            Kline,A.D., Krey,I., Kumar,S., Lu,W., Marco,E.J., Wentzensen,I.M.,
            Mefford,H.C., Platzer,K., Povolotskaya,I.S., Savatt,J.M.,
            Shcherbakova,N.V., Senguttuvan,P., Squire,A.E., Stein,D.R.,
            Thiffault,I., Voinova,V.Y., Somers,M.J.G., Ferguson,M.A.,
            Traum,A.Z., Daouk,G.H., Daga,A., Rodig,N.M., Terhal,P.A., van
            Binsbergen,E., Eid,L.A., Tasic,V., Rasouly,H.M., Lim,T.Y.,
            Ahram,D.F., Gharavi,A.G., Reutter,H.M., Rehm,H.L., MacArthur,D.G.,
            Lek,M., Laricchia,K.M., Lifton,R.P., Xu,H., Mane,S.M.,
            Sanna-Cherchi,S., Sharrocks,A.D., Raught,B., Fisher,S.E.,
            Bouchard,M., Khokha,M.K., Shril,S. and Hildebrandt,F.
  TITLE     Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic
            Urinary Tract Malformations
  JOURNAL   Am J Hum Genet 107 (4), 727-742 (2020)
   PUBMED   32891193
REFERENCE   6  (residues 1 to 1376)
  AUTHORS   ZeRuth,G.T., Williams,J.G., Cole,Y.C. and Jetten,A.M.
  TITLE     HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative
            Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity
  JOURNAL   PLoS One 10 (7), e0131303 (2015)
   PUBMED   26147758
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 1376)
  AUTHORS   Ren,M. and Cowell,J.K.
  TITLE     Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced
            T-cell lymphomas associated with atypical myeloproliferative
            disease
  JOURNAL   Blood 117 (25), 6837-6847 (2011)
   PUBMED   21527531
  REMARK    GeneRIF: The study demonstrates frequent, constitutive activation
            of Notch1 and its downstream target genes in T-cell lymphomas that
            arose in a murine model of Zmym2-Fgfr1 stem cell leukemia-lymphoma
            syndrome.
REFERENCE   8  (residues 1 to 1376)
  AUTHORS   Campbell,G.R., Baudhuin,A., Vranizan,K. and Ngai,J.
  TITLE     Transcription factors expressed in olfactory bulb local progenitor
            cells revealed by genome-wide transcriptome profiling
  JOURNAL   Mol Cell Neurosci 46 (2), 548-561 (2011)
   PUBMED   21194568
REFERENCE   9  (residues 1 to 1376)
  AUTHORS   Inoue,H., Nobuhisa,I., Okita,K., Takizawa,M., Pebusque,M.J. and
            Taga,T.
  TITLE     Negative regulation of hematopoiesis by the fused in
            myeloproliferative disorders gene product
  JOURNAL   Biochem Biophys Res Commun 313 (1), 125-128 (2004)
   PUBMED   14672707
REFERENCE   10 (residues 1 to 1376)
  AUTHORS   Warner,D.R., Roberts,E.A., Greene,R.M. and Pisano,M.M.
  TITLE     Identification of novel Smad binding proteins
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1185-1190 (2003)
   PUBMED   14651998
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ110016.1, AK135499.1,
            AK137720.1, CA536924.1, CV561457.1, AC154303.2, AV142652.2 and
            BE993957.1.
            
            On or before Feb 8, 2018 this sequence version replaced
            XP_006519728.1, NP_083774.1.
            
            Summary: This gene encodes a protein that contains nine MYM-type
            zinc finger motifs. Expression of this gene may mediate the
            inhibition of hematopoietic cell development during ontogeny, and
            the encoded protein may also play a role in transforming growth
            factor-beta signaling as a Smad binding protein. [provided by
            RefSeq, Feb 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.258645.1,
                                           SRR10223971.14771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1376
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.99 cM"
     Protein         1..1376
                     /product="zinc finger MYM-type protein 2 isoform 1"
                     /note="zinc finger protein 198; zinc finger MYM-type
                     protein 2"
                     /calculated_mol_wt=154511
     Region          30..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CU65.3)"
     Region          85..158
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CU65.3)"
     Region          269..304
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CU65.3)"
     Site            305
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBW7; propagated from
                     UniProtKB/Swiss-Prot (Q9CU65.3)"
     Region          326..362
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          367..408
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          419..455
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          461..501
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          530..569
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          633..670
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          721..757
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          763..798
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Site            837
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBW7; propagated from
                     UniProtKB/Swiss-Prot (Q9CU65.3)"
     Region          1027..1063
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CU65.3)"
     Site            1063
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9CU65.3)"
     Region          1191..1359
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     Site            1375
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9CU65.3)"
     CDS             1..1376
                     /gene="Zmym2"
                     /gene_synonym="5830413P05Rik; FIM; MYM; RAMP; SCLL;
                     Zfp198; Znf198"
                     /coded_by="NM_029498.4:170..4300"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS49506.1"
                     /db_xref="GeneID:76007"
                     /db_xref="MGI:MGI:1923257"
ORIGIN      
        1 mdtssvgtle ltdqtpvllg stamatsltn vgnsfsgppn plvsrsskfq nssveddddv
       61 vfiepvqppp ssaplvadqr pitftsskne elqgndpkil psskelapqk gsvsetivid
      121 deedmetnqg qeksssnfie rrpsetknrt ndvdfssstf srskvnagvs nsgittepds
      181 eiqianvttl etgvssvsdg qlestdgrdm nlmithvtsl hntslgdgsn glqssnfgvn
      241 iqtytpslts qtkagvgpfn pgrmnvagdv fqngesaphh npdswisqsa sfprnqkqqg
      301 vdslspvasl pkqifqpsnq qptkpvkvtc anckkplqkg qtayqrkgsa hlfcsttcls
      361 sfshkpapkk lcvmckkdit tmkgtivaqv dssesfqefc stsclslyed kqspakgaln
      421 ksrcticgkl teirhevsfk nmthklcsdh cfnryrmang limncceqcg eylpskgagn
      481 nvlvvdgqqk rfccqscvte ykqvgshpsf lkevrdhmqd sflmqpekyg klttctgcrt
      541 qcrffdmtqc igpngymepy cstacmnshk tkyaksqslg iichfckrns lpqyqatmpd
      601 gklynfcnss cvakfqalsm qsspngqfva psdiqlkcny cknsfcskpe ilewenkvhq
      661 fcsktcsddy kklhcivtyc eycqeektlh etvnfsgvkr pfcsegckll ykqdfarrlg
      721 lrcvtcnycs qlckkgatke ldgvvrdfcs edcckkfqew yykaarcdcc ksqgtlkerv
      781 qwrgemkhfc dqhcllrfyc qqnepnmttq kgpenlhydq gcqtsrtkmt gsapppsptp
      841 nkemknkail ckpltmtkat yckphmqtks cqtdenwkte yvpvpipvpv yvpvpmhmys
      901 qnipvpttvp vpvpvpvflp apldssekip atvedlkskv ssdpldsell tmtdmmteee
      961 gkaeasnins viietdiigs dltknsdpdi qsnmpdvpye pdldieidfp raaeeldmen
     1021 efllppvfge eyeeqprprs kkkgtkrkav sgyqshddss dnsecsfpfk ytygvnawkh
     1081 wvktrqlded llvldelkss ksvklkedll shttaelnyg lahfvneirr pngenyapds
     1141 iyylclgiqe ylcgsnrkdn ifidpgyqmf eqelnkilrs wqpsilpdgs ifsrveedyl
     1201 wrikqlgshs pvallntlfy fntkyfglkt veqhlrlsfg tvfrhwkknp ltmenkaclr
     1261 yqvsslcgtd nedkiatgkr kheddepvfe qventanpsr cpvkmfecyl skspqnlnqr
     1321 mdvfylqpec ssstdspvwy tstsldrntl enmlvrvllv kdiydkdnye ldedtd
//
