LOCUS       NM_172700               3398 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus zinc metallopeptidase, STE24 (Zmpste24), mRNA.
ACCESSION   NM_172700
VERSION     NM_172700.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3398)
  AUTHORS   Swahari,V., Nakamura,A., Hollville,E., Hung,Y.H., Kanke,M.,
            Kurtz,C.L., Caravia,X.M., Roiz-Valle,D., He,S., Krishnamurthy,J.,
            Kapoor,S., Prasad,V., Flowers,C., Beck,M., Baran-Gale,J.,
            Sharpless,N., Lopez-Otin,C., Sethupathy,P. and Deshmukh,M.
  TITLE     miR-29 is an important driver of aging-related phenotypes
  JOURNAL   Commun Biol 7 (1), 1055 (2024)
   PUBMED   39191864
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3398)
  AUTHORS   Li,Y., Cui,J., Liu,L., Hambright,W.S., Gan,Y., Zhang,Y., Ren,S.,
            Yue,X., Shao,L., Cui,Y., Huard,J., Mu,Y., Yao,Q. and Mu,X.
  TITLE     mtDNA release promotes cGAS-STING activation and accelerated aging
            of postmitotic muscle cells
  JOURNAL   Cell Death Dis 15 (7), 523 (2024)
   PUBMED   39039044
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3398)
  AUTHORS   Chen,Z., Chen,C., Yang,X., Zhou,Y., Cao,X., Han,C., Zhou,T.,
            Zhao,J. and Qin,A.
  TITLE     Dysfunction of STING Autophagy Degradation in Senescent Nucleus
            Pulposus Cells Accelerates Intervertebral Disc Degeneration
  JOURNAL   Int J Biol Sci 20 (7), 2370-2387 (2024)
   PUBMED   38725841
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3398)
  AUTHORS   Suo,J., Shao,R., Yang,R., Wang,J., Zhang,Z., Wang,D., Niu,N.,
            Zheng,X. and Zou,W.
  TITLE     Accelerated aging in articular cartilage by ZMPSTE24 deficiency
            leads to osteoarthritis with impaired metabolic signaling and
            epigenetic regulation
  JOURNAL   Cell Death Dis 14 (5), 336 (2023)
   PUBMED   37217512
  REMARK    GeneRIF: Accelerated aging in articular cartilage by ZMPSTE24
            deficiency leads to osteoarthritis with impaired metabolic
            signaling and epigenetic regulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3398)
  AUTHORS   Yue,X., Cui,J., Sun,Z., Liu,L., Li,Y., Shao,L., Feng,Q., Wang,Z.,
            Hambright,W.S., Cui,Y., Huard,J., Mu,Y. and Mu,X.
  TITLE     Nuclear softening mediated by Sun2 suppression delays mechanical
            stress-induced cellular senescence
  JOURNAL   Cell Death Discov 9 (1), 167 (2023)
   PUBMED   37198162
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3398)
  AUTHORS   Fong,L.G., Ng,J.K., Meta,M., Cote,N., Yang,S.H., Stewart,C.L.,
            Sullivan,T., Burghardt,A., Majumdar,S., Reue,K., Bergo,M.O. and
            Young,S.G.
  TITLE     Heterozygosity for Lmna deficiency eliminates the progeria-like
            phenotypes in Zmpste24-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 101 (52), 18111-18116 (2004)
   PUBMED   15608054
  REMARK    GeneRIF: the progeria-like phenotypes caused by the lack of
            Zmpste24 in knockout mice is eliminated by heterozygosity for Lmna
REFERENCE   7  (bases 1 to 3398)
  AUTHORS   Zeng,F. and Schultz,R.M.
  TITLE     Gene expression in mouse oocytes and preimplantation embryos: use
            of suppression subtractive hybridization to identify oocyte- and
            embryo-specific genes
  JOURNAL   Biol Reprod 68 (1), 31-39 (2003)
   PUBMED   12493692
REFERENCE   8  (bases 1 to 3398)
  AUTHORS   Bergo,M.O., Gavino,B., Ross,J., Schmidt,W.K., Hong,C.,
            Kendall,L.V., Mohr,A., Meta,M., Genant,H., Jiang,Y., Wisner,E.R.,
            Van Bruggen,N., Carano,R.A., Michaelis,S., Griffey,S.M. and
            Young,S.G.
  TITLE     Zmpste24 deficiency in mice causes spontaneous bone fractures,
            muscle weakness, and a prelamin A processing defect
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13049-13054 (2002)
   PUBMED   12235369
  REMARK    GeneRIF: Zmpste24 has a role in processing of prelamin A and lack
            of Zmpste24 results in a brittle bone phenotype
REFERENCE   9  (bases 1 to 3398)
  AUTHORS   Pendas,A.M., Zhou,Z., Cadinanos,J., Freije,J.M., Wang,J.,
            Hultenby,K., Astudillo,A., Wernerson,A., Rodriguez,F.,
            Tryggvason,K. and Lopez-Otin,C.
  TITLE     Defective prelamin A processing and muscular and adipocyte
            alterations in Zmpste24 metalloproteinase-deficient mice
  JOURNAL   Nat Genet 31 (1), 94-99 (2002)
   PUBMED   11923874
  REMARK    GeneRIF: Defective prelamin A processing and muscular and adipocyte
            alterations in Zmpste24 metalloproteinase-deficient mice.
REFERENCE   10 (bases 1 to 3398)
  AUTHORS   Leung,G.K., Schmidt,W.K., Bergo,M.O., Gavino,B., Wong,D.H., Tam,A.,
            Ashby,M.N., Michaelis,S. and Young,S.G.
  TITLE     Biochemical studies of Zmpste24-deficient mice
  JOURNAL   J Biol Chem 276 (31), 29051-29058 (2001)
   PUBMED   11399759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669949.11.
            
            On May 8, 2018 this sequence version replaced NM_172700.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023740.1, AK083566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               AL669949.11        78999-79332         c
            335-481             AL669949.11        76674-76820         c
            482-568             AL669949.11        68431-68517         c
            569-685             AL669949.11        64431-64547         c
            686-838             AL669949.11        63943-64095         c
            839-980             AL669949.11        62294-62435         c
            981-1165            AL669949.11        55595-55779         c
            1166-1270           AL669949.11        49832-49936         c
            1271-1414           AL669949.11        46936-47079         c
            1415-3398           AL669949.11        40359-42342         c
FEATURES             Location/Qualifiers
     source          1..3398
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 56.8 cM"
     gene            1..3398
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /note="zinc metallopeptidase, STE24"
                     /db_xref="GeneID:230709"
                     /db_xref="MGI:MGI:1890508"
     exon            1..334
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1639
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /EC_number="3.4.24.84"
                     /note="farnesylated-proteins converting enzyme 1; zinc
                     metallopeptidase, STE24 homolog; prenyl protein-specific
                     endoprotease 1; zinc metalloproteinase, STE24 homolog"
                     /codon_start=1
                     /product="CAAX prenyl protease 1 homolog"
                     /protein_id="NP_766288.1"
                     /db_xref="CCDS:CCDS18600.1"
                     /db_xref="GeneID:230709"
                     /db_xref="MGI:MGI:1890508"
                     /translation="MGMWASVDAMWDFPAEKRIFGAVLLFSWTVYLWETFLAQRQRRI
                     YKTTTRVPAELEQIMDSDTFEKSRLYQLDKSTFSFWSGLYSEVEGTFILLFGGIPYLW
                     RLSGQFCSSAGFGPEYEIIQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNHQTL
                     EFFMKDAIKKFIVTQCILLPVSALLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADY
                     IAPLFDKFTPLPEGKLKQEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKR
                     IVLFDTLLEEYSVPNKDNQEESGMEARNEGEGDSEEVKAKVKNKKQGCKNEEVLAVLG
                     HELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRRELFAAFGFYDSQPTLIGLLIIF
                     QFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDW
                     LFSTWHYSHPPLLERLQALKNAKQD"
     exon            335..481
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /inference="alignment:Splign:2.1.0"
     exon            482..568
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /inference="alignment:Splign:2.1.0"
     exon            569..685
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /inference="alignment:Splign:2.1.0"
     exon            686..838
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /inference="alignment:Splign:2.1.0"
     exon            839..980
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1165
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1270
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1414
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..3398
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3374..3379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /note="hexamer: ATTAAA"
     polyA_site      3398
                     /gene="Zmpste24"
                     /gene_synonym="A530043O15Rik; D030046F19; Face-1; FACE1;
                     MADB; STE24; Ste24p"
                     /note="major polyA site"
ORIGIN      
        1 gtcttattct agcagaaata agtaggtcct tgaagagtaa ggctggaggg aatcgtgtct
       61 ttgtgacact tctggcaaag ctgagggaat gggcgtctga agaagccctc ggaagggacc
      121 cgtattgttg tgacaccgct ggcactctcc gagggacgcg tgtcgctgag gcaccggtgc
      181 acgctaaagg agcgggtgag atagggtgac gatggggatg tgggcatcgg tggacgctat
      241 gtgggacttc cctgcggaga agcgaatctt cggggcggtg ttgctctttt cctggacggt
      301 gtatctttgg gagaccttcc tagcacagcg gcagagaagg atatacaaaa cgacgactcg
      361 cgtaccagca gagttagaac agatcatgga ttcggacacg tttgagaaat ctcgattgta
      421 tcaactggat aaaagtacct tcagcttctg gtcaggactc tactcagagg tggaaggcac
      481 ttttattctt ctctttggag gaatccctta cctctggaga ctttctgggc agttctgtag
      541 ttctgctggc tttggaccag aatacgagat cattcagtca ttggtgttcc tgctgttggc
      601 cacactcttc agtgcactga ctggcttgcc ctggagtctg tacaatactt ttgtaataga
      661 agaaaagcat ggcttcaatc accagacttt ggagtttttt atgaaagatg caatcaaaaa
      721 atttattgtg actcaatgta ttttattgcc tgtgtctgcc cttctgcttt acattattaa
      781 aattggaggt gactactttt ttatatatgc ctggctgttc acattagttg tttctctggt
      841 tcttgtcacc atttatgctg actatattgc ccctctgttt gacaaattca cacctctacc
      901 ggagggaaag cttaagcagg aaattgaagt gatggcaaag agtattgact tccctttgac
      961 taaggtgtat gttgttgaag gatctaagcg ttcctcccac agcaatgctt acttttatgg
     1021 cttcttcaag aacaagagaa tagttttgtt tgacactcta ctagaagagt actctgtacc
     1081 aaacaaagac aaccaggagg agtctggcat ggaagcccgc aatgaaggtg aaggggacag
     1141 tgaagaagta aaagctaaag tgaaaaataa gaaacaaggt tgtaaaaatg aggaggtact
     1201 ggctgtgctt ggccatgaac tgggacactg gaagttggga cacacagtaa aaaatatcat
     1261 tattagtcag atgaattctt tcctgtgttt tttcttgttt gctgtattaa ttggtcgaag
     1321 ggaacttttt gccgcctttg gtttttatga cagccaaccc actctgatcg gactcttgat
     1381 catctttcag tttattttct caccttacaa tgaggttctg tctttctgcc taacagtcct
     1441 gagccgcaga tttgaatttc aagctgatgc gtttgccaag aaacttggga aggctaaaga
     1501 cttatattct gctttgatca agctgaacaa agataacctg ggattcccgg tttctgactg
     1561 gttgttttca acatggcact attcacaccc tccgcttcta gagaggcttc aggctctgaa
     1621 aaatgcaaaa caagactgag ccactcaggc cccatgactg gatgctcttc cggttattct
     1681 gtcctggcag catgttccgg ctcttgatgt ttttaatttt tttaagaaaa atgattacgt
     1741 acataaaagt ccagatttaa atacatttac tatctcattt caaaaatgat tttaataatc
     1801 catttcttaa aacactggat aaaattttga ggcttaatat ttttaaagca tagttttatc
     1861 tagtatctta tttatcatca atttgtaaaa tggtttaagg aaatgcacaa cttgttttat
     1921 ttctgcacta tgtggaatct gcatagaggg ttttaggtca taagttcaaa ggtggaagca
     1981 tcacctccaa gcactttttg caaagcagaa acagagtggt cccaaaccac tgcgctgtac
     2041 ctacatggaa tttgttttta cctacgtgtt gttataattt agcccagcca atcagtgttt
     2101 taaataagga agaaaagtaa aaattagtaa ggctaatgct actgaaatga gttgttaggc
     2161 atgctatact gtcatagtta caaagcattc tgttctcttt cttgccacac caatcaggaa
     2221 ttccctccct ccttcctctc tcctttcctt ttttttccct aacataagat ctcactctag
     2281 tccttgctgg ccccaaattc attctttagc acaaggtggc ctagaacctg tatcaggcct
     2341 cctgcctcag tcttcctaat gttgggattg cagttgtgag ctgccacata tcgcttagga
     2401 attgttaata gtgcttgaaa ttagaaacct tttaaatcat tgactttggg tttgctttta
     2461 agaaggtctt aattttaaac caggcttggt agcacttaca tttaatctca gcaactgagg
     2521 cagaggcaga tggacctgtg agctaaggcc aagcctggtc gacatagcaa gttccaggcc
     2581 agtcaaactg gggtcttaaa ggtggtagag taaaagtcca tctcggtttt tatttaccct
     2641 cccttccatc gatcttatta taagtaaact agccttttct cattcatttt ttcccagtaa
     2701 ataatagtat atcctttaac tcagctgaaa ttgccatatt gtatacatct cccaatgtta
     2761 attatggcag aatataaaaa aaaagagggg ataacatttg aaaagacata aaggtgaaat
     2821 attcatgatt ctcttattac aggaaaatat agttttctat cttttttcaa ggacagaagt
     2881 ctctactttt atttttgtaa ttttttattc acaaatcata agtagaccag attccatttt
     2941 ttaaaaatta taattcttgg taggcaggca gatgttgact tgcagagaaa gcgccataaa
     3001 agatttccag tgggaaaagg tatgtgcttg actgcttcaa atgtctgtcc acgtcctaag
     3061 tgagagtcct gctgcgcctg ccacgcccag tcactggtag cgagtgcctc ctgggcattc
     3121 agtccacagt gtaatcgact ctacactatg gcatctgcac tctgctgaca agtgacaagg
     3181 catctgcgat gccttcacat ggaccatagt agcgtcagct cacactcagc actgcattgt
     3241 ttatttccta cagctacgca gagcagccca cggtttctct ccagcaccct ttcctgtgac
     3301 ttcatgctca gataactgcc tttccttcct tctgtgcctt taaaaacata tttcagttct
     3361 gcacaagtga gacattaaaa attgccaatg cagattta
//
