LOCUS       NM_001310666            7516 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus zinc finger, MIZ-type containing 1 (Zmiz1), transcript
            variant 2, mRNA.
ACCESSION   NM_001310666 XM_006519133
VERSION     NM_001310666.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7516)
  AUTHORS   K,C. R, Patel,N.R., Shenoy,A., Scallan,J.P., Chiang,M.Y.,
            Galazo,M.J. and Meadows,S.M.
  TITLE     Zmiz1 is a novel regulator of lymphatic endothelial cell gene
            expression and function
  JOURNAL   PLoS One 19 (5), e0302926 (2024)
   PUBMED   38718095
  REMARK    GeneRIF: Zmiz1 is a novel regulator of lymphatic endothelial cell
            gene expression and function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7516)
  AUTHORS   K,C. R, Tiemroth,A.S., Thurmon,A.N., Meadows,S.M. and Galazo,M.J.
  TITLE     Zmiz1 is a novel regulator of brain development associated with
            autism and intellectual disability
  JOURNAL   Front Psychiatry 15, 1375492 (2024)
   PUBMED   38686122
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7516)
  AUTHORS   Alghamdi,T.A., Krentz,N.A.J., Smith,N., Spigelman,A.F., Rajesh,V.,
            Jha,A., Ferdaoussi,M., Suzuki,K., Yang,J., Manning Fox,J.E.,
            Sun,H., Sun,Z., Gloyn,A.L. and MacDonald,P.E.
  TITLE     Zmiz1 is required for mature beta-cell function and mass expansion
            upon high fat feeding
  JOURNAL   Mol Metab 66, 101621 (2022)
   PUBMED   36307047
  REMARK    GeneRIF: Zmiz1 is required for mature beta-cell function and mass
            expansion upon high fat feeding.
REFERENCE   4  (bases 1 to 7516)
  AUTHORS   Wang,Q., Yan,R., Pinnell,N., McCarter,A.C., Oh,Y., Liu,Y., Sha,C.,
            Garber,N.F., Chen,Y., Wu,Q., Ku,C.J., Tran,I., Serna Alarcon,A.,
            Kuick,R., Engel,J.D., Maillard,I., Cierpicki,T. and Chiang,M.Y.
  TITLE     Stage-specific roles for Zmiz1 in Notch-dependent steps of early
            T-cell development
  JOURNAL   Blood 132 (12), 1279-1292 (2018)
   PUBMED   30076146
  REMARK    GeneRIF: Zmiz1 is a context-specific cofactor for Notch1 during
            Notch/Myc-dependent thymocyte proliferation, whether normal or
            malignant.
REFERENCE   5  (bases 1 to 7516)
  AUTHORS   Galazo,M.J., Emsley,J.G. and Macklis,J.D.
  TITLE     Corticothalamic Projection Neuron Development beyond Subtype
            Specification: Fog2 and Intersectional Controls Regulate Intraclass
            Neuronal Diversity
  JOURNAL   Neuron 91 (1), 90-106 (2016)
   PUBMED   27321927
REFERENCE   6  (bases 1 to 7516)
  AUTHORS   Li,X., Thyssen,G., Beliakoff,J. and Sun,Z.
  TITLE     The novel PIAS-like protein hZimp10 enhances Smad transcriptional
            activity
  JOURNAL   J Biol Chem 281 (33), 23748-23756 (2006)
   PUBMED   16777850
  REMARK    GeneRIF: A physiological role for Zimp10 in regulating
            Smad3/4-mediated transcription is demonstrated in mouse embryonic
            fibroblasts.
REFERENCE   7  (bases 1 to 7516)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   8  (bases 1 to 7516)
  AUTHORS   Tarunina,M., Alger,L., Chu,G., Munger,K., Gudkov,A. and Jat,P.S.
  TITLE     Functional genetic screen for genes involved in senescence: role of
            Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in
            senescence and cell survival
  JOURNAL   Mol Cell Biol 24 (24), 10792-10801 (2004)
   PUBMED   15572682
REFERENCE   9  (bases 1 to 7516)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   10 (bases 1 to 7516)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138053.1, BC058646.1, BU059092.1, AK132106.1 and BQ748452.1.
            
            On Jul 17, 2015 this sequence version replaced XM_006519133.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (2) has the same N- and C-termini, but is shorter
            than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AK138053.1         1-82
            83-5479             BC058646.1         1-5397
            5480-5792           BU059092.1         52-364
            5793-7501           AK132106.1         1-1709
            7502-7516           BQ748452.1         471-485
FEATURES             Location/Qualifiers
     source          1..7516
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 15.03 cM"
     gene            1..7516
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /note="zinc finger, MIZ-type containing 1"
                     /db_xref="GeneID:328365"
                     /db_xref="MGI:MGI:3040693"
     exon            1..372
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            373..477
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            478..557
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            558..666
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     CDS             607..3807
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /note="isoform 2 is encoded by transcript variant 2;
                     retinoic acid induced 17; zinc finger MIZ
                     domain-containing protein 1; PIAS-like protein Zimp10;
                     retinoic acid-induced protein 17"
                     /codon_start=1
                     /product="zinc finger MIZ domain-containing protein 1
                     isoform 2"
                     /protein_id="NP_001297595.1"
                     /db_xref="CCDS:CCDS79280.1"
                     /db_xref="GeneID:328365"
                     /db_xref="MGI:MGI:3040693"
                     /translation="MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRA
                     FQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEE
                     LGRLLLLRHQKSRQNDPPGKLPMQPPLSSMSSMKPTLSHSDGSFPYDSVPWQQNTNQP
                     PGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMSTSNPGINSPQFAG
                     QQQQFSTKAGPAQPYIQPNMYGRPGYPGSGGFGASYPGGPSAPAGMGIPPHTRPPADF
                     TQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPMGPTQAYNSQFMNQP
                     GPRGPASMGGSLNPAGMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPG
                     PRPQSLPIQSIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPTPNPPRPLTSPNYPGQRM
                     PSQPSTGQYPPPTVNMGQYYKPEQFNGQNNTFSSGSSYSSYSQGSVNRPPRPVPVANY
                     PHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLT
                     FPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTN
                     WPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQL
                     VHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVS
                     LKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQ
                     YMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIM
                     PNVMEMIAALGPGPSPYPLPPPPGGTSSNDYSSQGNNYQGHGNFDFPHGNPGGTSMND
                     FMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQ
                     AGPPLHHSGAPPPSQPPRQPPQAAPGNHPHSDLTFNPSSALEGQAGAQGASDMPEPSL
                     DLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN"
     exon            667..780
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            781..886
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1031
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1146
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1364
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1563
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1836
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2019
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2100
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2275
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2417
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2628
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2734
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2895
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..2963
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3032
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            3033..3277
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3444
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3699
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..7503
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7334..7339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /note="hexamer: AATAAA"
     polyA_site      7362
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /note="major polyA site"
     regulatory      7483..7488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /note="hexamer: AATAAA"
     polyA_site      7503
                     /gene="Zmiz1"
                     /gene_synonym="E330020C23; Gm10397; I920194n01; Rai17;
                     Zimp10"
                     /note="major polyA site"
ORIGIN      
        1 tttggaaata gaatagccaa tgtaatctga cacttcaact tgctcggctc cgggcgagtt
       61 gattcactta ctcaccccct aacgccgagt tccttttcac tgtctgtgga cattaaaaaa
      121 gcgagcggcg gcggcggcgg gcgcccggga gagcaagctg ccggccgggc gagcagcgat
      181 ccggctgcag agcaagcgag cagcgcccgc gcagcgcgct gaccctagcc ccggccggtg
      241 aggagccgga gccggagtcg gagccgagtg gatttccgcg ctctcgctgc gctcctcccg
      301 gctccagcct gccctacacg gcggtggcgg cggcgcgtcc tccagcggtg gcagtggtgc
      361 tcgcagcgcc cggactcaga cagcatagaa tctactcagc atctccttcg ccacagcctc
      421 ccttccccaa catcacatta gccttgagtt gtgatcgact ggcaggagcc ctagcaggag
      481 gatggacctt gagtgaagtg gaagagctgt gagtggctgg ccagcgcagg aacactagtg
      541 tctctcggct cactgaggct ggaccacgtt catggctctc gggtaggacc cagcgaaacg
      601 gccagaatga attctatgga caggcacatc cagcagacca atgaccgtct gcagtgcatc
      661 aagcagcact tacagaaccc cgccaacttc cacaatgctg ctacagagct gctggattgg
      721 tgtggagacc ctcgagcctt ccagaggccc tttgagcaga gcctcatggg ctgcctgacg
      781 gttgtcagcc gtgtggctgc ccaacaaggg tttgacctgg acctgggcta cagactcttg
      841 gctgtgtgcg ccgcaaatcg agacaagttc acccccaagt ctgctgccct gctgtcctcc
      901 tggtgtgaag aacttggccg cctgctgctg ctgcgacatc agaagagccg ccagaacgac
      961 ccccctggga aactgcccat gcagcccccc ctcagctcca tgagctccat gaaacccact
     1021 ctgtcgcaca gtgatgggtc atttccttat gactctgtcc cttggcagca gaacaccaat
     1081 cagcctcccg gctccctctc cgtggtcacc acggtgtggg gagtgaccaa cacatcccag
     1141 agtcaggtcc tcgggaaccc tatggccaat gccaacaacc ctatgaatcc aggtggcaac
     1201 cccatggcat caggcatgag caccagcaac cccggcatca actccccaca gttcgcaggg
     1261 caacagcaac agttctccac caaagctggc cctgcacagc cctatatcca gcccaacatg
     1321 tacggccgac ctggctaccc tggtagcggg ggctttgggg ccagttaccc tgggggtcct
     1381 agtgccccag caggcatggg catccctcca catactcggc ctcctgctga cttcacccag
     1441 ccagcggccg ctgctgcagc agctgcagta gcagccgccg ctgccacagc cacagccaca
     1501 gccacagcta cagtggcagc cttgcaagag acacagaaca aggatataaa ccagtatgga
     1561 ccgatgggtc ccacccaggc gtataacagc caattcatga accaacccgg gcctcggggg
     1621 cctgcctcca tggggggcag cctgaaccct gccggcatgg cagctggcat gacaccctcg
     1681 ggcatgagcg gccctcccat gggcatgaac cagccccgac cacccggcat cagccccttt
     1741 ggcacacacg ggcaaaggat gccccagcag acctacccag gcccccggcc ccagtccctt
     1801 cctattcaga gcataaagag gccatacccg ggagagccca actatggaaa ccagcaatat
     1861 ggaccaaaca gccagttccc cacccagcca ggccagtacc ctacccctaa ccccccaagg
     1921 ccactcacat ctcccaacta ccctggacaa aggatgccga gccaacccag caccggacag
     1981 tacccacccc ccacagtcaa catggggcag tattacaagc cagaacagtt taatggacag
     2041 aacaacacct tctcctccgg aagcagctac agcagctaca gccaagggag cgtcaacagg
     2101 cctcccaggc cggttcctgt ggcgaattac ccccactcac ctgttccagg gaaccccact
     2161 ccccccatga cgcccgggag cagcatacct ccctatctgt cccccagcca agatgtcaaa
     2221 ccacctttcc cacctgatat caagccaaat atgagtgctc tgccaccacc cccagccaac
     2281 cacaatgacg agctacggct cacattcccc gtgcgggatg gcgtggttct ggagcccttc
     2341 cgcctggagc acaaccttgc cgtcagcaac cacgtgttcc acctgcggcc cacggttcat
     2401 cagacgctga tgtggaggtc agacctggag ctgcagttca agtgctacca ccatgaagat
     2461 cgacagatga acaccaactg gccagcctcg gttcaggtca gcgtcaacgc cacacccctc
     2521 acgatcgagc ggggagacaa caagacctcc cacaagcccc tgcacctcaa gcatgtatgc
     2581 cagcctggcc ggaacaccat ccagatcact gtcaccgcct gctgctgttc ccacctcttt
     2641 gtgctgcagc tggtacaccg gccctctgtg cgctccgtgc tgcagggcct cctcaagaag
     2701 cgcctactgc ccgctgagca ctgcatcacg aaaatcaagc ggaatttcag cagtgtggct
     2761 gcctcctcgg gcaacacaac tctcaatggg gaggatggcg tggagcagac cgccatcaag
     2821 gtgtctctga agtgccccat cacattccgg cgcatacagc tgcctgctcg aggccacgat
     2881 tgcaagcatg tgcagtgctt tgacctggag tcatacctcc aactgaattg tgagcgaggg
     2941 acctggaggt gtcccgtgtg caataaaact gctctgctcg agggtctgga agtggatcag
     3001 tacatgtggg ggatcctgaa cgccatccaa cactccgagt ttgaagaggt caccattgac
     3061 cccacgtgca gctggcggcc agtacccatc aagtcagacc tccacatcaa ggatgacccc
     3121 gatggcatcc cctcaaagcg gttcaaaacc atgagcccca gccagatgat catgcccaat
     3181 gtcatggaga tgatcgccgc tctgggccct ggcccgtctc cctaccccct cccacctcct
     3241 cctgggggca ccagctccaa cgactacagc agccaaggaa acaactacca gggtcatggc
     3301 aactttgact tcccccatgg gaatcccgga gggacatcca tgaacgactt catgcacggt
     3361 cccccccagc tctcgcaccc accggacatg cccaacaaca tggccgccct cgagaaaccc
     3421 ctcagtcacc ccatgcagga aactatgccc cacgctggca gttctgacca gccccatccc
     3481 tccatacaac aaggtttgca cgtaccacac cccagcagcc aggcagggcc tccattacat
     3541 cacagtgggg ctcctcctcc ttcccagcct ccccggcagc caccacaggc cgctcccggc
     3601 aaccatccac acagcgacct gacctttaac ccctcctcag ccttagaggg tcaggccgga
     3661 gcacagggag catccgacat gccggaacct tcactggatc tactgccgga actcacaaac
     3721 ccggatgagc ttctttccta cctggacccc cccgaccttc caagcaatag caacgatgac
     3781 ctcctgtctc tctttgagaa caactgaagg ccactctcca ctggggccat ccctccccac
     3841 tctgcctcct accccatctg tcccacatcc tattcctccc aggagcccat gctcaggcct
     3901 cccacaccag gacctcaggc tgagagctga gcagagcaca ctaggcaggg aaagccatgt
     3961 gggtctccag tcctgtttgc ctgaatgctc tgggatctat gcctagagca agcctgaaga
     4021 cggcccctgg aagacaaacc caagctgagg gaatccaggc ccagcaagag acatgccaat
     4081 ggcgactgta ggtccctcca tgtgtgctga ctccagacaa ccgaccttcc agtgtcccaa
     4141 agttcttcca tgtttttaaa ccttatcccc gcctcttggc ccagagcctc cttcagatga
     4201 ctggaacccg aaagaagcct gtgctccggc ccccaggcca gggtagtgga caagccttgg
     4261 aggagtggtg acagtttgca gcagtgagga aggacacgca cacacacaca cacacaccac
     4321 agaaaagcac aaccctctgg ggaggagacc atccctcaag gccgggggtc gtggctttgg
     4381 cctctgactt ctaagccaag atgccctgta aacactctct cagcagaaca aggacaaagt
     4441 gccgtgtctg agagagagtg ccacaccttg tagggactgg caggaaacag gtcagggcct
     4501 tccccagagc caagacaatg cagaggaggg ctccttaact cagaccaggg ccatgccttg
     4561 cggggagcag agagtgtgtg caccacacca aagggagccc tccgttagtt agaggccaga
     4621 ggacgatgcc agccagagcc ccacagaagc agccagggcc ttgcagcttt gccccaagcc
     4681 aatccctgct tttaaatgac ccgcagcggg gagctctgaa gaaggagctc tgaaggaaag
     4741 gaacattgta tctggacagc aagcaagcca tttcccccca tgttctcttt ccttcctcct
     4801 acccatactt ccttctctga gactattcca tgggacccac ttccctctgg gttctccttt
     4861 ccccagacag ctgtaggggc acatggtagg gaagcagcat aggcccccag ggaaacgact
     4921 ccacagcagg gccttcatgg atctccaagt ctctcagtct ggtccagcag gttctctgct
     4981 caaagctgcc tgtctccagc ccagaccttt gctgggtgca ccagagcatc tcagcaggca
     5041 ggcattttgt ggcatttatg gcctgtcact ccctgtattt ctccctccat ccagagctcg
     5101 ctccacactc ctgctcaccc agcaagtgca gcctctggcc ctcctctgct ttttcactcc
     5161 atccagctta gagtcccctg ctggcttgtc actcgcctgc tttgtgccag gctggtctgt
     5221 gtccccctga gcctcatggc ctacggtgat gcctgtggtg atgccaggtt gtccgctcac
     5281 atgagtccca tctgtaaatt ctttgctccc ttctccgatg ctgccaccca aggccttctc
     5341 ctgcctcctg tccactgcca gcgtcctcat ttgtcatcgg tcattagcct ccctctgtgc
     5401 tccctggcac tcttaatata gattgaacca gaaaggtgac ccctagctgt tgacttattg
     5461 tcaccctaaa aaaaaaaaag gcacaaggaa agctgccacc tccccacccc tcctcttcct
     5521 ttgtcctgtt gttaaggttt tttcaagcag tgtgttcagt atgcaaatca attattttaa
     5581 gaatcgcttt tgtaaatatc tttgtgaata ttttagtatt gtctttgata atattcaaca
     5641 ttttcatgac ctggttatag cctttgctgg tgtttttaaa atatcttgac tcagtgacaa
     5701 aacccgagtc cttttttaaa aaaacaaaaa caaacaacaa aaacaaacaa aaaccaacca
     5761 gggctatttg tacagatgag agaggagcag aagaggcggc tgtgctcgag ttgagagacc
     5821 aggcaaccca ctgttgagaa ccactctcag tcagctggta gggacattac accaggtacc
     5881 ccgtggctat ccctacccag tgtcggtggc ccggcacagg gccgtgctct gtcggactgt
     5941 acggattgtt cagcttcaga ctgacaaatg cctttctcac aagttcctgc ttcttgccgt
     6001 gatactgtgc cccagaacag cctggggtcc ctgctagttc ctgtcaaggc atgcccaggt
     6061 tctccacagc tttccagtgc aaaaggccta gacactccca gtagcccagc ctctctggtc
     6121 atctctccgt tcacacccga ggctacacct gaggctgatt tcctaaggct ccctcccagg
     6181 caagtgccca ccagcaagtt caccacagag cctgaagccc acactccgga aatgtctcct
     6241 tccagagaaa tgttggagcc gatccagggt ttgagagagc tacaaagaca tcgggggctg
     6301 gagccatgcc ttggtagtga cagacgcagg taaaggtgac atccataaac agaggcaggc
     6361 ctaggctctg gaaagatcct cagtcctttc ttacaacaac ttggagccat agtaacctcc
     6421 gaaatgaggt ctcagcaagc cactttacca caacgagcaa cccacccata ggcacgtacc
     6481 agccgccact cagctaagcg gctgggctgg gagagagcat gcgcagatgg gaaaggcccc
     6541 gccccccgca caggcgatca ccctcatctt cttggtttga agctttattc atgtctcacg
     6601 tatcctgtag ccattttatt ttttaaaaga ttcctaacac tttctcccta acggaagccc
     6661 taaatcccag agagctacag gtctgctccc catgggccct cgggcctgac caatccagac
     6721 gaggcagaga gcagcagcga ctcaagggcc gtgtgtacat atgtaaatga gaaatagaca
     6781 tgtcaacaag atacattcat ttctcccgga atgtgtattg tttttatttt acaaaacaga
     6841 gaaacaacaa aaggcttgga actccttcat tctacgtgga atactagatc ccgtttgtta
     6901 gccttcgtga ctccgtcctt gtctcctgta atatactgac cctgtgtgca gaggcgtttt
     6961 tgttcccttt tgtttttatt tttacctaca tgtactattt accttctgtg tcctggccct
     7021 gccacctgtg tatttttagg gtgctatgga aacaatgaag agaaacgggg atttcagaag
     7081 aaaattgtaa ccaaattcat atactttgta taagtttttg atatcatgat cacaggtgat
     7141 tcacacgtac acacatccac acccacacgt gcagcctgaa gtgacgtcca cagaacccgc
     7201 ccttgtcttt gtacatcgta tgtacactgc aatcatttca tacttttgac tggtcagaaa
     7261 aaaaaaacta attgtgattt ctagtcttgc aaagctgtat gcagttagat gatgtgacct
     7321 ctaatattta tctaataaat atgtattcag atgaaacctg tatattaggt gttcatgtgg
     7381 ttattttgta tttaaagatc aaattatttg attattgcta gacatttcta tactctgttg
     7441 taacactgag gtatctcatt tgctcatgtt aatttttttc taaataaatg gacaaaaaat
     7501 gaaaaaaaaa aaaaaa
//
